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7005501 |
Purified mammalian cytokines; related reagents and methods
CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
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6998476 |
Nucleic acids encoding antagonists of interleukin-15
Disclosure herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
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6955807 |
IL-2 selective agonists and antagonists
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or...
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6936440 |
Selecting ligand agonists and antagonists
We have discovered that growth hormones from ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to...
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6927043 |
Interleukin-2 mutein expressed from mammalian cells
Glycosylated interleukin-2 muteins are described. A method of producing the muteins using mammalian cells is included. The muteins may be incorporated into pharmaceutical preparations useful for,...
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6891086 |
Plastid transformation of Brassica
A method is provided for transforming Brassica plants to express DNA sequences of interest from the plant cell plastid. The method allows the transformation of Brassica plant tissue with...
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6884603 |
Nucleic acids encoding IL13 mutants
This invention provides nucleic acid molecules encoding mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13...
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6843987 |
Mammalian cytokines; receptors; related reagents and methods
Nucleic acids encoding mammalian, e.g., rodent, IL-1δ, IL-1ε, purified IL-1δ and IL-1ε proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
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6825334 |
Peptides of IL-2 and derivatives thereof and their use as therapeutic agents
The present invention relates to new peptides of IL-2, derivatives thereof, and their use as therapeutic agents.
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6808902 |
Process for correction of a disulfide misfold in IL-1ra FC fusion molecules
The present invention concerns a process by which a misfold in an Fc fusion molecule can be prevented or corrected. In one embodiment, the process comprises (a) preparing a pharmacologically active...
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6753167 |
Preparation of heterologous proteins on oil bodies
The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the...
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6686178 |
Cytokine zalpha11 ligand polynucleotides
The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the...
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6680380 |
Nucleic acids encoding mammalian interleukin-1&zgr , related reagents and methods
Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided....
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6664077 |
DNA encoding ACPL
The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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6656462 |
Interleukin-1 muteins useful as vaccine adjuvants
The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example,...
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6649375 |
Adenoviral vectors for enhanced gene expression
An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount...
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6630576 |
Amino acid substitution mutants of interleukin 13
This invention provides mutant hIL13 molecules include those made by substituting one or more of the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other...
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6600020 |
Canine interleukin 18 polypeptide
The present invention relates to canine interleukin 18 and an interleukin 18 production method.
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6596853 |
DNA encoding peptides of IL-2
The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of...
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6583270 |
Interleukin-19
The present invention concerns a novel human cytokine. In particular, isolated nucleic acid molecules are provided encoding interleukin-19 (IL-19). IL-19 polypeptides are also provided, as are...
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6569645 |
IL-17 homologous polypeptides and therapeutic uses thereof
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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6562578 |
IL-17-like cytokine binding compounds and antibodies
IL-17-like cytokines from mammals, reagents and diagnostic kits related thereto including purified proteins, specific antibodies, and nucleic acids are provided. Methods of using the reagents and...
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6559298 |
Polypeptides that bind interleukin-18 (IL-18)
Disclosed are a polypeptide (including that in soluble form) as receptor for a novel cytokine, i.e., interleukin-18, a DNA encoding the polypeptide, and the uses of the polypeptide including...
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6555324 |
Method to distinguish hematopoietic progenitor cells
The expression of various cell adhesion molecules and growth factor receptor was examined on human progenitor cells (i.e., CD34 + /CD38 + ). Certain changes in the expression if one or more of...
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6551799 |
Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic...
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6548655 |
Interleukin-4 receptors
Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are...
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6537594 |
Vaccina virus comprising cytokine and/or tumor associated antigen genes
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6537781 |
Methods and compositions concerning canine interleukin 5
The present invention provides the nucleotide and amino acid sequences of canine IL-5. It also sets forth a recombinant DNA molecule, and conservative variants thereof, comprising the DNA sequence...
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6500417 |
Mutants of human interleukin-3
Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus...
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6495346 |
Complex-forming proteins
The invention relates to a complex of specifically complex-forming proteins which are not naturally occurring, comprising the following components: a) at least one ligand specific for a target...
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6479261 |
Methods of using interleukin-3 (IL-3) mutant polypeptides for ex-vivo expansion of hematopoietic stem cells
The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid...
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6475741 |
Neutrophil chemotactic factor cloned cDNA and monoclonal antibodies thereto
An isolated, synthetic preparation of a novel neutrophil-specific chemotactic factor (NCF), monoclonal antibodies having specific binding affinity for NCF and a clone containing the complete cDNA...
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6475755 |
Adenoviral vectors for mutants of human interleukin 6 (hIL-6) with hIL-6 antagonist activity, pharmaceutical compositions therewith and their uses
The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6)...
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6461604 |
Crystalline IL-6 and models of the molecular structure of IL-6
Crystallographic and NMR solution structures of human IL-6 are reported. The invention provides models and systems incorporating such structures which are useful for identifying IL-6/IL-6 receptor...
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6440407 |
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides
The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a variant of human interleukin-3 (hIL-3) which...
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6432678 |
Macaca cynomolgus IL 18
Macaca cynomolgus IL18 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds...
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6429188 |
Method for treating the endotoxic shock in mammals
Method for the treatment of endotoxic shock in mammals. The use of vasoactive intestinal peptide (VIP) and peptide activating hypofissiary adenylate cyclase (PACAP) is described in the treatment of...
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6428985 |
Immunosuppressive structural definition of IL-10
Disclosed is the surprising discovery that a single amino acid provides the demarcation between the immunosuppressive and immunostimulatory properties of the cytokine, IL-10. The present invention...
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6416954 |
Modulating Th2 cell levels via vMIP-I/CCR8 interaction
The present invention relates to the agonist properties of vMIP-I for the chemokine receptor CCR8 as expressed on Th2 cells. Methods of modulating a physiological signal specific to Th2 cells...
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RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins
Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector...
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6384194 |
Expression and purification of human interleukin-3 and muteins thereof
Methods are provided for improved production of hIL-3 either in glycosylated form from mammalian and yeast cells or in unglycosylated form from prokaryotes. Recombinantly produced human IL-3 is...
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6379662 |
Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines,...
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6365726 |
Polynucleotides encoding IL-1 Hy2 polypeptides
The present invention provides novel nucleic acids encoding IL-1 Hy2, a novel member of the Interleukin-1 Receptor Antagonist family, the novel polypeptides encoded by these nucleic acids and uses...
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6361977 |
Methods of using multivariant IL-3 hematopoiesis fusion protein
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) fused with other colony stimulating factors (CSF), cytokines, lymphokines, interleukins,...
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6361976 |
Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines,...
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6348191 |
Production and use of IL-6
IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other...
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6344192 |
Use of interleukin-15
The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of...
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6337072 |
Interleukin-1 receptor antagonist and recombinant production thereof
The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were...
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6309859 |
Method for removing N-terminal methionine
The present invention provides a method for chemically removing a N-terminal methionine residue selectively, specifically and efficiently from a peptide or a salt thereof having an optionally...
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6310045 |
Compositions and methods for cancer immunotherapy
The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting...
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