|
Match
|
Document |
Document Title |
|
|
8173396 |
Methods for reducing gluconoylation of proteins
The present invention relates to methods of preventing glyconoylation of polypeptides produced in micororganisms.
|
|
|
8168165 |
Alkylated interleukin-18 compositions
Alkylated interleukin-18 (IL-18), compositions comprising alkylated IL-18, kits comprising such compositions, methods of alkylating IL-18, and methods of using compositions comprising alkylated IL-18.
|
|
|
8163879 |
Fusion molecules and IL-15 variants
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention...
|
|
|
8133480 |
Cysteine variants of interleukin-11
Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
|
|
|
8133700 |
Latent phase viral interleukin-10-(VII-10) and uses thereof
The present invention relates to a purified nucleic acid sequence encoding a homologue of human interleukin 10 (IL-10), wherein said IL-10 homologue is expressed during the latent phase of...
|
|
|
8124084 |
Compositions and methods for immunomodulation in an organism using IL-15 and soluble IL-15Ra
The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention...
|
|
|
8119771 |
Products for altering IL-33 activity and methods thereof
Products for altering IL-33 activity including antibodies that specifically bind to an epitope with the polypeptide sequence of IL-33 such as antibodies that specifically bind to a protease...
|
|
|
8088600 |
Nucleic acids encoding cynomolgus IL-13 mutein proteins
The present invention relates to at least one novel cynomolgus IL-13 muteins (Mut-IL-13) proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or...
|
|
|
8084232 |
Polynucleotides encoding Papio cynocephalus toll-like receptor 3
Isolated polynucleotides encoding Papio cynocephalus Toll-Like Receptor 3 (Baboon TLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are...
|
|
|
8080392 |
IL-D80 polynucleotides
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are...
|
|
|
8062864 |
Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the...
|
|
|
8034326 |
IL-21 variants
IL-21 variant are provided wherein amino acids have been deleted and/or substituted in the region consisting of amino acid No. 65-96.
|
|
|
7982007 |
Cynomolgus toll-like receptor 3
Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these...
|
|
|
7968315 |
Production and purification of IL-29
The expression vectors and methods using an E. coli expression system for the large scale production of IL-29 are described. The vectors utilize the IL-29 coding sequence with specific changes in...
|
|
|
7947648 |
Methods for treating asthma in human and non human primates using IL-4 mutant compositions
The present invention relates generally to methods and compounds for treating pulmonary disorders, and more specifically to the inhalation administration and use of hIL-4 mutant proteins to treat...
|
|
|
7947474 |
Nucleic acid encoding cytokine receptor ZCYTOR17
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zyctor17, a novel cytokine receptor. The polypeptides may be used within...
|
|
|
7943738 |
IL-17 receptor like molecules and uses thereof
The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists...
|
|
|
7939297 |
Mammalian cytokines; related reagents and methods
Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. M...
|
|
|
7935340 |
Antibodies to IL-6 and use thereof
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and...
|
|
|
7928198 |
IL-B50 polypeptide
Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using...
|
|
|
7928197 |
Feline IL-18 proteins
The present invention relates to canine and feline proteins. In particular, the present invention discloses feline interleukin-18, feline caspase-1, feline interleukin-12 single chain and canine...
|
|
|
7910331 |
Nucleic acids encoding murine IL-174
CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
|
|
|
7906117 |
Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a...
|
|
|
7888071 |
DNA encoding IL-2 fusion proteins with modulated selectivity
The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are...
|
|
|
7875709 |
Nucleic acids encoding interleukin-18 mutants
The invention provides mutants of IL-18 with lower affinity to IL-18BP than the wild type IL-18 molecule.
|
|
|
7846652 |
Method for identifying a substance which mediates interaction between interleukin 22 and an interleukin 22 receptor
Interleukin-22 interacts with its receptor, referred to as IL-22R, and instigates a series of reactions, leading to activation of various molecules, such as JAK-1, Tyk2, and others. One can...
|
|
|
7833754 |
IL-12 for expression in mammalian cell
The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in...
|
|
|
7834152 |
Antagonists of interleukin-15
Disclosed herein are mutant IL-15 polypeptides and methods for using these polypeptides to modulate the immune response in a patient.
|
|
|
7820181 |
Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens
Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric...
|
|
|
7803564 |
EGF-like nucleic acids and polypeptides and uses thereof
The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1,2, and 3). ELVIS nucleic acid molecules encode...
|
|
|
7767793 |
Antibodies to SIGIRR
DNA encoding SIGIRR polypeptides and methods for using the encoded polypeptides are disclosed.
|
|
|
7767199 |
Compositions of IL-21 produced in prokaryotic hosts
The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in...
|
|
|
7759092 |
Production and purification of IL-29
The expression vectors and methods using an E. coli expression system for the large scale production of IL-29 are described. The vectors utilize the IL-29 coding sequence with specific changes in...
|
|
|
7758853 |
IFN-γ production inducing protein (IGIF, IL-18)
A protein which induces the IFN-γ production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on ch...
|
|
|
7745176 |
IL-21 production in prokaryotic hosts
The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in...
|
|
|
7705128 |
IL-1-like cytokine
Nucleic acids encoding mammalian, e.g., primate, IL-1ζ, purified IL-1ζ polypeptides and fragments thereof. Binding proteins, e.g., antibodies, both polyclonal and monoclonal, are also provided. M...
|
|
|
7704710 |
Interleukin-9 receptor mutants
This invention relates to the diagnosis, treatment and methods for discovery of new therapeutics for atopic asthma and related disorders based on variants of Asthma Associated Factor 2. One...
|
|
|
7666628 |
Preparation of heterologous proteins on oil bodies
The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the...
|
|
|
7662590 |
Polynucleotide encoding an IL-28A polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
|
|
|
RE41129 |
Cytokine zalpha11 ligand polynucleotides
The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the...
|
|
|
7629148 |
Polynucleotide encoding an IL-28B polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
|
|
|
7629149 |
Polynucleotide encoding an IL-28A polypepide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
|
|
|
7625720 |
Nucleic acids encoding IL-174
CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and...
|
|
|
7598058 |
Nucleic acids encoding IL13 mutants
This invention provides nucleic acid molecules encoding mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13...
|
|
|
7595174 |
Polynucleotide encoding an il-29 polypeptide
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
|
|
|
7544779 |
Homogeneous preparations of IL-28
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
|
|
|
7541040 |
Chimeric molecule for the treatment of th2-like cytokine mediated disorders
The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2...
|
|
|
7534585 |
Multifunctional cytokines
The present invention relates to a novel fusion protein with the formula X—Y, or Y—X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating pol...
|
|
|
7521537 |
Cytokine receptor zcytor17
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within...
|
|
|
7517961 |
Homogeneous preparations of IL-28 and IL-29
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine...
|