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7390638 |
S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants
When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this...
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7390637 |
Keratinocyte derived interferon
The present invention relates to a novel KDI protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a human interferon polypeptide,...
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7381795 |
Modified interferon beta with reduced immunogenicity
A modified interferon beta (INFβ) is provided, which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered to a human in vivo. The modified INFβ comprises an amino acid residue...
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7345149 |
Cysteine substitution variants of beta interferon
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7338788 |
Interferon-β variants and conjugates
The present invention provides new interferon β conjugates, methods of preparing such conjugates and the use of such conjugates in therapy, in particular for the treatment of multiple sclerosis.
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7270809 |
Cysteine variants of alpha interferon-2
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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RE39821 |
Manufacture and expression of large structural genes
Illustrated is the preparation and expression of manufactured genes capable of directing synthesis of human immune and leukocyte interferons and of other biologically active proteinaceous products,...
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RE39788 |
Gene therapy
Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy.
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7235232 |
Interferon alpha hybrids
Hybrid human interferon-α polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these peptides, and the use of these polypeptides to...
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7232562 |
E38N interferon gamma polypeptide variants
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7230081 |
Interferon gamma conjugates
A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence...
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7198919 |
Use of alpha factor sequences in yeast expression systems
The isolation of the yeast α-factor genes is described. The promoter and signal peptide portions are isolated and joined to DNA coding for proteins heterologous to yeast in a plasmid which is used...
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7183108 |
Selection and uses of lactic acid bacteria strains modulating non-specific immunity
The invention concerns lactic acid bacteria strains capable of regulating the production of NO and inflammatory cytokines by enterocytes, depending on the inflammatory condition of said...
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7141392 |
Latent fusion protein
The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent...
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7129390 |
Poultry Derived Glycosylated Interferon Alpha 2b
This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the...
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7052867 |
Expression and secretion vector for human interferon alpha and process for producing human interferon alpha by employing same
Disclosed in this invention are an expression vector for the secretive production of human interferon alpha (hIFNα) comprising a polynucleotide encoding a modified E. coli thermostable...
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7052687 |
Human recombinant beta-interferon with improved solubility
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu (5), Phe(8), Phe(15),...
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6958388 |
Interferon gamma polypeptide variants
When interferon gamma (IFNG) is produced in mammalian cell lines a heterogenous population of IFNG polypeptides is obtained due to C-terminal processing of the IFNG polypeptide. Clearly, this...
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6936440 |
Selecting ligand agonists and antagonists
We have discovered that growth hormones from ternary complexes with their receptors in which site 1 on the hormone first binds to one molecule of receptor and then hormone site 2 then binds to...
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6891086 |
Plastid transformation of Brassica
A method is provided for transforming Brassica plants to express DNA sequences of interest from the plant cell plastid. The method allows the transformation of Brassica plant tissue with...
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6875588 |
Ovomucoid promoter and methods of use
The present invention provides novel isolated nucleic acids comprising an avian nucleic acid sequence encoding an ovomucoid gene expression control region. The ovomucoid promoter region of the...
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6843988 |
Synferon
The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon...
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6833256 |
Interferon tau mutants and methods for making them
The present invention is directed to the field of animal and human health, and more particularly to pharmacological uses of analogs or mutants of interferon-tau (IFN-τ) that differ from native...
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6815184 |
Expression of biologically active polypeptide in duckweed
Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered...
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6794162 |
Phage-dependent super-production of biologically active protein and peptides
This invention relates to a method for enhancing the production of biologically active proteins and peptides in bacterial cells by infecting bacterial cells of the producer strain, which contain a...
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6773899 |
Phage-dependent superproduction of biologically active protein and peptides
This invention relates to a method for enhancing the production of biologically active proteins and peptides in bacterial cells by infecting bacterial cells of the producer strain, which contain a...
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6753165 |
Methods for making proteins containing free cysteine residues
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the...
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6749847 |
Hybrid cytokine of IL-7 and β-chain of hepatocyte growth factor
A hybrid cytokine comprising the B-chain of hepatocyte growth factor and IL-7, linked by a linker molecule, having pre-pro-B growth stimulating activity.
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6747131 |
Phosphorylated fusion proteins
Modified proteins, modified interferons α's and β's, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-α-like...
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6716607 |
Chicken interferon gene and novel recombinant DNA
A chicken interferon gene coding for the amino acid sequence of SEQ ID NO:1 is disclosed. There is also disclosed a method of producing chicken interferon recombinantly, a method of isolating other...
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6703225 |
Interferon-α
A novel human IFN-α subtype and its derivative having an unprecedentedly high specific activity, DNA encoding these proteins, an expression vector having said DNA, a transformant transformed with...
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6663878 |
Anti-inflammatory bioactive glass particulates
Compositions and methods for systemically minimizing the inflammatory effects of TNF-α are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20...
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6649375 |
Adenoviral vectors for enhanced gene expression
An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount...
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6610830 |
Microbial production of mature human leukocyte interferons
Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases.
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6572853 |
Recombinant human beta interferon with enhanced solubility
The invention relates to variants of recombinant human beta interferon and to a method for the production thereof, wherein at least one of the following amino acids Leu(5), Phe(8), Phe(15),...
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6544505 |
Interferon-epsilon
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain...
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6537594 |
Vaccina virus comprising cytokine and/or tumor associated antigen genes
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6524570 |
Polyethylene glycol modified interferon therapy
A method comprising administering a PEG 12000 -IFN alpha conjugate to an individual afflicted with a viral infection susceptible of treatment with interferon alpha, preferably chronic hepatitis C,...
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6514729 |
Recombinant interferon-beta muteins
The invention relates to novel interferon-beta activity (IbA) proteins and nucleic acids. The invention further relates to the use of the IbA proteins in the treatment of IFN-β related disorders.
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6509171 |
Aspartic proteinase deficient filamentous fungi
This invention relates to novel mutant filamentous fungi which are deficient in the gene for the corresponding aspartic proteinase. These organisms are useful production hosts in the production of...
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6497871 |
Recombiniant gamma interferons having enhanced stability and methods therefor
The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties...
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6475983 |
Water-soluble polypeptides having a high affinity for α and β interferons
Water-soluble polypeptides having high affinity for interferons α and β; DNA sequences and expression cells; a preparation method therefor; drugs; compositions containing same; and uses thereof...
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6448070 |
Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid
A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such...
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6432677 |
Non-human animal interferons
Distinct α-, β- and γ-interferon genes from various animal species have been identified, cloned and expressed to produce the corresponding non-human animal interferon proteins. Specifically...
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RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins
Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector...
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6391296 |
Method of stabilizing useful protein and useful protein compositions
A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon...
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6372207 |
IFNAR2/IFN complex
The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon α/β receptor (IFNAR)....
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6350443 |
Method of treatment for feline leukemia virus infections
A method of treatment for feline leukemia virus infections by continuously administering a feline interferon preparation containing a feline interferon as a main component daily to a cat is...
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6342216 |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions...
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6329175 |
Interferon-ε
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain...
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