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6448070 |
Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid
A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such...
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6432677 |
Non-human animal interferons
Distinct α-, β- and γ-interferon genes from various animal species have been identified, cloned and expressed to produce the corresponding non-human animal interferon proteins. Specifically...
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RE37767 |
Highly stable recombinant yeasts for the production of recombinant proteins
Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector...
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6391296 |
Method of stabilizing useful protein and useful protein compositions
A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon...
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6372207 |
IFNAR2/IFN complex
The in vivo effect of Type I interferon (IFN) can be prolonged by administering the interferon in the form of a complex with an IFN binding chain of the human interferon α/β receptor (IFNAR)....
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6350443 |
Method of treatment for feline leukemia virus infections
A method of treatment for feline leukemia virus infections by continuously administering a feline interferon preparation containing a feline interferon as a main component daily to a cat is...
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6342216 |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions...
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6329175 |
Interferon-ε
Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain...
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6323006 |
Recombinant human beta-CIS interferon
The invention provides a new human interferon (IFN)-β variant cloned from an amniotic cell library, a cDNA encoding it, and processes for its production and purification. The variant, termed...
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6319691 |
Fusion proteins comprising IFN-alpha2b and TM-alpha1
A fusion protein which comprises human IFN-alpha2b and human TM-alpha1. Such fusion proteins have enhanced biological activity and are useful for the treatment of viral, neoplastic and...
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6310045 |
Compositions and methods for cancer immunotherapy
The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting...
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6300474 |
Modified interferons
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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6299871 |
Orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases
Disclosed are an orally-administrable therapeutic and/or prophylactic agent for HTLV-1-related diseases, which comprises an interferon-γ as an effective ingredient and a...
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6299869 |
Human interferon-epsilon: a type I interferon
The invention concerns a human interferon-ε, originally designated PRO655, and its variants and derivatives. The interferon is related to but distinct from members of the IFN-α family and from...
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6300475 |
Interferon PRO655
The invention concerns a human interferon, designated PRO655, and its variants and derivatives. The interferon is related to but distinct from members of the IFN-α family and from IFNs-β and -γ....
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6299870 |
Mutant human interferons
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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6284520 |
Process for the production of proteins
The invention pertains to the field of recombinant DNA technology and concerns a method for the production of a protein heterologous to yeast in a homogenous form with the aid of Saccharomyces...
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6274341 |
Cytostatic process increases the productivity of cultured cells
Provided by the invention are novel methods, vectors and cells for the recombinant production of desired gene products. In particular, the invention relates to increased production of desired gene...
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6270989 |
Protein production and delivery
The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and β-interferon by homologous recombination. The...
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6204022 |
Low-toxicity human interferon-alpha analogs
The invention describes a method of reducing the cytotoxicity of interferon-alpha by making defined amino acid substitutions in the N-terminal portion of the polypeptide sequence. Also described...
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6200780 |
Human interferon-ε(IFN-ε), a type I interferon
The invention concerns a novel human interferon-ε, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-α family...
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6197292 |
Therapeutic agent and treatment for canine intractable dermatitis
The present invention relates to a therapeutic agent, composed of canine interferon-γ, for canine intractable dermatitis and a treatment for canine intractable dermatitis using the agent.
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6187304 |
Effects of IFN-γ on cardiac hypertrophy
The invention concerns the treatment of cardiac hypertrophy by interferon-gamma (IFN-γ). Cardiac hypertrophy may result from a variety of diverse pathologic conditions, including myocardial...
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6174996 |
Hybrid interferon τ/type I interferon polypeptides
The invention provides fusion proteins comprising an N-terminal region derived from an interferon-tau (IFN-τ) polypeptide and a C-terminal region derived from another type I interferon...
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6114145 |
Synferon, a synthetic interferon
The present invention relates to a novel Synferon protein which is a member of the interferon family. In particular, isolated nucleic acid molecules are provided encoding a synthetic interferon...
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6096547 |
Method and transgenic plant for producing mammalian peptides
Constructs are provided for expression of physiologically active mammalian proteins in plant cells, either in culture or under cultivation. The constructs provide a promoter functional in a plant...
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6083724 |
Recombinant avian interferon-gamma (IFN-γ)
A cDNA corresponding to the chicken interferon-γ (IFN-γ) gene has been isolated. The invention thus provides avian IFN-γ polypeptides, nucleic acids encoding them, and their recombinant...
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6046034 |
Thermostable variants of human interferon-γ(IFN-γ)
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6040498 |
Genetically engineered duckweed
Methods and compositions for the efficient transformation of duckweed are provided. Preferably, the methods involve transformation by either ballistic bombardment or Agrobacterium. In this manner,...
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6030609 |
Method and composition for treating paramyxovirus
The present invention relates to a method of treating respiratory syncytial virus (RSV) through the exogenous administration of recombinant or natural interferon-beta (IFN-β) to lung epithelial...
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6020465 |
Recombinant avian type i interferon
The present invention relates to a chicken interferon gene coding for the amino acid sequence of SEQ ID NO: 2. The present invention also relates to a method of producing chicken interferon...
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5994104 |
Interleukin-12 fusion protein
This invention relates to Interleukin-12 fusion proteins and nucleic acid constructs encoding them, and to the use of such fusion proteins and constructs in tumour therapy, especially therapy of...
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5968774 |
Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production
The present invention relates to novel host cells and to methods of producing proteins. More specifically the invention relates to a host cell useful for the expression of heterologous proteins,...
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5968735 |
Vector for the expression of therapy-relevant genes
A vector for expression of relevant therapeutic genes in mammalian cells which utilizes the mdr promoter, and optionally, the mdr enhancer, operably linked to the therapeutic gene.
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5962268 |
DNA encoding an immune cell cytokine
Human Immune Cell Cytokine-like Hormone polypeptide and DNA (RNA) encoding such polypeptide in a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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5958402 |
Antitumor therapy using ovine or bovine interferon-tau
The invention provides antitumor therapeutic methods employing bovine or ovine interferon-tau (IFN-τ) proteins and polypeptides. The IFN-τ proteins exhibit the antiviral and antiproliferative...
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5942223 |
Antiviral therapy using ovine or bovine interferon-tau
The invention provides antiviral therapeutic methods employing bovine or ovine interferon-tau (IFN-τ) proteins and polypeptides. The IFN-τ proteins exhibit the antiviral and antiproliferative...
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5939288 |
Plant secretory signal peptides and nectarins
Provided herein are signal peptides, and constructs and vectors having signal peptides, as well as methods of using signal peptides to deliver proteins into secretory material. The invention...
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5939286 |
Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them
The present invention describes hybrid interferon fusion polypeptides formed of a first segment that contains the N-terminal amino acid sequence of an interferon-tau polypeptide, and a second...
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5935789 |
Autonomously replicating sequences, GAPDH gene and promoter derived from Hansenula polymorpha, expression vectors containing same and method for the selection of transformants
Autonomously replicating sequences(ARS), glyceraldehyde-3-phosphate dehydrogenase(GAPDH) gene and GAPDH promoter derived from Hansenula polymorpha DL-1(ATCC 26012); a vector for H. polymorpha which...
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5891680 |
Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12
Fusion proteins, such as a bio active IL-12 polypeptide, which comprise at least two polypeptide monomers (chains of amino acids) joined through a heterologous polypeptide linker and which are...
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5869293 |
DNA encoding human interferon IFN -α001
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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5833975 |
Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
Attenuated vaccinia or canarypox recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed...
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5827694 |
DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
Distinct α-, β- and γ-interferon genes from various animal species have been identified, cloned and expressed to produce the corresponding non-human animal interferon proteins. Specifically...
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5821080 |
Cell line
A Namalwa cell line which is free of squirrel monkey retrovirus is useful for alpha-interferon production. The cell line can be used for the expression of recombinant polypeptides. It can be...
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5814485 |
Production of interferon-β (IFN-β) in E. coli
Methods for the production of interferon-β polypeptides by bacterial cells, by culturing cells capable of producing IFN-β polypeptide under conditions that induce increased production of IFN-β...
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5798228 |
Recombinant production of dog and horse type I interferons
This invention relates to a process for preparing recombinant horse and dog interferons and the interferons themselves.
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5795779 |
Human interferon-β (IFN-β) produced in Chinese hamster ovary (CHO) cells
β-interferon is produced in Chinese hamster ovary cells (CHO) in high amounts.
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5792935 |
Agrobacterium tumefaciens transformation of Musa species
Methods are provided for transforming Musa plants. In particular, methods for wounding meristematic Musa plant tissue to facilitate access of Agrobacterium tumefaciens comprising...
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5789551 |
Human leukocyte interferon Hu-IFN-α001
A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and...
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