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6372456 |
Polynucleotides encoding chemokine α-6
The present invention relates to a novel CK(α-6 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-6...
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6362325 |
Murine 4-1BB gene
The present invention includes the receptor protein 4-1BB and the cDNA gene encoding for receptor protein 4-1BB. The nucleotide sequence of the isolated cDNA is disclosed herein along with the...
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6361976 |
Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines,...
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RE37582 |
Cytokine designated LERK-6
The invention is directed to LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.
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6348334 |
DNA encoding Fas ligand
This invention provides a novel polypeptide useful in the field of medicines, a novel DNA which encodes the novel polypeptide, a recombinant DNA molecule which contains the novel DNA, a...
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6344192 |
Use of interleukin-15
The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of...
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6342585 |
Method of activating denatured protein
The invention relates to a method for forming a mixed disulfide of recombinant proteins, by solubilizing with a denaturing agent in the presence of a disulphide component, and then adding a...
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6338844 |
Genomic nucleic acids, cDNA and mRNA which code for polypeptides with IL-16 activity, processes for the production thereof and their use
A nucleic acid with which expression of a polypeptide having interleukin-16 activity can be achieved or regulated in a prokaryotic or eukaryotic host cell, wherein in the region coding for the...
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6328954 |
Use of the IL-4 receptor for the therapy prophylaxis and diagnosis of allergic viral parasitic and bacterial diseases and of fungal infections
The use of the IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases and of fungal infections. The invention relates to the use of the IL-4...
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6320023 |
Macrophage derived chemokine
The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C-C chemokine designated MDC. Also provided are materials and methods for the...
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6316254 |
Methods for stimulating erythropoiesis using hematopoietic proteins
Methods for stimulating erythropoiesis using the hematopoietic protein thrombopoietin, optionally in combination with erythropoietin, are provided. The methods provided may be used to stimulate...
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6313267 |
Calcium-binding proteins
A bovine- or human-derived calcium-binding protein with a prescribed amino acid sequence, a method for its production, and antibodies against the protein and uses thereof.
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6310045 |
Compositions and methods for cancer immunotherapy
The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting...
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6303769 |
LERK-5 DNA
LERK-5 polypeptides are disclosed, along with DNA sequences, vectors and transformed host cells useful in producing LERK-5. The LERK-5 polypeptides bind to elk and to hek, which are members of the...
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6294164 |
Natural killer cell enhancing factor C
A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are...
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6291661 |
flt3-L mutants and method of use
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are...
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6284485 |
Nucleic acids encoding osteoprotegerin
The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone...
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6284236 |
Cytokine that induces apoptosis
A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with...
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6277598 |
DNA molecule encoding interferon-gamma (IFN-λ) inducing factor (IGIF, IL-18) and DNA fragment thereof
A protein which induces the IFN-γ production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8±1.0 on...
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6274342 |
Nucleic acid molecules encoding monocyte chemotactic protein 5 (MCP-5) molecules and uses therefor
The present invention relates to the discovery of novel genes encoding Monocyte Chemotactic Protein-5 (MCP-5) polypeptides. Therapeutics, diagnostics and screening assays based on these molecules...
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6274341 |
Cytostatic process increases the productivity of cultured cells
Provided by the invention are novel methods, vectors and cells for the recombinant production of desired gene products. In particular, the invention relates to increased production of desired gene...
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6261548 |
Leukaemia inhibitory factor
The present invention provides isolated DNA molecules encoding human and murine LIF and methods of producing LIF by the expression of the isolated DNA and suitable host cells. The invention further...
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6255079 |
Polynucleotides encoding natural killer cell enhancing factor C
A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are...
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6255468 |
MPROT12 polynucleotides and methods thereof
MPROT12 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MPROT12 polypeptides and...
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6245550 |
Cytokine family member EF-7
EF-7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EF-7 polypeptides and...
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6218148 |
DNS encoding stem cell factor
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6214968 |
Fibroblast stimulating growth factor 1 (FsF-1) and the early detection of fibrosis
A method for identifying individuals with a propensity for pathological fibrosis. The method involves providing a sample from an individual with a chronic inflammatory disease, contacting the...
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6214584 |
Human Interferon-γinducing factor
A polypeptide which has a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The polypeptide strongly induces the IFN-γ production by immunocompetent...
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6207413 |
Nucleic acids encoding novel orphan cytokine receptors
The present invention provides for nucleic acid sequences that encode novel mammalian receptor polypeptides, designated OCR1. The invention also provides assay systems that may be used to detect...
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6207417 |
DNA encoding stem cell factor
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6207798 |
Modified PE40 toxin fusion proteins
We have modified PE 40 toxin by removing at least two of its four cysteine amino acid residues and have formed hybrid molecules containing modified PE 40 linked to a cell recognition protein that...
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6204021 |
DNA encoding a cytokine
The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also...
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6204020 |
DNA encoding N∇2 CSF-1 (short form) and carboxy truncated fragment thereof
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from...
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6204372 |
DNA encoding a human tubby homolog
The present invention provides a novel human tubby homolog (NHT) and polynucleotides which identify and encode NHT. The invention also provides expression vectors, host cells, agonists, antibodies,...
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6197550 |
DNA sequences encoding growth/differentiation
The invention provides DNA sequences encoding novel members of the TGF-β family of proteins. The TGF-β family comprises proteins which function as growth and/or differentiation factors and which...
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6194381 |
Therapeutic agent and method for feline AIDS virus infections and feline atopic dermatitis
A therapeutic agent for feline immunodeficiency virus (FIV) infections, (including the treatment of the anemia and chronic stomatitis caused by infection with a FIV) comprising a feline interferon...
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6184370 |
Receptor-binding determinant from leukaemia inhibitory factor
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6180111 |
Vaccine delivery system
The invention relates to a hyperblebbing strain of Neisseria gonorrhoeae which produces large amounts of blebs useful for production of blebosomes containing antigens for use as a vaccine delivery...
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6177556 |
Human SCF, a splice variant thereof, its pharmaceutical use
SCF which includes the following C-terminal sequence: Glu Ile Cys Ser Leu Leu Ile Gly Leu Thr Ala Tyr Lys Glu Leu Ser Leu Pro Lys Arg Lys Glu Thr Cys Arg Ala Ile Gln His Pro Arg Lys Asp or a...
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6177543 |
Recombinant lymphotoxin
Biologically active lymphotoxin polypeptides are synthesized in recombinant cell culture. Novel nucleic acid and vectors incorporating same are provided. The compositions and processes herein...
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6174671 |
Genomics via optical mapping ordered restriction maps
A method of producing high-resolution, high-accuracy ordered restriction maps based on data created from the images of populations of individual DNA molecules (clones) digested by restriction...
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6171584 |
Method of treatment with growth/differentiation factors of the TGF-β family
The invention concerns a protein of the TGF-β family, the DNA coding therefor and a pharmaceutical composition containing such protein.
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6165746 |
Preventing endogenous aminopeptidase mediated n-terminal amino acid cleavage during expression of foreign genes in bacteria
A process for the recombinant preparation in a bacterial host of the mature form of a mammalian protein or peptide of formula X-Pro-Z, which is subject to processing by endogenous bacterial...
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6159711 |
DNA encoding rantes peptide fragments and methods of treatment with the fragments
Modifications to RANTES can result in the modified polypeptide acting as a RANTES or MIP-1α antagonist. Such antagonists can be used in therapy to reduce inflammation. They are also useful in...
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6153441 |
Methods of screening for agonists and antagonists for human CCR7 receptor and CKβ-9 ligand and interaction thereof
Disclosed are methods for discovering agonists and antagonists of the interaction between a secreted human protein, chemokine CKβ-9, and its cellular receptor, human CCR7, which may have utility...
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6146851 |
DNA encoding NV2 (long form) and carboxy truncated fragments thereof
A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other...
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6143866 |
Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from...
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6139832 |
Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1...
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6127150 |
Purification cloning of peptides
The present invention is directed to a protein purification construct having three tandem, coupled segments composed of a binding protein, an interconnecting linker and a variable fused polypeptide...
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6120760 |
Growth/differentiation factors of the TGF-β family
The invention provides DNA sequences encoding novel members of the TGF-β family of proteins. The TGF-β family comprises proteins which function as growth and/or differentiation factors and which...
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