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6884419 |
hG-CSF fusion polypeptide having c-mpl activity, DNA coding for same and methods of treating anemia using same
The present invention relates to a fusion polypeptide which comprises a polypeptide having G-CSF activity and a polypeptide having TPO activity and DNA which codes for the fusion polypeptide, to a...
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6884770 |
Methods and compositions for treating or preventing peripheral neuropathies
The present application is directed to the discovery that hedgehog gene products are able to protect peripheral nerve cells under conditions which otherwise result in peripheral neuropathy. Certain...
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6863885 |
Method of decreasing radiation or radio-mimetic chemotherapy for hematopoietic pluripotent cell engraftment
The present invention provides a method of engrafting donor mammalian hematopoietic pluripotent cells in a mammalian recipient using a decreased amount of radiation, comprising: (a) administering...
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6864232 |
Agent for treating visual cell function disorder
The present invention provides an agent for treating retinopathy containing a tricyclo compound of formula (I)
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6838262 |
Isolated DNA molecule encoding rank ligand
Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also...
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6812327 |
Neutrokine-alpha polypeptides
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In...
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6812004 |
Mammalian dendritic cell chemokine reagents
A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. Methods of using said reagents and...
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6811773 |
Human monocyte colony inhibitory factor (M-CIF) polypeptides
There are disclosed therapeutic compositions and methods using a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ chemokine β1(CKβ1 or ckb-1)), as well as...
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6808902 |
Process for correction of a disulfide misfold in IL-1ra FC fusion molecules
The present invention concerns a process by which a misfold in an Fc fusion molecule can be prevented or corrected. In one embodiment, the process comprises (a) preparing a pharmacologically active...
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6803209 |
Preparation for use in cell culture in which an interfering compound is absent or depleted
A cell culture preparation and methods are provided which are suitable for production in cells of a first protein in a class of proteins where the medium is deficient in a second protein in a...
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6793917 |
Type CC chemokine-like protein
An isolated novel type CC chemokine-like protein which is expressed from peripheral blood mononuclear cells under an immunological stimulus and has a cell migration activity; a DNA encoding the...
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6794149 |
GABA B receptors
The invention relates to polypeptides which exert the biological activity of GABA B receptors, and to nucleic acids which encode these polypeptides, and in particular to their use for finding...
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6790947 |
Polynucleotides encoding macrophage derived chemokine
The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C—C chemokine designated MDC. Also provided are materials and methods for...
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6787645 |
DNA encoding human JE cytokine
A novel human cytokine, JE factor, and processes for producing it are disclosed. JE may be used in pharmaceutical preparations for stimulating and/or enhancing immune responsiveness and in wound...
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6780973 |
Eotaxin: an eosinophil chemoattractant
Disclosed is substantially pure eotaxin DNA sequence and eotaxin polypeptide, and methods of using such DNA and polypeptide to direct chemotaxis of eosinophils. Methods are provided for the...
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6777202 |
Recombinant expression of S-layer proteins
The invention concerns a process for the recombinant production of S-layer proteins in gram-negative host cells. Furthermore the nucleotide sequence of a new S-layer gene and processes for the...
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6776984 |
Induced regeneration and repair of damaged neurons and nerve axon myelin
A method of treatment of and composition for human degenerative neurologic diseases discloses the administration of therapeutically amounts of an enhancement agent, such as thrombopoietin, to...
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6759215 |
Method of preparing human stem cell factor polypeptide
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6740735 |
DNA encoding human apoB48R: a monocyte-macrophage apolipoprotein B48 receptor gene and protein
The present invention provides an isolated DNA molecule that codes for a cell-surface binding protein in human monocytes and macrophages. In addition, an amino acid sequence derived from the...
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6740505 |
Production of proteins
A process for the production of a protein by cell culture, said process comprising culturing eukaryotic cells which constitutively produce said protein in a medium which comprises an alkanoic acid...
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6737511 |
Receptor-mediated uptake of an extracellular BCL-xL fusion protein inhibits apoptosis
Apoptosis-modifying fusion polypeptides, and the corresponding nucleic acid molecules, are disclosed. Pharmaceutical compositions comprising these polypeptides, and the use of these polypeptides to...
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6733982 |
Method for screening compounds for alpha1B adrenergic receptor antagonist and analgesic activity
A method for identifying compounds that can be useful for producing analgesia is disclosed. In particular, the method involves providing preparation of a cell, that expresses an alpha 1B ...
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6716606 |
Production of pluripotent granulocyte colony-stimulating factor
Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of a mammalian (e.g., human) pluripotent granulocyte...
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6692926 |
Recombinant human SM-11044-binding receptor proteins exhibiting ligand-binding activities, and their use
Transformed cells designed to express a recombinant human SMBP at an elevated level to the extent that its ligand-binding activity can be measured, and cellular membrane fractions thereof;...
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6692735 |
Variant of C6 β-chemokine leukotactin-1(shLkn-1) with enhanced biological activity
The present invention relates to a variant of Lkn-1(shLkn-1) with enhanced biological activity, which is a truncated form of Lkn-1, a process for preparing a recombinant shLkn-1 by employing...
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6670151 |
Porcine stem cell factor varients and recombinant cells expressing such polypeptides
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production and isolation...
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6663878 |
Anti-inflammatory bioactive glass particulates
Compositions and methods for systemically minimizing the inflammatory effects of TNF-α are disclosed. The compositions include particles of bioactive glass with a particle size less than about 20...
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6656462 |
Interleukin-1 muteins useful as vaccine adjuvants
The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example,...
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6649164 |
Method for enhancing the functional capacity of dendritic cells
Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to enhance the functional capacity of dendritic cells.
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6649375 |
Adenoviral vectors for enhanced gene expression
An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount...
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6645740 |
Nucleic acids encodings equine GM-CSF
The invention relates to the equine GM-CSF, its nucleotide coding sequence and its amino acid sequence, as well as its use as adjuvant in equine vaccination and as non-specific immunity stimulant....
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6635741 |
G-protein coupled receptor BCA-GPCR-3
The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of...
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6632935 |
Genome DNA of bacterial symbiont of aphids
The present invention provides a genomic DNA of Buchnera. That is, this invention provides genes derived from Buchnera sp., comprising DNA of the following (a) or (b); (a) a DNA selected from a...
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6627734 |
Identification and characterization of multiple splice variants of the Kappa3-related opioid receptor (KOR-3) gene
The present invention encompasses novel splice variant forms of the muopioid receptor-1 (KOR-3) and the polynucleotide sequences encoding the KOR-3 splice variants. The invention further...
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6623942 |
Macrophage inflammatory protein-4 (MIP-4) polynucleotides
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3...
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6616926 |
Methods of modulating lipid metabolism and storage
Anti-hedgehog antibodies directed at blocking the binding of hedgehog to its receptor patched-1, will impair lipid metabolism and storage. This invention presents methods for the treatment of a...
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6610515 |
Feline granulocyte colony-stimulating factor
The present invention provides a medicine which promotes the production of neutrophiles in case the number of the neutrophiles decreases upon treating the tumor of a cat, and does not have...
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6608176 |
Taste receptor for umami (monosodium glutamate) taste
A metabotropic glutamate taste receptor having a molecular weight of approximately 68 kDa, encoded by a cDNA sequence having the mRNA sequence of SEQ ID NO:1 is disclosed, which functions as a...
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6599719 |
Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed...
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6586210 |
Polynucleotides encoding T1 receptor like ligand II
The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II...
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6586582 |
Human GABA receptor proteins and polynucleotides encoding the same
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
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6576445 |
Chemokine α-4
The present invention relates to a novel CKα-4 protein which is a member of the CXC chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-4 protein....
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6573366 |
Process for the purification of human interleukin-1 receptor antagonist from recombinant E. coli
A process for purifying human Interleukin-1 receptor antagonist (IL-1ra), obtained by fermenting a strain of recombinant E. coli , which comprises: a) loading the mixture to be purified, which has...
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6569997 |
Antibody specific for H4-1BB
Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The...
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6566503 |
Mammalian CX3C chemokine
Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using...
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6566501 |
Transcription factor regulating TNF-α
Disclosed herein is an isolated polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1. The isolated polypeptide binds to the DNA binding domain located from −550 to −487 in...
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6566097 |
Feline cytokine protein
A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing...
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6558925 |
Stem cell inhibitor
The present invention provides a Stem Cell Inhibitor (SCI) protein which comprises at least one amino acid alteration from its native form which protein does not significantly aggregate but which...
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6555520 |
Human TSLP DNA and polypeptides
The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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6548654 |
DNA encoding mammalian CX3C chemokine genes
Nucleic acids encoding a new family of chemokines, the CX 3 C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using...
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