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8178107 |
Method of treatment of thrombocytopenia or risk thereof using MPL ligand (thrombopoietin), variants, and fragments thereof
Isolated mpl ligand, isolated DNA encoding mpl ligand, and recombinant or synthetic methods of preparing mpl ligand are disclosed. These mpl ligands are shown to influence the replication,...
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8173117 |
Mouse CX3C chemokine polypeptides
Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using...
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8148507 |
Nucleic acid encoding TNFx protein
Nucleic acids encoding mammalian, e.g., primate or rodent, genes, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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8148500 |
Method of preparing cysteine mutants of human recombinant GM-CSF
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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8148109 |
Interferon-like proteins and uses thereof
The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and...
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8147844 |
Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
Isolated thrombopoietin (TPO), isolated DNA encoding TPO, and recombinant or synthetic methods of preparing and purifying TPO are disclosed. Various forms of TPO are shown to influence the...
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8124378 |
Murine zcytor17 ligand polynucleotides
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for...
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8119401 |
IL-10 gene transfer to peripheral mononuclear cells
The present invention to methods for producing mononuclear cells overexpressing IL-10. The method comprises the ex vivo introduction of an expression construct comprising a nucleotide sequence...
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8119131 |
IL-17 antagonistic antibodies
An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains...
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8110378 |
Nucleic acids encoding DCRS5
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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8066981 |
Compositions and methods related to toll-like receptor-3
The invention relates to compositions and methods related to Toll-like receptor (TLR) polypeptides. In some embodiments, the invention relates to managing TLR3 related diseases. In further...
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8053560 |
Modified human plasma polypeptide or Fc scaffolds and their uses
Modified human plasma polypeptides or Fc and uses thereof are provided.
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8034337 |
Interleukin-1α antibodies
Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the ...
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8021862 |
Process for preparing human G-CSF
The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
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8013210 |
Multi-generational pharmaceutically active protein production in corn
The present invention provides multi-generational production methods for producing pharmaceutically active proteins and other proteins in corn. The present invention also provides methods for...
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8012464 |
G-CSF-albumin fusion proteins
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors...
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8003350 |
Mutant firefly luciferase, gene, recombinant vector, transformant, and method for production of mutant firefly luciferase
The present invention provides a mutant firefly luciferase consisting of a mutant amino acid sequence derived from the amino acid sequence of a wild-type firefly luciferase by at least substitution...
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7972812 |
DNA encoding a soluble fragment of TRAIL polypeptide
A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with...
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7939059 |
Method for the generation of antigen-specific lymphocytes
The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting...
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7927834 |
Recombinant production of mixtures of antibodies
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding...
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7888466 |
Human G-protein chemokine receptor HSATU68
Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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7862827 |
Combination neisserial compositions
Compositions comprising a first biological molecule from a Neisseria bacterium and a second biological molecule from a Neisseria bacterium. The term “biological molecule” includes proteins and nuc...
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7858765 |
OX40R binding agents
The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such...
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7858345 |
Immunogenic Mycoplasma hyopneumoniae polypeptides
Mycoplasma hyopneumoniae polypeptides and nucleic acids, as well as nucleic acid expression vectors and host cells containing nucleic acid vectors are provided. In addition, compositions containing...
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7858297 |
Chemokine-binding protein and methods of use
Described herein are chemokine-binding domains of THAP-family polypeptides and pharmaceutical compositions which include a polypeptide comprising a chemokine-binding domain of a THAP-family...
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RE41887 |
Treatment of autoimmune disease
The present invention features a novel combination therapy useful in the treatment of autoimmune disease that increases or maintains the number of functional cells of a predetermined type in a...
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7812126 |
DIRS1 polypeptides
Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of...
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7811591 |
Chimeric vaccine for haemophilus influenzae-induced disease
The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides...
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7807808 |
Bacteria with increased levels of protein secretion, nucleotide sequences coding for a SecA protein with increased levels of protein secretion, and method for producing proteins
The invention relates to bacteria that have increased levels of protein secretion due to genetic modification, to nucleotide sequences and gene structures containing at least one gene coding for a...
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7807155 |
IL-17 antagonistic antibodies
An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains...
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7807413 |
GAG binding protein
A method is provided for introducing a GAG binding site into a protein comprising the steps: identifying a region in a protein which is not essential for structure maintenanceintroducing at least...
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7794726 |
Mutants of lysine decarboxylase, vaccines for periodontitis, and methods of use
The present invention is directed to mutants of lysine decarboxylase, nucleic acids encoding the mutants, and vaccines comprising the mutants for inhibiting and reducing the development of...
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7785580 |
Modified IL-4 mutein receptor antagonists
This invention relates to modified IL-4 mutein receptor antagonists comprising an IL-4 mutein receptor antagonist coupled to polyethylene glycol. Related formulations and dosages and methods of...
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7780959 |
Feline granulocyte macrophage colony stimulating factor nucleic acid molecules
The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon...
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7776336 |
Compositions comprising Yersinia pestis antigens
Disclosed are several Y. pestis antigens that are particularly suitable for immunisation purposes, particularly when used in combinations.
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7776564 |
Stromal cell-derived factor-1 polypeptides, polynucleotides, modulators thereof and methods of use
Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also...
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7767211 |
S.aureus polypeptides
The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to...
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7749518 |
Polypeptides from non-typeable Haemophilus influenzae
Polypeptides comprising non-typeable Haemophilus influenzae (NTHi) amino acid sequences. Over 2500 specific NTHi proteins are disclosed. The invention also provides related polypeptides, nucleic...
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7749506 |
Proteins derived from white spot syndrome virus and uses thereof
Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for...
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7744907 |
Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed...
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7740834 |
Murine zcytor17 ligand polypeptides
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for...
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7736638 |
Interleukin-15 antagonist peptide
Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity,...
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7722888 |
Streptococcus pneumoniae proteins and nucleic
Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
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7722877 |
Coccidiosis vaccines
The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers...
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7718182 |
Polypeptides for inducing a protective immune response against Staphylococcus aureus
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such...
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7713534 |
Streptococcus pneumoniae proteins and nucleic acid molecules
Protein antigens from Streptococcus pneumoniae are disclosed, together with nucleic acid sequences encoding them. Their use in vaccines and in screening methods is also described.
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7705134 |
Antibodies that bind to BGS-4
The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic...
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7704709 |
Modified human granulocyte-colony stimulating factor and process for producing same
A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to...
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7691981 |
Growth factor homolog zvegf3
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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7691610 |
Human zven polynucleotides
The present invention provides a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gas...
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