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7390654 |
Avoidance of undesirable replication intermediates in plasmid propagation
Disclosed herein are improved plasmid shuttle vectors, vaccines based on them, and methods related to their construction and use. Particular arrangements of functional elements of such plasmids,...
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7381804 |
G-CSF analog compositions and methods
The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions...
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7361486 |
Polynucleotide, vector, host cell and method for producing human hepatoma-derived growth factor 5 polypeptide
The invention provides a cDNA sequence of human hepatoma derived growth factor 5 (HDGF5). The present invention also relates to the polypeptides encoded by the nucleotide sequences, the uses of...
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7358341 |
Beta-like glycoprotein hormone polypeptide and heterodimer
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods...
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7354739 |
TML polynucleotides
The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in...
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7351815 |
Canine pre-proGHRH and mature GHRH genes
The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The...
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7345154 |
Cysteine variants of erythropoietin
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7338787 |
Nucleic acids encoding OBG3 globular head and uses thereof
The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight...
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7317095 |
Mutant glycoproteins
The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the...
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7314734 |
Muteins of placental growth factor type 1, preparation method and application thereof
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino...
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7314626 |
Use of peptide vectors to improve the immune response to antigens
The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups...
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7294483 |
Process for producing recombinant polypeptides via a glycerol phosphate or sugar phosphate feed
A process is described for producing a polypeptide heterologous to E. coli wherein E. coli cells comprising nucleic acid encoding the polypeptide are cultured in a culture medium while feeding...
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7291483 |
FGF-CX polynucleotide sequences and methods of producing same
The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant,...
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7262166 |
Chemically modified novel erythropoietin stimulating protein compositions and methods
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
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7259293 |
Expression of eukaryotic peptides in plant plastids
Constructs and methods are provided for expressing peptides derived from eukaryotic organisms in plant plastids. Constructs have a promoter functional in a plant plastid, a DNA sequence encoding a...
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7247452 |
Truncated keratinocyte growth factor (KGF) having increased biological activity
The present invention relates to a keratinocyte growth factor fragment, KGF des1-23 , or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length...
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7244591 |
Yeast transformant producing recombinant human parathyroid hormone and method for producing the hormone
Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains acre genetically disrupted in at least one of the genes encoding the yapsin...
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7238790 |
PRO1313 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7238657 |
Cartilage/Bone inducing materials for preparation
A cartilage and bone morphogenetic repairing composition which contains a bone morphogenetic protein and a polyoxyethylene-polyoxypropylene glycol is disclosed. It is preferable that the molecular...
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7232667 |
Keratinocyte growth factor-2 polynucleotides
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such...
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7229793 |
Constructs and cells for production of small peptides
The present invention features a nucleic acid construct for expressing a product, e.g., a small peptide such as GLP-1. The construct includes a nucleic acid sequence encoding a signal peptide and a...
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7226758 |
Nucleic acids encoding glial cell line-derived neurotrophic factor (GDNF)
A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells....
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7223564 |
Four-helical bundle protein zsig81
This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in...
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7223563 |
Fibroblast growth factor (FGF23) nucleic acids
The invention relates to novel nucleic acids encoding a fibroblast growth factor-23(FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR)....
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7193042 |
Methods for purifying authentic IGF from yeast hosts
Methods for purifying authentic, properly folded IGF polypeptides from yeast transformants are disclosed. The methods include a refolding step and provide for high yields of authentic IGF from a...
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7179621 |
Pigment epithelium-derived factor: sequence of the PEDF gene
Nucleic acids encoding the neurotrophic protein known as pigment epithelium derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such...
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7166446 |
Method for expression of heterologous proteins in yeast
Compositions and methods for expression of heterologous mammalian proteins and their secretion in the biologically active mature form using a yeast host cell as the expression system are provided....
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7153943 |
Derivatives of growth hormone and related proteins, and methods of use thereof
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7148333 |
Cysteine variants of granulocyte-macrophage colony-stimulating factor
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active...
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7141392 |
Latent fusion protein
The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent...
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7141389 |
Chromosome DNA coding for human hepatocyte growth factor
A chromosome DNA which codes for human hepatocyte growth factor, a recombinant expression vector capable of expressing the DNA, a transformant transformed with the expression vector and a method of...
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7129211 |
Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin
The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte...
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7122654 |
Vascular endothelial growth factor D (VEGF-D) antibodies and vectors, and methods of use
VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as...
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7122351 |
Dimerized PDGF-D and materials and methods for producing it
Proteins consisting of two PDGF-D polypeptide chains, polynucleotides encoding the polypeptides, and materials and methods for making the proteins are disclosed. Each of the polypeptide chains...
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7101981 |
Bovine growth hormone recombinantly produced in E. coli
Recombinant materials have been obtained which permit the production of bovine growth hormone in E. coli.
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7094411 |
Avirulent, immunogenic flavivirus chimeras
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric...
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7091401 |
Expression of epidermal growth factor in plant seeds
The present invention provides a method of preparing epidermal growth factors in plants and transgenic plant seeds containing epidermal growth factors. The method provides an economical way to...
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7090834 |
Vascular endothelial cell growth factor variants and uses thereof
The present invention provides VEGF variants having one or more amino acid mutations in the KDR and/or FLT-1 receptor binding domains in the native VEGF sequence and selective binding affinity for...
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7087739 |
Nucleic acid encoding recombinant salmon calcitonin, expression vector thereof, and method for producing recombinant salmon calcitonin therewith
Nucleic acid encoding recombinant salmon calcitonin, expression vector thereof, and method for producing recombinant salmon calcitonin therewith. The nucleic acid encoding recombinant salmon...
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7087408 |
Method for making insulin precursors and insulin precursor analogs
Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors...
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7070788 |
Follicle stimulating hormone superagonists
The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of...
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7060795 |
Wound care compositions
The invention provides polypeptides that can inhibit the activity of matrix metalloproteinases. Such polypeptides are useful for treating wounds, for example, chronic wounds.
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7037684 |
Process for producing polypeptide having disulfide bond
The invention relates to a DNA that enables co-expression of a protein disulfide isomerase and a polypeptide having disulfide bonds. The invention further relates to a process of producing...
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6987172 |
Multifunctional single chain glycoprotein hormones comprising three or more β subunits
Glycosylated or nonglycosylated molecules of the formula
β 1 -(linker 1 ) n 1 -β 2 -(linker 2 ) n 2 -β 3 -(linker 3 ) n 3 -α; ...
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6967092 |
Multi-functional chimeric hematopoietic receptor agonists
Disclosed are novel multi-functional chimeric hematopoietic receptor agonist proteins, DNAs which encode the multi-functional chimeric hematopoietic receptor agonist proteins, methods of making the...
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6967091 |
OBG3 globular head and uses thereof for decreasing body mass
The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight...
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6962796 |
Production of human parathyroid hormone from microorganisms
The invention provides recombinant plasmids containing in DNA sequences coding for human preproparathyroid hormone. The invention further provides microorganisms, for example E. coli , transformed...
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6953844 |
Isolation of neurotrophins from a mixture containing neurotrophin variants using hydrophobic interaction chromatography
Methods are provided for large scale purification of neurotrophins, including mature NGF, suitable for clinical use. The methods provide means to separate neurotrophins from various less desirable...
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6949365 |
Polynucleotides encoding lamprey GnRH-III
Novel isolated cDNA encoding the precursor of the novel gonadotropin-releasing hormones in four species of the fish lamprey is disclosed. The use of such cDNA's in studying the phylogenetic...
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6946444 |
Lipoprotein-regulating medicaments
Methods and pharmaceutical compositions useful for modulating lipoprotein levels in vivo. The invention stems from the discovery that activity of the Lipolysis Stimulated Receptor (LSR) can be...
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