|
Match
|
Document |
Document Title |
|
|
7387886 |
Prion protein dimers useful for vaccination
Described is a prion protein, wherein said prion protein is a homodimer or heterodimer. The prion protein dimers are highly immunogenic capable of inducing an immune response in a mammal, thus...
|
|
|
7384775 |
Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae , wherein the open reading frames encode...
|
|
|
7384640 |
Mutant cholera holotoxin as an adjuvant
A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an...
|
|
|
7381411 |
Aglyco products and methods of use
Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which...
|
|
|
7378257 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
|
|
|
7371821 |
Cloning and expression of the full length 110 kDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus
The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi , Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa...
|
|
|
7368556 |
DNA and proteins or peptides specific of bacteria of the Neisseria meningitidis species, methods for obtaining them and biological applications thereof
The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis , but not in Neisseria gonorrhoeae , or...
|
|
|
7368261 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
|
|
|
7365184 |
B. anthracis prevention and treatment: mutant B. anthracis lacking luxS activity and furanone inhibition of growth, AI-2 quorum sensing, and toxin production
The present invention pertains to the discovery that B. anthracis possesses a luxS gene that encodes a functional LuxS polypeptide, and that B. anthracis synthesizes a functional AI-2...
|
|
|
7351550 |
Exoenzyme toxin of Aeromonas salmonicida, and uses thereof
A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent...
|
|
|
7348015 |
Antigen modified cancer cell vaccines for cancer therapy
Disclosed are methods for treating cancers, particularly tumorigenic types. Cancer cells are modified to express highly immunogenic antigens so that the cells will generate a defensive response in...
|
|
|
7344719 |
Homologous 28-kilodalton immunodominant protein genes of Ehrlichia canis and uses thereof
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family...
|
|
|
7338786 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
|
|
|
7335369 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M....
|
|
|
7332170 |
Classical swine fever virus virulence determinant and a novel classical swine fever vaccine
Transposon linker insertion mutagenesis of a full-length infectious clone of the highly pathogenic classical swine fever virus (CSFV) isolate Brescia (pBIC) was used to identify genetic...
|
|
|
7329512 |
Allergenic latex protein
The present invention relates to a protein found in natural rubber that can induce an allergic reaction in persons who have been sensitised to it. The invention provides for the process of...
|
|
|
7329511 |
Nucleic acid encoding GAD65
The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD 65 which encode at least one epitope for autoantibodies to GAD 65 . The invention also provides cloning vehicles...
|
|
|
7326543 |
Gene encoding protein from merozoite of Babesia caballi, recombinant protein obtained with said gene and use thereof
The present invention provides a gene encoding a protein from merozoite of Babesia caballi , a recombinant protein of Babesia caballi , and an antibody capable specifically binding to a 48 kDa...
|
|
|
7319144 |
Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen...
|
|
|
7314925 |
Constructs and methods for expression of recombinant HCV envelope proteins
The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian...
|
|
|
7314710 |
Method for replicating the hepatitis C virus
The invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for...
|
|
|
7314625 |
Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences
The invention provides chimeric proteins comprising a non-toxic Pseudomonas exotoxin A sequence and a Type IV pilin loop sequence, wherein the Type IV loop sequence is inserted within the...
|
|
|
7306806 |
Recombinant P. falciparum merozoite protein-142 vaccine
In this application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-1 42 . The method of the present invention produces a highly purified protein which retains...
|
|
|
7297337 |
EphA2 T-cell epitopes and uses therefor
EphA2 T-cell epitope are provided herein. The epitopes include peptides corresponding to specific fragments of human EphA2 protein containing one or more T-cell epitopes, and conservative...
|
|
|
7288256 |
T cell epitopes of the major allergens from dermatophagoides (house dust mite)
The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides . Peptides within the scope of the invention comprises at least one T cell epitope, or...
|
|
|
7285397 |
Insect poison allergens with reduced IgE reactivity and method producing the same
The invention relates to recombinant insect poison allergens and to a specific method for producing them. Said allergens can be varied according to whether they are produced using folds...
|
|
|
7282580 |
Protein molecule useful for inhibition of anthrax toxin
The present invention relates to a novel molecule useful for anthrax toxin inhibition in vivo and also provides a method for in vivo inhibition of anthrax toxin action using the new molecule.
|
|
|
7279295 |
Allergen
The present invention relates to a novel allergen from timothy grass ( Phleum pretense ) pollen, Phl p11 as disclosed in SEQ ID NO:2, and use thereof as a reagent and in a diagnositic kit as well...
|
|
|
7273930 |
Immunization of dairy cattle with GapC protein against Streptococcus infection
The GapC plasmin binding protein genes of Streptococcus dysgalactiae ( S. dysgalactiae ), Streptococcus agalactiae ( S. agalactiae ), Streptococcus uberis ( S. uberis ), Streptococcus...
|
|
|
7273695 |
HIV immunoassays using synthetic envelope polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
|
|
|
7273605 |
Vaccine
The present invention relates to a fowlpox virus genome which has modifications in one or more wild-type FPV genes. The present invention also relates to a viral particle comprising such a genome...
|
|
|
7264817 |
Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it
Disclosed is an invention related to the preparation and use of vaccines against pathogenic organisms, such as herpes virus. The vaccines hereof are based upon the use of truncated, membrane-free...
|
|
|
RE39815 |
Method for determining ion channel activity of a substance
A method for determining the ion channel activity of a substance comprises the steps of (i) expressing the substance as a heterologous protein in a host cell, and (ii) determining changes in...
|
|
|
7262024 |
Streptococcus antigens
The present invention relates to polypeptides of Streptococcus pneumoniae which may be used for prophylaxis, diagnostic and/or therapy purposes.
|
|
|
7261899 |
Method of producing thy A-strains of Vibrio cholerae, such strains and their use
A method of producing a thy A − strain of vibrio cholerae comprising the step of site-directed mutagenesis in the V. cholerae chromosome at the locus of the thy A gene SEQ ID NO: 1 of FIG. 1...
|
|
|
7261897 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The...
|
|
|
7244712 |
Aminoglycoside antibiotics and methods of using same
The present invention relates to aminoglycoside compounds having antibiotic activity. Moreover, the present invention relates to L-aminoglycoside compounds and diastereomers thereof which posses...
|
|
|
7244580 |
Epsilon immunoglobulin chain derived peptides for induction of anti-IgE antibodies
The present invention relates to identification of polypeptides useful for generating antibodies specific for non-human IgE, particularly equine IgE. The invention, therefore, also relates to...
|
|
|
7241742 |
CYP1B1 nucleic acids and methods of use
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the...
|
|
|
7241582 |
Diagnostic test kits
This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus...
|
|
|
7238345 |
Recombinant microorganism expressing meningococcal class 1 outer membrane protein
Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis, fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal...
|
|
|
7235243 |
Immunological combination compositions and methods
Immununological compositions and methods for making and using them. The compositions contain at least one antigen and at least one lipoprotein and optionally an adjuvant. The lipoprotein can itself...
|
|
|
7227010 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain...
|
|
|
7223412 |
Staphylococcal enterotoxin SEC-SER, expression vector and host cell, production method thereof, and manufacturing method of vaccine
The present invention relates to a method of producing recombinant modified Staphylococcal toxin having improved stability, comprising the steps of preparing a modified toxin in which a specific...
|
|
|
7217541 |
Method of making CS6 antigen vaccine for treating, preventing, or inhibiting enterotoxigenic Escherichia coli infections
Disclosed herein are methods for making large amounts of highly pure colonization factors. The methods of the present invention differ from prior art methods in that host cells which express the...
|
|
|
7211408 |
Recombitope peptides
The present invention provides peptides having T cell stimulating activity termed recombitope peptides. Recombitope peptides of the invention preferably comprise at least two T cell epitopes...
|
|
|
7205101 |
Human immunodeficiency virus (HIV) nucleotide sequences, recombinant polypeptides, and applications thereof
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
|
|
|
7176286 |
Antigen fragments for the diagnosis of Toxoplasma gondii
The invention described herein relates to a method for identifying antigen fragments of Toxoplasma gondii proteins, and their use as diagnostic and immunogenic agents. Said method is implemented...
|
|
|
7166287 |
Viral agent
The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts...
|
|
|
7153510 |
Recombinant vesiculoviruses and their uses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
|