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6602506 |
Delivery of proteins into eukaryotic cells with recombinant Yersinia
The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.
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6593463 |
Modified MSP-1 nucleic acid sequences and methods for increasing MRNA levels and protein expression in cell systems
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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6589530 |
Hepatitis B surface antigen vaccine
HBV surface antigen particles, prepared by recombinant DNA technology are described, said particles being composed of epitopes from the group of surface peptides and/or core peptide of non-A, non-B...
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6589755 |
Assay for quantifying arthritic conditions
The present invention is drawn to a novel and newly discovered low molecular weight protein fragments that are degradation products of COMP and have a molecular weight of about 14-33 kilodaltons...
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6589531 |
Recombinant yellow fever virus and method of use thereof
The present invention provides recombinant yellow fever viruses (YFV), particularly live attenuated recombinant YFV, which comprise exogenous (i.e., non-YFV) nucleotide sequences which encode...
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6589532 |
Papilloma viruses, means for the detection thereof and therapy for diseases caused thereby
The invention relates to DNA coding for a peptide of a papilloma virus major capsid protein or a papilloma virus genome. The invention also relates to proteins coded by the papilloma virus genome...
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H002071 |
Streptococcus pneumoniae gene HI0454
The invention provides isolated nucleic acid compounds encoding the 454 gene of Streptococcus pneumoniae . Also provided are vectors and transformed host cells for expressing the encoded protein,...
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6579676 |
Rapid mutational analysis method and compositions
A novel rapid mutational analysis method for mapping protein epitopes is disclosed. This method has been used to identify the binding sites for 16 anti-CD2 and anti-CD4 monoclonal antibodies. The...
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6569635 |
Growth state-specific immunofluorescent probes for determining physiological state and method of use
A novel method for examining bacterial growth state is carried out by measuring the levels of conserved cytosolic proteins specific for alternative growth states, using bacterial specific antibody...
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6570061 |
Targeted replacement of an immunoglobulin gene without endogenous and selectable residual sequences in mice
Transgenic mice that produce high levels of humanized antibodies are described. Targeted gene replacement exchanges constant regions of the mouse immunoglobulin heavy and light chain genes with...
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6569433 |
Compounds and methods for the diagnosis and treatment of B. microti infection
Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B....
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6562597 |
Papilloma viruses, agents for detecting them and for treating diseases caused by such viruses
This invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein. Moreover, this invention deals with a papilloma virus genome containing such a DNA. Furthermore, this...
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6562348 |
Recombinant M. tuberculosis auxotrophic for leucine and vaccines using same
The present invention provides a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine. The present invention also provides a vaccine comprising a recombinant M. tuberculosis...
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6555347 |
Human minor vault protein p193
A polynucleotide molecule encoding human minor vault protein p193, or its complementary strands. A purified and isolated polynucleotide molecule consisting essentially of a nucleotide sequence...
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6551594 |
Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in said method
The invention relates to an ex vivo animal or challenge model as a method to identify protective (recombinant) proteins and rapidly measure protective immunity in intestinal segments directed...
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6551820 |
Expression of immunogenic hepatitis B surface antigens in transgenic plants
Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression...
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6551597 |
Vaccine compositions for human papillomavirus
Large quantities of soluble multimers of human papillomavirus L1 proteins can be produced in bacterial expression systems and used as therapeutic and diagnostic tools. L1 multimers can be used in...
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6548287 |
Non-pyrogenic bacterial strains and use of the same
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said...
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6544522 |
Fusion proteins of mycobacterium tuberculosis antigens and their uses
The present invention relates to fusion proteins of Mycobacterium tuberclosis antigens. In particular, it relates to two fusion proteins, each of which contains three individual M. tuberculosis ...
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6541459 |
Soluble herpesvirus glycoprotein complex vaccine
The invention is directed to a herpes simplex virus vaccine comprising a herpes simplex virus glycoprotein H-glycoprotein L complex. The invention is also directed to a vaccine comprising a DNA...
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6538126 |
Hepatitis C diagnostics and vaccines
The present invention provides polynucleotides derived from cDNA of novel type of hepatitis C virus named Korean type hepatitis C virus (KHCV), polypeptides encoded therein, and antibodies directed...
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6537769 |
Purified and recombinant antigenic protein associated with abdominal aortic aneurysm (AAA) disease, and diagnostic and therapeutic use thereof
This invention provides an isolated protein of approximately 40 kDa which is purified from human aortic tissue and immunoreactive with AAA-associated immunoglobulin. Also provided are a method of...
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6537594 |
Vaccina virus comprising cytokine and/or tumor associated antigen genes
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6534638 |
Recombinant DNA molecules encoding aminopeptidase enzymes and their use in the preparation of vaccines against helminth infections
The present invention provides nucleic acid molecules containing nucleotide sequences encoding helminth aminopeptidase enzymes, and antigenic fragments and functionally-equivalent variants thereof,...
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6531313 |
Invasive bacterial vectors for expressing alphavirus replicons
The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to...
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6528063 |
Recombinant vaccines against IBDV
There is provided a stable vaccine for providing protection against disease having viral proteins transgenically expressed in plant cells. Also provided is a stable vaccine which provides...
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6525173 |
Process for expression and production of recombinant protein hybrid protein (p24/p17) derived from human immunodeficiency viruses (HIV-1)
The present invention describes recombinant p24/p17 hybrid protein derived from the human immunodeficiency virus, their corresponding encoding recombinant DNA molecule and the process of production...
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6524588 |
Attenuated vaccination and gene-transfer virus, a method to make the virus and a pharmaceutical composition comprising the virus
RNA polymerase I transcription in vivo in transiently DNA-transfected cells has been used for expression of influenza vRNA molecules coding for chloramphenicol acetyltransferase (CAT) in anti-sense...
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6521746 |
Polynucleotides encoding LKT 111
New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to...
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6517844 |
Compositions and method for immunizing polutry
The present invention is directed to vaccine compositions and methods for immunizing poultry. The vaccine compositions comprise inactivated bacterial organisms which can be administered to the...
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6514501 |
Recombinant vaccine against dengue virus
A recombinant protein encompassing the complete envelope glycoprotein and a portion of the carboxy-terminus of the membrane/premembrane protein of dengue 2 virus was expressed in baculovirus as a...
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6509017 |
66 KDA antigen from Borrelia
The present invention relates to nucleic acid molecules, polypeptides encoded by the same, antibodies directed thereto and a method of preparing such polypeptides including: (a) inserting an...
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6495143 |
Botulinum neurotoxin vaccine
Using the nontoxic heavy chain fragment from botulinum neurotoxins A-G, compositions and methods of use in inducing an immune response which is protective against intoxication with botulinum in...
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6491921 |
Avian polyomavirus vaccines in psittacine birds
The invention provides a nucleic acid vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order comprising a...
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6488935 |
Papilloma viruses, products for the detection thereof as well as for treating diseases caused by them
The present invention relates to a DNA coding for a peptide of a papilloma virus major capsid protein and a papilloma virus genome, respectively. Furthermore, the present invention concerns...
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6485904 |
DNA encoding a plasminogen activating protein
The present invention provides polynucleotide molecules comprising nucleotide sequences encoding plasminogen activating (PauA) proteins from Streptococcus uberis , and substantially homologous...
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6475727 |
Primers and methods for the detection of disseminated tumor cells
The present invention relates to primers that specifically hybridize to nucleic acid molecules complementary to the messenger RNA transcribed from genes encoding MAGE tumor-specific antigens or a...
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6472183 |
Immunity against Actinobacillus pleuropneumoniae's RTX toxins APX
Disclosed herein is a modified microorganism which produces an RTX toxin, wherein said RTX toxin is partially or fully inactivated. Also disclosed is a modified microorganism wherein an RTX toxin...
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6472518 |
Invasion associated genes from Neisseria meningitidis serogroup B
Genes isolated from Neisseria memingitidis , as well as isolated nucleic acids, probes, expression cassettes, polypeptides, antibodies, immunogenic compositions, antisense nucleic acids,...
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6469152 |
Flea allantoinase nucleic acid molecules, proteins and uses thereof
The present invention relates to flea allantoinase proteins; to flea allantoinase nucleic acid molecules, including those that encode such flea allantoinase proteins; to antibodies raised against...
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6461618 |
74 kilodalton outer membrane protein from moraxella catarrhalis
A protein from the M. catarrhalis designated the 74 kD protein is isolated and purified. The 74 kD protein has an amino-terminal amino acid sequence which is conserved among various strains of ...
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6461614 |
Fibronectin binding proteins
The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant...
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6461811 |
Gamma-herpes virus DNA and methods of use
Isolated polynucleotides and polypeptides derived from the genome of swine gamma-herpesviruses are disclosed, including recombinant cells and vectors encoding such polypeptides and expressing such...
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6458562 |
Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines
The invention relates to the expression of open reading frame 2 (ORF-2) proteins of a strain of hepatitis E virus from Pakistan (SAR-55) in a eukaryotic expression system. The expressed proteins...
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6458527 |
HIV immunoassays using gag polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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6448043 |
Enterococcus faecalis EF040 and uses therefor
The present invention relates to a novel gene from E. faecalis, EF040, and the encoded polypeptides. Also provided are vectors, host cells, antibodies and methods for producing the same. The...
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6447786 |
Blocking expression of virulence factors in S. aureus
This invention provides peptides which inhibit agr transcription in S. aureus and thereby block the expression of virulence factors in S. aureus , pharmaceutical compositions comprising these...
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6448037 |
PgsA
The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6448036 |
ribB
The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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6448038 |
BirA from staphylococcus aureus
The invention provides birA polypeptides and polynucleotides encoding birA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for...
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