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6958235 |
Recombinant protein containing a C-terminal fragment of plasmodium MSP-1
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19)...
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6951742 |
Methods and vectors for generating antibodies in avian species and uses therefor
The present invention relates to processes for producing polyclonal and monoclonal antibodies to an antigen in an avian species, preferably in a chicken, using polynucleotide vaccination. The...
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6936256 |
Sub-unit vaccine for infectious pancreatic necrosis virus
The present invention relates to sub-unit vaccines comprising structural polypeptides of Infectious Pancreatic Necrosis Virus (IPNV) comprising structural proteins VP2 and VP3 folded as an empty...
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6936257 |
Recombinant Venezuelan equine encephalitis virus vaccine
A prophylactic or therapeutic vaccine for use in protecting mammals such as humans or animals against Venezelan Equine Encephalitis virus (VEE) is described. In particular, the vaccine comprises a...
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6936258 |
Staphylococcus antigen and vaccine
A negatively-charged Staphylococcus antigen contains amino acids and a N-acetylated hexosamine as a major carbohydrate component. The antigen is common to many coagulase-negative strains of ...
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6933130 |
Recombinants process for preparing a complete malaria antigen, gp190/MSP1
The present invention relates to a method for producing recombinants intended for use in the complete cell-surface protein gp190/MSP1 from plasmodium, especially plasmodium falciparum, as well as...
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6921534 |
Hepatitis B virus treatment
The invention relates to HBV antigen-containing compositions that are useful in treating or preventing HBV infection. The content of the compositions can vary, as described herein, but the...
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6921536 |
Lawsonia intracellularis vaccine
The present invention relates i.a. to nucleic acid sequences encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live...
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6919196 |
Parvovirus NS1 variants
The present invention relates to a parvovirus NS1 variant having a shifted equilibrium between the DNA replication and transcription activities (a) and the cytotoxicity activity (b). Furthermore,...
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6919210 |
Method for identifying autoimmune disease, method for detecting anti-Reg protein autoantibody and diagnostics for autoimmune disease
A method for judging an autoimmune disease by detecting the existence of an anti-Reg protein autoantibody in a specimen; and a method for judging insulin-dependent or non-insulin-dependent diabetes...
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6908619 |
Camp factor of streptococcus uberis
The CAMP factor gene of Streptococcus uberis ( S. uberis ) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the...
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6905845 |
House dust mite allergen, Der f VII, and uses therefor
Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a...
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6905691 |
Vaccines containing attenuated bacteria
The invention relates to a vaccine comprising a bacterium attenuated by a non-reverting mutation in a gene encoding a protein which promotes folding of extracytoplasmic proteins. Such mutations...
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6900018 |
Method of screening for a biological response using linear and circular expression elements
The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention...
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6899885 |
74-kilodalton outer membrane protein from Moraxella catarrhalis
A protein from M. catarrhalis , designated the 74 kD protein, is isolated and purified. The 74 kD protein has an amino-terminal amino acid sequence which is conserved among various strains of M....
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6891029 |
Isolated polynucleotide sequences encoding a fertility associated antigen
The present invention provides an isolated polynucleotide sequence and amino acid sequence for a bovine fertility associated antigen (FAA), methods of producing recombinant bovine FAA protein;...
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6884414 |
Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents
The present invention relates to the engineering of recombinant influenza viruses that express tumor-associated antigens. Expression of tumor-associated antigens by these viruses can be achieved by...
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6881411 |
Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
This invention satisfies needs in the art by providing intimin, the Enterohemorrhagic Escherichia coli (EHEC) adherence protein, alone or as a fusion protein with one or more other antigens,...
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6875859 |
Heterocyclic compounds and their use in the detection of nucleic acids
The invention concerns compounds of the general formula (I) in which the residues R 1 to R 7 have the meanings given in the application as well as methods for their preparation. The compounds are...
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6875612 |
Monocyte-specific particulate delivery vehicle
The inventive vector specifically directs entry into a cell of monocytic origin. The vector is composed of a nucleic acid component, a lysosome evading component and a particle that can be...
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6872398 |
Conjugate vaccine against gram-negative bacterial infections
The present invention relates to a broadly reactive vaccine against Gram-negative bacteria which is composed of a biological glycan-pilus conjugate. The conjugate core is a common pilus type to...
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6872550 |
Immunogenic formulation of OspC antigen vaccines for the prevention and treatment of lyme disease and recombinant methods for the preparation of such antigens
A novel approach to Borrelia vaccine formulation taking into account serological, genotypic and epidemiological information by which OspC proteins from different strains of B. burgdorferi are...
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6869793 |
Recombinant MVA virus expressing dengue virus antigens, and the use thereof in vaccines
Recombinant MVA viruses containing and/or capable of expressing dengue virus antigens and the use of such recombinant MVA for vaccination.
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6870041 |
MurE protein and gene of pseudomonas aeruginosa
This invention provides isolated polynucleotides that encode the MurE protein of Pseudomonas aeruginosa . Purified and isolated MurE recombinant proteins are also provided. Nucleic acid sequences...
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6867353 |
Production method of recombinant rotavirus structural proteins and vaccine composition
The present invention relates to a method for producing recombinant rotavirus structural proteins by culturing a transformed plant cell, and to a vaccine composition comprising the same as an...
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6855317 |
Immunological herpes simplex virus antigens and methods for use thereof
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
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6855322 |
Isolation and purification of P. falciparum merozoite protein-142 vaccine
This application is the expression and purification of a recombinant Plasmodium falciparum (3D7) MSP-1 42 . The method of the present invention produces a highly purified protein which retains...
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6855319 |
Gene encoding merozoite protein of Babesia caballi, recombinant protein obtained therefrom and utilization thereof
The present invention provides a gene encoding a protein from merozoite of Babesia caballi , a recombinant protein of Babesia caballi , and an antibody capable specifically binding to a 48 kDa...
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6855318 |
Multi-mer peptides derived from hepatitis C virus envelope proteins for diagnostic use and vaccination purposes
Multimer peptides (e.g. 30- to 45-mer peptides) derived from hepatitis C virus envelope proteins reacting with the majority of anti-HCV antibodies present in patient sera are described. The usage...
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6849427 |
Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a λgt11 library of D. pteronyssinus cDNA. The nucleic acid...
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6846652 |
Viral vectors having enhanced effectiveness with reduced virulence
The present invention provides methods of use of recombinant vaccinia virus from which the region encoding the N-terminal 83 or 54 amino acids of the E3L gene product has been deleted, or amino...
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6846487 |
Therapeutic compositions for treating infection by Lawsonia spp.
The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia...
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6844171 |
Oligomerization of hepatitis delta antigen
This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising...
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6844188 |
Methods and modified cells for the treatment of cancer
The present invention provides methods of preventing and/or treating cancers (including tumors). In one preferred embodiment, the invention is practiced to induce regression of an existing cancer...
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6841358 |
RECOMBINANT PROTEINS OF FILAMENTOUS HAEMAGGLUTININ OF BORDETELLA, PARTICULARLY BORDETELLA PERTUSSIS, METHOD FOR PRODUCING SAME, AND USES THEREOF FOR PRODUCING FOREIGN PROTEINS OF VACCINATING ACTIVE PRINCIPLES
A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the reading frame to a sequence (2) located...
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6841353 |
Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue
Antibodies to two new epitopes on the HCV envelope proteins were identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes...
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6841360 |
Nucleotide sequences coding for the export of branched-chain amino acids, process for the isolation thereof and use thereof
This invention relates to isolated polynucleotides containing at least one of the polynucleotide sequences selected from the group
a) polynucleotide which is at least 70% identical to a...
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6838236 |
VPR function and activity
Pharmaceutical compositions comprising the HIV protein vpr or nucleic acid molecule encoding vpr are disclosed. Also disclosed are methods of treating patients suffering from diseases characterized...
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6835384 |
Nucleic acids and polypeptides specific of the neisseria genus pathogenic strains
The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.
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6815183 |
Plasmodium sp. chitinase
The present invention is directed to isolated nucleic acid molecules encoding Plasmodium sp. chitinases . Expression vectors and host cells comprising the nucleic acid molecules are also...
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6815173 |
Method for detecting syphilis using synthetic antigents
An antigen composition and method for the detection of antibodies to Treponema pallidum and the diagnosis of syphilis are described. The antigen composition contains synthetic cardiolipin and...
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6815174 |
Thioredoxin-glutamate decarboxylase 65 fusion protein
The present invention relates to a novel protein, a recombinant fusion hybrid, thioredoxin-human glutamate decarboxylase 65 and to a method of using such fusion protein in assaying anti-human...
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6814970 |
Methods and compositions including a 13 kD B. burgdorferi protein
All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were...
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6815172 |
Methods and compositions for opsonophagocytic assays
Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides...
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6811787 |
Over-expressing homologous antigen vaccine and a method of making the same
This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering...
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6806065 |
Rickettsia felis outer membrane protein
The present invention is directed to isolated nucleic acid molecules encoding Rickettsia felis outer membrane proteins ( R. felis omp). Expression vectors and host cells comprising the nucleic...
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6805868 |
Moraxella catarrhalis antigen, corresponding gene and uses thereof
The invention provides BASB109 polypeptides and polynucleotides encoding BASB109 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6803035 |
Anti-diarrheal and method for using the same
A food product and method for treating and preventing diarrhea in a subject animal suffering from or susceptible to diarrhea. The method comprises administering an egg product to the subject animal...
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6803043 |
Basbo27 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses
The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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6800442 |
Methods of selecting polynucleotides encoding antigens
The present invention relates to novel methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of...
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