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5962261 |
Polynucleotides encoding a neuronal extracellular matrix protein
The present invention provides a human neuronal extracellular matrix protein (HNEP) and polynucleotide which encode HNEP. The invention also provides expression vectors, host cells, agonists,...
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5961982 |
Recombinant herpesvirus of turkeys and uses thereof
The present invention provides a recombinant herpesvirus of turkeys designated S-HVT-050 (ATCC Accession No. VR 2400). A vaccine is provided which comprises an effective immunizing amount of...
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5958733 |
Threonyl tRNA synthetase polynucleotides
The invention provides thrS polypeptides and DNA (RNA) encoding thrS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing thrS...
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5958734 |
Polynucleotides encoding gluS polypeptides of streptococcus pneumoniae
The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS...
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5958736 |
Recombinant DNA coding for signal peptide, selective interacting polypeptide and membrane anchoring sequence
Tripartite recombinant DNA encoding fusion proteins which comprise three sequences, i.e., a signal peptide which is operable in a Gram positive bacterium, an immunogenic polypeptide linked thereto...
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5955077 |
Tuberculosis vaccine
The invention relates to novel secreted antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in...
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5955312 |
DNA encoding a novel microtubule-associated protein
The present invention provides a human microtubule-associated protein (hLC3) and the polynucleotides which identify and encode hLC3. The invention also provides genetically engineered expression...
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5955088 |
Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins
The present invention relates to the field of infectious diseases and ophthalmology. More particularly, the invention relates to compositions and methods for vaccination against Herpes Simplex...
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5955356 |
Nucleic acids, vectors, and host cells including mycobacterium derived sequences
The invention relates to nucleic acids which contain particularly a nucleotide sequence extending from the extremity constituted by the nucleotide at position (1) to the extremity constituted by...
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5955272 |
Detection of individual gene transcription and splicing
Disclosed are in situ hybridization methods for differentially detecting an RNA and the gene from which it was transcribed, while preserving the spatial relationship of the RNA transcript and the...
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5955313 |
Nucleic acid molecule encoding a bifunctional protein, the protein so encoded uses thereof
The invention involves the identification of an isolated nucleic acid molecule which encodes a tumor rejection antigen. Various uses of this nucleic acid molecule and the protein it encodes are...
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5955596 |
NucA protein of Haemophilus influenzae and the gene encoding that protein
A protein from H. influenzae designated NucA is isolated and purified. The NucA protein has the amino acid sequence of amino acids 26-603 of SEQ ID NO:2 or a biologically equivalent amino acid...
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5955264 |
Rapid mutational analysis method
A rapid mutational analysis method for mapping protein epitopes is disclosed. This method has been used to identify the binding sites for 16 anti-CD2 and anti-CD4 monoclonal antibodies. The...
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5952196 |
Prolyl tRNA synthetase polynucleotides
The invention provides proS polypeptides and DNA (RNA) encoding proS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing proS...
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5952195 |
Promoters for expressing proteins of interest in yeast
The present invention provides novel nucleic acid fragments isolated from the genomic DNA of yeast and having transcription promoter activity, as well as expression cassettes, vectors, and host...
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5952216 |
Synthetic HPV 16 virus-like particles
A series of synthetic virus-like particles useful in the characterization of human papillomavirus type 16 (HPV16) infection and assays employing the synthetic particles are provided.
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5952487 |
DNA sequences of the papillomavirus HPV42 for use in diagnosis
DNA sequences derived from human papillomavirus HPV42 are disclosed. Also disclosed are methods of using these sequences as hybridization probes in diagnostic assays.
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5948646 |
Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes
The present invention relates to methods for preparing immunogenic, prophylactically and therapeutically effective complexes of heat shock proteins noncovalently associated with antigenic peptides...
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5948676 |
Immediate early protein from Kaposi's sarcoma-associated herpesvirus, DNA encoding same and uses thereof
This invention provides an isolated nucleic acid molecule which encodes Kaposi's Sarcoma-Associated Herpesvirus (KSHV) immediate early protein (IEP). This invention provides an isolated polypeptide...
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5948644 |
Polynucleotides encoding excretory/secretory proteins of parasitic nematodes, host cells transformed therewith
The invention provides excretory/secretory antigens derived from parasitic nematode species which are capable of inducing protective immunity against infection by parasitic nematode species, and...
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5948645 |
Biosynthetic gene muri from Streptococcus pneumoniae
The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host...
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5945278 |
Method and system for enhanced production of commercially important exoproteins in gram-positive bacteria
The invention provides a method and expression system for enhancing secretion of hyperproduced homologous and heterologous exoproteins in gram-positive bacteria such as Bacillus sp. The method and...
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5942434 |
Nucleic acid constructs comprising hypoxia response elements
Nucleic acid constructs comprising hypoxia response elements in operable linkage with a coding sequence of a gene of interest are disclosed. In particular, such nucleic acid constructs comprise...
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5935580 |
Recombinant mutants for inducing specific immune responses
This invention relates to a recombinant plasmid comprising the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella adenylate cyclase in a transformed host cell. This...
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5935838 |
Method of cultivating bacteria proteins that are expressed in a temperature regulated manner
A method of cultivating bacteria having genes in plasmids which code for surface or membrane bound antigens or other proteins and which are expressed in a temperature regulated manner for the...
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5935570 |
Synthesis of immunologic, therapeutic and prophylactic compounds by transformed clavibacter
A process for the synthesis and delivery of bioactive compounds, compounds that have a therapeutic, biochemical, or immunologic, effect on an animal, such as human. In the process, clavibacter is...
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5935818 |
Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof
This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM') antigen. This invention provides an isolated nucleic acid...
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5932225 |
Vaccine comprising eimeria spp. gametocyte antigen
Substantially purified Eimeria maxima gametocytes have been prepared and methods for their preparations are disclosed. A proteinaceous extract derived from the gametocytes comprises at least nine...
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5932219 |
Hepatitis delta virus p27.sup.δ and p24.sup.δ vaccine
The entire genome of the hepatitis D virus has been shown to be a circular single-stranded RNA of 1679 bases. Several open reading frames in both the genomic and complementary strands indicate...
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5932705 |
Methods and compositions for the treatment and diagnosis of shipping fever
Novel compositions are disclosed for use in the treatment or diagnosis of bovine pasteurellosis, commonly referred to as Shipping Fever. Cell-free Pasteurella haemolytica supernatants are employed...
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5932220 |
Diagnostic tests for a new spirochete, Borrelia lonestari sp. nov.
Bites from Amblyomma americanum, a hard tick, have been associated with a Lyme disease-like illness in the southeastern and south-central United States. Present in 2% of ticks collected in four...
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5928651 |
Gene encoding high molecular surface protein-2 non-typeable haemophilus
High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two...
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5928901 |
Molecules containing at least one peptide sequence carrying one or several epitopes characteristic of a protein produced by P. falciparum in hepatocytes and compositions containing them
The invention relates to a molecule comprising one or more peptide sequences of formula: TBL Leu-Ala-Lys-Glu-Lys-Leu-Gln-X-Gln-Gln-Ser-Asp-Leu- Glu-Gln-Glu-Arg in which X is Glu or Gly. It also...
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5928895 |
IgA Fc binding protein
The invention provides IgA Fc binding protein polypeptides and DNA (RNA) encoding IgA Fc binding protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also...
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5925734 |
Isolated Epstein-Barr virus BZLF2 proteins that bind MHC class II βchains
Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to a β chain of a Class II Major Histocompatibility Complex antigen, thereby...
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5922327 |
Equine herpes virus glycoproteins
Equine rhinopneumonitis and equine abortion are horse diseases caused by two distinct but antigenically related viruses designated as equine herpes virus 4 (EHV4) and equine herpes virus 1 (EHV1)....
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5919454 |
Nucleotide and peptide sequences of a hepatitis C virus isolate, diagnostic and therapeutic applications
This invention relates to human or murine monoclonal antibodies specific for a peptide sequence of HCV E1, fragments of said monoclonal antibodies, hybridomas producing said monoclonal antibodies,...
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5919664 |
Peptide release factor, prfC (RF-3), a GTP-Binding protein
The invention provides prfC polypeptides and DNA (RNA) encoding prfC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing prfC...
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5919462 |
Nucleic acid fragments derived from the HIV-1 virus genome, corresponding peptides and their applications as reagents for evaluation of the risk of maternofoetal transmission of HIV-1
This invention provides specific amino acid sequences encoded by nucleic acid fragments derived from the genome of the human immunodeficiency virus type 1 (HIV-1) and to peptides containing such...
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5916768 |
Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides
The present invention relates to contraceptive vaccines based on cloned zona pellucida genes and the strategy of alloimmunization with zona pellucida polypeptides. In particular, the present...
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5910405 |
HCV diagnostic agents
The present invention relates to the epitopes of hepatitis C virus (HCV) core protein and non-structural 3 protein (NS3), and the epitopes of envelope protein, epitopes of non-structural 4 protein,...
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5908627 |
Antigen associated with Type I diabetes mellitus
A 69 kD protein, designated PM-1, is expressed in human pancreatic islet cells and a human insulinoma. The amino acid sequence of the protein has been determined. Autoantibodies to the PM-1 protein...
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5891442 |
Infectious bursal disease virus recombination poxvirus vaccine
What is described is a recombinant poxvirus, such as fowlpox virus, containing foreign DNA from infectious bursal disease virus. What is also described is a vaccine containing the recombinant...
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5891676 |
Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
A method to express rotavirus genes in a baculovirus system. Different clones are used to express rotavirus genes for all of the viral proteins. These proteins are isolated in their native...
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5891670 |
Tetracycline resistance protein
The invention provides tetracycline resistance protein polypeptides and DNA (RNA) encoding tetracycline resistance protein polypeptides and methods for producing such polypeptides by recombinant...
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5891678 |
DNA encoding the SecA1 polypeptide of Staphylococcus aureus
The invention provides secA1 polypeptides and DNA (RNA) encoding secA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
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5891677 |
Actinobacillus pleuropneumoniae outer membrane lipoprotein A and uses thereof
Novel vaccines for use against Actinobacillus pleuropneumoniae are disclosed. The vaccines contain at least one Actinobacillus pleuropneumoniae outer membrane lipoprotein A, or an immunogenic...
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5888770 |
Spoiiie
The invention provides spoIIIE polypeptides and DNA (RNA) encodig spoIIIE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utlizng...
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5888516 |
Recombinant papillomavirus vaccines
Recombinant expression vectors encoding the L1 and L2 proteins of papillomavirus, methods of making and using the recombinant proteins and purified virus-like particles comprised of the recombinant...
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5888513 |
Recombinant PRRSV proteins, diagnostic kits and vaccines containing such recombinant PRRSV proteins
Recombinant proteins of the causative virus of porcine reproductive and respiratory syndrome (PRRS), corresponding to ORFs 2 to 7 of the PRRSV Spanish isolate (PRRS-Olot), have been produced in...
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