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6020154 |
H. influenzae HxuB and HxuC genes, proteins and methods of use
Disclosed are hxuB and hxuC genes and DNA segments from H. influenzae such as H. influenzae type b (Hib) and nontypeable H. influenzae (NTHI). The HxuB and HxuC proteins, being surface expressed,...
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6017542 |
Nucleotide and amino acid sequences of canine herpesvirus GD and uses therefor
Disclosed and claimed are nucleotides for genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues. These genes encode polypeptides of 879, 459 and 345 amino acids, respectively, which...
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6017535 |
cDNA sequence of Dengue virus serotype 1 (Singapore strain)
DENI-S275/90 (ECACC V92042111) is a new strain of Dengue virus serotype 1. The complete cDNA sequence of this virus has been cloned and protein-coding fragments thereof have been used in the...
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6017730 |
Method of limiting the survival of genetically engineered microorganisms in their environment
The survival of cells is limited by introducing into the cells a regulatably expressible gene whose expression results in the formation of a cytoplasmatically active hydrolytic enzyme. Populations...
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6015694 |
Method for stimulating an immune response utilizing recombinant alphavirus particles
The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector...
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6015696 |
Mycobacterial secretory expression vectors and transformants
A secretory vector expressed in mycobacteria comprising a promoter, a signal sequence having ligated therewith a DNA nucleotide sequence encoding heterologous polypeptide and replicator region...
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6013481 |
Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof
A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor...
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6013432 |
Immunoassay of HIV antibodies using recombinant or synthetic selected pol sequence
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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6013262 |
Recombinant papilloma virus L1
This invention relates to a recombinant papilloma virus L1 protein which can elicit an immune response which recognises papilloma virus VLP including L1 protein and can form extracellularly a...
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6013261 |
Recombinant Marek's disease virus (MDV) and vaccine
A recombinant herpes virus is provided which efficiently expresses an exogenous protein of interest in an inoculated animal host to thereby endow the host with excellent immunization. A recombinant...
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6010704 |
Polypeptides and antibodies characteristic of papillomavirus, and diagnostic procedures and vaccines making use of them
The present invention provides papillomavirus DNA, and more particularly DNA probes derived from papillomavirus. The present invention also provides procedures for the use of DNA derived from...
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6008021 |
DNA encoding serS polypeptides
The invention provides serS polypeptides and DNA (NA) encoding serS polypeptide and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing serS...
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6008342 |
DNA encoding eimeria antigen
The invention provides an immunogenic polypeptide having the amino acid sequence TBL M A K S M L S G I V F A G L V A A A A A - S S A N S A A N V S V L E S G P A V Q E - V P A R T V T A R L A K P L...
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6001599 |
DNAs encoding mammalian ZPBs
A method for specifically inducing transient infertility or permanent sterility in a host animal by selective vaccination with specific zona pellucida proteins or immunocontraceptively active...
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6001600 |
DNA encoding tests polypeptides
Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for...
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6001603 |
Phosphoribosyl transferase
The invention provides phosphoribosyl transferase polypeptides and DNA (RNA) encoding phosphoribosyl transferase polypeptides and methods for producing such polypeptides by recombinant techniques....
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6001972 |
Splicing variant of the epstein-barr virus-induced G-protein coupled receptor
EBI 3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing EBI 3 polypeptides and...
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6001602 |
DNA encoding Chlamydia trachomatis isoleucyl tRNA synthetase polypeptides
The invention provides ileS polypeptides and DNA (RNA) encoding ileS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ileS...
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6001360 |
Method and compositions for early detection and treatment of insulin dependent diabetes mellitus
Compositions and methods for the treatment or prevention of insulin dependent diabetes (IDD) are provided. Specifically, glutamic acid decarboxylase (GAD) proteins, and fragments. thereof, can be...
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5998584 |
Reagents and methods for the diagnosis and treatment of diabetes and stiff man syndrome
The invention provides fragments of GAD 65 that are specifically reactive with at least one class of GAD 65 autoantibody. Most fragments are substantially free of N-terminal amino acids that...
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5993821 |
Modified papilloma virus L2 protein and VLPs formed therefrom
The invention, in one aspect, is directed to a modified papilloma virus L2 protein which does not bind DNA or which has a substantially impaired ability to bind DNA compared to wild-type papilloma...
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5994525 |
Nucleic acid encoding Actinobacillus pleuropneumoniae cytolytic proteins
The invention provides a vaccine for the prevention and/or the treatment of infection by Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, which vaccine contains at...
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5993826 |
Methods and compositions relating to useful antigens of moraxella catarrhalis
The present disclosure relates to Moraxella catarrhalis outer membrane vesicle (OMV) compositions, to selected antigenic proteins from the outer membranes of M. catarrhalis which have a variety of...
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5993824 |
Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is...
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5994101 |
DNA encoding gidA1 polypeptides
The invention provides gidA1 polypeptides and DNA (RNA) encoding gidA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing...
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5989864 |
DNA encoding spo-rel polypeptides
Spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such...
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5985285 |
Vaccines for plague
A method of protecting a human or animal body from the effects of infection with Y. pestis is provided comprising administering to the body a vaccine including Yersinia pestis V antigen and...
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5985609 |
Process for preparing hepatitis C virus envelope glycoproteins
The present invention relates to a novel process for preparing hepatitis C virus (HCV) envelope glycoproteins employing Chinese Hamster Ovary (CHO) cells transformed with recombinant expression...
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5981224 |
Bovine heat shock promoter and uses thereof
A novel expression system using the heat-inducible bovine hsp70A promoter and associated cis-acting elements is disclosed. The system provides for the continuous production of a highly pure,...
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5981229 |
Bacterial exported proteins and acellular vaccines based thereon
Provided herein are novel nucleic acids which encode exported proteins of Gram positive bacteria, and the proteins encoded by such nucleic acids. Also provided are methods of producing such...
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5981228 |
Mammalian ZPAs
A method for specifically inducing transient infertility or permanent sterility in a host animal by selective vaccination with specific zona pellucida proteins or immunocontraceptively active...
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5976552 |
Virus vaccines
Improved mammalian virus vaccines are combinations that contain an immunogenic amount of inactivated virus, such as influenza virus, Herpes varicella virus, measles virus, Epstein Barr virus,...
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5977339 |
Methods and compositions for diagnosing lyme disease
A chromosomal gene of Borrelia burgdorferi which encodes a conserved antigen of approximately 79 kD has been isolated and sequenced. The chromosomal gene, the gene product, and antibodies to the...
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5976840 |
Polynucleotides encoding gluS polypeptides of streptococcal pneumoniae
The invention provides gluS polypeptides and DNA (RNA) encoding gluS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gluS...
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5977306 |
Parasitic helminth P39 proteins, and uses thereof
The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to...
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5976839 |
Immunopotentiation through covalent linkage between immunogen and immunopotentiating molecules
A class of carrier molecules which when covalently linked to an immunogen enhances the host's immune response to that immunogen, regardless of whether the complex of carrier and immunogen is...
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5972659 |
Multispecific antigenic proteins
A novel conjugated protein produced by recombinant DNA techniques comprises a low molecular weight carrier protein portion that is normally self-aggregating to an immunogenic higher molecular...
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5972657 |
Gene encoding outer membrane protein B1 of moraxella catarrhalis
Nucleotide sequences, derived from Moraxella catarrhalis, which encode one or more epitopes of outer membrane protein B1 are disclosed. Recombinant B1 protein or B1 peptides may be produce by...
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5972656 |
Mercury binding polypeptides and nucleotides coding therefore
Metal binding polypeptides which include an amino acid sequence coding for a variable region of a monoclonal antibody which immunoreacts with a mercury cation and nucleotides which include a...
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5972597 |
Methods using modified vaccinia virus
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia...
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5968522 |
Immunogenic compositions and antibodies directed against human papillomavirus type 49 (HPV 49), type 50 (HPV 50), type 54 (HPV 54), and type 55 (HPV 55).
The invention relates to papillomavirus probes derived from new DNA-HPVs deposited with the CNCM on the May 6, 1988 under the following filing numbers: PGEM 4 HPV49: I-754 PSP 65 HPV50: I-755...
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5968777 |
DNA encoding seryl t-RNA synthetase
The invention provides serS polypeptides and DNA (RNA) encoding serS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing serS...
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5968775 |
Hepatitis C virus infected cell systems
The present invention is directed to extracorporeal cell systems infected with hepatitis C virus (HCV). The present invention also relates to products of such cell systems and their use as vaccines...
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5965139 |
Chicken infectious anemia virus vaccine
Novel sequences in the genome of a wild type isolate of chicken infectious anemia virus are described, The amino acid sequence of a polypeptide, VP1, encoded by a novel sequence is also disclosed....
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5965401 |
Purified mammalian NK antigens and related reagents
NK cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen. Methods of using those reagents and...
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5965400 |
DNA encoding a truncated pneumogoccal surface protein (PspA)
A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble...
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5965140 |
Hybrid particle immunogens
Novel immunogenic compositions are provided involving viral particles composed at least in part of hybrid proteins of at least a portion of a particle forming protein and one or more polypeptides...
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5965124 |
Replication-competent recombinant viral vaccines and method of producing same
Replication-competent recombinant viruses, particularly replication-competent recombinant polioviruses, which include (1) exogenous nucleic acid sequences which encode an exogenous polypeptide and...
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5965402 |
DNA encoding phoH polypeptides
The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods...
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5961983 |
Stable pura vectors and uses therefor
This invention pertains to a complementation system for the selection and maintenance of expressed genes in bacterial hosts. The invention provides stable vectors which can be selected and...
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