|
Match
|
Document |
Document Title |
|
|
7384907 |
Method of treating infection with ABl tyrosine kinase inhibitors
The present invention relates to a method of preventing or treating a pathogen infection comprising administering to a mammal in need thereof an effective amount of an inhibitor of Abl tyrosine...
|
|
|
7381537 |
Use of inhibitors of glutaminyl cyclases for treatment and prevention of disease
The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screeing for such effectors, and the use of such...
|
|
|
7369946 |
Method of identifying inhibitors of Tie-2
The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the...
|
|
|
7364910 |
Methods of inducing ovulation
The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the...
|
|
|
7342108 |
De novo DNA cytosine methyltransferase genes, polypeptides and uses thereof
De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine...
|
|
|
7335492 |
Process for partitioning of proteins
The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest...
|
|
|
7311907 |
Lentiviral packaging cells
Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing...
|
|
|
7306938 |
High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
Methods for identifying compounds that are inhibitors of bacterial fatty acid biosynthesis are disclosed. Such compounds can be used as lead compounds in methods for preparing antibacterial agents...
|
|
|
7297514 |
Method for preventing superoxide damage to cells and oxygen-labile proteins
A method of reducing superoxide damage to a cell is disclosed. In one embodiment, this method comprises the step of engineering the cell to produce more than a native amount of the YggX protein or...
|
|
|
7285406 |
Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where...
|
|
|
7282325 |
Method of preparing pharmaceutical compositions
A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is...
|
|
|
7279302 |
Methods for identifying herbicidal compounds
The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive...
|
|
|
7276348 |
Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and...
|
|
|
7270979 |
DNA for expression of alpha 1-antitrypsin in methylotropic yeast
Alpha 1-antitrypsin is prepared by growing in a fermentor methylotropic yeast transformants containing in their genome at least one copy of DNA encoding alpha 1-antitrypsin, in operational linkage...
|
|
|
7264809 |
Methods of inhibiting platelet activation and recruitment
The present invention provides soluble CD39 polypeptides and compositions, and methods for inhibiting platelet activation and recruitment in a mammal comprising administering a soluble CD39...
|
|
|
7258984 |
Compositions and methods for identifying agents which regulate autolytic processes in bacteria
A nucleic acid sequence which regulates the autolytic activity of bacteria is provided. Methods for identifying and using agents which interact with the gene to inhibit bacterial growth and...
|
|
|
7256267 |
Polynucleotide encoding a novel human serpin secreted from lymphoid cells, LSI-01
The present invention provides novel polynucleotides encoding LSI-01 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic...
|
|
|
7256028 |
Methods for screening compounds that modulate lipid metabolism
Drug screening assays useful in the discovery of pharmaceutically active compounds for use in the treatment of diseases involving abnormal lipid metabolism including diabetic neuropathy are taught....
|
|
|
7256013 |
Kit for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase
The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method...
|
|
|
7252952 |
In vivo production of cyclic peptides for inhibiting protein—protein interaction
The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting...
|
|
|
7247704 |
Multifunctional protease inhibitors and their use in treatment of disease
Fusion proteins of protease inhibitors are provided, in particular fusion proteins of alpha 1-antitrypsin (AAT) and a second protease inhibitor, such as secretory leukocyte protease inhibitor...
|
|
|
7244708 |
Inhibitors of memapsin 2 and use thereof
Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
|
|
|
7244590 |
Regulatory protein for Nox enzymes
The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell...
|
|
|
7241582 |
Diagnostic test kits
This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus...
|
|
|
7238779 |
Acyl CoA:cholesterol acyltransferase (ACAT-2)
Nucleic acid compositions encoding novel ACAT proteins, as well as the novel ACAT-2 proteins, (ACAT-2) are provided. Also provided are methods of producing the subject nucleic acid and protein...
|
|
|
7238470 |
Method of treating or inhibiting obesity
A method for the discovery of compounds suitable for the treatment and/or prophylaxis of obesity, in which the ability of the test compounds to inhibit de novo lipogenesis in mammals and/or man is...
|
|
|
7226729 |
Method for inhibiting degradation of brain natriuretic peptides
A method for inhibiting the degradation of mammalian natriuretic peptides, in particular BNP, by using containers wherein the face coming into contact with specimens are made of silicone or...
|
|
|
7220552 |
Bifunctional molecules and their use in the disruption of protein-protein interactions
Bifunctional inhibitor molecules and methods for their use in the inhibition of protein—protein interactions are provided. The subject bifunctional inhibitor molecules are conjugates of a target...
|
|
|
7205127 |
Methods of treating insulin resistance with an inhibitor of an NAD(P)H oxidase
The present invention relates to the use of NAD(P)H oxidase inhibitors to increase cellular uptake of glucose and in the treatment and/or prevention of diseases caused by insulin resistance or...
|
|
|
7195894 |
MKK7 activation inhibitor
PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3...
|
|
|
7195889 |
Process for stabilizing enzymes with phosphine or phosphite compounds
The invention relates to processes for stabilizing the activity of an enzyme, comprising mixing a phosphine or phosphite with an oxidoreductase enzyme.
|
|
|
7183070 |
Inhibition of Aβ production by β-secretase BACE2
The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of...
|
|
|
7176281 |
Phospholipase A2-inhibitory peptide with anti-arthritic and neuroprotective activities
Peptides that have potent PLA 2 -inhibitory activity are disclosed. Homology searches of known PLA inhibitory molecules were used to identify and subsequently design potent peptide molecules that...
|
|
|
7176005 |
Modulation of sulfate permease for photosynthetic hydrogen production
Sustained hydrogen production is obtained by the culturing of a genetically-modified algae, where the ability of the chloroplasts to intake sulfate is reduced or eliminated compared to wild-type...
|
|
|
7175999 |
Polynucleotide and polypeptide fat metabolism regulators and uses thereof
In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and...
|
|
|
H002181 |
Human tPA production using vectors coding for DHFR protein
A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through...
|
|
|
7160700 |
Glycosyltransferase genes
A nucleic acid encoding a protein which has an amino acid sequence according to SEQ ID NO: 2, 12, or 14, or the amino acid sequence modified by addition or deletion of one or more amino acids...
|
|
|
7157240 |
MID 4460, a human tyrosine phosphatase family member and uses therefor
The invention provides isolated nucleic acids molecules, designated MID 4460 nucleic acid molecules, which encode novel tyrosine phosphatase family members. The invention also provides antisense...
|
|
|
7153824 |
Inhibitors of phosphodiesterases in infertility
The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation...
|
|
|
7150969 |
Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of acetyl-CoA carboxylase 2 (ACC2). The polynucleotide sequence of ACC2sv1 is provided by SEQ ID...
|
|
|
7147855 |
GIPs, a family of polypeptides with transcription factor activity that interact with goodpasture antigen binding protein
The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical...
|
|
|
7135307 |
Gamma three protease
Gamma three protease is provided, a novel aspartyl class protease that is capable of taking part in the processing of amyloid precursor protein (APP) to Aβ peptide. Gamma three protease may be...
|
|
|
7132264 |
Human serpin polypeptides
This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to...
|
|
|
7132231 |
Fluorescence polarization method for determining viral inhibitors
Methods for determining inhibitors of protein interactions are provided. The method involves evaluation of potential inhibitors that can inhibit or prevent protein interactions. The method provides...
|
|
|
7122516 |
Stabilized bioactive peptides and methods of identification, synthesis and use
An intracellular selection system allows concurrent screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression...
|
|
|
7097993 |
Method for identifying an agent that modulates type 1 phosphatidylinositol phosphate kinase isoform β661 activity
The present invention relates to methods of identifying agents which modulate the activity of PIPKIγ661. Methods of using such agents to prevent or treat a cell migration-mediated condition or...
|
|
|
7094575 |
Therapeutic and prophylactic agents and methods of using same
A phospholipase A 2 inhibitor protein designated “Phospholipase Inhibitor from Python” (PIP)—formerly designated “Python Antitoxic Factor” (PAF)—is given by SEQ ID NO:2. The partial...
|
|
|
7094571 |
Combinatorial protein library screening by periplasmic expression
The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides. In the technique, libraries...
|
|
|
7094411 |
Avirulent, immunogenic flavivirus chimeras
Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural proteins of a flavivirus. Chimeric...
|
|
|
7087399 |
β-secretase and modulation of β-secretase activity
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and...
|