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7524667 |
Mutated 6-phosphogluconate dehydrogenase
The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to...
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7524666 |
Reductase gene and use thereof
Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint,...
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7524643 |
CDNA encoding the human alpha2 delta4 calcium channel subunit
The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used...
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7524664 |
Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
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7524647 |
Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases,...
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7524645 |
Fully active alternansucrases partially deleted in its carboxy-terminal and amino-terminal domains and mutants thereof
Nucleic acid sequences of truncated or mutated alternansucrases, vectors containing these nucleic acids sequences, host cells transformed with the nucleic acid sequences encoding truncated or...
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7524655 |
Synthesis of oligosaccharides, glycolipids, and glycoproteins using bacterial glycosyltransferases
This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori . The invention also provides methods to use the fucosyltransferases to synthesize...
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7525016 |
Identification of syn-copalyl diphosphate synthase
The present invention relates to the isolation, purification, sequencing, and functional characterization of the class I and II terpene sequences OsCPS1 ent , OsCPS2 ent , OsCPS4 syn , and OsDTS2....
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7524815 |
Osteoprotegerin in milk
The present invention pertains to osteoprotegerin obtainable from milk sources, in particular human and bovine milk. The present invention also relates to the use thereof for preparing an...
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7524674 |
Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and animals
Novel double and triple fusion reporter gene constructs harboring distinct imageable reporter genes are provided, as well as applications for the use of such double and triple fusion constructs in...
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7524933 |
Maize cellulose synthases and uses thereof
The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels...
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7521217 |
Carbonic anhydrase having increased stability under high temperature conditions
The present invention relates to polynucleotide and polypeptide sequences of carbonic anhydrase variants having increased stability under high temperature conditions compared to native carbonic...
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7521202 |
Method and apparatus for the production of soluble MHC antigens and uses thereof
The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one...
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7521207 |
Rhesus monkey Nur77
The Macaca mulatta (rhesus monkey) Nur77 (rhNur77) nuclear receptor and the nucleic acid encoding the rhNur77 nuclear receptor are described. Further described are methods for identifying...
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7521216 |
Nitrilases and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7521208 |
Vectors encoding interleukin-17 receptor homologue
Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”
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7521205 |
Genes and polypeptides relating to prostate cancers
The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as...
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7521059 |
Kennel cough vaccine
Improved, low cost vaccines for administration to living subjects such as mammals and birds are provided, which include killed recombinantly modified microorganisms (whole cell recombinant bacterin...
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7521221 |
Staphylococcus aureus strain CYL1892
This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus...
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7521204 |
Bacillus host cell
A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s)...
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7521548 |
Apoptosis modulator Bcl-B and methods for making and using same
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human...
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7517684 |
Nucleic acid and amino acid sequences relating to Pseudomonas aeruginosa for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against...
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7517666 |
Methods of inhibiting Helicobacter pylori
This application relates to methods of screening molecules capable of inhibiting the survival of Helicobacter pylori in vivo by specifically inhibiting the activity of UreI, to the molecules...
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7517960 |
Rat KCNQ5 voltage-gated potassium channel
Disclosed herein are nucleic acid and polypeptide sequences of a novel rat voltage-gated potassium channel, KCNQ5. Also disclosed herein are methods related to the use of the aforementioned...
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7517670 |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins...
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7517676 |
Human cyclooxygenase-3 enzyme and uses thereof
The present invention provides nucleic acid and polypeptide sequences describing a neve isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase 3. The isolated nucleic acid or...
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7517671 |
Methods and compositions for concentrating secreted recombinant protein
Methods and compositions are described that relate to obtaining concentrated preparations of secreted recombinant proteins. These proteins are expressed in the form of fusion proteins with a...
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7517672 |
Nucleic acids encoding mammalian T-type calcium channels
Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the α 1G , α 1H and α 1I subunits are...
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7517678 |
Method for protein production
Provided is a novel comprising culturing host cells into which a foreign gene has been introduced for producing a protein in a soluble form encoded by the foreign gene, recombinant cells are...
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7517668 |
Process for the production of protein products in aspergillus
A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding...
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7517669 |
Gene regulation therapy involving ferritin
A method is described for regulating gene expression related to iron metabolism to ameliorate diseases that include sickle cell disease, cancers, neurodegenerative diseases, Friedreich's ataxia and...
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7517949 |
Livin-derived peptides, compositions and uses thereof
The present invention relates to livin-derived peptides with pro-apoptotic activity. More specifically, the present invention provides peptides p30-Livin α and p28-Livin β, derived from Livin α...
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7517647 |
Genetic screen for bioactive peptides
A method of screening for a protein involved in the extracellular regulation of latent TGFβ activation by transducing a cell line with a retroviral cDNA library to create a reporter cell line that...
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7514238 |
Growth factor homolog zvegf4
Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that...
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7514239 |
Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods...
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7514250 |
Coenzyme-binding glucose dehydrogenase
The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has...
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7514398 |
Growth factor complex
An isolated protein complex is provided which includes a growth factor, growth factor binding protein and vitronectin. Preferably, the isolated protein complex includes an insulin-like growth...
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7514222 |
Site selective acylation
Disclosed are novel polypeptides of a four helix bundle formed of two dimerized helix-loop-helix motifs, wherein either both have a sequence according to SEQ. ID No. 1, SEQ. ID No. 2, SEQ. ID No....
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7514253 |
URA5 gene and methods for stable genetic integration in yeast
A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous...
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7514237 |
Systems and methods for protein production
The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing...
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7514545 |
Inducible eukaryotic expression system
Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a...
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7514072 |
Method for the treatment of cerebral ischaemia and use of erythropoietin or erythropoietin derivatives for the treatment of cerebral ischaemia
The present invention relates to a method for the treatment of cerebral ischaemia and a drug for the treatment of cerebral ischaemia in particular in humans, as occurs for example in the case of...
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7514547 |
Helicobacter felis vaccine
The present invention relates to novel Helicobacter felis urease subunit polypeptides and to nucleic acid sequences encoding these subunit polypeptides, to DNA fragments and recombinant DNA...
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7514597 |
Glycosyltransferase gene
The present invention provides an enzyme which catalyzes a reaction to transfer sugar to a hydroxyl group at position 2′ of chalcones and a gene thereof, and preferably an enzyme which catalyzes...
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7510861 |
Gluconate dehydratase
A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell...
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7510854 |
Corynebacterium glutamicum genes encoding metabolic pathway proteins
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7510853 |
Nucleic acids encoding DCRS5
Nucleic acids encoding mammalian, e.g., primate, receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the...
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7510860 |
Xylanases with enhanced thermophilicity and alkalophilicity
The present invention provides a xylanase, or a modified xylanase enzyme comprising at least one substituted amino acid residue at a position selected from the group consisting of amino acid 11,...
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7510851 |
Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia
The present invention provides compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia. In particular, the invention provides methods of identifying...
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7510852 |
Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use
Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are...
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