|
Match
|
Document |
Document Title |
|
|
7544661 |
Self-assembling peptide amphiphiles and related methods for growth factor delivery
Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related...
|
|
|
7544482 |
Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
|
|
|
7544486 |
Nell peptide expression systems and bone formation activity of nell peptide
The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone...
|
|
|
7544487 |
Fusion proteins containing recombinant cytotoxic RNAses
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse...
|
|
|
7544483 |
Method for the production of protamine
The present invention generally relates to the fields of genetic engineering and biochemistry. In particular, it relates to a novel method for the production of protamine as well as to novel method...
|
|
|
7544776 |
Long wavelength engineered fluorescent proteins
Engineered fluorescent proteins, nucleic acids encoding them and methods of use.
|
|
|
7544484 |
Nucleic acids encoding membrane-binding proteins and methods of using same
A secretory or membrane-binding chimeric protein composed of an energy-generating protein and an energy-receiving protein linked one another wherein energy transfer can arise between the...
|
|
|
7544488 |
Secretion, transcription and sporulation genes in Bacillus clausii
The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to...
|
|
|
7544788 |
Isolated nucleic acid molecule encoding a neurotrophic growth factor
There is disclosed an isolated nucleic acid molecule encoding a human neurotrophic growth factor designated enovin and having the amino acid sequence illustrated in FIG. 1, 21, 23 or 24 or...
|
|
|
7541162 |
Method for producing factor G derived from horseshoe crab
The invention provides a virus harboring a DNA encoding a subunit of limulus-derived factor G, the virus being capable of mass-producing a (1→3)-β-D-glucan assay reagent of satisfactory quality,...
|
|
|
7541333 |
Angiogenically effective unit dose of FGF-2 and method of use
The present invention has multiple aspects. In particular, in one aspect, the present invention is directed to a unit dose composition comprising 0.2 μg/kg to 48 μg/kg of an FGF-2 of SEQ ID NO:...
|
|
|
7541434 |
Polypeptide for a TRP channel family member, TRP-PLIK2, and splice variants
The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and...
|
|
|
7541040 |
Chimeric molecule for the treatment of th2-like cytokine mediated disorders
The invention provides uses and methods for alleviating respiratory tract symptoms of allergy, asthma, and of viral, bacterial, fungal and parasitic infections by shifting inappropriate TH2...
|
|
|
7541446 |
Tet repressor-based transcriptional regulatory proteins
The present invention provides a panel of transcriptional activator fusion proteins which comprises both tetracycline controlled transactivator proteins and reverse tetracycline transactivator...
|
|
|
7541044 |
Administration of 5T4 antigen and immune response of cells expressing 5T4 and CEA antigens
The invention provides the use of an enzyme and a prodrug in the manufacture of a medicament for use in inducing an anti-tumor immune response in a human patient.
|
|
|
7541441 |
Antibodies that specifically bind to TL5
The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune...
|
|
|
7541179 |
Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
|
|
|
7541170 |
Nucleic acid modifying enzymes
This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a...
|
|
|
7541450 |
Ligand-dependent protein splicing
Ligand-dependent inteins allow for modulation of a protein's activity in vivo. Upon binding of the ligand to the ligand-dependent intein inserted into the protein of interest, the hybrid protein...
|
|
|
7537914 |
Nucleic acid and allergenic polypeptides encoded thereby in cashew nuts (Anacardium occidentale)
The invention describes an isolated nucleic acid sequence comprising the nucleotide sequence of SEQ ID NO:1 or a degenerate variant of SEQ ID NO:1. The nucleic acid sequence encodes an Ig-E binding...
|
|
|
7537922 |
Proteases and variants thereof
The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and...
|
|
|
7537916 |
Efficient production of F(ab')2 fragments in mammalian cells
The present invention provides immortalized eukaryotic cells and methods useful for the production of immunologically active bivalent antibody fragments, such as F(ab′) 2 fragments. The methods...
|
|
|
7538209 |
Lactobacillus acidophillus nucleic acid sequences encoding cell surface protein homologues and uses therefore
Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface...
|
|
|
7537919 |
Cytochrome P450RAI-2 and related proteins
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
|
|
|
7534445 |
Chlamydia protein, sequence and uses thereof
A high molecular weight (“HMW”) protein of chlamydia , the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence...
|
|
|
7534436 |
Peptide fragments of the harp factor inhibiting angiogenesis
The invention concerns peptide fragments 13-39 and 65-97 of the HARP factor, which inhibit angiogenesis. Advantageously, said peptides can be associated with the peptide 111-136 of HARP. The...
|
|
|
7534935 |
Phospholipid:diacylglycerol acyltransferases
This invention relates to an isolated nucleic acid fragment encoding an acyltransferase, more specifically a phospholipid:diacylglycerol acyltransferase. The invention also relates to the...
|
|
|
7534876 |
Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface...
|
|
|
7534594 |
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated nucleic acids encoding the polypeptides. The invention also relates to nucleic acid...
|
|
|
7534874 |
Gene involved in V(D)J recombination and/or DNA repair
The invention related to a new gene and protein involved in V(D)J recombination and/or DNA repair. The invention also relates to methods of diagnosis and therapy using these gene and protein. The...
|
|
|
7534861 |
Compositions and methods for immunoaffinity purification
A hybrid polypeptide composed of a p53 epitope peptide and a desired functional protein are produced by recombinant DNA techniques. A DNA expression vector is constructed that includes segments of...
|
|
|
7531336 |
Methods for producing recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides
The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of...
|
|
|
7531626 |
Tenebrio antifreeze proteins
A novel class of thermal hysteresis (antifreeze) proteins (THP) that have up to 100 times the specific activity of fish antifreeze proteins has been isolated and purified from the mealworm beetle, ...
|
|
|
7531322 |
Cell-specific retroviral vectors with antibody domains and method for the production thereof for selective gene transfer
The invention relates to cell-specific retroviral vectors with antibody recognition domains (scFv), which are suitable for cell-specific transduction of a selected mammal cell type (cell...
|
|
|
7531628 |
Canine CD20 compositions
The invention provides canine CD20 nucleotide and protein sequences. These compositions are useful in the diagnosis and treatment of, e.g., CD20+ B-cell lymphoma, immune-mediated hemolytic anemia,...
|
|
|
7531523 |
Sodium channel protein type III alpha-subunit splice variant
The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same.
|
|
|
7531169 |
High affinity anti-human IgE antibodies
The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and...
|
|
|
7531332 |
Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine using Escherichia bacteria
A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by...
|
|
|
7531317 |
Fluorescence polarization assay to detect protease cleavage
The invention discloses a method of determining protease activity, in real time, using fluorescence polarization technology. In particular, the invention provides vectors and a method for their...
|
|
|
7531321 |
Fibroblast growth factor-like molecules and uses thereof
The present invention provides Fibroblast Growth Factor-Like (FGF-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host...
|
|
|
7531320 |
Modulation of β-catenin/TCF-activated transcription
The present invention provides compounds and methods for modulating transcription activated by β-catenin/TCF, such as the selective inhibition of genes targeted by the Wnt/β-catenin pathway.
|
|
|
7531327 |
Methods and compositions for increasing longevity and protein yield from a cell culture
Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as...
|
|
|
7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
|
|
|
7531351 |
Liquid-gas-phase exposure reactor for cell culturing
Initiation of growth and cultivation of cells can be performed by introducing the cells into culture compartments of a liquid-gas-phase exposure bioreactor containing a supply chamber in which...
|
|
|
7531323 |
Diabetes-mediating proteins and therapeutic uses thereof
Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for...
|
|
|
7531325 |
Method for cleavage of fusion proteins
An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The...
|
|
|
7531335 |
Modified cytochrome p450 monooxygenases
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
|
|
|
7527958 |
Truncated 1,3-1,4-β-D-glucanase
A truncated 1,3-1,4-β-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
|
|
|
7527943 |
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of...
|
|
|
7527957 |
Methods of altering the sensitivity of a xylanase to a xylanase inhibitor
The present invention relates to a variant xylanase polypeptide, or fragment thereof having xylanse activity, comprising one or more amino acid modifications such that the polypeptide or fragment...
|