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7537919 |
Cytochrome P450RAI-2 and related proteins
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
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7534445 |
Chlamydia protein, sequence and uses thereof
A high molecular weight (“HMW”) protein of chlamydia , the amino acid sequence thereof, and antibodies that specifically bind the HMW protein are disclosed as well as the nucleic acid sequence...
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7534436 |
Peptide fragments of the harp factor inhibiting angiogenesis
The invention concerns peptide fragments 13-39 and 65-97 of the HARP factor, which inhibit angiogenesis. Advantageously, said peptides can be associated with the peptide 111-136 of HARP. The...
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7534935 |
Phospholipid:diacylglycerol acyltransferases
This invention relates to an isolated nucleic acid fragment encoding an acyltransferase, more specifically a phospholipid:diacylglycerol acyltransferase. The invention also relates to the...
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7534876 |
Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
Cell wall, cell surface and secreted protein nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, cell wall, cell surface...
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7534594 |
Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated nucleic acids encoding the polypeptides. The invention also relates to nucleic acid...
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7534874 |
Gene involved in V(D)J recombination and/or DNA repair
The invention related to a new gene and protein involved in V(D)J recombination and/or DNA repair. The invention also relates to methods of diagnosis and therapy using these gene and protein. The...
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7534861 |
Compositions and methods for immunoaffinity purification
A hybrid polypeptide composed of a p53 epitope peptide and a desired functional protein are produced by recombinant DNA techniques. A DNA expression vector is constructed that includes segments of...
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7531336 |
Methods for producing recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides
The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of...
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7531626 |
Tenebrio antifreeze proteins
A novel class of thermal hysteresis (antifreeze) proteins (THP) that have up to 100 times the specific activity of fish antifreeze proteins has been isolated and purified from the mealworm beetle, ...
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7531322 |
Cell-specific retroviral vectors with antibody domains and method for the production thereof for selective gene transfer
The invention relates to cell-specific retroviral vectors with antibody recognition domains (scFv), which are suitable for cell-specific transduction of a selected mammal cell type (cell...
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7531628 |
Canine CD20 compositions
The invention provides canine CD20 nucleotide and protein sequences. These compositions are useful in the diagnosis and treatment of, e.g., CD20+ B-cell lymphoma, immune-mediated hemolytic anemia,...
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7531523 |
Sodium channel protein type III alpha-subunit splice variant
The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same.
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7531169 |
High affinity anti-human IgE antibodies
The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and...
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7531332 |
Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine using Escherichia bacteria
A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by...
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7531317 |
Fluorescence polarization assay to detect protease cleavage
The invention discloses a method of determining protease activity, in real time, using fluorescence polarization technology. In particular, the invention provides vectors and a method for their...
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7531321 |
Fibroblast growth factor-like molecules and uses thereof
The present invention provides Fibroblast Growth Factor-Like (FGF-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host...
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7531320 |
Modulation of β-catenin/TCF-activated transcription
The present invention provides compounds and methods for modulating transcription activated by β-catenin/TCF, such as the selective inhibition of genes targeted by the Wnt/β-catenin pathway.
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7531327 |
Methods and compositions for increasing longevity and protein yield from a cell culture
Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as...
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7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
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7531351 |
Liquid-gas-phase exposure reactor for cell culturing
Initiation of growth and cultivation of cells can be performed by introducing the cells into culture compartments of a liquid-gas-phase exposure bioreactor containing a supply chamber in which...
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7531323 |
Diabetes-mediating proteins and therapeutic uses thereof
Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for...
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7531325 |
Method for cleavage of fusion proteins
An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The...
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7531335 |
Modified cytochrome p450 monooxygenases
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
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7527958 |
Truncated 1,3-1,4-β-D-glucanase
A truncated 1,3-1,4-β-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
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7527943 |
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of...
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7527957 |
Methods of altering the sensitivity of a xylanase to a xylanase inhibitor
The present invention relates to a variant xylanase polypeptide, or fragment thereof having xylanse activity, comprising one or more amino acid modifications such that the polypeptide or fragment...
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7527944 |
Taste receptors of the T1R family from domestic cat
The present invention relates to the discovery of several genes of the domestic cat ( Felis catus ) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of...
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7528242 |
Methods and compositions comprising Renilla GFP
The invention relates to methods and compositions utilizing Renilla green fluorescent proteins (rGFP), and Ptilosarcus green fluorescent proteins (pGFP). In particular, the invention relates to...
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7527927 |
Stable recombinant yeasts for fermenting xylose to ethanol
Described are recombinant yeast which ferment xylose to ethanol and which maintain their ability to do so when cultured for numerous generations in non-selective media. The preferred yeast contain...
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7527956 |
Modified human acid sphingomyelinase having increased activity, and methods for making the same
Deficiencies in the enzymatic activity of acid sphingomyelinase (ASM) result in Niemann-Pick disease. A variety of modifications which eliminate the activity of the free thiol on the C-terminal...
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7527951 |
Engineering fungi for the utilisation of L-arabinose
A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and...
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7528245 |
Efficient protein expression system
Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified...
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7528244 |
Regulators of apoptosis
The invention provides methods and compositions relating to apoptosis regulating proteins, known as Casper proteins, and related nucleic acids. The proteins may be produced recombinantly from...
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7527952 |
Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA)
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of...
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7527950 |
Method for producing an L-amino acid by enhancing expression of the yfiK gene in an Escherichia bacterium
A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of the yfiK...
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7527945 |
Transfection kinetics and structural promoters
The invention features methods of analyzing the kinetics properties of transfection reactions. Also featured are methods for creating structural promoters which are effectively unregulated by...
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7527942 |
Transcription amplification system for molecular imaging
The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product...
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7524648 |
Expression system for enhancing solubility and immunogeneicity of recombinant proteins
Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric...
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7524660 |
Utilization of fructose in microbial production strains
A process has been developed for the utilization of fructose by PTS − microorganisms. Providing the microorganisms with increased fructokinase activity, and optionally with increased fructose...
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7524657 |
Alleles of the sigA gene from coryneform bacteria
The invention relates to alleles of the sigA gene from coryneform bacteria which code for sigma factors A and a process for the fermentative preparation of L-lysine using bacteria which contain...
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7524646 |
Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases
The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function...
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7524507 |
Recombinant microorganisms
A method of enhancing expression of a desired protein at mucosal effector sites, the method including placing the protein to be expressed under the control of a promoter having SEQ ID NO: 2, SEQ ID...
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7524644 |
Method for oxygen regulated production of recombinant staphylokinase
The present invention relates to a nucleotide sequence of expression cassette OXY-1 of SEQ ID No. 1, a modified staphylokinase SAK-2 gene of SEQ ID No. 2, a peptide sequence of modified...
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7524667 |
Mutated 6-phosphogluconate dehydrogenase
The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to...
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7524666 |
Reductase gene and use thereof
Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint,...
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7524643 |
CDNA encoding the human alpha2 delta4 calcium channel subunit
The present invention provides nucleic acid and polypeptide sequences describing an isoform of the α2δ-4 subunit of a voltage gated calcium channel. The nucleic acids described herein can be used...
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7524664 |
Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
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7524647 |
Site specific incorporation of keto amino acids into proteins
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases,...
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7524645 |
Fully active alternansucrases partially deleted in its carboxy-terminal and amino-terminal domains and mutants thereof
Nucleic acid sequences of truncated or mutated alternansucrases, vectors containing these nucleic acids sequences, host cells transformed with the nucleic acid sequences encoding truncated or...
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