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9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9040257 Basidiomycetous yeast mutant  
The present invention provides a host for genetic recombination useful in the production of heterologous proteins in a large scale, by suppressing the production of extracellular polysaccharides...
9040676 Vigilant cells  
The invention concerns a system for modulating tissue physiology, for example, to prevent or reverse tissue damage caused by disease. The system utilizes vigilant cells that include stable vectors...
9040302 Genetically modified Streptococcus thermophilus bacterium  
Methods and compositions for targeted delivery of biotherapeutics are provided. The compositions comprise bile-sensitive St. thermophilus bacteria modified to release a biotherapeutic agent...
9034650 Site-specific serine recombinases and methods of their use  
The present invention provides a method for obtaining site-specific recombination in a eukaryotic cell, the method comprising providing a eukaryotic cell that comprises a first recombination...
9034608 Polypeptides with permease activity  
The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO:...
9034599 Polynucleotides encoding monomeric variants of the tetrameric eqFP611  
DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA...
9034643 Connective tissue growth factor antibodies  
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention...
9034628 Induction of gene expression using a high concentration sugar mixture  
Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.
9034649 Protein production method  
This invention relates to a method for producing a protein of interest, comprising introducing a protein expression vector which comprises a gene fragment a gene fragment comprising a DNA encoding...
9034598 Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases  
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use...
9029522 Recombinant fusion interferon for animals  
A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a Fc region of an animal immunoglobulin G (IgG). The animal interferon and the Fc...
9028844 Vaccine against Trypanosoma cruzi infection  
The present invention relates to a vaccine against Trypanosoma cruzi infection, useful in the prevention and/or treatment of the Chagas disease. More specifically, the present invention relates to...
9029112 Ketoreductase-mediated stereoselective route to alpha chloroalcohols  
The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α-chloroalcohols from α-chloroketones. Also provided are polynucleotides encoding...
9029508 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
9023617 Insulated herpesvirus-derived gene expression cassettes for sustained and regulatable gene expression  
Disclosed are genetic expression cassettes, and vector comprising them useful for the delivery of nucleic acid segments encoding selected therapeutic constructs (including for example, peptides,...
9023620 Method of providing color clarification of laundry  
The present invention relates to enzyme preparations consisting essentially of an enzyme which has cellulytic activity, which perform very well in industrial applications such as laundry...
9023989 Protein-based photovoltaics and methods of use  
Protein-based photovoltaic cells and the manufacture and use of protein-based photovoltaic cells are described. In one embodiment, bacteriorhodopsin from Halobacterium salinarum, which undergoes...
9023618 Engineering complex microbial phenotypes with transcription enhancement  
The present invention relates to a recombinant E. coli exhibiting a complex phenotype, comprising one or more RNA polymerase subunit genes, one or more functional genes, and, optionally, one or...
9023637 Enhanced citric acid production in Aspergillus with inactivated asparagine-linked glycosylation protein 3 (Alg3), and/or increased LaeA expression  
Provided herein are fungi, such as Aspergillus niger, having a dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase (Alg3) gene genetic inactivation, increased expression of a loss of...
9023619 Non-natural gelatin-like proteins with enhanced functionality  
The invention concerns non-natural Gly-Xaa-Yaa-protein monomers and non-natural Gly-Xaa-Yaa-proteins comprising or consisting of multimers of the monomers. The non-natural Gly-Xaa-Yaa-proteins can...
9023621 Methods for identifying and isolating cells expressing a polypeptide  
The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific...
9017967 Modular DNA-binding domains and methods of use  
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in...
9017965 Hybrid 3′ untranslated regions suitable for efficient protein expression in mammalian cells  
The present invention describes the use of hybrid short 3′ untranslated (3′UTR) regions which are composed of two regions, one region from an 3′ untranslated region of a stable eukaryotic mRNA,...
9017695 Chimeric therapeutics, compositions, and methods for using same  
Chimeric therapeutics are disclosed that include a modified viral core protein comprising at least one mutation or modification in an immunogenic epitope and a therapeutic agent. The therapeutic...
9018450 Genes that increase plant oil and method for using the same  
This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per...
9017966 E. coli plasmid DNA production  
General methods and strains of bacteria are described, that dramatically simplify and streamline plasmid DNA production. In one preferred embodiment, endolysin mediated plasmid extraction combined...
9017987 Expression of proteins in plants  
The invention relates to a method of producing an influenza virus H5 polypeptide in a plant comprising the steps of cloning an influenza H5 gene or nucleic acid encoding its functional equivalent...
9012197 Production of hemagglutinin-neuraminidase protein in microalgae  
The present invention is directed to recombinant microalgal cells and their use in production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well as compositions and uses thereof.
9012177 Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels  
The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure...
9012199 Recombinant carrier molecule for expression, delivery and purification of target polypeptides  
Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides)...
9012189 Modified alcohol dehydrogenases for the production of fuels and chemicals  
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
9012726 Genes that increase plant oil and method for using the same  
This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per...
9012176 Chinese hamster ovary cell lines  
We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in...
9012727 Genes that increase plant oil and method for using the same  
This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per...
9012616 Polynucleotide for improving protein production in microorganisms of the phylum labyrinthulomycota  
The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal...
9012731 Soybean variety XB05L13  
A novel soybean variety, designated XB05L13 is provided. Also provided are the seeds of soybean variety XB05L13, cells from soybean variety XB05L13, plants of soybean XB05L13, and plant parts of...
9012175 Mutant AOX1 promoters  
A mutant Pichia pastoris alcohol oxidase 1 (AOX1) promoter of the wild type Pichia pastoris AOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a)...
9012220 Cells, nucleic acid constructs, cells comprising said constructs and methods utilizing said cells in the treatment of diseases  
The present invention relates to cells capable of expressing IDO, nucleic acid constructs for expression of IDO, cells comprising said constructs and methods of utilizing said cells in the...
9006408 Modified lecithin-cholesterol acyltransferase enzymes  
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of...
9005973 Targeted genomic modification with partially single-stranded donor molecules  
Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules...
9005948 EGVII endoglucanase and nucleic acids encoding the same  
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and...
9005921 Polynucleotides encoding IL-31 monoclonal antibodies  
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the...
9005947 BGL7 beta-glucosidase and nucleic acids encoding the same  
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host...
9005949 Pregnancy-associated plasma protein-A2 (PAPP-A2) polynucleotides  
The present invention provides pregnancy associated plasma protein A2 (PAPP-A2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode PAPP-A2,...
9005938 Aldolases, nucleic acids encoding them and methods for making and using them  
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these...
9006412 Expression vector for pseudonocardia autotrophica  
An expression vector capable of expressing a foreign gene in Pseudonocardia autotrophica; a transformant of Pseudonocardia autotrophica produced by using the expression vector; a method for...
9006520 DIG-3 insecticidal Cry toxins  
DIG-3 Cry toxins, polynucleotides encoding such toxins, and transgenic plants that produce such toxins are useful to control insect pests.
8999668 Glycosylated protein expression in prokaryotes  
The present invention relates to a prokaryotic host cell comprising eukaryotic glycosyltransferase activity, where the eukaryotic glycosyltransferase activity is eukaryotic dolichyl-linked...
8999324 Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity  
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with...