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8802395 Method for protein isolation in anoxic conditions  
The present invention relates to a method for the isolation of proteins that comprise disulfide bonds in their native conformation. Essentially, a method of the present invention makes use of...
8802816 Method of obtaining a purified, biologically active heterologous protein  
The invention relates to methods of separation and/or purification of impurities yielding a purified heterologous protein product devoid of related impurities or with substantially minimal...
8802401 Methods and compositions for preparation of selectively protected carbohydrates  
The disclosure relates to engineered P450 polypeptides and use of such polypeptides in chemoenzymatic methods to construct selectively protected carbohydrates, which are useful as building blocks...
8802080 Raav expression systems for genetic modification of specific capsid proteins  
Disclosed are improved recombinant adeno-associated viral (rAAV) vectors having mutations in one or more capsid proteins. Exemplary vectors are provided that have altered affinity for heparin or...
8802393 Arabinose isomerase expressed from Corynebacterium genus and tagatose manufacturing method by using it  
The present invention relates to a thermophilic arabinose isomerase and a method of manufacturing tagatose using the same, and more precisely, a gene encoding arabinose isomerase originating from...
8796005 Surfactant tolerant cellulase and method for modification thereof  
A method for suppressing a reduction in an endoglucanase activity in the presence of a surfactant, characterized by modifying a protein having the endoglucanase activity in which the N-terminus is...
8796438 Nucleic acids encoding inactive variants of human telomerase  
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically inactive variants...
8796007 Method for production of polypeptide  
The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising...
8795990 Recombinant enzyme with altered feedback sensitivity  
The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase...
8796419 Hydrophobic interaction chromatography method  
Herein is reported a method for purifying a polypeptide comprising a histidine-tag comprising the steps of i) applying a solution comprising the polypeptide with a histidine-tag to a hydrophobic...
8795675 Allergy inhibitor compositions and kits and methods of using the same  
Compositions, methods, and kits for inhibiting an allergic response against an allergenic protein are disclosed. Compositions, methods and kits for inhibiting an allergic response against an a...
8795981 Cell detection  
In one aspect the present invention provides a method of identifying a cell or cell colony which produces a polypeptide of interest, the method comprising exposing one or more cells to a marker...
8796002 Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols  
The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding...
8795667 Compositions for the prevention and treatment of smallpox  
The present invention relates to improved compositions for the prevention and treatment of smallpox, and in particular to the use of compositions containing an antibody that binds to an epitope...
8795959 Isolated glucokinase genomic polynucleotide fragments from chromosome 7  
Provided are isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit...
8796008 Influenza A virus vaccines and inhibitors  
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the...
8795984 Production of glycoproteins with reduced O-glycosylation  
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an...
8790639 Enhanced antimicrobial lytic activity of a chimeric Ply187 endolysin  
Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall binding domain is a potent agent...
8790911 Increased ethanol production by genetic engineering of microorganisms to express hemoglobin  
The present disclosure describes novel bacterial strains which express a pyruvate decarboxylase gene and at least one alcohol dehydrogenase gene from a bacteria of the genus Zymomonas and also...
8790896 Method for increasing protein expression in cells  
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or...
8790928 Utilisation of constructs comprising recombination sequence motifs for enhancing gene expression in moss  
A method of amplifying gene expression in a moss plant cell or moss tissue, DNA constructs therefor, moss plant cells and uses thereof for the production of protein.
8791238 Artificial binding proteins based on ubiquitin  
The invention relates to modified proteins of the superfamily of “ubiquitin-like proteins”, proteins that have a ubiquitin-like fold and fragments or fusion proteins thereof. As a result of said...
8790895 Generation of artificial binding proteins on the basis of ubiquitin proteins  
The invention relates to modified proteins of the superfamily of “ubiquitin-like proteins”, proteins that have a ubiquitin-like fold and fragments or fusion proteins thereof. As a result of said...
8791249 Nucleic acid encoding humanized c-kit antibody  
This invention relates to compositions and methods for treating c-Kit associated disorders such as fibrosis, and more particularly, to compositions containing humanized c-Kit antibodies.
8790897 Treatment of mucus hypersecretion  
The present invention relates to treatment of mucus hypersecretion, to compositions therefore and manufacture of those compositions. The present invention relates particularly, though not...
8790906 Lysophospholipid acyltransferase  
The present invention provides novel lysophospholipid acyltransferases. The object of the present invention is attained by the nucleotide sequences of SEQ ID NOs: 1 and 6 and the amino acid...
8785153 Antibodies against human IL33R and uses thereof  
An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that...
8785162 Aminotransferase and oxidoreductase nucleic acids and polypeptides and methods of using  
The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and...
8785152 Process for production of non-natural protein having ester bond therein  
A non-natural protein having at least one ester bond in its polypeptide main chain is synthesized by using an in vivo translation system in a ribosome. The following components (a) to (c) are...
8784813 L-amino acid oxidase with cytotoxic activity from Aplysia punctata  
The present invention relates to a cytotoxic polypeptide which is an L-amino acid oxidase isolated from the ink of the sea hare Aplysia punctata.
8785161 Method for producing L-amino acids using bacteria of the enterobacteriaceae family  
There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae...
8785159 Extracellular secretion of recombinant proteins  
Nucleic acids encoding secretion signals, expression vectors containing the nucleic acids, and host cells containing the expression vectors are disclosed. Also disclosed are polypeptides that...
8784799 Duplexed parvovirus vectors  
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
8778654 Recombinant bacteria for producing deoxyviolacein and uses thereof  
Recombinant bacteria for producing deoxyviolacein and uses thereof are provided, wherein the recombinant bacteria is obtained by introducing the deoxyviolacein synthesis-related gene cluster into...
8778632 Δ6-desaturase genes and uses thereof  
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 6 (i.e., “Δ6-desaturase”). In particular, Δ6-desaturase may be...
8778649 Use of acidothermus cellulolyticus xylanase for hydrolyzing lignocellulose  
A thermophilic endo-beta-1,4-xylanase derived from Acidothermus cellulolyticus is disclosed. The xylanase exhibits xylanase activity at an optimal temperature of 90° C. and an optimal pH range of...
8778635 Thermostable proteins and methods making and using thereof  
The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also...
8778645 Method for the production of glutaconate  
The present invention relates to a novel method for the biocatalytic production of unsaturated dicarboxylic acids by cultivating a recombinant microorganism co-expressing a glutaconate...
8778633 Transcription factor modulator  
The present invention relates to novel agents that are useful for modulating transcription factor activity. In particular, the present invention relates to a transcription factor modulator...
8778358 Immunogenic compositions for gram positive bacteria such as Streptococcus agalactiae  
The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to...
8778651 Nitrilases, nucleic acids encoding them and methods for making and using them  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
8778634 Non-cytotoxic protein conjugates  
The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a...
8778878 Use of ferritin to treat iron disorders  
Methods and compositions for treating an iron disorder in a patient are presented, including methods for delivering a therapeutically effective amount of iron to the brain. Iron disorders that may...
8778353 Influenza virus-like particle (VLP) compositions  
Influenza virus-like particles (VLPs) comprising influenza antigenic polypeptides are described. Also described are compositions comprising these VLPs as well as methods of making and using these...
8771671 Induced activation in dendritic cells  
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
8771986 Engineered cleavage half-domains  
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and...
8771987 Mammalian cell lines for increasing longevity and protein yield from a cell culture  
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies,...
8771989 Vectors and yeast strains for protein production: Ca2+ ATPase overexpression  
Lower eukaryote host cells in which an endogenous or heterologous Ca2+ ATPase is overexpressed are described. Also described are lower eukaryote host cells in which a calreticulin and/or ERp57...
8771985 Genome editing of a Rosa locus using zinc-finger nucleases  
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain....
8771998 Process for the production of gamma-aminobutyric acid  
The present invention relates to a novel method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate...