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8877462 Combinatorial DNA library for producing modified N-glycans in lower eukaryotes  
The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar...
8871490 Alpha-4-beta-7 heterodimer specific antagonist antibody  
There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.
8871491 Capsular gram-positive bacteria bioconjugate vaccines  
The present invention encompasses a novel S. aureus bioconjugate vaccine. More generally, the invention is directed to Gram-positive and other bioconjugate vaccines containing a protein carrier,...
8871466 Method for enhancing the production yield of human papillomavirus L1 protein  
This invention is a method for improving production yield of HPV L1 protein including the phase of culturing cell expressing HPV L1 protein in a medium containing high concentration of carbon...
8871468 Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins  
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs)...
8871478 Coryneform bacterium transformant and process for producing isobutanol using the same  
A Corynebacterium glutamicum transformant having the capability of producing isobutanol and the following genes (1) to (5): (1) a gene which encodes an enzyme having acetohydroxy acid synthase...
8871999 Protection against herbivores  
The present invention relates to genes, proteins and methods comprising molecules that alter amino acid levels. In one embodiment, the present invention relates to altering guanidino substrate...
8871516 Use of tailored recombinases for the treatment of retroviral infections  
The present invention is directed to a method for preparing an expression vector encoding a tailored recombinase, wherein said tailored recombinase recombines asymmetric target sites within the...
8865428 Protein production method, fusion protein, and antiserum  
Disclosed are a highly efficient method for production of heterologous proteins performed by utilizing microorganisms, as well as fusion proteins, and an antiserum. The method includes a method...
8865411 Methods of identifying modulators of TDP-43 mediated cellular toxicity  
Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.
8865429 Increased oil content by increasing Yap1 transcription factor activity in oleaginous yeasts  
Transgenic oleaginous yeast having increased oil content comprising increased Yap1 transcription factor activity, wherein the increased oil content is compared to the oil content of a...
8859230 Polypeptides comprising an ice-binding activity  
The present invention relates to novel polypeptides comprising an ice-binding capability resulting in an ice crystal formation and/or growth reducing or inhibiting activity. The present invention...
8859252 Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same  
The present invention relates generally to prostatic acid phosphatase (PAP), compositions comprising the same, and methods for producing and/or purifying the same.
8859229 Transient transfection with RNA  
A method of mRNA production for use in transfection is provided, that involves in vitro transcription of PCR generated templates. This RNA can efficiently transfect different kinds of cells. This...
8859236 Microorganism with improved production of 5′-xanthosine monophosphate and 5′-guanine monophosphate, and production method of 5′-xanthosine monophosphate and 5′-guanine monophosphate using same  
The present invention relates to a microorganism with improved production of 5′-xanthosine monophosphate and 5′-guanine monophosphate, and more specifically, to a Corynebacterium sp. microorganism...
8859232 Genetically encoded photomanipulation of protein and peptide activity  
The present invention relates to fusion proteins comprising protein light switches and methods of photomanipulating the activity of the proteins. The invention further relates to polynucleotides...
8852612 Universal carrier for targeting molecules to Gb3 receptor expressing cells  
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys,...
8853145 BLID; a novel protein domain for interaction with the Bcl-2 family of proteins  
In this invention, a novel protein interaction domain is provided along with several of its variants. This domain is involved in protein-protein interactions with the Bcl-2 family of proteins. It...
8852909 Ketoreductase polypeptides for the reduction of acetophenones  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8852913 Variants of beta-glucosidases  
The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842...
8853154 Fibronectin based scaffold domain proteins that bind to myostatin  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
8852887 Antibodies against human tweak and uses thereof  
An antibody binding to TWEAK comprising as heavy chain variable domain a CDR3H selected from the group consisting of SEQ ID NO: 8, 16 or 24.
8853374 Process for production of recombinant proteins as a soluble form  
A target protein is prepared as soluble protein using a recombinant protein expression system. An expression vector is used that includes (1) an expression-inducible promoter sequence; (2) a first...
8853492 Plants having improved growth characteristics and a method for making the same  
The present invention relates generally to the field of molecular biology and concerns a method for improving plant growth characteristics relative to corresponding wild type plants. More...
8852912 Compositions and methods comprising alpha-amylase variants with altered properties  
Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference...
8853381 Signal peptide for producing a polypeptide  
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
8852910 Modified polymerases for improved incorporation of nucleotide analogues  
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3′ position of the sugar moiety that are larger in size...
8853369 Anti-Axl antibodies and methods of use  
The invention provides anti-Axl antibodies and methods of using the same.
8852888 Method of producing recombinant high molecular weight vWF in cell culture  
Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13...
8846352 Genetically engineered microorganisms that metabolize xylose  
The invention provides methods of cultivating oil-bearing microbes using xylose as a fixed carbon source. Also provided are microorganisms that have been genetically engineered to metabolize...
8846030 Compounds and methods to enhance rAAV transduction  
Agents and methods to alter rAAV transduction are provided.
8847012 Genes that increase plant oil and method for using the same  
This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per...
8846341 Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation  
The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other...
8846888 Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same  
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
8846369 Cyanobacterium sp. host cell and vector for production of chemical compounds in cyanobacterial cultures  
A cyanobacterial host cell, Cyanobacterium sp., that harbors at least one recombinant gene for the production of a chemical compounds is provided, as well as vectors derived from an endogenous...
8846385 Method and means for producing high titer, safe recombinant lentivirus vectors  
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional...
8846031 Simian adenovirus 41 and uses thereof  
Novel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and...
8846362 Variant LOVD polypeptides and their uses  
The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
8846890 Microbial nanowires  
The application describes electrically conductive nanowires, as well as genetically and/or chemically modified nanowires with modified conductive, adhesive and/or coupling properties.
8846371 Methods and compositions for producing alkanes and alkenes  
Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
8847011 Genes that increase plant oil and method for using the same  
This invention is intended to be used to search for a transcription factor having novel functions of increasing the weight of an individual plant, increasing the weight of a given tissue per...
8846340 Carbohydrate-binding modules of a new family  
The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61...
8846343 High-expression promoter derived from Kluyveromyces marxianus  
Provided is a novel high-expression promoter, namely a GAL1 promoter, derived from Kluyveromyces marxianus. Also provided are the following, characterized by the use of the provided...
8846342 Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells  
The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising...
8841126 Method for gene transfer  
Disclosed is a method for introducing a gene into a target cell using a retrovirus vector, which is simple and highly efficient. Specifically disclosed is a method for introducing a gene into a...
8841088 Method for mRNA stabilization  
A method to increase the production of a desired chemical compound in a microorganism by introduction of a DNA sequence at the 5′ end of the encoding DNA gene sequence capable of forming a stem...
8841114 Genetically modified organism for the production of lipids  
The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA: sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or...
8841089 Polynucleotides for enhancing expression of a polynucleotide of interest  
The present invention relates to polynucleotides comprising a first nucleic acid sequence for a chromatin element, which is capable of enhancing expression, and at least one second nucleic acid...
8841099 Cell-based production of nonulosonates  
The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the...
8841090 L-arabinose fermenting yeast  
An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into...