Match Document Document Title
8916370 Isoprene synthase variants for improved microbial production of isoprene  
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
8916684 Bioengineered protein pores  
A mutant Escherichia coli β-barrel monomeric protein pore bioengineered to remove a lumen-occluding domain and modify some of its extracellular domains. The modified protein, FhuA Δ/CΔ4L, forms a...
8916691 Methods of expressing LIM mineralization protein  
Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in...
8916369 Trichoderma reesei α-amylase is a maltogenic enzyme  
A maltogenic a-amylase from Trichoderma reesei (TrAA) and variants thereof are useful in the production of high-maltose syrups from liquefied starch. Particularly high maltose concentrations are...
8916361 Elongase gene and uses thereof  
The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., “Δ9-elongase”) and...
8911975 Method for producing virus vector for gene transfer  
The present invention discloses a cell system, as a host cell to be infected with an F gene-deficient virus, which can constitutively and stably express the F protein, and a method for producing...
8911953 TDF-related compounds and analogs thereof, analogs and bioactive fragments  
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing,...
8911746 Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis  
Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in...
8912145 Vaccine composition for prophylaxis and/or therapy of Alzheimer's disease  
A vaccine composition for prophylaxis and/or therapy of Alzheimer's disease, which comprises a fusion protein prepared by inserting a single or tandemly repeated multiple copies of amyloid β...
8906367 Method of providing disease-specific binding molecules and targets  
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which...
8907164 Regulating nutrient allocation in plants  
The invention provides coding and promoter sequences for a VS-1 and AP-2 gene, which affects the developmental process of senescence in plants. Vectors, transgenic plants, seeds, and host cells...
8906663 Nitrilases  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
8907062 Method of producing and purifying soluble recombinant COQ5 protein and soluble recombinant COQ5 protein thereof  
The present invention relates to a producing and purifying method of soluble recombinant coenzyme Q5 homolog (COQ5) protein, which is expressed in soluble form by Escherichia coli (E. coli), under...
8906648 Recombinant production of vascular endothelial growth factor  
A process for recovering and purifying refolded heparin binding proteins produced in heterologous host cells includes the step of incubation of the solubilized protein with a polyanionic species...
8900847 Polynucleotides encoding recombinant C1 beta-glucosidase for production of sugars from cellulosic biomass  
The invention relates to expression of a recombinant C1 β-glucosidase. The invention also provides methods for producing a fermentable sugar from cellobiose by contacting celiobiose with a...
8901286 DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia  
The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and...
8901374 Fatty acid dehydratases and uses thereof  
The invention provides isolated nucleic acid molecules which encode novel fatty acid dehydratase family members. The invention also provides recombinant expression vectors containing dehydratase...
8901283 Anti-NKG2A antibodies and uses thereof  
Described herein are anti-NKG2A antibodies suitable for human therapy, including humanized versions of murine anti-NKG2A antibody Z270, as well as related methods and materials for producing and...
8895263 Methods for suppressing toll-like receptor activity  
Agents interfering with translocation of Toll-like receptor 3 (TLR3), methods of making and using the foregoing are disclosed.
8895284 Class II human histone deacetylases, and uses related thereto  
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II...
8895273 Conversion of hexuronic acid to hexaric acid  
The present invention relates to a method and microbial host strain for converting a hexuronic acid to a hexaric acid. In particular, the invention relates to the conversion of D-galacturonic acid...
8895306 Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex  
The present invention relates to methods to use non-steroidal ligands in nuclear receptor-based inducible gene expression system to modulate exogenous gene expression in which an ecdysone receptor...
8895806 Fucosyl transferase gene  
A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 1 having an open reading frame from base pair 211 to base pair 1740 or having at least 50% homology to the...
8895264 Methods and compositions for modification of the HPRT locus  
Nucleases and methods of using these nucleases for modification of an HPRT locus and for increasing the frequency of gene modification at a targeted locus and clones and for generating animals.
8895283 Nucleic acid modifying enzymes  
This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a...
8889385 Fermentive production of four carbon alcohols  
Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium...
8889374 Recombinant codon optimised factor H  
The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.
8889391 Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production  
The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing...
8889389 Process for producing protein A-like protein with use of Brevibacillus genus bacterium  
The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production...
8889419 Methods for enhanced virus-mediated DNA transfer using molecules with virus- and cell-binding domains  
A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The...
8883735 Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs  
The present invention relates to LRP6 constructs that bind to LRP6 receptor. The LRP6 constructs comprise at least one LRP6 binding moiety and a half-life extender molecule such that the LRP6...
8883447 Anti-GLP-1R antibodies and their uses  
The present invention relates to antibodies reactive with GLP-1R, and methods of making and using them.
8883466 Bacterial cells exhibiting formate dehydrogenase activity for the manufacture of succinic acid  
The present invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous polypeptide having formate dehydrogenase activity. The present invention also relates to a...
8883458 Process for preparing L-amino acids using improved strains of the Enterobacteriaceae family  
The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino...
8883161 Fusion polypeptide against EB virus-induced tumor and colicin Ia mutant  
The present invention provides a fusion polypeptide against EB virus-induced tumor, which comprises an antibody or a mimetic antibody against EB virus and an ion channel forming colicin selected...
8883434 Mutant enzyme and application thereof  
An object is to provide a novel enzyme that exhibits glucose dehydrogenase activity. Furthermore, another object is to provide a novel method pertaining to enzyme modification. Provided is a...
8883970 Alpha-amylase variants  
The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one...
8883446 Human long pentraxin 3 expression system and uses thereof  
The present invention relates to an eukaryotic expression vector comprising a nucleotide sequence encoding for the human long pentraxin PTX3 protein under the control of an effective promoter and...
8883467 Production of fatty alcohols with fatty alcohol forming acyl-CoA reductases (FAR)  
The disclosure relates to methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes. The disclosure further...
8883450 Signal peptide, and use thereof for producing recombinant proteins  
A use of a signal peptide for producing a recombinant polypeptide of interest in an expression system, the signal peptide includes at least 12 amino acids of formula (I): (X1)iX2X3X4SX5X6X7,...
8883478 Methods of preparing tissues for xenotransplantation using α-galactosidases  
This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family...
8882484 Methods and compositions for production of recombinant protein in HBX-expressing mammalian cells  
The method of the invention provides for producing a heterologous protein in mammalian host cells having nucleic acid encoding Hepatitis B X protein and the heterologous protein, by growing...
8883445 Protein glycosylation modification in methylotrophic yeast  
The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified...
8883993 Tetraselmis promoters and terminators for use in eukaryotic cells  
The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes...
8877466 Bacterial cells having a glyoxylate shunt for the manufacture of succinic acid  
The present invention is concerned with bacteria for the production of succinic acid. Specifically, the invention relates to a bacterial cell of the genus Pasteurella comprising a heterologous...
8877478 Phytases, nucleic acids encoding them and methods for making and using them  
This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides...
8877463 Rhodanobacter ginsenosidimutans KCTC22231T-derived ginsenoside glycosidase, and use thereof  
The present invention relates to Rhodanobacter ginsenosidimutans KCTC22231T-derived ginsenoside glycosidase and use thereof. The polypeptide has an activity of converting PPD...
8877479 Halomonas strain WDG195-related alpha-amylases, and methods of use, thereof  
Compositions and methods relating to an alpha-amylase enzyme obtained from Halomonas variabilis WDG195 are described.
8877461 Method for producing beta-santalene  
A method of producing β-santalene by contacting at least one polypeptide with farnesyl pyrophosphate (FPP). This method may be carried out in vitro or in vivo to produce β-santalene, a very useful...
8877915 Transcription regulatory factors for mannanases or cellulases, and genes for the transcription regulatory factor  
Disclosed are: transcription regulatory factors capable of regulating the transcription or expression of genes for mannanases or cellulases, as mentioned below; and others. Specifically disclosed...