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8603776 Method for preparing xylose-utilizing strain  
A method for preparing a xylose-utilizing strain of Saccharomyces cerevisiae and the Saccharomyces cerevisiae are introduced. The preferred recombinant strain contains multiple copies of...
8603779 Non-cytotoxic protein conjugates  
The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a...
8603822 Method for designing heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase and heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase  
A method for designing a heat-resistant mutant enzyme, the method including the step of reducing a distance between the α4 helix and the α6 helix in a protein three-dimensional structure to become...
8603785 Method of organic polymer degradation by dihydrolipoamide dehydrogenase  
A dihydrolipoamide dehydrogenase (DLD) in a germ is recombined. The new DLD is applied in a solution to degrade an ether bond of an organic polymer. With the present invention, bioremediation is...
8603824 Process for improved protein expression by strain engineering  
This invention is a process for improving the production levels of recombinant proteins or peptides or improving the level of active recombinant proteins or peptides expressed in host cells. The...
8603807 Methods of making modular fusion protein expression products  
The invention relates to methods of making modular chimeric protein expression products and compositions utilized in the methods. In particular, the invention relates to sequential, directional...
8603476 Humanized anti-human α9-integrin antibody  
The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a...
8603466 Agonist antibodies against TSHR  
The invention provides antibodies that bind the thyroid stimulating hormone receptor (TSHR), especially in humans, and their uses in diagnostic and therapeutic roles. The invention also provides...
8603459 Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use  
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also...
8603996 Modular aptamer-regulated ribozymes  
An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is...
8603774 Extract of E. coli cells having mutation in ribosomal protein S12, and method for producing protein in cell-free system using the extract  
It is intended to provide an extract, kit and a process for synthesizing a protein in a cell-free system. The extract is characterized by being prepared from mutant Escherichia coli cells having a...
8597901 2,5-diketo-L-gluconic acid reductases and methods of use  
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
8597909 Use of HSA-producing cells  
The present invention refers to the area of cell culture technology and relates to methods for multiplying/cloning cells, preferably cell lines, which are important to the production of...
8597907 Method of producing proteins  
The present invention provides a method for efficiently producing an industrially useful protein in coryneform bacteria, and more particularly, a method for efficiently producing a protein for...
8597906 Glycosylation of molecules  
Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered...
8597908 Process for producing protein A-like protein with use of Brevibacillus genus bacterium  
The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production...
8597950 Two-component RNA virus-derived plant expression system  
A process for replicating or for replicating and expressing a sequence of interest in a plant, comprising: (i) an RNA replicon or a precursor thereof, said RNA replicon being derived from a...
8597924 γ-butyrobetaine hydroxylase originated from Neurospora crassa  
Disclosed is a polynucleotide encoding γ-butyrobetaine hydroxylate (γ-BBH) originating from Neurospora crassa. Also disclosed are a recombinant vector comprising the polynucleotide, a transformant...
8598412 Seed specific USP promoters for expressing genes in plants  
The present invention relates to the field of plant genetic engineering. More specifically, the present invention relates to seed specific gene expression. The present invention provides promoters...
8597951 Transgenic photosynthetic microorganisms  
Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms...
8591916 Flavivirus vaccine vector against influenza virus  
This invention relates to chimeric flavivirus vectors that can be used, for example, in the prevention and treatment of influenza virus infection, compositions including such viral vectors, and...
8592192 Protein stabilization by domain insertion into a thermophilic protein  
A strategy to improve protein stability by domain insertion. TEM 1 beta-lactamase (BLA) and exo-inulinase, as model target enzymes, are inserted into a hyperthermophilic maltose binding protein...
8592195 Fungal endoglucanases, their production and use  
Novel fungal endoglucanases Ce15 and Ce112 are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases...
8591894 Humanized antibodies that sequester amyloid beta peptide  
A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble...
8592179 Artificial binding proteins based on a modified alpha helical region of ubiquitin  
The present invention is directed to a method for the generation of binding proteins derived from the protein super-family of ubiquitin like proteins with modifications in their alpha helical...
8592180 Botryoccocus braunii triterpene synthase proteins and nucleic acid molecules, and methods for their use  
This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are...
8591909 Recombinant carrier molecule for expression, delivery and purification of target polypeptides  
Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides)...
8592161 Mutational profiles in HIV-1 protease correlated with phenotypic drug resistance  
The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention...
8592557 Multimeric TNF receptor fusion proteins and nucleic acids encoding same  
The present invention refers to fusion proteins comprising a TNF receptor family extracellular domain fused to a trimerization domain, and a nucleic acid molecule encoding the fusion protein. The...
8592553 Cloned glucagon-like peptide-2 receptors  
The invention relates to nucleotides and amino acid sequences encoding Glucagon-like peptide-2 receptors, recombinant host cells transformed with such nucleotides, and methods of using the same in...
8592144 Beta-sheet proteins with specific binding properties  
The present invention describes novel beta-sheet proteins having specific binding properties and catalytic properties and also methods for preparing these proteins.
8586039 Degraded TPO agonist antibody  
The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by...
8586329 Neurotoxins exhibiting shortened biological activity  
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect...
8586328 Method for producing sclareol  
The present invention provides a method of producing sclareol, said method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In...
8586327 Detection of bacteria belonging to the genus Campylobacter by targeting cytolethal distending toxin  
An objective of the present invention is to provide the cytolethal distending toxin (CDT) of C. hyointestinalis and polynucleotides encoding it, and novel methods for detection of C....
8586048 G-CSF immunoglobulin fusion proteins  
Disclosed are fusion proteins comprising a biologically active molecule and an immunoglobulin (Ig) Fc domain which is linked to the biologically active molecule. The Fc domain is a hybrid human Fc...
8586346 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
8586038 Chimeric immunoglobulin fusion proteins  
Disclosed are fusion proteins comprising a biologically active molecule and an immunoglobulin (Ig) Fc domain which is linked to the biologically active molecule. The Fc domain is a hybrid human Fc...
8586531 Erythropoietin immunoglobulin fusion proteins  
Disclosed are fusion proteins comprising a biologically active molecule and an immunoglobulin (Ig) Fc domain which is linked to the biologically active molecule. The Fc domain is a hybrid human Fc...
8586037 Antibodies against IL-17BR  
The invention provides the antibody D9.2 and antibody molecules based on D9.2 which bind interleukin-17 receptor B. These may be useful in therapy, e.g. the treatment of asthma, ulcerative colitis...
8586356 Gal α1-3gal-containing N-glycans in glycoprotein products derived from CHO cells  
The present invention provides methods of evaluating CHO cells.
8586326 Molecules involved in protein folding  
The present invention provides a method of identifying a molecule which functions as a catalyst of protein folding in a cell, which comprises: (a) transforming a library of cells with a gene...
8580549 Esterases for separating plastics  
The invention relates to agents containing esterases, and to the use thereof for dressing fibres, in particular, artificial fibres, washing and cleaning agents comprising esterases and...
8580271 Detection kit containing a novel recombinant 15-kDA polypeptide useful for detecting human infection with Bartonella henselae  
Disclosed are the cloning and expression of a novel antigen of Bartonella henselae. The recombinant polypeptide is found to be highly immunogenic and is useful as a diagnostic test antigen. The...
8580937 cDNA-derived nucleic acids encoding red-shifted channelrhodopsins  
Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted...
8580279 Compounds  
The invention provides BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and polynucleotides encoding BASB082, BASB083, BASB091, BASB092 and BASB101 polypeptides and methods for...
8580536 Compositions for saccharification of cellulosic material  
The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof.
8580553 Phage-associated lytic enzymes for treatment of Bacillus anthracis and related conditions  
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The...
8580555 Recombinant halohydrin dehalogenase polypeptides  
The present disclosure provides engineered halohydrin dehalogenase (HHDH) polypeptides having improved enzyme properties as compared to the wild-type HHDH enzyme HheC and other reference...
8580721 Composition comprising substituted cellulosic polymer and amylase  
A solid particulate laundry detergent composition including: (a) substituted cellulosic polymer including carboxymethyl substituent groups, and having a degree of substitution (DS) of at least...