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8637293 Cellobiohydrolase I enzymes  
Provided herein is an isolated Cel7A polypeptide comprising mutations in the catalytic domain of the polypeptide relative to the catalytic domain of a wild type Cel7A polypeptide, wherein the...
8637732 Plant MYB transcription factor homologs  
This invention relates to an isolated nucleic acid fragment encoding a Myb-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion...
8637464 P75NTR screening assay  
The present invention provides a method to identify a test compounds capability to modulate p75NTR induced apoptosis, said method comprising: i. Transfecting a suspension of eukaryotic cells with...
8637651 Protein production in microorganisms of the phylum labyrinthulomycota  
The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal...
8637272 Halohydrin epoxidase  
The present invention provides an industrially useful improved halohydrin epoxidase, a method for producing the same, and a method for producing an epihalohydrin or 4-halo-3-hydroxybutyronitrile...
8633006 Polypeptides having alpha-glucosidase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
8633164 Antimicrobial peptides  
The present invention relates to a peptide of linear, non-cyclic structure consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the...
8632995 High-cell density fed-batch fermentation process for producing recombinant protein  
Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and...
8628938 Polynucleotide encoding UDP-glucuronyl transferase  
The present invention provides a novel UDP-glucuronosyltransferase and a polynucleotide encoding the same, for example, a polynucleotide comprising nucleotides 1 to 1359 of SEQ ID NO: 4,...
8628939 Expression vector containing the major envelope protein P9 of cystovirus PHI6 as a fusion partner, and process for producing a membrane protein using the same  
The present invention relates to a membrane protein expression vector containing the major envelope protein P9 of Cystovirus phi6 as a fusion partner, to cells transformed by the expression...
8629244 Interleukin-6 receptor binding polypeptides  
The invention relates to amino acid sequences that are directed against and/or that can specifically bind to IL-6 receptor, compounds or constructs that comprise said amino acid sequence, nucleic...
8629323 Methods and materials for making and using transgenic dicamba-degrading organisms  
The invention provides isolated and at least partially-purified dicamba-degrading enzymes, isolated DNA molecules coding for dicamba-degrading enzymes, DNA constructs coding for dicamba-degrading...
8623614 Method for the recombinant production of magnetic nanoparticles  
The present invention relates to methods and compositions for the size-adjusted recombinant production of magnetic nanoparticles. More particular, the invention relates to a method, comprising:...
8624000 Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof  
A monomer of an I-CreI meganuclease variant wherein said monomer comprises mutations in the amino acid sequence of SEQ ID NO: 34, wherein said mutations include, (i) at least one and up to five...
8623626 Extract of E. coli cells having mutation in ribosomal protein S12, and method for producing protein in cell-free system using the extract  
It is intended to provide an extract, kit and a process for synthesizing a protein in a cell-free system. The extract is characterized by being prepared from mutant Escherichia coli cells having a...
8623618 Engineered cleavage half-domains  
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and...
8623629 Polypeptides with xylanase activity  
Polypeptides with xylanase activity modified to increase bran solubilization and/or xylanase activity. The modification comprises modification of one or more amino acids in position 113, 122 or...
8623353 TLR2 antagonistic antibody and use thereof  
The present invention is directed to a cross-reactive antibody that specifically inhibits or blocks mammalian Toll-like receptor 2 (TLR2)-mediated immune cell activation. The invention is further...
8624010 Nucleic acids encoding B7RP1  
Polypeptides comprising ligands and receptors involved in T-cell activation are disclosed. Nucleic acid molecules that encode such polypeptides, and vectors and host cells for expressing...
8623625 Sulfotransferase, peptide thereof and DNA encoding the same  
A glycosaminoglycan sulfotransferase, a peptide thereof, a nucleic acid comprising a nucleotide sequence encoding the same, an enzyme agent for the synthesis of a glycosaminoglycan, which...
8623615 Solubilization and purification of a target protein fused to a mutant maltose-binding protein  
Methods and compositions are provided that relate to a composition that includes a modified maltose-binding protein (MBP) which when fused to a protein results in an increase in binding affinity...
8623810 Protease for wound conditioning and skin care  
We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds....
8617844 Use of cytokine receptors as biomarkers and therapeutic targets in human cancer  
Nucleic acids encoding erythropoietin receptor isoforms are described, as well as the encoded isoforms, methods of detecting the same, and methods of screening for and treating cancer.
8617837 Method of hydrolyzing soluble starch with an alpha-amylase variant  
The present invention relates to variants (mutants) of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits altered properties relative to the parent...
8618024 Nucleic acid binding polypeptide library  
The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger...
8617565 Surface exposed Haemophilus influenzae protein (protein E; pE)  
The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ...
8617841 Protein and production process and use thereof  
[PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant...
8618275 Efficient cell culture system for hepatitis C virus genotype 5A  
The present inventors developed 5a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and all of or part of NS2 were replaced by the corresponding genes of the...
8617881 Methods for producing recombinant proteins  
Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
8617843 Recombinant peptide production using a cross-linkable solubility tag  
The invention relates to the recombinant expression of a peptide of interest in the form of a fusion protein comprising a solubility tag. The fusion protein comprises at least two portions...
8617842 Enzymes for use in enzymatic bleaching of food products  
The present invention relates to novel polypeptides according to caroase 01-05 or any functional equivalents of any of them, suitable for use in a method for preparing a food products having...
8614068 Process for producing hepcidin  
The present invention provides a novel method for producing biologically functional hepcidin in Pichia pastoris. The invention further provides novel tagged hepcidin, antibodies and their uses in...
8614092 Nucleotide-specific recognition sequences for designer TAL effectors  
The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the...
8614085 Yeast with increased butanol tolerance involving a multidrug efflux pump gene  
Increasing tolerance to butanol in yeast has been accomplished by decreasing activity of Pdr5p encoded by an endogenous PDR5 gene. A deletion mutation of the PDR5 gene led to improved growth yield...
8609374 Cell extract promoted cloning  
Methods are disclosed for assembling a plurality of double-stranded DNA fragments into DNA molecules in a single in vitro recombination reaction comprising contacting the plurality of...
8609370 Highly active glycoproteins-process conditions and an efficient method for their production  
The present invention relates to highly active glycoproteins with specific sialylation degrees, a pharmaceutical composition for use in diagnosis or therapy comprising the glycoproteins, a method...
8609371 Isoprenoid compounds  
The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes....
8609107 Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics  
The invention provides methods of treating subject with polypeptides having at least 80% identity to SEQ ID NO: 5326. The methods stimulate an immune response in the subject and provide methods...
8609348 Bacteriophage adhesion proteins  
Bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, but lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides, are described, as...
RE44648 Enzyme for the production of long chain peracid  
The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods...
8609404 Vaccines containing canine parvovirus genetic variants  
Canine parvovirus vaccines and diagnostics and methods for their use are provided. The vaccines are effective against emerging canine parvovirus variants.
8609386 Polypeptides having tyrosinase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having tyrosinase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
8609372 Glycosyl transferase from Chinese hamster and related methods  
A glycosyl transferase from Chinese hamster and related methods are described.
8609378 Polyhydroxyalkanoate production from polyols  
Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase,...
8603780 Methods and compositions for enhanced expression and secretion of proteins  
Optimized signal peptide coding sequences for enhanced expression and secretion of protein from a cell and related compositions and methods are described. The optimized signal peptide coding...
8604181 Promoter variants for expressing genes in a fungal cell  
The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance,...
8604281 Transgenic plants with controlled distribution of a trait to progeny  
A process of producing transgenic multi-cellular plants or parts thereof expressing a trait of interest that has a controlled distribution of said trait to progeny, comprising (i) producing a...
8603973 Skincare composition comprising HSA fusion protein, preparation method and uses thereof  
The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and...
8603781 Prevention of incorporation of non-standard amino acids into protein  
The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard...
8603775 Method of disulfide crosslink forming in vitro protein synthesis  
It is an objective of the present invention to provide a method of synthesizing a protein having disulfide bonds using a reconstituted protein synthesizing system in a convenient manner with high...