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8691506 Gene expression profiles being predictive for the response of tumors to pharmaceutically effective compounds  
The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a pharmaceutically effective compound, the...
8691527 Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to...
8691535 Sucrose mutase with improved product specificity  
For the biotechnological production of isomaltulose and compositions containing isomaltulose from saccharose the invention provides improved means, particularly a sucrose mutase with improved...
8691529 Increasing protein production by increasing ABC50 expression or activity  
The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell ABC50 expression or activity is increased which increases...
8685703 Coryneform bacterium transformant having improved D-xylose-utilizing ability  
A coryneform bacterium transformant prepared by transferring an exogenous gene which encodes a protein having a sugar transporter function into a coryneform bacterium capable of utilizing D-xylose.
8686218 Strategies for the transgenic manipulation of filamentous fungi  
Disclosed is a new technology that enables the transgenic modification of a mushroom-forming fungus to confer a transgenic genotype and/or phenotype. According to the invention herein, one can...
8686110 Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same  
The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides...
8685691 Method for producing aminopeptidase  
Disclosed is an efficient method for production of aminopeptidase. The method comprises either transforming host bacteria with an aminopeptidase gene and with a neutral protease gene, or...
8685668 Method of expressing proteins with disulfide bridges  
This invention relates to methods of expressing eukaryotic proteins in prokaryotic hosts, particularly eukaryotic proteins that require formation of disulfide bridges for biological activity....
8686224 Plant defense signal peptides  
A 23 amino acid peptide, AtPep1, plays an important role as a signaling component of the innate immune system of Arabidopsis. The peptide precursor gene is transcribed in response to elicitors...
8685667 Nucleic acid encoding a self-assembling split-fluorescent protein system  
The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with...
8685681 Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms  
Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding...
8686227 Polynucleotides, polypeptides encoded thereby, and methods of using same for increasing abiotic stress tolerance and/or biomass and/or yield in plants expressing same  
Provided are methods of increasing tolerance of a plant to abiotic stress, and/or increasing biomass, growth rate, vigor and/or yield of a plant. The methods are effected by expressing within the...
8685669 Nucleic acid molecules encoding humanized antibody molecules specific for IL-31  
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the...
8685738 Methods of obtaining genetic competence in bacillus cells  
The present invention relates to methods of obtaining genetic competence in non-competent Bacillus cells for their transformation with exogenous DNA.
8685729 Heterologous expression of extremophile heat shock proteins and chaperones in microorganisms to increase tolerance to toxic compounds  
The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating...
8685718 Mucosal immunization to prevent prion infection  
Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a...
8685720 Engineered cellular pathways for programmed autoregulation of differentiation  
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for...
8679818 BGL7 beta-glucosidase and nucleic acids encoding the same  
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host...
8679785 Knobs and holes heteromeric polypeptides  
The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins, heteromultimers and antibody-immunoadhesin chimeras....
8679782 Production of triacylglycerides, fatty acids, and their derivatives  
The invention relates to production of triacylglycerols in cells.
8679742 Method for determining the presence of an enzyme in a sample  
This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and...
8677934 Sex-peptides resistant to proteolytic degradation and their use in biological control of insects  
An isolated nucleic acid molecule comprising, or consisting of, a polynucleotide sequence encoding an oligopeptide capable of inducing post-mating depression of receptivity to mating in female...
8679780 Method of reducing immunological tolerance to malignancy  
Disclosed are therapeutic formulations comprising myristoylCoA and N-myristoyl transferase and methods of using such formulations to stimulate the immune system of a mammal afflicted with...
8679814 Protein and DNA sequence encoding a cold adapted xylanase  
A method of preparing a cold adapted xylanase by use of recombinant DNA techniques. A nucleic acid and corresponding amino acid sequences of a cold adapted xylanase, isolated from antarctic marine...
8679837 Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors  
Production of clinical grade gene therapy vectors for human trials remains a major hurdle in advancing cures for a number of otherwise incurable diseases. Disclosed herein are systems based on a...
8679783 Recombinant factor X with no glycosylation and method for preparing the same  
A Factor X (hereinafter referred to as “FX”) with a high activity is provided. The present invention relates to a method for efficiently preparing a recombinant, two-chain FX which comprises...
8679490 Binding polypeptides with diversified and consensus VH/VL hypervariable sequences  
The invention provides variant hypervariable regions comprising selected amino acid sequence diversity. Libraries comprising a plurality of these polypeptides are also provided. In addition,...
8680050 Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same  
The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host...
8679502 Monoclonal antibodies that bind to HGM-CSF and medical compositions comprising same  
Disclosed herein are anti-hGM-CSF monoclonal antibodies and antigen-binding fragments of such antibodies, with improved neutralizing capacity to hGM-CSF activity. Pharmaceutical compositions...
8679790 Leader sequence to boost gene expression  
The invention provides compositions and methods for enhanced gene expression. The invention provides a composition comprising a 28-codon leader sequence operably linked to a desired gene which...
8679821 Bacteriophage derived methods to control lactic acid bacterial growth  
Compositions and methods for protection against bacterial contamination are disclosed Antibacterial proteins and methods of use thereof are also disclosed.
8679810 Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation  
The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion...
8680236 Altered OspA of borrelia burgdorferi  
Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA...
8679784 mTOR ligands and polynucleotides encoding mTOR ligands  
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and...
8679822 Xylose utilization in recombinant zymomonas  
Xylose-utilizing Zymomonas strains studied were found to accumulate ribulose when grown in xylose-containing media. Engineering these strains to increase ribose-5-phosphate isomerase activity led...
8679816 Cellulase variants with improved expression, activity and stability, and use thereof  
The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are...
8679781 In vitro peptide expression library  
The invention provides a method for making in vitro peptide expression libraries, and for the isolation of nucleotide sequences encoding peptides of interest, wherein the peptides or proteins are...
8679749 Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation  
Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission...
8679813 Polypeptides having lipase activity and polynucleotides encoding same  
The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.
8673312 Method for one-step purification of recombinant Helicobacter pylori neutrophil-activating protein  
Helicobacter pylori is closely associated with chronic gastritis, peptic ulcer disease, and gastric adenocarcinoma. Helicobacter pylori neutrophil-activating protein (HP-NAP), a virulence factor...
8673611 Variant Humicola grisea CBH1.1  
Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant...
8673592 Anti system ASC amino acid transporter 2 (ASCT2) antibody  
An object of the present invention is to provide a monoclonal antibody which is useful for treating or diagnosing a disease relating to system ASC amino acid transporter 2 (ASCT2) or a method...
8673607 Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8673609 Buttiauxella sp. phytase variants  
Provided herein are variants of Buttiauxella sp. phytases that may be used in industrial applications including methods for starch liquefaction, alcohol fermentations and for enhancing phosphate...
8674083 Polypeptide variants with altered effector function  
The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function...
8673591 Genetic incorporation of 3-aminotyrosine into reductases  
This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino...
8673590 Method for producing dipeptide  
The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a...
8673589 Inducible eukaryotic expression system  
Compositions and methods for the inducible expression of genes in eukaryotic cells are provided. Expression of a nucleotide sequence of interest encoding a protein of interest is controlled by a...
8669051 Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to...