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8716441 Ubiquitin binding polypeptides  
The invention relates to Tandem Ubiquitin Affinity Entities (TUBES) which are fusion polypeptides comprising at least two ubiquitin binding domains connected to each other by non-naturally...
8716208 Composition comprising polyethylene glycol polymer and amylase  
A solid particulate laundry detergent composition including: (a) polyethylene glycol polymer including a polyethylene glycol backbone and polyvinyl acetate side chains, wherein the average...
8715997 Variant Hypocrea jecorina CBH2 cellulases  
Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
8715977 Ethanol production from ocean biomass  
An object of the present invention is to provide a method for producing ethanol from polysaccharide alginate contained in a large amounts in brown algae, using the alginate assimilation capacity...
8715962 Production of geranyl diphosphate  
The invention relates to recombinant geranyl diphosphate (GPP) synthases, genes encoding the synthases, vectors and host cells comprising the same. More particularly, the invention relates to a...
8715960 Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor  
The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or...
8715984 Modified tRNA containing unnatural base and use thereof  
In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA...
8716459 Isolated nucleic acid molecules encoding variant activin receptor polypeptides  
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present...
8715971 Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol  
The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13-BDO) and...
8715993 Glycosidase enzymes  
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can...
8715963 Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris  
Described is a method for increasing the N-glycosylation site occupancy of a therapeutic glycoprotein produced in recombinant host cells modified as described herein and genetically engineered to...
8715961 Methods of obtaining a specific binding member that binds eotaxin  
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The...
8716022 Modulation of meiotic recombination  
The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to...
8709754 Recombinant vectors for use in position-independent transgene expression within chromatin  
The embodiments of the present invention are directed to discrete, cis-acting regulatory elements that include a barrier element, an insulating element, a silencing element, and matrix attachment...
8709781 System and method for the heterologous expression of polyketide synthase gene clusters  
A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts in Escherichia coli for the production and discovery of secondary metabolites. Genomic...
8710186 Taste receptors of the T1R family from domestic cat  
The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of...
8709442 Recombinant negative strand virus RNA expression systems and vaccines  
The present invention relates to recombinant RNA virus templates derived from and applicable to negative strand naturally non-segmented viruses, including the families Bornaviridae, Filoviridae,...
8709772 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them  
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity,...
8709756 Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy  
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a...
8709755 Mirac proteins  
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly...
8710205 Transcription factor  
The present invention relates to a transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in...
8710015 Tropoelastin derivatives  
The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of...
8709773 DFPase enzymes from Aplysia californica  
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic...
8709759 Method for increasing expression of active tumor necrosis factor receptor family member-Ig fusion proteins  
Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification.
8709778 Method of adenoviral vector synthesis  
This invention provides methods for adenoviral vector synthesis. The present invention further provides methods for binding adenovirus terminal protein obtained from virus to linear DNA. The...
8703471 System and method for the production of recombinant glycosylated proteins in a prokaryotic host  
A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic...
8703131 Nanobodies against tumor necrosis factor-alpha  
The present invention relates to improved Nanobodies™ against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially consisting of one or more of such...
8703926 Modified lecithin-cholesterol acyltransferase enzymes  
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of...
8703127 Methods and materials for the diagnosis of prostate cancers  
Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological...
8703927 Isolated nucleotide sequences encoding GDF traps  
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly...
8703443 γ-L-PGA producing microorganism, method of producing γ-L-PGA using the microorganism, crosslinked substance produced using the microorganism, and external dermal agent produced using the microorganism  
There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a...
8703444 Pichia pastoris deficient in endogenous secreted protease  
The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins...
8703905 Endoplasmic reticulum localization signals  
The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form. The localization signals...
8703459 Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity  
Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor...
8703915 Mutant proteins and methods for producing them  
A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence...
8697856 Plasmodium vivax hybrid circumsporozoite protein and vaccine  
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
8697394 Production of modified glycoproteins having multiple antennary structures  
The present invention relates to eukaryotic host cells, especially lower eukaryotic host cells, having modified oligosaccharides which may be modified further by heterologous expression of a set...
8697427 Recombinant microalgae cells producing novel oils  
Disclosed herein are obligate heterotrophic microalgae cells containing an exogenous gene. In some embodiments the gene is a sucrose utilization gene, and further disclosed are methods of...
8697414 Degradable clostridial toxins  
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions...
8697416 Recombinant polynucleotide, host cells containing the same and a process for producing a protein having aldolase activity  
4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic...
8697395 Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof  
Use of meganucleases for cleaving DNA in a non-human or an isolated human cell and, in some instances, inducing homologous recombination in said cells and to its application for genome engineering...
8697842 Maize cellulose synthases and uses thereof  
The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels...
8697636 RumC peptides with antimicrobial activity  
The present invention relates to the RumC1, RumC2 and RumC3 peptides with antimicrobial activity, and also to the genes encoding these peptides and isolated from Ruminococcus gnavus E1.
8697364 High throughput transfection of filamentous fungi  
The present invention provides a method for the transfection of filamentous fungal cells, comprising providing a multitude of containers, filling into each container an amount of polymer needed...
8697410 SSO7-polymerase conjugates with decreased non-specific activity  
Improved Sso7-polymerase conjugate proteins are provided.
8691505 Promoter for use in transformation of algae  
The problem to be solved by the present invention is to provide a highly-efficient transformation technology, specifically, a highly-efficient promoter used for transforming algae, a vector...
8691528 Cell penetrating peptide  
According to the present invention, it is possible to provide a novel cell penetrating peptide that transports proteins into cells and/or into nuclei at higher frequency than conventional cell...
8691210 Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof  
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for...
8692066 Bacillus thuringiensis gene with coleopteran activity  
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
8691208 Compositions and methods for treating hypophosphatasia  
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by...