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8716441 |
Ubiquitin binding polypeptides
The invention relates to Tandem Ubiquitin Affinity Entities (TUBES) which are fusion polypeptides comprising at least two ubiquitin binding domains connected to each other by non-naturally... |
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8716208 |
Composition comprising polyethylene glycol polymer and amylase
A solid particulate laundry detergent composition including: (a) polyethylene glycol polymer including a polyethylene glycol backbone and polyvinyl acetate side chains, wherein the average... |
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8715997 |
Variant Hypocrea jecorina CBH2 cellulases
Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability. |
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8715977 |
Ethanol production from ocean biomass
An object of the present invention is to provide a method for producing ethanol from polysaccharide alginate contained in a large amounts in brown algae, using the alginate assimilation capacity... |
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8715962 |
Production of geranyl diphosphate
The invention relates to recombinant geranyl diphosphate (GPP) synthases, genes encoding the synthases, vectors and host cells comprising the same. More particularly, the invention relates to a... |
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8715960 |
Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor
The present invention provides novel mitochondrial fusion transcripts, the parent mutated mtDNA molecules, and the resulting translation products (proteins) for predicting, diagnosing and/or... |
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8715984 |
Modified tRNA containing unnatural base and use thereof
In the method for introducing a noncanonical amino acid residue into a desired position in a protein, the structure of tRNA is so modified as to have improved affinity for aminoacyl-tRNA... |
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8716459 |
Isolated nucleic acid molecules encoding variant activin receptor polypeptides
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present... |
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8715971 |
Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol
The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13-BDO) and... |
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8715993 |
Glycosidase enzymes
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can... |
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8715963 |
Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
Described is a method for increasing the N-glycosylation site occupancy of a therapeutic glycoprotein produced in recombinant host cells modified as described herein and genetically engineered to... |
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8715961 |
Methods of obtaining a specific binding member that binds eotaxin
Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The... |
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8716022 |
Modulation of meiotic recombination
The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to... |
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8709754 |
Recombinant vectors for use in position-independent transgene expression within chromatin
The embodiments of the present invention are directed to discrete, cis-acting regulatory elements that include a barrier element, an insulating element, a silencing element, and matrix attachment... |
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8709781 |
System and method for the heterologous expression of polyketide synthase gene clusters
A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts in Escherichia coli for the production and discovery of secondary metabolites. Genomic... |
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8710186 |
Taste receptors of the T1R family from domestic cat
The present invention relates to the discovery of several genes of the domestic cat (Felis catus) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of... |
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8709442 |
Recombinant negative strand virus RNA expression systems and vaccines
The present invention relates to recombinant RNA virus templates derived from and applicable to negative strand naturally non-segmented viruses, including the families Bornaviridae, Filoviridae,... |
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8709772 |
Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity,... |
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8709756 |
Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a... |
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8709755 |
Mirac proteins
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly... |
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8710205 |
Transcription factor
The present invention relates to a transcription factor found in filamentous fungi, especially in Aspergillii, DNA sequences coding for said factor, its transformation into and expression in... |
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8710015 |
Tropoelastin derivatives
The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of... |
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8709773 |
DFPase enzymes from Aplysia californica
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic... |
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8709759 |
Method for increasing expression of active tumor necrosis factor receptor family member-Ig fusion proteins
Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification. |
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8709778 |
Method of adenoviral vector synthesis
This invention provides methods for adenoviral vector synthesis. The present invention further provides methods for binding adenovirus terminal protein obtained from virus to linear DNA. The... |
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8703471 |
System and method for the production of recombinant glycosylated proteins in a prokaryotic host
A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic... |
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8703131 |
Nanobodies against tumor necrosis factor-alpha
The present invention relates to improved Nanobodies™ against Tumor Necrosis Factor-alpha (TNF-alpha), as well as to polypeptides comprising or essentially consisting of one or more of such... |
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8703926 |
Modified lecithin-cholesterol acyltransferase enzymes
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of... |
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8703127 |
Methods and materials for the diagnosis of prostate cancers
Methods for diagnosing the presence of prostate cancer in a subject are provided, such methods including detecting the levels of expression of multiple polypeptide biomarkers in a biological... |
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8703927 |
Isolated nucleotide sequences encoding GDF traps
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly... |
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8703443 |
γ-L-PGA producing microorganism, method of producing γ-L-PGA using the microorganism, crosslinked substance produced using the microorganism, and external dermal agent produced using the microorganism
There are provided a microorganism characterized by producing poly-γ-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a... |
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8703444 |
Pichia pastoris deficient in endogenous secreted protease
The present invention relates to micro-organisms and to methods of producing proteins. More specifically, the inventions relates to a host cell useful for the expression of heterozygous proteins... |
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8703905 |
Endoplasmic reticulum localization signals
The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form. The localization signals... |
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8703459 |
Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity
Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor... |
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8703915 |
Mutant proteins and methods for producing them
A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more mutations in the amino acid sequence... |
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8697856 |
Plasmodium vivax hybrid circumsporozoite protein and vaccine
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any... |
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8697394 |
Production of modified glycoproteins having multiple antennary structures
The present invention relates to eukaryotic host cells, especially lower eukaryotic host cells, having modified oligosaccharides which may be modified further by heterologous expression of a set... |
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8697427 |
Recombinant microalgae cells producing novel oils
Disclosed herein are obligate heterotrophic microalgae cells containing an exogenous gene. In some embodiments the gene is a sucrose utilization gene, and further disclosed are methods of... |
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8697414 |
Degradable clostridial toxins
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions... |
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8697416 |
Recombinant polynucleotide, host cells containing the same and a process for producing a protein having aldolase activity
4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic... |
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8697395 |
Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof
Use of meganucleases for cleaving DNA in a non-human or an isolated human cell and, in some instances, inducing homologous recombination in said cells and to its application for genome engineering... |
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8697842 |
Maize cellulose synthases and uses thereof
The invention provides isolated cellulose synthase nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering cellulose synthase levels... |
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8697636 |
RumC peptides with antimicrobial activity
The present invention relates to the RumC1, RumC2 and RumC3 peptides with antimicrobial activity, and also to the genes encoding these peptides and isolated from Ruminococcus gnavus E1. |
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8697364 |
High throughput transfection of filamentous fungi
The present invention provides a method for the transfection of filamentous fungal cells, comprising providing a multitude of containers, filling into each container an amount of polymer needed... |
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8697410 |
SSO7-polymerase conjugates with decreased non-specific activity
Improved Sso7-polymerase conjugate proteins are provided. |
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8691505 |
Promoter for use in transformation of algae
The problem to be solved by the present invention is to provide a highly-efficient transformation technology, specifically, a highly-efficient promoter used for transforming algae, a vector... |
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8691528 |
Cell penetrating peptide
According to the present invention, it is possible to provide a novel cell penetrating peptide that transports proteins into cells and/or into nuclei at higher frequency than conventional cell... |
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8691210 |
Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for... |
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8692066 |
Bacillus thuringiensis gene with coleopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,... |
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8691208 |
Compositions and methods for treating hypophosphatasia
The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by... |