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7391015 |
System and method for data collection in recursive mass analysis
Systems, methods, and computer programming for collecting data using a mass spectrometer comprising a particle detector or other mass analyzer. A data collection such as a tree or array structure...
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7387884 |
Yeast extract solution for cell-free protein synthesis, method for preparation thereof and method for cell-free protein synthesis using same
The present invention provides a preparation method of a yeast extract solution for cell-free protein synthesis, which solution is easy to prepare and is capable of synthesizing a higher amount of...
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7384754 |
Enrichment and tagging of glycosylated proteins
A method useful in the analysis of glycosylated proteins, in which a mixture containing glycosylated proteins and unglycosylated proteins is contacted with a resin that includes a nucleophile bound...
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7375081 |
Therapeutic combination of a pneumocandin derivative and an antifungal agent
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the invention...
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7368260 |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
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7364875 |
Method for producing medical and commercial grade poly-gamma-glutamic acid of high molecular weight
Methods for producing high molecular weight poly-gamma-glutamic acid (PGA). The PGA is produced by fermentation, and purified by use of tangential flow filtration, followed by diafiltration, as...
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7354734 |
Fungal proteins and nucleic acids encoding same
Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants,...
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7351563 |
Cell-free extracts and synthesis of active hydrogenase
Enzymatically active hydrogenase is synthesized in a cell-free reaction. The hydrogenases are synthesized in a cell-free reaction comprising a cell extract derived from microbial strains expressing...
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7338780 |
Method for producing tripeptides and/or peptides longer than tripeptides
A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A...
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7335492 |
Process for partitioning of proteins
The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest...
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7329520 |
Fructosyl peptide oxidase and utilization thereof
The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of...
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7323332 |
Preparation method of insect cell extract solution for cell-free protein synthesis, the insect cell extract solution and cell-free synthesis method of protein using the insect cell extract solution
The present invention provides a preparation method of an insect cell extract solution for cell-free protein synthesis, the insect cell extract solution, a protein synthesis method in a cell-free...
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7319014 |
Overexpression, purification and characterization of a thermolabile phosphatase
Compositions for an alkaline phosphatase and methods for over-expression and purification of thermolabile Antarctic phosphatase (TAP) are provided. Uses for TAP include dephosphorylation of nucleic...
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7312192 |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
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7312049 |
Total amino acid stabilization during cell-free protein synthesis
Compositions and methods are provided for the enhanced in vitro synthesis of protein molecules, by optimizing the metabolism of amino acids present in the reaction mix, preferably all amino acids...
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7297513 |
Gene encoding glutathione synthetase from Candida utilis
A gene encoding glutathione synthetase from Candida utilis is provided and food containing γ-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by...
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7297512 |
Method for producing amino acid components by enzymatic hydrolysis of fish egg skin
From fish egg skin produced by utilization of roe grains of various fish, constituent proteins thereof are enzymatically degraded to obtain peptides and amino acids, of which effective utilization...
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7297511 |
Interferon alpha: remodeling and glycoconjugation of interferon alpha
The invention includes a multitude of methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition...
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7297354 |
Protein material
A method of treating a proteinaceous material having a first concentration of β-conglycinin, the method including combining the proteinaceous material with an enzyme to form a reaction mixture,...
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7288532 |
Modified chitosan polymers and enzymatic methods for the production thereof
The present invention is directed to homogeneous phase enzyme-catalyzed processes for producing modified chitosan polymers or oligomers. An enzyme is reacted with a phenolic substrate in the...
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7288389 |
Peptide-forming enzyme gene
DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a...
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7288388 |
Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method
The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from...
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7282354 |
Method for producing fermented milk product
There is provided a fermented milk product that contains lactic acid bacteria capable of producing a large amount of lactotripeptide and a large amount of active ingredient having hypotensive...
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7279304 |
Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal...
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7271147 |
Antibiotics, tripropeptins and process for producing the same
By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the...
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7270985 |
Process for the preparation of aldehyde from a proteinous source for industrial applications
A process is disclosed to treat the protein hydrolysate, prepared conventionally from a proteinous source, with alkali metal hydride to obtain alcohol which is subsequently oxidized to obtain...
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7270950 |
Nucleic acid-protein fusions and methods of making and selecting fusions
Described herein are RNA-protein fusion production methods which involve a high salt post-translational incubation step.
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7270807 |
Cosmetic composition containing oyster flash enzymatic hydrolysates
The invention concerns the use of an oyster enzymatic hydrolysate of oyster flash hydrolyzed by a protease as a cosmetic composition.
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7259242 |
Methods for production of proteins
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the...
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7258996 |
Metalloproteinase inhibitory agent
The present invention relates to an active agent, in particular a metalloproteinase inhibitory agent of casein-derived peptides obtained by hydrolysis of casein by a food grade bacteria. The...
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7244708 |
Inhibitors of memapsin 2 and use thereof
Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
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7238513 |
Nucleic acid sequences encoding Conus protein disulfide isomerase
Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the ...
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7229787 |
Method of N-terminal cleavage using an aminopeptidase
A gram-negative bacterial cell is described that is deficient in a chromosomal gene present in a wild-type such cell which gene shares at least 80% sequence identity with the native sequence of the...
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7223556 |
Targeted proteolysis by recruitment to ubiquitin protein ligases
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and...
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7211424 |
Mammalian Subtilisin/kexin isozyme SKI-1: a proprotein convertase with a unique cleavage specificity
Using RT-PCR and degenerate oligonucleotides derived from the active site residues of subtilisin-kexin-like serine proteinases, we have identified a highly conserved and phylogenetically ancestral...
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7208594 |
Isoflavone concentrates as well as methods for their production
Isoflavone concentrates are described, which contain at least about ten to about twenty weight parts of polysorbate to one weight part of isoflavone containing a genistein, and/or daidcein, and/or...
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7192767 |
Matrix reactor and a method for producing products in said reactor
The present invention concerns a matrix reactor for reactions in which low-molecular and high-molecular reactants are involved wherein the reactor space V R contains a matrix and comprises a...
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7192735 |
Phosphopantetheinyl transferases and uses thereof
The invention pertains to isolated phosphopantetheinyl transferases, such as the E. coli acyl carrier protein synthase, which transfer a phosphopantetheinyl group onto a substrate. The enzyme can...
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7189528 |
Extract solution for cell-free protein synthesis, method for cell-free protein synthesis using same and method for preparation of the extract solution
The present invention provides a novel extract solution for cell-free protein synthesis, which contains at least an extract derived from a Bombyx mori L. tissue and an exogenous mRNA, which is...
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7179793 |
Anti-hypertensive dietary supplement
An anti-hypertensive fish protein hydrolysate is provided, wherein the fish is of the genus Salmo or Oncorhynchus , and wherein the fish protein hydrolysate comprises at least 1 peptide selected...
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7179617 |
Factor IX: remolding and glycoconjugation of Factor IX
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying...
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7169989 |
Process for creating a 3-dimensional configuration on a substrate
The invention provides a process for introducing a three-dimensional configuration of micron to sub-micron size in a polymeric substrate comprising applying a catalyst for the selective removal of...
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7166571 |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
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7148037 |
Platelet-derived growth factor D, DNA coding therefor, and uses thereof
PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing...
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7148034 |
Bioactive whey protein hydrolysate
The present invention relates to a process of preparing a whey protein hydrolysate from a WPI substrate having improved flavour, functionality and ACE-I inhibiting properties.
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7147871 |
Submucosa gel compositions
A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically...
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7144854 |
Long lasting anti-angiogenic peptides
Modified anti-angiogenic peptides are disclosed. The modified peptides are capable of forming a peptidase stabilized anti-angiogenic peptide. The modified anti-angiogenic peptides, particularly...
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7138255 |
Method of isolation and self-assembly of small protein particles from blood and other biological materials
Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the...
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7129059 |
Process for the preparation of compounds with enhanced optical purity
A process for preparation of a compound with enhanced optical purity is disclosed wherein a mixture of the enantiomers of a chiral amine is brought into contact with an enzyme having peptide...
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7125685 |
Stable isotope, site-specific mass tagging for protein identification
Proteolytic peptide mass mapping as measured by mass spectrometry provides an important method for the identification of proteins, which are usually identified by matching the measured and...
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