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6989262 Plasmin variants and uses thereof  
The invention concerns plasmin variants. Polynucleotides the disclosed plasmin variants are provided. Additionally, methods of using the plasmin polynucleotides and polynucleotides are provided...
6984488 Determination and control of bimolecular interactions  
Methods of using overlapping peptides for the discovery of discontinuous epitopes, as vaccines, for drug design, for diagnostic purposes and for the elucidation of three-dimensional protein...
6972282 Process for producing a product containing antihypertensive tripeptides  
The invention relates to a process for preparing a product containing antihypertensive peptides by fermenting a casein-containing starting material with lactic acid bacteria. The invention also...
6960451 Proteolytic fermenter  
A process of controlling the production of enzymatic protein hydrolysate from cold water animals, containing up to 90% free amino acids, cold fish oil, hydroxilaptite (calcium orthophosphate),...
6955877 In vitro selection and optional identification of polypeptides using solid support carriers  
A method for the selection of one or more desired polypeptides includes cell free expression of nucleic acid molecules immobilized on a solid support system to produce polypeptides. The solid...
6953574 Method for producing a fermented hydrolyzed medium containing microorganisms  
A method of producing a hydrolyzed fermented medium containing microorganisms includes providing at least one solid plant product reduced to small pieces and mixed with sugar and biocompatible...
6951734 Methods for producing proteins by using cell-free protein synthesis systems  
A method for producing a protein suitable for X-ray crystallographic analysis, in a cell-free protein synthesis system comprising a cell-free extract, a nucleic acid coding for said protein, and...
6946272 Transition state analogs  
Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable...
6929929 Method for the expression of proteins in in vitro translation systems with coexpression of folding helper proteins  
The present invention concerns a method for the expression of target proteins in in vitro translation systems, characterized in that folding helper proteins are co-expressed in this system. The...
6924120 Chaperone protein containing an intramolecular chaperone-like sequence and its application to insulin production  
The present invention relates to a chimeric protein containing an intramolecular chaperone (IMC) like sequence linked to a target protein, preferably an insulin precursor. The present invention...
6916623 Methods for producing protein domains and analyzing three dimensional structures of proteins by using said domains  
There is provided a method for producing a soluble protein domain comprising: (a) preparing two or more DNA fragments by partially digesting a DNA coding for a protein; (b) expressing the protein...
6913903 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same  
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide...
6908634 Transglutaminase soy fish and meat products and analogs thereof  
This invention relates to a transglutaminase-coupled vegetable protein composition and a process for preparing said composition. Further, this invention relates to soy fish and meat products and...
6908619 Camp factor of streptococcus uberis  
The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the...
6905856 Soluble GlcNAc phosphotransferase  
The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same.
6902912 Process for producing glutathione  
There is disclosed a fermentation process for producing glutathione which comprises (a) the obtainment of a biomass pre-culture by pre-cultivating, in aerobic conditions, a strain of a glutathione...
6900240 Method of preparing and using compositions extracted from vegetable matter for the treatment of cancer  
A composition is prepared by extracting and isolating phytochemical fractions from plant matter for treatment of cancer and especially for breast, prostate, skin, colon, urinary and bladder...
6890717 OBP1: a novel protein selectively expressed in osteoblasts  
The invention provides nucleic acid molecules derived from human osteoblasts. The nucleic acid molecules are used in applications such as diagnostic methods, screening assays and as hybridization...
6887682 Chaperonin and osmolyte protein folding and related screening methods  
The invention describes an inexpensive in vitro protein folding process for preventing large scale protein misfolding and aggregation, for concentrating aggregation prone chaperonin-protein...
6875740 Combination of a cyclic hexapeptide with antifungal drugs for treatment of fungal pathogens  
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the...
6875456 Protein hydrolysates  
The present invention describes protein hydrolysates: obtainable by the hydrolysis of a protein containing substrate; comprising free amino acids and peptides; and wherein the molar fraction of at...
6869774 Methods of synthesizing cell-free protein  
One embodiment of the present invention is a diffusion continuous batch cell-free protein-synthesis method characterized simultaneously by continuously supplying substrate and energy source...
6867176 Method for preparing zinc-oligopeptide easily absorbable by the human body  
Disclosed is a method for preparing zinc-oligopeptides easily absorbable by the human body. A suspension of protein in deionized water at a neutral pH range in the presence of a protease is...
6861231 Suppression of cross-reactivity and non-specific binding by antibodies using protein A  
The structure, formation and use of blocked antibodies, especially those blocked with Protein A, or active fragments of Protein A, are disclosed as well as processes of producing such antibodies....
6858405 Process for producing protein hydrolyzate  
The present invention relates to a method which can prevent browning of hydrolyzed protein obtained by enzymatic hydrolysis of vegetable protein material. A vegetable protein material containing...
6858382 Detection systems for registering protein interactions and functional relationships  
Disclosed herein are methods for detecting complex protein interactions and protein functional relationships, and reagents for carrying out those methods.
6855515 Autoantigenic fragments, methods and assays  
The present invention provides a method of producing autoantigens, compositions comprising autoantigenic fragments and methods of using autoantigenic fragments in the treatment of a condition...
6855506 Feline pancreatic lipase composition and method of preparing and using such composition  
A novel form of lipase, namely feline pancreatic lipase (also termed feline classical pancreatic lipase) has an N-terminal amino acid sequence as shown in SEQ ID NO. 1. A method of purifying this...
6852513 Method for extracting an insulin using enzymes which are bonded to a non-porous polymer support  
The invention relates to a method for catalysing complex reactions or large molecules, more specifically, to enzyme-catalysed reactions during which undesirable consecutive or subsidiary reactions...
6849428 Intein-mediated protein ligation of expressed proteins  
A method for the ligation of expressed proteins which utilizes inteins, for example the RIR1 intein from Methanobacterium thermotrophicum, is provided. Constructs of the Mth RIR1 intein in which...
6846667 Virulence genes and proteins, and their use  
The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The identification...
6841171 Use of oyster flesh enzymatic hydrolysates for preparing compositions eliminating free radicals  
The invention concerns the use of an oyster enzymatic hydrolysate for preparing a composition eliminating free radicals. The invention is characterized in that said hydrolysate is obtainable by...
6838432 Treatment of sepsis with TAFI  
A method for inhibiting and for reversing the dysfunctional response of vascular endothelial cells to an inflammatory stimulus in a subject in need of such therapy has been developed in which an...
6828133 Recombinant vanadium haloperoxidases and their uses  
The present invention provides new recombinantly produced vanadium bromoperoxidases. The enzymes are useful in a number of industrial applications.
6825003 Cyclic lipopeptide acylase  
The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog...
6815533 Cryogranulation of activated protein C  
The present invention is directed at a method of processing an aqueous solution of protein C into a state suitable for storage, handling, and recovery. The present invention provides aqueous...
6815427 Sericin-containing material, process for producing the same method of using the same  
The object of the present invention is to elucidate a biologically active function of a component constituting undegraded sericin and to provide a novel medical material, cosmetic material, etc....
6806077 Method for screening substances with therapeutic action in the treatment of transmissable subacute spongiform encephalopathies  
The invention concerns a method for screening substances capable of having therapeutic action in the treatment of transmissible subacute spongiform encephalopathy (TSSE) or prion diseases...
6800736 Hydrolyzed jojoba protein  
Hydrolyzed jojoba protein is provided which can be used in a variety of cosmetic formulations to enhance the desirable properties thereof. The preferred hydrolyzed jojoba is in the form of an...
6800453 Nucleic-acid programmable protein arrays  
Arrays of polypeptides are generated by translation of nucleic acid sequences encoding the polypeptides at a plurality of addresses on the array.
6794159 Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase  
This invention describes a method of removing N-terminal alanine residues from polypeptides, preferably recombinant proteins, using an aminopeptidase derived from the marine bacterium Aeromonas...
6794181 Method of purifying lantibiotics  
Disclosed is a method for purifying a antibiotic from a crude or partially purified solution containing the lantibiotic. In preferred embodiments, the lantibiotic is nisin, although the common...
6787330 Method and kit for identifying or characterizing polypeptides  
Polypeptides which have been separated by gel electrophoresis can be identified or characterized by a procedure which has two main stages. In the first stage the gel is digested with a...
6787168 Peptide product  
a peptide product is made by enzymatically hydrolyzing a protein, such as whey protein concentrate, in two stages. A fungal protease is used to hydrolyze the protein in each stage. The hydrolyzed...
6780607 Method for cell-free protein complete post-translational modification  
The present invention relates to methods of production of the completely post-translationally modified protein by combination of cell-free protein synthesis and cell-free co- and...
6767718 Lipodepsipeptide antibiotics and methods of preparation  
Novel cyclodepsipeptide intermediates have been prepared from the A21978 complex and used to synthesize new lipodepsipeptide antibiotics. The three intermediates can be readily derivatized to give...
6759188 Method for producing interleukin 1 receptor antagonists, a therapeutic activity protein, from body fluids  
The present invention relates to a method for producing a prophylactically or therapeutically active protein, the syringe being filled with a body fluid and incubated, and the prophylactically or...
6753155 Protein biomarker for mustard chemical injury  
This invention relates to the discovery that toxicity to mustard may be evaluated by diagnostic test means disclosed herein. Upon electrophoretic separation (sodium dodocyl sulfate polyacrylamide...
6737243 Determination of the hydrophobic pulmonary surfactant protein SP-C  
Methods for determining the strongly hydrophobic pulmonary surfactant protein SP-C, SP-C specific antibody and a reagent kit for carrying out the methods are described.
6733988 Inhibition of telopeptide lysyl hydroxylase activity or production as anti-fibrotic therapy  
The invention uses the existence of tissue-specific telopeptide lysyl hydroxylases, enzymes that hydroxylate lysine residues of the telopeptides of collagen, and the discovery that collagen...