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7476546 Method for single oxygen atom incorporation into digested peptides using peptidases  
Optimized enzymatic conditions incorporate a single oxygen atom into digested peptides using a peptidase. The incorporation of a single oxygen atom is especially useful for proteolytic 18O...
7470397 Disintegratable films for diagnostic devices  
The invention provides disintegratable film compositions for diagnostic test devices. The films are prepared with a combination of components that yield films of sufficient film strength and...
7445911 Enzymatic reactions in the presence of keto acids  
Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X—NH2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished...
7439043 Galactosyl nucleotide sugars  
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a...
7431685 Method and device for investigating substance libraries  
The aim of the invention is to investigate the bonding of substances to target molecules. This is achieved by means of a densely packed device wherein various target molecules are bonded in a...
7429467 Emulsion compositions  
An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a...
7422884 Feedback-resistant mevalonate kinases  
The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors...
7417135 Plasmidic gene, ways of acquiring this gene, the amylolytic enzyme it encodes and its application  
The object of the invention is a novel plasmidic gene encoding an amylolytic enzyme which after introduction into a microbial strain, favorably bacterial, especially Lactococcus lactis, enables...
7416876 N-carbobenzyloxy (N-CBZ)-deprotecting enzyme  
This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications,...
7416858 Pharmaceutical compositions of glycoconjugates  
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a...
7410777 Non-endogenous, constitutively activated human G protein-coupled receptors  
Disclosed herein are constitutively activated, non-endogenous versions of endogenous human G protein-coupled receptors comprising (a) the following amino acid sequence region (C-terminus to...
7410775 Method for making recombinant peptides or proteins using soluble endoproteases  
The present invention relates to the expression and secretion in Saccharomyces cerevisiae of readily purifiable soluble variants of the Kex1 endopeptidase of Kluyveromyces lactis and the...
7405057 Cytochrome P450s and uses thereof  
The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention...
7399610 Method for cell-free protein synthesis using extract solution derived from insect cell  
The present invention provides a simple cell-free protein synthesis method capable of affording synthesis of a protein in a high amount in a short time at a low cost. A method for cell-free...
7393659 Analytical method for the determination of infant formula protein digestibility in vitro  
A method for in vitro determination of the digestibility of proteins in a nutritional product. The method utilized gastric and intestinal enzymes that are standardized for in vitro digestion...
7393549 Defructosylation method  
The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of...
7391015 System and method for data collection in recursive mass analysis  
Systems, methods, and computer programming for collecting data using a mass spectrometer comprising a particle detector or other mass analyzer. A data collection such as a tree or array structure...
7387884 Yeast extract solution for cell-free protein synthesis, method for preparation thereof and method for cell-free protein synthesis using same  
The present invention provides a preparation method of a yeast extract solution for cell-free protein synthesis, which solution is easy to prepare and is capable of synthesizing a higher amount of...
7384754 Enrichment and tagging of glycosylated proteins  
A method useful in the analysis of glycosylated proteins, in which a mixture containing glycosylated proteins and unglycosylated proteins is contacted with a resin that includes a nucleophile...
7375081 Therapeutic combination of a pneumocandin derivative and an antifungal agent  
There is described antifungal combination use of known antifungal agents such as the azoles or polyenes in combination with a lipopeptide compound antifungal agent. More particularly, the...
7368260 Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same  
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide...
7364875 Method for producing medical and commercial grade poly-gamma-glutamic acid of high molecular weight  
Methods for producing high molecular weight poly-gamma-glutamic acid (PGA). The PGA is produced by fermentation, and purified by use of tangential flow filtration, followed by diafiltration, as...
7354734 Fungal proteins and nucleic acids encoding same  
Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants,...
7351563 Cell-free extracts and synthesis of active hydrogenase  
Enzymatically active hydrogenase is synthesized in a cell-free reaction. The hydrogenases are synthesized in a cell-free reaction comprising a cell extract derived from microbial strains...
7338780 Method for producing tripeptides and/or peptides longer than tripeptides  
A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A...
7329520 Fructosyl peptide oxidase and utilization thereof  
The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of...
7323332 Preparation method of insect cell extract solution for cell-free protein synthesis, the insect cell extract solution and cell-free synthesis method of protein using the insect cell extract solution  
The present invention provides a preparation method of an insect cell extract solution for cell-free protein synthesis, the insect cell extract solution, a protein synthesis method in a cell-free...
7319014 Overexpression, purification and characterization of a thermolabile phosphatase  
Compositions for an alkaline phosphatase and methods for over-expression and purification of thermolabile Antarctic phosphatase (TAP) are provided. Uses for TAP include dephosphorylation of...
7312192 Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same  
Methods for synthesizing proinsulin polypeptides are described that include contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s)...
7312049 Total amino acid stabilization during cell-free protein synthesis  
Compositions and methods are provided for the enhanced in vitro synthesis of protein molecules, by optimizing the metabolism of amino acids present in the reaction mix, preferably all amino acids...
7297512 Method for producing amino acid components by enzymatic hydrolysis of fish egg skin  
From fish egg skin produced by utilization of roe grains of various fish, constituent proteins thereof are enzymatically degraded to obtain peptides and amino acids, of which effective utilization...
7297354 Protein material  
A method of treating a proteinaceous material having a first concentration of β-conglycinin, the method including combining the proteinaceous material with an enzyme to form a reaction mixture,...
7297511 Interferon alpha: remodeling and glycoconjugation of interferon alpha  
The invention includes a multitude of methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the...
7297513 Gene encoding glutathione synthetase from Candida utilis  
A gene encoding glutathione synthetase from Candida utilis is provided and food containing γ-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by...
7288532 Modified chitosan polymers and enzymatic methods for the production thereof  
The present invention is directed to homogeneous phase enzyme-catalyzed processes for producing modified chitosan polymers or oligomers. An enzyme is reacted with a phenolic substrate in the...
7288389 Peptide-forming enzyme gene  
DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a...
7282354 Method for producing fermented milk product  
There is provided a fermented milk product that contains lactic acid bacteria capable of producing a large amount of lactotripeptide and a large amount of active ingredient having hypotensive...
7279304 Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby  
The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal...
7271147 Antibiotics, tripropeptins and process for producing the same  
By culturing Lysobacter sp. BMK333-48F3 (deposit number of FERM BP-7477), an antibiotic, tripropeptin Z, tripropeptin A, tripropeptin B, tripropeptin C or tripropeptin D represented by the general...
7270985 Process for the preparation of aldehyde from a proteinous source for industrial applications  
A process is disclosed to treat the protein hydrolysate, prepared conventionally from a proteinous source, with alkali metal hydride to obtain alcohol which is subsequently oxidized to obtain...
7270950 Nucleic acid-protein fusions and methods of making and selecting fusions  
Described herein are RNA-protein fusion production methods which involve a high salt post-translational incubation step.
7270807 Cosmetic composition containing oyster flash enzymatic hydrolysates  
The invention concerns the use of an oyster enzymatic hydrolysate of oyster flash hydrolyzed by a protease as a cosmetic composition.
7265085 Glycoconjugation methods and proteins/peptides produced by the methods  
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a...
7259242 Methods for production of proteins  
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the...
7244708 Inhibitors of memapsin 2 and use thereof  
Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
7238513 Nucleic acid sequences encoding Conus protein disulfide isomerase  
Protein disulfide isomerase is a major component of Conus venom ducts. The invention relates to a protein disulfide isomerase (PDI) from Conus snails, a nucleic acid sequence encoding the Conus...
7232884 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Methods of production of proteins
 
The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the...
7229787 Method of N-terminal cleavage using an aminopeptidase  
A gram-negative bacterial cell is described that is deficient in a chromosomal gene present in a wild-type such cell which gene shares at least 80% sequence identity with the native sequence of...
7223556 Targeted proteolysis by recruitment to ubiquitin protein ligases  
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and...
7211424 Mammalian Subtilisin/kexin isozyme SKI-1: a proprotein convertase with a unique cleavage specificity  
Using RT-PCR and degenerate oligonucleotides derived from the active site residues of subtilisin-kexin-like serine proteinases, we have identified a highly conserved and phylogenetically ancestral...