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8431355 Process for screening glycoform-specific antibodies  
The present invention relates to the use of the assessment of the binding between—antibodies elicited against a first glycoprotein, and—at least one glycoform of a second glycoprotein, said second...
8404462 Synthetic pathway enzymes for the production of argyrins  
The invention provides the amino acid sequences comprised in or constituting the synthetic pathway enzymes participating in the production of Argyrins, as well as the nucleic acid sequences...
8394605 Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine  
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells...
8394604 Protein splicing using short terminal split inteins  
The invention provides methods of producing functional split inteins having small N-intein and/or small C-intein. Using these split inteins with their protein trans-splicing and cleavage...
8388976 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor  
A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the...
8383110 Modulators of Candida hyphal morphogenesis and uses thereof  
The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof.
8367326 In vitro sorting method  
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements...
8367391 Method for detecting or determining abnormal prion protein associated with transmissible spongiform encephalopathy in blood-derived specimen or body fluid-derived specimen  
A pretreatment method of a specimen used for detecting or determining abnormal prion protein (PrPres) associated with transmissible spongiform encephalopathy (TSE), wherein (1) a specimen which...
8361770 Genetically programmed expression of selectively sulfated proteins in Eubacteria  
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such...
8357779 Polymer-von Willebrand factor-conjugates  
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to...
8354247 Glycoprotein synthesis and remodeling by enzymatic transglycosylation  
A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and...
8354502 Bioactive peptides identified in enzymatic hydrolyzates of milk caseins and method of obtaining same  
The invention relates to the production of bioactive products that are derived from milk proteins for the production of bioactive milk products derived from milk proteins, particularly caseins....
8338156 Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same  
The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
8334114 Lactoferrin cleavage of neisserial proteins  
Meningococcal antigens are cleaved by human lactoferrin. The invention is based on the identification of the cleavage products of this reaction, and provides a method for cleaving a neisserial...
8329428 Enzyme that catalyzes a peptide-forming reaction from a carboxy component and an amine component, microbe producing the same, and a method of producing a dipeptide using the enzyme or microbe  
DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a...
8304522 Soy protein gel and method of producing the same  
It is intended to provide a soy protein gel which has such gel properties that have never been obtained hitherto and is excellent in taste and color tone, and a soy protein food taking advantage...
8304210 Method for the secretory production of heterologous protein in Escherichia coli  
The present invention relates to a signal sequence peptide for the improvement of extracellular secretion efficiency of a heterologous protein in E. coli. More particularly, the present invention...
8299210 Methods for purifying pertussis toxin and peptides useful therefor  
The present invention relates to reagents and methods for purifying pertussis toxin (PT).
8298793 Methods for isolating proteons from plasma samples  
Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the...
8283147 Pancreatin and method for reducing the viral and microbial contamination of pancreatin  
The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual...
8278045 Methods for the detection, analysis and isolation of nascent proteins  
This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins...
8268322 Polypeptide specifically binding to vascular endothelial growth factor, fusion protein including polypeptide, and methods therefor  
A polypeptide inhibiting binding between a vascular endothelial growth factor and a vascular endothelial growth factor receptor, a fusion protein including the same, and a method of preparing the...
8268581 Carboxy terminal residues as predictors and regulators of protein stability  
Compositions and methods are provided that are useful for predicting and controlling the stability of expressed polypeptides. The compositions and methods may be used to predict and as desired,...
8241885 Engineered proteases for affinity purification and processing of fusion proteins  
The present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present...
8222372 Whey protein hydrolysate  
The present invention relates to a method of producing a whey protein hydrolysate using a microbial endopeptidase which specifically cleaves on the carboxy terminal side of arginine or lysine. The...
8206945 Biomaterial capable of successively performing a solution/gel transition and then a gel/solution transition  
The invention relates to a biomaterial which can successively carry out a solution/gel transition then a gel/solution transition with given kinetics, said biomaterial comprising at least one...
8206739 Fish protein hydrolyzate  
The present invention relates to the use of a enzyme treated fish protein hydrolyzate (FPH). The FPH material lowers the concentration of cholesterol in plasma, and triglycerides in the liver. FPH...
8206773 Nanoloom for controlling polymer assembly  
Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without...
8183010 Cell-free synthesis of membrane bound polypeptides  
Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane-associated polypeptides.
8178316 Evaluating proteins  
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence...
8173014 Apparatus for hydrolysis of a protein containing raw material and application of the resulting hydrolysis products  
Apparatus and methods for hydrolyzing protein-containing raw material into water soluble protein and other products. The apparatuses and methods include an optional collection or processing stage...
8163871 Enzymatic reactions in the presence of keto acids  
Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X-NH2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished...
8163518 Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry  
Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate...
8163285 Nogo-A binding molecules and pharmaceutical use thereof  
The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such...
8153395 Method of making activated carboxypeptidases  
The invention is related to a method for making an activated carboxypeptidase in a fungi cell comprising introducing a DNA sequence encoding a proform of the carboxypeptidase wherein a Kex2 site...
8153396 Method for producing a casein hydrolysate  
The present invention relates to a method for producing a casein hydrolysate using a microbial endopeptidase.
8148062 Detection of disease related genes  
The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA...
8148324 Chemoenzymatic methods for the synthesis of statins and statin intermediates  
The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and...
8137929 Basic protein purification tags from thermophilic bacteria  
The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange...
8129589 Protoporphyrinogen oxidase having activity of imparting resistance against acifluorfen and gene thereof  
Protoporphyrinogen oxidase having an activity of imparting acifluorfen resistance and gene thereof are provided. Cyanobacterium protoporphyrinogen oxidase gene is identified by introducing a...
8124372 Selective enzymatic amidation of C-terminal esters or acids of peptides  
The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide...
8124074 Fusion proteins  
The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein...
8124373 Isomaltulose synthases, polynucleotides encoding them and uses therefor  
The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose...
8119364 Methods for generating analogs of coenzyme A  
Methods to generate analogs of coenzyme A in vivo are disclosed. The methods to generate analogs of coenzyme A in a cell comprise reacting pantetheine or a derivative thereof with a reporter to...
8114652 Genetically programmed expression of selectively sulfated proteins in eubacteria  
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such...
8105802 Method of producing microbial transglutaminase  
The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral...
8101377 Protein hydrolysates and method of making  
Methods of making protein hydrolysates are described. The methods may include the steps of providing a solution comprising protein, and adjusting a pH of the solution to about 10.4 or more to form...
8101375 Compositions and methods for detecting phosphomonoester  
The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and...
8093023 De-fatted soy production process and value added by-products from de-fatted soy flour  
An improved process for producing de-fatted soy utilizing a de-fatted soy flour and for producing value added by-products from de-fatted soy flour wherein soybeans are de-hulled and the de-hulled...
8088601 Expression systems for functional membrane polypeptides  
Expression systems and methods for the expression of functional membrane polypeptides such as human cytochrome b5 are provided. The systems include recombinant expression vectors capable of...