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4647554 Biologically active substances from fibrinogen their preparation and compositions containing them  
New immunostimulant substances are obtained by hydrolyzing reduced and alkylated bovine fibrinogen with a proteolytic enzyme and fractionating the product.
4645740 Process for enzymatic replacement of the B-30 amino acid in insulins  
The B-30 amino acid in insulins is replaced enzymatically by reacting as substrate component the selected insulin Ins-X, wherein X represents the B-30 amino acid with an amine component selected...
4636388 Preparing protein for hydrolysis and product  
A purified protein particularly adapted for enzymatic hydrolysis can be prepared by gelling the protein followed by breaking the gel into particles and washing the particles in sufficient liquid...
4634671 Water-soluble cross-linked polymer of lysyl endopeptidase, process for preparing same and use of same  
A water-soluble cross-linked polymer of the enzyme lysyl endopeptidase produced by Achromobacter lyticus and a process for preparing the polymer as well as a semi-synthesis of human insulin using...
4632903 Enzyme modified soy protein for use as an egg white substitute  
Enzymatic hydrolysis of soy protein with microbial rennet to DH 0.25-2.5% to produce an egg white substitute. The soluble hydrolysate produced by treatment with Mucor miehei proteinase exhibits...
4627983 Functional protein hydrolyzates, a process for their preparation, use of these protein hydrolyzates as a food additive, and foods containing these protein hydrolyzated  
Functional hydrolyzates are prepared from microbial protein isolates, with a protein content of more than 90% by weight, a nucleic acid content of less than 2% by weight, a lipid content of less...
4627982 Partially purified bone-inducing factor  
A partially purified proteinaceous bone-inducing factor of 10,000 to 30,000 daltons is described. It is derived from demineralized bovine bone by extraction with a chaotropic agent, gel...
4621055 Process for producing biologically active factors  
A process for producing biologically active factors from a substrate, in the form of cell homogenates of organ tissues, of microorganisms, plant components and/or body fluids. To this end, the...
4614717 Process for cultivation of organisms wherein a uniform protein from microorganisms is enzymatically degraded  
Products which are soluble without opalescence even at pH 3 and which, because of their reproducible composition, are particularly well suited as a source of nitrogen for organisms are obtained by...
4606855 Monoclonal antibody to digoxin  
A method of determining the concentration of an antigen in a sample solution comprising (a) coating an antigen-protein conjugate onto a solid matrix, (b) conjugating an enzyme to an antibody...
4601979 Process for preparing human insulin or B-30 esters thereof  
Human insulin or B-30 esters thereof are prepared by reacting an insulin derivative of the formula ##STR1## wherein R is hydroxyl or an amino acid radical being different from threonine, and -A-...
4597762 Collagen preparation  
A collagen preparation comprising collagen-I for human or veterinary medicine obtainable by proteolyzing, cross-linking, reducing, optionally heat treating, and finally sterilizing mammalian...
4598046 Mutant strain of Escherichia coli and its use for the preparation of glutathione  
The present invention relates to a new mutant strain of Escherichia coli and its use for the preparation of glutathione.The present invention is based upon the discovery that a certain mutant...
4596775 Microorganism and its use for the preparation of glutathione  
The present invention relates to a new mutant strain induced from a wild strain of the genus Escherichia, which is active upon a γ-glutamyl-L-cystein synthesizing enzyme system and capable of...
4588685 Process for the preparation of a new-type active substance selectively inhibiting food intake  
The invention involves isolating a food intake suppressant by subjecting blood serum to ultrafiltration transmitting up to a molecular weight of 30,000 daltons, partially evaporating the filtrate,...
4587214 Process for preparation of aspartylphenylalanine alkyl esters  
α-L-aspartylphenylalanine lower alkyl esters are prepared by a process wherein fumaric acid, ammonia and a lower alkyl ester of L-phenylalanine are contacted with a culture or treated culture of a...
4587018 Fibrin gel  
There is disclosed a filter comprising fibrin in gel form, the gel having substantially uniform pore sizes, and the filter comprising means for retaining the shape of at least one surface of the...
4585653 Neuraminidase treated ancrod  
Disclosed is a pharmaceutically effective agent and method of use, comprising ancrod which has been incubated with neuraminidase. The neuraminidase-treated ancrod (NTA) can be substituted for...
4584197 Process for preparation of fish and shellfish extracts having pharmaceutical functions  
A process for the preparation of fish and/or shellfish extracts having various pharmaceutical functions is provided. The process comprises decomposing raw fish and/or shellfish at a pH of 6.0 to...
4572894 Process for synthesizing peptides or peptide derivatives  
A process for synthesizing peptides or peptide derivatives is disclosed. The process involves using aminoacyl-tRNA synthetase as a condensing agent when synthesizing peptides or peptide...
4559307 Treatment of yeast cells with proteolytic enzymes  
Functional protein having reduced nucleic acid content is produced without initial denaturation of the protein by contacting undenatured yeast cells with an alkaline protease at a temperature of...
4552761 Method for influencing the immune systems of mammals using leukorecruitin  
The invention relates to SERUM-DERIVED "LEUKORECRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte...
4544638 Synthesis of cross-links in the helical domain of collagen using pyridoxal 5-phosphate and copper or iron  
Aldehyde cross-link intermediates and cross-links are generated in the central helical portion of collagen by incubating collagen with pyridoxal-5-phosphate and either cupric copper ion or ferrous...
4543350 Carcinostatic agent  
A carcinostatic agent having an immunopotentiating carcinostatic effect which contains as an active ingredient Eisenin (tripeptide) of the general formula: L-Pyroglu-L-Glu-L-Alawherein Pyroglu,...
4543329 Process for the specific cleavage of protein sequences from proteins  
A process for cleavage of a protein (a) sequence from a protein containing the tetrapeptide sequence Pro-Xyz-Gly-Pro, wherein Xyz can be any desired amino acid, and reacting the protein with a...
4535083 Cleavage products of 4',6'-didesoxy-4'-thio-,6'-amino-hepturonic acid nucleosides  
The invention relates to compounds of the formula ##STR1## said compounds being obtainable by cleavage of compounds of formula ##STR2## The compounds of the invention as well as compositions and...
4532207 Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase  
A method for the production of polypeptides utilizing a polymer of charged amino acids and an exopeptidase. A DNA sequence coding for the charged amino acid polymer is inserted adjacent to one end...
4524135 A-21978C cyclic peptides  
A-21978C cyclic peptides of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, an amino-protecting group , 8-methyldecanoyl, 10-methylundecanoyl,...
4521514 Process for producing an addition compound of a dipeptide ester and an amino acid ester  
A process for producing an addition compound of N-benzyloxycarbonyl-α-L-aspartyl-L-phenylalanine methyl ester and phenylalanine methyl ester. Benzyloxycarbonylation of the amino group of...
4515891 Process for the production of disaccharide-tripeptide and disaccharide-tetrapeptide  
Process for the production of a disaccharide-tripeptide and disaccharide-tetrapeptide which comprises applying an endo-N-acetylmuramidase from Streptomyces globisporus and a...
4511653 Process for the industrial preparation of collagenous materials from human placental tissues, human collagenous materials obtained and their application as biomaterials  
This process of preparation consists in subjecting said placental tissue after pressing, grinding and washing in a neutral and acid medium to a treatment in alkaline medium at a temperature less...
4501693 Method of preparing immunostimulant proteoglycans which induce production of interferon, proteoglycans obtained and pharmaceutical compositions containing them  
The present invention relates to a method of preparing bacterial membranous proteoglycans with an action which induces interferon from soluble membranous proteoglycans of a strain of gram-negative...
4500453 Cross-linked protein composition using aluminum salts of acetic acid  
This invention relates to cross-linked collagen-derived protein compositions having improved Bloom gel strength and increased viscosity. More particularly, it relates to improvement by...
4495176 Phosphopeptides from casein-based material  
Phosphopeptides useful as alimentary products or as medicaments are obtained by a method of subjecting phosphocaseinates of monovalent cations or paracasein derived therefrom to enzymatic...
4489159 Process for preparing esters of human insulin  
A process for converting human des-B30-insulin, namely ##STR1## into h-In-ThrB30 esters through amidation with an L-threonine ester in a mixture of water and a water miscible solvent in the...
4478856 Production of purified vegetable protein  
A process for recovering purified vegetable protein particularly soymeal protein by enzymatic treatment to dissolve the remanence employing a novel enzyme composition agent adapted to decompose a...
4473589 Protein liquefication process and products  
Sources of protein, such as residues and waste products from processing fish, poultry, pork and beef as well as single cell microorganisms, are hydrolyzed to provide liquid products containing...
4468457 Method for producing a CSAp tryptic peptide and anti-CSAp antibodies  
A tryptic peptide is produced by partial tryptic digestion of purified, high molecular size colon-specific antigen-p (CSAp), to produce a lower molecular size antigen carrying the CSAp antigenic...
4462990 Biologically active substances, their obtainment from human casein and compositions containing said substances  
New biologically active substances obtained by treating human casein with trypsin then fractionating and optionally purifying. They have immunological properties.
4452888 Process for producing a low-molecular weight peptide composition and nutrient agent containing the same  
A low-molecular weight peptide composition mainly based on dipeptides and tripeptides is produced by dispersing protein raw material from any suitable source in water at a concentration of 5 to 20...
4452735 Leukorecruitin  
The invention relates to SERUM-DERIVED "LEUKORECRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte...
4451567 Method for pretreatment of cellulosic materials  
The disclosure is concerned with a pretreatment process for removing lignin from lignocellulosic material so as to enhance enzymatic or microbial decomposability of cellulose. The pretreatment...
4443540 Protein hydrolysis  
The present invention prepares protein hydrolyzates by reacting selected protein material with at least one proteolytic enzyme and recovering the low molecular weight protein material by...
4439510 Method for the production of dry toner for electrostatography using interfacial polycondensation techniques  
Disclosed is a method of preparing electroscopic marking particles comprising encapsulating an ink using an aqueous phase emulsion solution including an albumin stabilizer which becomes...
4438198 Biochemically active matrix for use in a bio-artificial organ  
A biochemically active matrix for use in a bio-artificial organ is disclosed. The biochemically active matrix has an enzyme covalently bonded to a matrix of organochemically cross-linked fibrin....
4436724 Method of producing γ-globulin for intravenous injection and therapeutic agent produced thereby  
A method of producing γ-globulin which can be administered intravenously without adverse reactions and loss of opsonic activity is provided. The method comprises treating γ-globulin with pepsin or...
4431629 Method of producing an egg white substitute material  
Method of producing an egg white substitute material from soy protein. The method comprises extraction of a defatted soy bean material at a pH between about 6.0 and 10.5, separation, subjection of...
4427658 Total enzymatic hydrolysate from whey proteins and process of obtaining the same  
A total enzymatic hydrolysate from whey proteins is disclosed comprising peptidic hydrolysate with substantially no residual proteins, at least 50% of the peptides containing 2 to 5 amino acids....
4415553 Compositions, processes for their preparation and method for treatment of neoplasms  
The invention comprises preparations for the treatment of neoplasms, the methods of treatment of neoplasms using such preparations, and processes for preparing such preparations, including the...
4411915 Heme-iron-enriched amino acid and a process for the preparation of heme-iron-enriched amino acid  
There is disclosed heme-iron-enriched amino acid preparation consisting of aggregates of heme-protein fragments with heme bonded to histidine groups present in the fragment and a method for...