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5126250 Method for the reduction of heterogeneity of monoclonal antibodies  
Novel methods for reducing the heterogeneity of secreted monoclonal antibodies are disclosed. The first method comprises incubating the heterogeneous antibodies at low pH for a length of time...
5112812 Peptide preparation, a process for producing it and use of the peptide preparation  
A peptide preparation from hydrolysis of whey containing peptides with a molecular weight of up to 6,000 Dalton. Such a preparation is hypoallergenic and therefore useful in food products and...
5109116 Immunosuppressive glycoprotein  
The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and...
5108911 Process for preparing bovine interleukin-Iβ  
A process for preparing bovine interleukin Iβ (bIL-1β) by culturing a microbial host transformed by a vector containing a DNA sequence encoding bIL-1β under conditions suitable for the expression...
5108908 Process for the treatment of proteinic solutions containing pigments such as heminic groups or chlorophylls in view of their decolorization and products thus obtained  
A process for pigments such as the treatment of proteinic solutions containing heminic groups or chlorophylls in view of their decolorization, and products thus obtained.The proteinic solution is...
5099005 Method of enhancing immunoglobulin fragment production  
Methods of enhancing immunoglobulin fragment yield of immunoglobulins exhibiting anomalous bands when analyzed by SDS-PAGE techniques are provided. Such yield enhancement methods include the steps...
5097020 Immunogenic conjugates  
An immunogenic conjugate which is the reductive amination product of an immunogenic capsular polymer fragment having at least one reducing group and derived from a bacterial capsular polymer of a...
5091308 Process for the enzymatic dispersal of Mycobacterium bovis - BCG  
Mycobacterium bovis BCG suspensions are treated with a protease enzyme such as pronase, resulting in the production of suspensions having smaller aggregates and single cells. Such suspensions,...
5084160 Method for solubilization of low-rank coal using low molecular weight cell-free filtrates derived from cultures of coriolus versicolor  
A method is provided for isolating a less than 5,000 dalton molecular weight extracellular product from Coriolus versicolor. The extracellular product is useful for biosolubilizing low-rank coals...
5082930 Coupling agents for joining radionuclide metal ions with biologically useful proteins  
This invention relates to bifunctional coupling agents useful in forming conjugates with biologically useful molecules, such as antibodies. These conjugates can be complexed with radionuclide...
5079148 Peptide antibiotics  
Novel peptides of the formula ##STR1## wherein R is CH3 --(CH2)6, CH3 --(CH2)4 --CHCH--(CH2)2 and CH3 (CH2)8 having antibiotic and antitumor activity are prepared by cultivation of the novel...
5077204 Yeast endopeptidase for basic amino-acid site cleavage, preparation and use  
Methods and compositions are provided for endopeptidase production, enhanced efficiencies of processing in vivo and in vitro to provide for process polypeptides, and purified enzyme for in vitro...
5073677 Herbicidal tolerant plants containing rat glutathione S-transferase gene  
The invention relates to plant cells and dicotyledonous plants transformed with chimeric rat glutathione-S-transferase gene constructs. Transgenic tobacco plants and progeny expressed the chimeric...
5073630 Polymeric anhydride of magnesium and proteic ammonium phospholinoleate with antiviral, antineoplastic and immunostimulant properties  
The invention relates to a polymeric anhydride of magnesium and proteic ammonium phospholinoleate having the following distribution of components expressed in percentage of magnesium (20.1±0.9%),...
5071960 High molecular weight protein/fatty acid condensation products which are very well tolerated by the skin and mucosa  
High molecular weight protein/fatty acid condensation products obtained by reaction of one mole of a protein hydrolysate of average molecular mass 3,000 to 7,000 with 0.5 to 3, preferably 2 to...
5063161 Method of degrading keratinaceous material and bacteria useful therefor  
A method of degrading keratinaceous material is disclosed. The method comprises the steps of combining the keratinaceous material with Bacillus licheniformis to form a fermentation media and then...
5061622 Process for the production of κ-casein glycomacropeptide  
Disclosed herein is a process for the efficient production of κ-casein GMP on an industrial scale. The production of high-purity κ-casein GMP is realized by using an effluent of rennet-casein curd...
5057415 Continuous enzymatic process for preparing peptides  
Peptide preparation is carried out by a continuous process by supplying a serine protease or peptidase enzyme retained in a reaction vessel with an alkyl ester of an N-protected amino acid or...
5055399 Enzymatic synthesis of alpha-L-aspartyl-L-phenyalanine lower alkyl esters  
Enzyme-catalyzed synthetic reactions having otherwise unfavorable equilibria are facilitated by recovery of polypeptides by electrodialysis. A process of preparing polypeptides is provided that...
5053234 Method for producing a proteinaceous product by digestion of raw animal parts  
A particulate proteinaceous product is prepared from waste raw protein-containing animal parts with a method and an apparatus having a mulling stage wherein the raw animal parts are reduced to a...
5047333 Method for the preparation of natural human growth hormone in pure form  
An improved method is described for the preparation of natural human growth hormone (hGH) in pure form, which comprises the preparation of a precursor of hGH by means of the culture of Bacillus...
5043429 Protein fragments containing Factor VIII binding domain of von Willebrand Factor  
Peptides which inhibit the binding of von Willebrand Factor to Factor VIII. Monoclonal antibodies capable of specifically binding to the region of von Willebrand Factor containing the Factor VIII...
5030717 Antibodies which catalyze hydrolysis of ester bonds  
An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor...
5028589 Casein phosphopeptide salts  
Casein phosphopeptide salts of calcium, magnesium or both are produced having less than 4% by weight of aromatic amino acids, greater than 8% and less than 20% by weight serine, less than 3% free...
5028695 Process for the manufacture of collagen membranes used for hemostasis, the dressing of wounds and for implants  
The invention concerns a process for the manufacture of collagen membranes for medical applications, in which process the collagen raw materials obtained from cattle or pig collagen are...
5024938 Recombinant DNA inserted with hepatitis B virus gene, mammalian cells transformed with cloned viral DNA, and production of hepatitis B virus proteins  
A recombinant DNA comprising 3 fragments of Hepatitis B virus DNA recombined with a vector consisting essentially of 0.31 Kb replication orgin of SV40 DNA inserted into EcoRI cleavage site of...
5021337 Non-intrusive process for monitoring the production of recombinant proteins  
A process is described for monitoring the production of recombinant proteins. It is based on the discovery that infrared spectra of E. coli strains and transformants which overproduce recombinant...
5021338 Enzyme extract from germinated sorghum for hydrolysis of protein material  
An enzyme system for hydrolysis of protein material from plant and animal sources is obtained by extracting germinated sorghum seeds. The enzyme system contains a proteolytic component active on...
5015569 Acceleration of nucleic acid hybridization  
This invention relates to an improvement in nucleic acid hybridization technology. Nucleic acids bind to complementary partners in a predictable manner such that the detection of complementary...
5002872 Enzyme mediated coupling reactions  
Disclosed herein is an enzymatic process to bind two amino acids in the presence of a water-miscible solvent. Preferably the amino acids are precursors of aspartame and a preferred solvent is...
4983521 Transmembrane integrator sequences  
Novel DNA constructions are provided, as well as their expression products, involving the use of transmembrane integrator sequences joined from one to two open reading frames and optionally a...
4975527 Tissue-affinitive collagen for osteogenesis and method of producing the same  
A good tissue-affinity and lack of antigenicity are required for the collagen used as the carrier of BMP. Conventional collagens have these properties only insufficiently. When the tyrosine...
4963656 Emulsified compositions containing elastin hydrolysate  
Emulsified compositions comprising an elastin hydrolyzate having a molecular weight not lower than 200,000 (preferably in the range from 1,000,000 to 2,000,000) maintain a stable emulsion state...
4960696 Process for producing physiololgically active substance by multienzyme process  
A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50° C. to...
4956279 Biotransformation of L-tyrosine and L-phenylalanine to 2,5-dihydroxyphenylacetic acid  
Disclosed is a method for the production of homogentisic acid which involves growing a fungus (typically a yeast of the species Yarrowia lipolytica) which has been mutated to provide a strain...
4948874 Purified protein G from streptococcal bacteria  
A process is disclosed for recovering a cell wall protein, particularly a Fc-receptor, from streptococcal bacteria. In the process, streptococcal bacteria are treated with at least one proteolytic...
4948876 Keratin polymer containing S-sulphocysteine residues, process for its preparation and the compositions containing it  
A novel keratinic polymeric product is described which can be used for cosmetic purposes. This product comprises keratin peptide chains of different molecular weights, formed of amino acids bonded...
4945052 Production of a Vitamin C precursor using genetically modified organisms  
An enzyme for conversion of 2,5-diketo-D-gluconate (2,5-DKG) to 2-keto-L-gulonic acid (2-KLG) and a genetically modified organism that expresses all the fermentation enzymes needed to convert...
4940662 Low-molecular weight peptide mixture and method of producing same  
A method of producing a low-molecular weight peptide mixture, comprising the steps of dissolving a first protease in a buffer solution adjusted to an optimum pH for the protease ranging from pH 3...
4937183 Method for the preparation of antibody-fragment conjugates  
A novel method for preparing soluble antibody fragment compositions having superior characteristics for targeted delivery when administered in vivo are disclosed. The antibody fragment...
4937190 Translation enhancer  
Disclosed in this patent are DNA sequences, RNA sequences, vectors, and hosts that incorporate a translation enhancer region derived from the 5' non-coding region of a cardiovirus. The enhancer...
4935355 Preparation of dipeptides  
A process for forming a dipeptide which is substantially free of solid dipeptide-amino acid adduct by reacting the amino acid reactants in the presence of a polyol.
4925796 Method for enhancing glycoprotein stability  
A method for modifying eukaryotic and prokaryotic proteins to extend their in vivo circulatory lifetimes. In the preferred embodiment, enzymatic and/or chemical treatments are used to produce a...
4921797 C-terminal alpha-amidating enzyme and process for production and use thereof  
C-terminal α-amidating enzyme preparations, including preparations AE-I, AE-II, AE-IIa and AE-IIb, from the skin of Xenopus laevis, wherein all components can convert a peptide having a glycine...
4918008 Process for the preparation of protein hydrolysate and medicaments containing these hydrolysates  
Protein hydrolysates are described; they may be obtained by the enzymatic decomposition of whey protein, lactalbumin, α-lactalbumin, β-lactoglobulin, lysozyme, lactoferrin or serum albumin. These...
4916062 Enzyme, its method of production and its application to the preparation of methyl N-(L-aspartyl-1) L-phenylalaninate  
A polymeric enzyme having a molecular weight higher than or equal to 200,000 and not exhibiting any proteolytic activity on casein derived from a culture of Micrococcus caseolyticus is disclosed,...
4892820 Solvent system for enzymatic coupling process  
Alkylphosphate solvents are disclosed for use in an amino acid and amino acid ester enzymatic coupling process. α-Aspartylphenylalanine methyl ester and intermediates thereof are prepared...
4879222 Method of isolating tumor-secreted products using a novel protein-free medium  
A medium for the maintenance of mammalian anchorage-dependent colonic adenocarcinoma cells comprising a solution of an effective maintenance amount of buffered salts, L-glutamine and glucose,...
4879223 Method for producing protein containing nonprotein amino acids  
A protein having nonprotein amino acids can be produced by a method which comprises providing a protein-producing organism with a nutrient containing nonprotein amino acids, cells being cultured...
4879226 Novel human physiologically active polypeptide  
A human physiologically active polypeptide, human Tumor Necrosis Factor (human TNF), comprising a specific amino acid sequence of 155 amino acid residues. The base sequence of the DNA coding for...