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5478730 Method of preparing polypeptides in cell-free translation system  
Cell-free production of protein is provided by employing a barrier which defines a reaction region for maintaining the high molecular weight components of the cell-free system while providing...
5476773 Flavorant composition prepared by fermentation  
A flavorant composition is prepared by inoculating and fermenting a protein-rich material, particularly pulse seeds and in particular, cooked pulse seeds, and then, the fermented material is mixed...
5468623 Method of converting big endothelin-1 to endothelin-1 with human apolipoprotein B  
A method for converting big endothelin-1 to endothelin-1 by contacting big endothelin-1 with a commercially available preparation of apolipoprotein B is presented. The apolipoprotein B itself has...
5464817 Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I  
The invention is generally directed to methods of promoting normal respiratory tract airflow in subjects with restricted airflow and ciliary clearance caused by the presence of pathological airway...
5459051 Methods and vectors for over-expression of ubiquitin fusion proteins in host cells  
The invention is directed to recombinant DNA vectors and methods of use thereof. The vectors allow over-expression of proteins in bacterial host cells. The vectors contain a first gene encoding a...
5457066 Process for transforming a human insulin precursor to human insulin  
This specification describes a process for converting a human insulin precursor to human insulin, which comprises treating such human insulin precursor with trypsin and carboxypeptidase B in an...
5457033 Preparation of polypeptides having an amide carboxyl terminal end  
Polypeptides having a carboxamide carboxyl terminal end and a methionine residue, which is optionally bonded to a bacterial protein, on the amino end can be prepared by synthesis by genetic...
5449758 Protein size marker ladder  
The invention relates to a multidomain protein comprising sites for cleavage of the protein into at least 3 polypeptide domains; nucleic acid encoding the multidomain protein; a protein ladder...
5436135 New preparation of placenta collagen, their extraction method and their applications  
Human or animal placenta is subjected to moderate enzymatic digestion, in particular with pepsin at an acid pH, then, after separation of the residual tissue the impurities are separated at a...
5434250 Process for manufacturing high α-lactalbumin content composition  
The present invention relates to a process for manufacturing a composition highly containing α-lactalbmin. This process comprises adjusting, to pH of 2-4 or 5 or higher, cheese whey, acid casein...
5432062 Method of proteolytically cleaving prothrombin to produce thrombin  
Prothrombin is cleaved by proteases in the presence of a detergent or certain chaotropic substances to produce thrombin. Under these conditions, controlled and restricted proteolysis occurs such...
5427921 Method of preparing yeast extract containing hydrolyzed non-yeast protein with yeast autolytic enzymes  
Non-yeast protein is mixed with yeast, and enzymatic hydrolysis is carried out with yeast autolytic enzymes and optionally added exogenous enzymes to produce a yeast extract containing hydrolyzed...
5418146 Process for preparing dipeptides  
This invention relates to an improvement in a method for manufacturing dipeptides by coupling N-blocked aspartic acid and a phenylalanine lower alkyl ester in a medium containing a water-miscible...
5418147 Glycosyl-phosphatidylinositol-specific phospholipase D  
The present invention involves the protein glycosyl-phosphatidyl-specific phospholipase D (GPI-PLD) in a substantially pure form, an isolated nucleotide sequence encoding GPI-PLD, vectors...
5416007 Enhanced proteolytic cleavage of recombinant fusion proteins  
Disclosed are methods for increasing the yield of intact target proteins by cleaving fused polypeptides made by recombinant DNA techniques. The fused polypeptides are designed at the DNA level to...
5416196 Method for preparing a transparent adjusted milk whey protein and an adjusted milk whey protein product  
A transparent adjusted milk whey protein is prepared by a method in which milk whey protein is purified and then the pH of a solution containing the milk whey protein is adjusted to not higher...
5411887 Method for the production of collagen: collagen produced through the method and use of collagen  
The present invention relates to a process for the production of collagen from animal intestines etc. It is characterized in that the starting material is mixed with ice-water at a pH of 5,5, that...
5405756 Transparent acid drink containing acid-soluble casein phosphopeptide  
A transparent storage stable acidic beverage or other alimentary product containing casein phosphopeptide is obtained by reacting casein with trypsin, precipitating insoluble components at acid...
5397701 Azido-substituted fatty acid analog enzyme substrates  
Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure: Z--(CH2)x...
5389611 Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent  
Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than...
5384249 α2➝3 sialyltransferase  
There are provided a novel α2➝3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the α2➝3 sialyltransferase, a method for detecting or suppressing the expression of...
5382428 Method for preparing a purified extraction residue fraction and its use in stimulating the immune response  
A method is disclosed for preparing a purified extraction residue fraction (antigen) of a microorganism isolated from the blood or urine of a warm-blooded animal or tumor carried by a warm-blooded...
5374539 Process for purifying collagen and generating bioprosthesis  
A process is described to purify collagen fibers while allowing the individual constituent molecules to retain their native configuration and 3-dimensional arrangement characteristic of the...
5369017 Process for solid phase glycopeptide synthesis  
A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support...
5369015 Method for producing an angiotensin converting enzyme inhibitor-containing composition  
Disclosed is a method for producing an angiotensin converting enzyme inhibitor composition from natural materials, which composition is of use as an antihypertensive drug or diet. The method...
5369018 Method of producing peptides  
The biocatalytic production of a peptide is carried out with a zymogen instead of the customarily used protease. Since zymogens are proteolytically inactive precursors of proteases, proteolytic...
5369016 Peptide amidase and the use thereof  
A peptide amidase isolated from the flavedo of citrus fruits, preferably oranges, which is capable of catalyzing the selective hydrolytic elimination of the free amino group on the C-terminal end...
5366661 Method for forming a stabilized aqueous dispersion of inorganic particles or organic particles for food stuffs  
A method for forming a stabilized aqueous dispersion which is useful for reducing viscosity of a stabilized aqueous dispersion wherein various water-insoluble or sparingly soluble inorganic and/or...
5362854 Factor VIII coagulant polypeptides: method of making  
Fragments of Factor VIII:C polypeptide have been discovered which exhibit highly specific factor VIII activity. Monoclonal antibodies to the polypeptide fragments and methods for the isolation and...
5360727 C-terminal α-amidating enzyme and process for production thereof  
The invention relates to a C-terminal α-amidating enzyme of porcine origin having the following properties: (1) the action is on a peptide or protein represented by the formula: X-R-Gly,wherein...
5358853 Liquid thromboplastin reagent  
The invention is a stable liquid thromboplastin reagent used for measuring the performance of the coagulation system, with a shelf life of greater than 16 months, and a method of producing this...
5356637 Method for preparing an enzymatic hydrolysate  
An enzymatic hydrolysate having a high di- and tripeptide content is prepared by subjecting to enzymatic proteolysis a protein mixture preliminarily prepared by means of a thermal treatment. The...
5356794 Purified enzymatic preparation derived from chromobacterium violaceum, method for preparing it and its use in the production of α, β-dehydrotryptophanyl-peptides  
Purified enzymatic preparation derived from Chromobacterium violaceum, having a dehydrogenase activity, method for preparing it and its use in the production of...
5354675 C-terminal amidating enzyme composition, process for preparing, and use of the same  
A C-terminal amidating enzyme composition is disclosed having the ability to amidate the C-terminus of peptides with a C-terminal glycine. The C-terminal amidating enzyme is characterized by...
5352476 Nutrient composition containing non-phosphorylated peptides from case in based material  
Non-phosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced by proteolytic enzyme hydrolysis of a casein-based material. Membrane ultrafiltration is...
5352769 Enzymatic removal of a protein amino-terminal sequence  
This disclosure relates to new compounds and to a process for the controlled conversion of such compounds to produce a Protein that comprises an amino acid sequence which is useful as a precursor...
5350682 Process for preparing peptides  
The invention relates to a process for preparing chirally uniform peptides. The aim of the invention is the preparation of chirally uniform peptides with the aid of proteolytic enzymes. The object...
5350681 Enzymatic membrane method for the synthesis and separation of peptides  
The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha...
5348863 Process for the enzymatic preparation of basic fibroblast growth factor  
A bFGF is prepared by:(i) forming an adduct between heparin or heparan sulphate and a bFGF which has the 9-10 Leu-Pro bond;(ii) treating the adduct with pepsin A or cathepsin D, thereby cleaving...
5346696 Asialoglycoprotein - conjugated medicinal agent  
The present invention relates to a conjugated medicinal agent prepared by combining asialoglycoprotein with a medicine which acts specifically on the liver. The conjugated medicinal agent of the...
5344820 Infection protectant  
Disclosed herein is an infection protectant which is excellent in infection protective effects and is also safe. κ-Casein, a sialic-acid-conjugated protein derived from cow milk, and a...
5338668 Opioid peptides derived from wheat proteins  
Disclosed are opioid peptides recovered from hydrolysates of wheat proteins with an acid protease and further a neutral or alkaline protease. Of those peptides, the structure of four opioid...
5336601 Enzymatic membrane method for the snythesis and separation of peptides  
The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha...
5334408 Nutrient composition containing non-phosphorylated peptides from casin-based material  
Non-phosphorylated peptides and phosphopeptides useful as alimentary products or medicaments are produced. A hydrolyzate containing non-phosphorylated peptides and phosphopeptides is prepared by...
5330907 Method of preparing activated protein C  
To produce activated protein C, protein C is treated with plasmin. Activation is effected in a quick and simple manner. Contamination of the activated protein C with thrombin is avoided.
5328834 Method for preparing immunoglobulin fragments  
A method for preparation of immunoglobulin fragments by specific fragmentation of immunoglobulins, comprising treating a solution of immunoglobulins with a soluble protease so as to achieve...
5320949 Process for producing aglucone isoflavone enriched vegetable protein fiber  
The present invention relates to an aglucone isoflavone enriched vegetable protein fiber wherein a vegetable protein material is extracted to form a slurry of protein, fiber and glucone...
5318897 Monoclonal antibody and antibody components elicited to a polypeptide antigen ground state  
What is disclosed is a catalytic monoclonal antibody able to cleave a polypeptide and in particular, a catalytic monoclonal antibody elicited by a ground state antigen is disclosed. Antigens...
5317084 Process for large-scale production of antimicrobal peptide in high purity  
Lactoferricin (Trade Mark), also called LFCIN (Trade Mark), a potent antimicrobial peptide, is produced by contacting an enzymatic hydrolysate of bovine lactoferrin or any mixture of peptides...
5316935 Subtilisin variants suitable for hydrolysis and synthesis in organic media  
In accordance with the present invention, there are provided novel, modified subtilisin enzyme(s) having improved catalytic activity and/or stability in organic media.