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6232093 Process for the production of heparin  
The invention relates to a simplified process for the extraction of heparin from animal mucosa tissue. The method consists of an enzymatic hydrolysis step of the raw material at ambient...
6221423 Short-chained peptide material  
A short chain peptide material is provided containing a peptide material derived from a protein material. At least a majority of the peptides in the peptide material have a peptide chain length of...
6221626 Kit for electroblotting polypeptides separated on an electrophoresis gel  
Polypeptides separated on a gel are identified by cleaving the separated polypeptides with an immobilized cleaving reagent such as an enzyme, and transferring the fragments to a hydrophobic...
6221623 Biochemical methods for detecting cervical dysplasia and cancer  
Primary screening for cervical dysplasia is effected by measuring a biochemical marker of apoptosis and/or angiogenesis in each of a population of cells derived from convenient, superficial...
6214571 Method for inhibiting adenylosuccinate synthetase activity in malignant methylthioadenosine phosphorylase deficient cells  
An in vivo method for depleting mammalian cells of adenosine 5'-monophosphate (AMP) useful in the treatment of certain cancers is provided. According to the method, a population of cells is...
6214576 Bacteria useful for degrading keratin  
Bacillus licheniformis O.W.U. 138B and 88B and other bacterial strains capable of degrading feathers isolated from wild birds, are disclosed. The strains and the keratinases produced by these...
6214585 Protein hydrolysis  
A slurry of enzymatically hydrolyzed protein containing polypeptides is incubated with a culture of a food-grade microorganism, particularly Lactobacillus helveticus, which produces peptidases to...
6214617 Centrifugal fermentation process  
The present invention comprises a novel culture methods and devices in which living cells or subcellular biocatalysts are immobilized by the opposition of forces. The immobilized cells or...
6210917 Method for suppressing multiple drug resistance in cancer cells  
Methods for treating and preventing the onset and maintainance of multiple drug resistance (MDR) in animals undergoing chemotherapy for cancer are provided. According to the methods, target cells...
6210929 Fusion protein comprising a furin derivative or a derivative of a furin analogue and a heterologous sequence  
Fusion proteins of an optionally C-terminally deleted furin derivative, or of a derivative of a furin analogue, and a heterologous sequence, methods of preparing the same and methods of recovering...
6194190 Amino-terminal deblocking enzyme  
To provide an amino terminal protecting group-releasing enzyme characterized in that the enzyme possesses an activity for releasing a protecting group by acting on a peptide of which amino...
6194550 Systematic polypeptide evolution by reverse translation  
A method for preparing polypeptide ligands of target molecules wherein candidate mixtures comprised of ribosome complexes or mRNApolypeptide copolymers are partitioned relative to their affinity...
6190879 Microbial transglutaminases, their production and use  
A method for identifying a transglutaminase-producing microorganism based on a selective assay is disclosed.
6187579 Customized proteases  
The invention provides customized proteases (i.e., mutant enzymes), methods of making customized proteases, as well as methods of using customized proteases. The customized proteases of the...
6180385 Picornavirus I proteinase and methods of making and using thereof  
Methods of making and using Picornavirus L proteinase peptides (PLPPs) are provided, including, but not limited to, expression of DNA encoding all or a portion thereof, such as a Picornavirus L...
6174700 Purification of a polypeptide compound having a polysaccharide binding domain by affinity phase separation  
A compound having a polysaccharide binding domain such as contained by a cellulose and essentially lacking in polysaccharidase activity is purified from other ingredients in a mixture using an...
6171813 Enzyme catalysis in organic solutions containing water  
A method is presented for catalyzing the conversion of substrate into product in an organic reaction solvent with an enzyme-surfactant ion pair. The enzyme-surfactant ion pair comprises the enzyme...
6168931 Enhanced in vitro synthesis of biological macromolecules using a novel ATP regeneration system  
Compositions and methods are provided for the enhanced in vitro synthesis of biological molecules where ATP is required for synthesis. Of particular interest is the synthesis of polymers, e.g....
6169172 Use of a prolactin receptor or growth hormone receptor intracytoplasmic domain for achieving protein secretion  
The use of a prolactin receptor intracytoplasmic domain or a growth hormone receptor intracytoplasmic domain, or of a fragment of either one of said domains, for achieving the secretion of a...
6162903 Immunoglobulin binding proteins derived from L protein and their uses  
Synthetic molecules are provided comprising one or more immunoglobulin binding domains as well as sequences which have at least 90% homology to these domains.
6150172 Method and kit for extracting prion protein  
A method for extracting prion protein from a biological material, e.g., an animal tissue or product. In a specific example, abnormal prion protein is extracted from homogenized sheep brain with...
6146668 Preparation of isoflavones from legumes  
Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the...
6129937 Flavoring agent  
Flavoring agent obtained by a process in which seeds of an edible plant are germinated, the sprouts obtained are matured under the effect of their endogenous enzymes, an optional fermentation of...
6127142 Microbially derived enzymes having enhanced milk clotting activity and method of producing same  
A method of producing a milk clotting enzyme including the steps of (a) fermenting a strain of Rhizomucor miehei or Aspergillus oryzae to form a fermentation product having a glycoslated...
6127150 Purification cloning of peptides  
The present invention is directed to a protein purification construct having three tandem, coupled segments composed of a binding protein, an interconnecting linker and a variable fused...
6127143 Preparation of purified and biocompatible collagen using two proteolytic enzyme treatments and a reducing agent  
Purified collagen is produced by a method containing steps of contacting a collagen sample with a first proteolytic enzyme followed by contacting with a reducing agent and a second proteolytic...
6107055 Method and device for carrying out biochemical reactions  
Method and apparatus for carrying out biochemical reactions in particular for cell-free polypeptide biosynthesis. A bioreactor has, within a housing, a reaction chamber containing a producing...
6103489 Cell-free protein synthesis system with protein translocation and processing  
An amphibian egg extract is added to a cell-free translation system to obtain in vitro translocation and processing of newly synthesized peptide. The egg extract produces near complete signal...
6096353 Calf milk replacer  
The invention relates to a composition useful as a protein source for a milk replacer in animal feed. Specifically, the milk replacer is used for pre-ruminant and young ruminant calves, suckling...
6096546 Methods for recovering polypeptides from plants and portions thereof  
Methods for using plants or intact portions thereof to produce and exude heterologous polypeptides are disclosed. The methods of the invention use whole plants or portions thereof that are intact,...
6096512 Cloned DNA encoding a UDP-GalNAc: Polypeptide, N-acetylgalactosaminyltransferase  
The present invention relates to a method for the isolation and expression of a glycosyltransferase enzyme for use in the synthesis of oligosaccharide or polysaccharide structures on...
6077516 Live vaccine against colibacillosis  
A vaccine for the immunization of domestic fowl, such as turkeys and chickens, against E. coli infections (Colibacillosis) is disclosed which contains an effective amount of a live temperature...
6074837 Assays using a soluble fibrin-like monomer  
An assay method that requires a soluble fibrin monomer or a soluble fibrin monomer reagent as one of the components of the assay. The reagent is a fibrin-like material having a solubility and...
6069234 Modified coagulation agent  
The present invention is directed to a modified coagulation factor Xa which has an improved capacity of forming crystals compared to its native form. Such crystals or crystalline composition are...
6069129 Elastin derived composition and method of using same  
The present invention is directed to a formulation or composition which is used to enhance the softness, elastin, or appearance of tissue by increasing the endogenous elastin production....
6063592 Kell protein proteolytic activity  
A method for cleaving polypeptides includes contacting a polypeptide with a recombinant or isolated Kell protein having proteolytic activity for the polypeptide. A method for converting big...
6060269 Method of producing a peptide mixture  
The present invention relates to a method for industrial production of a peptide preparation having specific specifications by hydrolysis of a protein material, preferably based on whey. The...
6057122 Antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis  
Mammalian kringle 5 fragments and kringle 5 fusion proteins are disclosed as a compounds for treating angiogenic diseases. Methods and compositions for inhibiting angiogenic diseases are also...
6051399 Production of C-terminal amidated peptides from recombinant protein constructs  
A method for the production of C-terminal amidated recombinant peptides is provided. The method employs a recombinant protein construct having multiple copies of a target peptide linked by...
6048715 Two-phase partition affinity separation system and affinity separated cell-containing composition  
A two-phase partition system is provided for affinity separation of a composition containing a polysaccharide binding peptide from a mixture such as a fermentation broth. The peptide may be from...
6046024 Method of producing a fibrin monomer using a biotinylated enzyme and immobilized avidin  
Compositions and methods for avidin immobilized on an inert support material, e.g. agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking...
6040136 Enrichment method for variant proteins with altered binding properties  
A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method...
6037144 Method of preparing a biological material for use in ophthalmology  
A collagen containing substrate comprising cattle basal membrane is conditioned by incubating the membranes in a mixture of pepsin, hyaluronidase and acetic acid and separating the collagen from...
6036983 Method of obtaining protein hydrolysates  
The present invention relates to a method of obtaining protein hydrolysates useful as flavoring agents. More specifically, the invention provides a method of obtaining from a proteinaceous...
6030949 Macrophage stimulating protein for the treatment of pathologies of the nervous system  
The present invention refers to the use of Macrophage Stimulating Protein (MSP) for the preparation of a medicament for the treatment of pathologies of the central and peripheral nervous system of...
6027911 Bovine dipeptidylaminopeptidase 1  
The present invention provides the cDNA sequence encoding bovine dipeptidylaminopeptidase 1. The invention demonstrates that bovine DAP 1 coded by a single cDNA. The mature protein is derived from...
6022702 Process for producing a soy protein hydrolysate  
The present invention provides a soy protein hydrolysate with a low content of glycinin wherein glycinin as a major component in soybean protein is selectively decomposed and a process for...
6013289 Flavorant prepared from Trigonela foenum-graecum seeds  
A flavorant composition is prepared by hydrolyzing Trigonell foenum-graecum seed material with enzymes, heating the hydrolyzate obtained at a temperature for a time to inactivate the enzymes,...
6010871 Modification of peptide and protein  
PCT No. PCT/JP95/01994 Sec. 371 Date Sep. 8, 1997 Sec. 102(e) Date Sep. 8, 1997 PCT Filed Sep. 29, 1995 PCT Pub. No. WO96/10089 PCT Pub. Date Apr. 4, 1996A process for modifying a physiologically...
6005077 Use of von willebrand factor and pharmaceutical formulation  
The invention relates to the use of von Willebrand Factor (vWF) with a prolonged biological half-life for the production of a preparation for stabilization of blood coagulation Factor VIII...