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8168568 |
Combinatorial therapy for protein signaling diseases
A method for selecting combinations of drugs for treatment of diseases that arise from deranged signaling pathways is disclosed. The method involves measuring the activity states for signaling...
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8158595 |
Modular aptamer-regulated ribozymes
An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is...
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8143067 |
Hydrophilic, high protein binding, low fluorescence, western blotting membrane
Hydrophilic membrane particularly suited for blotting applications, preferably Western blotting. A pre-wet hydrophobic membrane substrate, preferably made of PVDF, is contacted with a monomer...
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8129176 |
Integrated active flux microfluidic devices and methods
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
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8114593 |
Cancer biomarker genes and gene products and methods for using the same
Using gene expression analysis, specific biomarker genes and gene products have been identified which are activated in transformed cells, but suppressed in nontransformed cells; or suppressed in...
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8101416 |
Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a...
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8097405 |
Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs
A process for determining the sequence of nucleic acids of interest employs nucleotides or nucleotide analogs that have been made detectable by non-radioactive modifying or labeling. Such...
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8092855 |
Click chemistry surface functionalization for resonant micro-cavity sensors
Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional...
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8084213 |
Selection
The present invention to a nucleotide sequence encoding one or more Arc DNA binding domains, one or more Arc DNA binding sites and at least one polypeptide domain.
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8080379 |
Branched and multi-chain nucleic acid switches for sensing and screening
Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a...
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8071288 |
Methods and reagents for detecting target binding by nucleic acid ligands
The present invention provides novel methods and reagents for detecting the binding of protein targets to nucleic acid ligands. Using Universal Protein Stains (UPS), proteins bound by nucleic acid...
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8067167 |
Hybrid antibodies
Hybrid antibodies and/or hybrid antibody fragments and methods of making them are provided. In one embodiment the hybrid antibodies and/or hybrid antibody fragments contain heavy and/or light...
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8026054 |
Antibodies against cells of fetal origin
This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal...
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8017322 |
Method for rapid detection and identification of bioagents
Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers...
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7985539 |
Nanoparticle probes with raman spectroscopic fingerprints for analyte detection
The invention encompasses reagents comprising particles with at least one Raman dye and a specific binding members bound thereto and methods of using such reagents. The invention also encompasses...
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7985557 |
Polymeric carriers for immunohistochemistry and in situ hybridization
Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers...
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7981599 |
Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
This invention is related to novel non-nucleic acid probes, probe sets, methods and kits pertaining to the detection, identification or quantitation of human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8,...
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7981615 |
Compositions and methods for treating diseases associated with T-box and N-Myc
The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by...
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7977048 |
Detection and quantification of analytes in solution using polymers
The invention relates to methods and systems for identifying, quantitating and/or analyzing analytes from samples. The analytes may be organic or inorganic in nature and include but are not limited...
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7964355 |
Assays based on detection of photobleaching reaction products from dye catalytic complex
The present invention relates to the methods for assaying an analyte comprising a nucleic acid analog binding substrate in a sample, comprising reacting a catalytic complex comprising a nucleic...
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7947462 |
Methods for identifying Kremen polypeptide binding partners
The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g....
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7947450 |
Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction....
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7947309 |
Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants
Compositions are provided which include hyaluronic acid derivatives in combination with vaccine antigens, and optionally adjuvants, for mucosal delivery. Also provided are methods of making the...
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7943300 |
Method for improved protein expression in bacteria by monitoring and modulating protein folding
This invention relates to a new method for improving functional protein expression whereby the folding process is monitored by online measurement and, if required, the protein folding is influenced...
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7943304 |
Method and apparatus for chromosome profiling
A method and apparatus for generating an Interphase chromosome profile. The method comprises obtaining a sample containing cells having chromosomes for profiling; obtaining species specific DNA...
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7943321 |
Rapid, sensitive and quantitative methods for tissue and cell-based proteomics via consecutive addition of quantifiable extenders
Methods, systems and kits are provided for detecting and quantifying multiple immunogens in a sample via consecutive addition of quantifiable extenders to immunogen bound complexes of immunogen...
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7939313 |
Biosensors for detecting macromolecules and other analytes
The invention generally provides molecular biosensors. In particular, the invention provides molecular biosensors having one or more aptamers. The molecular biosensors are useful in several methods...
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7935489 |
Methods and devices for analyte detection
Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as...
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7932093 |
One step oligochromatographic device and method of use
The present invention relates to methods and devices for detecting one or more analytes in a biological sample, preferably a clean liquid sample. This invention in particular relates to improved...
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7910063 |
Drift compensated magnetic permeability detector
A device for detection of magnetic permeability μ or, alternatively, relative magnetic permeability μr or, alternatively, relative magnetic susceptibility (μr−1) of a sample, wherein said devi...
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7901892 |
Methods and compositions for determining the purity of chemically synthesized nucleic acids
This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which...
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7892725 |
Process for storing a sperm dispersion
Processes of storing sorted and unsorted spermatozoa, in the form of a sperm dispersion, having reduced motility relative to endogenous ejaculated sperm are disclosed. The immotile spermatozoa of...
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7892742 |
PCR screening method
A tooling system (1) having a number of elements (2) arranged in an array, which elements define a contoured surface, or a section of a contoured surface. The tooling system also including means...
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7893253 |
Solid-phase oligosaccharide tagging: a technique for manipulation of immobilized carbohydrates
The invention relates to methods of manipulating immobilised carbohydrates by derivatisation. Depending on the nature of the derivatisation, the carbohydrate may thereby be more easily detected...
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7879534 |
Fabrication of a high resolution biological molecule detection device
The present invention relates to a method of manufacturing a detection device which involves providing a substrate having a layer of electrically conductive material and a first layer of...
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7867710 |
Polymorphism in bovine prion protein gene sequence
A specific, non-synonymous SNP in the Prnp gene encoding the bovine prion protein affects the susceptibility of bovine animals to bovine spongiform encephalopathy (BSE). Depending on the number of...
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7867780 |
Lateral flow format, materials and methods
The present invention provides a lateral flow format and materials and methods for using the format in a variety of applications. More particularly, the present invention provides single-layer...
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7863003 |
Apparatus for implementing non-destructive quality control of substrates and printed biological microarrays
Apparatus implements non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays...
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7838222 |
Methods, devices and kits for multiplex blotting of biological samples from multi-well plates
The present disclosure provides methods, devices and kits that permit large numbers of target biomolecules to be detected simultaneously in samples originating from a multi-sample holder, such as a...
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7838210 |
Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations
Sperm cell suspensions comprising a motility inhibitor are disclosed. The cells contained in such suspensions tend to have a greater capacity for enduring the various process steps typically...
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7833708 |
Nucleic acid amplification using microfluidic devices
The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certaom devices include a rotary microfluidic channel and a plurality...
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7833701 |
Biomolecule substrate, and test and diagnosis methods and apparatuses using the same
An object of the present invention is to provide a test apparatus for testing a DNA substrate on which a plurality of DNA fragments for testing are arranged, wherein absolute precision is not...
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7829504 |
Carbon nanotube binding peptides
Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length....
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7816120 |
Temperature controller for structure
A temperature controller for controlling temperature of a first structure having a first flat face comprises a second structure having a second flat face for planar contact with the first flat...
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7815854 |
Electroluminescent illumination source for optical detection systems
An optical detection system that utilizes an electroluminescent (EL) illumination source is provided. Unlike illumination sources used with some conventional optical detection systems, an EL device...
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7808628 |
Method for nanoscale spatial registration of scanning probes with substrates and surfaces
Embodiments in accordance with the present invention relate to methods and apparatuses for aligning a scanning probe used to pattern a substrate, by comparing the position of the probe to a...
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7807348 |
Optical imaging of nanostructured substrates
A method of imaging phenomena that occurs on a surface of a substrate includes contacting a fluid with a top surface of the substrate, and imaging phenomena that occurs on the top surface of the...
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7803539 |
Method of isolating and purifying nucleic acids using immobilized hydrogel or PEG-hydrogel copolymer
Provided is a method of isolating and purifying nucleic acids using an immobilized hydrogel or polyethylene glycol (PEG)-hydrogel copolymer. The method includes: immobilizing a functional...
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7799197 |
Nanopump devices and methods
A nanopump for pumping small volumes of electrolyte solution under the control of a voltage source is described. The device includes a chamber and a nanopore membrane which partitions the chamber...
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7794943 |
Modified nucleic acid probes
Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or...
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