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9029342 Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof  
A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or...
9029106 Transaminase polypeptides  
The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides...
9012189 Modified alcohol dehydrogenases for the production of fuels and chemicals  
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
9005985 Optical reporter compositions  
This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to...
9000027 Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, bcl-2 and caspase-3  
The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or...
8999643 Methods and assays for the detection of alternative lengthening of telomeres (ALT) activity in cells  
The invention relates to methods and assays for the detection of active Alternative Lengthening of Telomeres (ALT) activity in cells. The methods and assays involve detecting or assaying for...
9000265 Corn plants and seed enhanced for asparagine and protein  
The present invention relates to a corn plant and seed with enhanced levels of protein and amino acids. The invention also relates to DNA constructs that provide expression in transgenic corn...
8993277 Polynucleotides encoding beta-glucosidase variants  
The present invention provides compositions and methods for the expression of recombinant β-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
8986960 Microorganisms with extended substrate utilization range  
Disclosed are microorganisms of the genus Cupriavidus or Ralstonia, which are genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein (EC1.3.1.74)...
8962239 Methods useful for vitamin D deficiency and related disorders  
Methods for diagnosing, treating, and preventing catabolism-related vitamin D deficiency and related disorders, related compositions, apparatus and kits, are disclosed. A method involves measuring...
8945849 Method for diagnosing esophageal cancer  
This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of...
8945851 Quantitative assay for membrane association of proteins  
The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes...
8945869 Factor VIII glycoforms  
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked...
8940497 Enzyme regulating ether lipid signaling pathways  
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly...
8940479 Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity  
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal...
8921332 Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site  
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in...
8916532 Methods for enhancing utrophin production via inhibition of microRNA  
This invention provides a method for enhancing utrophin protein production in a cell by inhibiting an utrophin microRNA molecule. Moreover, the invention provides that methods for enhancing...
8916357 Dynamic monitoring of activation of receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology  
Methods for identifying a compound capable of interacting with a Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance, adding test cells...
8906629 Method for screening ameliorants of dry skin caused by atopic dermatitis using bleomycin hydrolase activity as indicator  
The present invention provides a method for screening and evaluating ameliorants of dry skin caused by atopic dermatitis, comprising: evaluating a candidate drug as being an ameliorant of dry skin...
8895245 Inhibitors of human EZH2 and methods of use thereof  
The invention relates to inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2, the catalytic subunit of the PRC2 complex which catalyzes the mono- through...
8883144 Treatment of pulmonary vascular remodeling with neprilysin  
The present invention relates to agonists of Neprilysin and their use in preventing and treating pulmonary vascular remodeling. Also described are diagnostic and screening applications stemming...
8871506 Methods for treating cardio pulmonary diseases with NO group compounds  
The present invention relates to methods of treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation; treatment of cardiac and blood...
8858915 Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome  
The object is to provide: a therapeutic or prophylactic agent for metabolic syndrome, which has improved stability in a living body; and others. The therapeutic or prophylactic agent for metabolic...
8846311 Map kinase kinase kinase kinase 3 (MAP4K3) as a biomarker and therapeutic target for autoimmune disease, cancer, inflammation and IL-17-associated disease  
Methods for identifying a therapeutic agent for treating a Germinal Center Kinase (GCK)-Like Kinase (GLK)-mediated disease are disclosed. Methods for detecting a modulation of GLK signaling by a...
8841924 Fingered electrodes for microfluidic single particle analysis  
The electrical properties of particle solutions can be investigated on a single particle basis by using micro fluidic channels. The impedance can be measured across the channel using at least one...
8822153 Molecular diagnosis and typing of lung cancer variants  
Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample....
8822145 Identification of POLD2 sequences  
Provided are isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit...
8809027 Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase  
Microorganism compositions are described that comprise combinations of genetic modifications that include a genetic modification to increase oxaloacetate alpha-decarboxylase enzymatic activity. By...
8796438 Nucleic acids encoding inactive variants of human telomerase  
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically inactive variants...
8795962 Expression vectors based on modified ribosomal protein promoters and uses thereof in post-transcriptional assessment  
The present invention relates to expression vector comprising (a) a promoter region comprising a non-inducible constitutively active ribosomal protein gene promoter, (b) an operably linked...
8795959 Isolated glucokinase genomic polynucleotide fragments from chromosome 7  
Provided are isolated genomic polynucleotide fragments that encode human SNARE YKT6, human glucokinase, human adipocyte enhancer binding protein (AEBP1) and DNA directed 50 kD regulatory subunit...
8785128 Genetic diagnosis of hepatic steatosis  
Disclosed are methods of identifying a genetic variant in a person determined to have or be predisposed having a fatty liver by determining whether the person has PNPLA3-I148M. Also disclosed are...
8784799 Duplexed parvovirus vectors  
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
8778647 Methods of producing isoprene comprising a membrane bioreactor  
The invention provides improved methods for the production of isoprene from biological materials using a membrane bioreactor to culture isoprene-producing cells.
8778608 CA9 gene single nucleotide polymorphisms predict prognosis and treatment response of metastatic renal cell carcinoma  
Methods and compositions for providing a prognosis or diagnosis for a human patient having renal cell cancer are provided. The method relates to the discovery of SNPs which are associated with a...
8771937 Methods for diagnosing and treating a pathology associated with a synonymous mutation occuring within a gene of interest  
The present invention relates to a method for diagnosing and/or prognosing a pathology (such as inflammatory disease, especially Crohn disease) associated with a synonymous mutation occurring...
8771959 Methods for the production of plants resistant to HPPD herbicides  
Methods for making transgenic plants that are resistant to HPPD herbicides are presented. Polynucleotides other than those from Pseudomonas fluorescens that encode resistant HPPD enzymes are...
8753837 Designer Oxyphotobacteria and greenhouse distillation for photobiological ethanol production from carbon dioxide and water  
The present invention provides a photobiological ethanol production and harvesting technology using greenhouse distillation systems with designer photosynthetic organisms, such as designer...
8741610 Yeast mutant and substance production method using the same  
The present invention provides, inter alia, an improvement in the production of a desired product from yeast, wherein the growth rate and fermentation rate of the yeast are maintained at excellent...
8722331 Method for selecting a treatment for non-small cell lung cancer using gene expression profiles  
The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased...
8715957 Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene  
The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate,...
8715927 Inhibition of DNA polymerases to augment chemotherapeutic and antimicrobial agents  
Disclosed herein is the identification of human DNA polymerase κ (pol κ) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a...
8709774 Sperm factor sequences  
A nucleic acid sequence, including an isolated, purified or recombinant nucleic acid sequence, includes: (a) a nucleic acid sequence encoding a polypeptide encompassed by the present invention,...
8691507 Inhibitors of human EZH2 and methods of use thereof  
The invention relates to determining the presence of an EZH2 gene mutation in a sample from a subject and inhibition of wild-type and certain mutant forms of human histone methyltransferase EZH2,...
8691782 Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton  
Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule...
8679742 Method for determining the presence of an enzyme in a sample  
This invention provides tandem fluorescent protein construct including a donor fluorescent protein moiety, an acceptor fluorescent protein moiety and a linker moiety that couples the donor and...
8679832 Detection of protein translocation by beta-galactosidase reporter fragment complementation  
Methods and compositions are provided for detecting molecular translocations, particularly protein translocations within and between sub-cellular compartments, using at least two components that...
8673268 Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases  
The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO:...
8658369 Methods for evaluating the methylation status of a polynucleotide  
The invention provides methods related to evaluating the methylation status of a polynucleotide that includes an internal control.
8658356 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA  
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the...