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9029322 Compounds for enhancing p21 expression and methods of use thereof  
The present invention relates to a method for identifying a drug candidate for enhancing expression of p21cip1/waf1 in a human patient suffering from a medical condition that can be treated by...
9012619 Probe for detecting ABL gene mutation and uses thereof  
Detection probes are provided that are capable of detecting a sequence to be detected containing a mutation even when a sequence not to be detected containing no mutation coexists with the...
9000145 Control of insect pests through RNAi of pheromone biosynthesis activating neuropeptide receptor  
Disclosed are dsRNA constructs and methods to control insects via double stranded RNA interference of insect PBAN receptor genes.
8940732 Diagnosis of autism spectrum disorders and its treatment with an antagonist or inhibitor of the 5-HT2c receptor signaling pathway  
The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and...
8936907 Neural transfection reagents  
The invention is directed to transfection reagents for the delivery of nucleic acids into neural cells, compositions including the reagents, methods of preparation of such reagents, methods of...
8924232 Device and method for comparing molecular signatures  
A method (10) for clinical decision support by comparison of multiple molecular signatures of biological data is provided. The method comprises comparing at least two of said molecular signatures...
8912316 Compositions and methods for inhibiting expression of CD45 gene  
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the CD45 gene.
8889397 Nucleotides for prevention and treatment of bacterial and fungal pathologies  
A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a...
8865883 Multiple exon skipping compositions for DMD  
Provided are antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon skipping, and methods of use thereof to treat muscular dystrophy.
8865411 Methods of identifying modulators of TDP-43 mediated cellular toxicity  
Compositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.
8859518 Modulators of coagulation factors  
The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acid ligands to provide ideal modulators of coagulation. These improved nucleic...
8853166 Neurotrophic factor MANF and uses thereof  
The present invention generally relates to the field of treatment of neuronal disorders and more particularly to neurotrophic factor MANF and uses thereof. The present invention provides a...
8828685 Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities  
Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
8802646 Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
8785410 Antisense composition and method for treating muscle atrophy  
A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit...
8772042 Biomarkers for diagnosing alzheimer's disease  
A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies...
8754202 RNAi-related inhibition of TNFα signaling pathway for treatment of ocular angiogenesis  
RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme...
8753818 Methods of detecting amyotrophic lateral sclerosis (ALS)  
In one aspect, the invention is directed to a method of identifying an individual that has amyotrophic lateral sclerosis (ALS) or is at risk of developing ALS comprising detecting one or more...
8748106 Methods of identifying a compound that increases or decreases the interaction of Hn-33 with synaptotagmin II  
This application is based, inter alia, on the discovery of a binding interaction between the Hn-33 hemagglutinin polypeptide of the type A Clostridium botulinum neurotoxin complex and synaptosomal...
8735071 Compositions for promoting epigenetic DNA demethylation and methods of use therefore  
The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the...
8728724 Identification of micro-RNAs involved in neuromuscular synapse maintenance and regeneration  
The present invention relates to the identification of miRNAs that are involved in the process of neuromuscular synaptic maintenance and regeneration following injury or disease. Modulation of...
8715643 TDP-43-storing cell model  
Disclosed is a transformed cell (a cell model) which can form a cytoplasmic inclusion body derived from TAR DNA-binding protein of 43 kDa (TDP-43) that is found in the brain of a patient suffering...
8669048 Pluripotent cell lines and methods of use thereof  
Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation...
8663927 Systems and methods for diagnosis and monitoring of bacteria-related conditions  
The presently-disclosed subject matter provides systems, methods, and kits for diagnosing and/or monitoring a bacteria-related condition of interest in a subject by providing a cell sensing...
8626337 Method and computer program product for distinguishing and sorting seeds containing a genetic element of interest  
A method and computer program product for distinguishing and sort seeds containing a genetic element of interest from a bulk sample. In various embodiments, the present invention comprises...
8598515 Mass spectrometry systems  
Described herein are methods that may be used related to mass spectrometry, such as mass spectrometry analysis, mass spectrometry calibration, identification of proteins/peptides by mass...
8597576 Analyzer for glycan or complex carbohydrate  
An analyzer of the present invention for analyzing a glycan or a complex glycan includes a substrate, a fluorescent labeling excitation means and a fluorescent intensity measurement means. The...
8592200 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8580493 Screening for compounds that modulate GPR3-mediated beta-arrestin signaling and amyloid beta peptide generation  
The invention relates to the field of disorders of the peripheral or central nervous system, in particular, Alzheimer's disease, and the prevention and/or treatment thereof. In particular, the...
8574861 PPM1E proteins and nucleic acids as targets for neurodegenerative diseases  
1. Use of (v) a gene coding for a protein phosphatase 1 E having SEQ ID NO:1 or SEQ ID NO:2, and/or(vi) a transcription product of the gene coding for a protein phosphatase 1 E having SEQ ID NO:1...
8563252 Methods for distinguishing between lung squamous carcinoma and other non small cell lung cancers  
The present invention provides nucleic acid sequences that are used for identification, classification and diagnosis of specific types of nonsmall-cell lung cancers (NSCLC). The nucleic acid...
8560246 Method for adjusting results of a polymerase chain reaction (PCR) instrument  
Methods of managing results of a real-time polymerase chain reaction (PCR) instrument and software associated with such methods are described herein. One disclosed method, among others, comprises...
8551694 Isolation and use of ryanodine receptors  
The genes encoding ryanodine receptor homologs have been characterized from multiple insect families. The genes and their corresponding polypeptides have a number of uses including but not limited...
8551693 Mutated voltage-gated sodium channel Nav alpha subunit for identification of modulators  
Reagents, methods and kits for screening for compounds that modulate the activity of voltage-gated sodium channels (NaV), such as human NaV1.5/SC-N5A/hH1 are described. The reagents, methods and...
8546079 Reporter gene construct, assay kit and detection method  
According to one embodiment, there is provided a reporter gene construct. The reporter gene construct comprises a transcriptional regulatory sequence and a reporter gene that is functionally bound...
8546348 Upregulation of opioid receptors for management  
Disclosed are methods for treating pain in a subject. The method includes upregulating expression of opioid receptors in the subject's dorsal root ganglion or trigeminal neurons. Also disclosed...
8512958 Methods of identifying agents that modulate mitochondrial function  
The present invention provides isolated cells comprising a nucleic acid encoding a toxic form of apoE. The present invention further provides screening methods for identifying compounds that...
8501705 Methods and materials for treating autoimmune and/or complement mediated diseases and conditions  
Disclosed are methods for treating an autoimmune and/or complement mediated disease or condition in a subject. The methods include administering to the subject a compound which inhibits the...
8486632 Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the KLK8 gene encoding kallikrein 8 and use thereof for prognosticating survival  
A method for the in vitro diagnosis of bronchopulmonary carcinoma, in particular of non-small cell bronchial carcinoma, that includes a stage of detecting, in a biological sample derived from a...
8465966 Post protein hydrolysis removal of a potent ribonuclease inhibitor and the enzymatic capture of DNA  
The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate...
8466121 Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
8445410 Ligand screening and discovery  
Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second...
8426130 Methods of diagnosing alzheimer's disease and markers identified by set association  
The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association...
8426187 Immunoglobulin libraries  
Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble...
8415465 Compositions and their uses directed to huntingtin  
Disclosed herein are compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal. Further provided are methods of slowing or preventing Huntington's...
8415106 Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination  
This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or...
8409809 KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders  
The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase...
8394589 Methods for diagnosing scapuloperoneal spinal muscular atrophy or Charcot-Marie-Tooth disease type 2C by detecting mutations in TRPV4  
The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are...
8389284 Screening and treatment methods using IGS5 enzymes of the metalloprotease family  
Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing...
8372817 Small interfering RNA for gene knockdown of the subcutaneous N-methyl-D-aspartate receptor NR1 subunit, and it's application on pharmaceutics  
A small interfering RNA for gene knockdown of the N-methyl-D-aspartate receptor NR1 subunit comprises 21 to 25 ribonucleic acids, which are homologous to the RNA sequence of N-methyl-D-aspartate...