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8183012 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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8182996 |
Compositions and methods for detecting Klebsiella pneumoniae
Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to...
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8183375 |
Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings
The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength...
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8183648 |
Nanoscopic electrode molecular probes
The present invention relates to a method and apparatus for enhancing the electron transport property measurements of a molecule when the molecule is placed between chemically functionalized...
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8183217 |
Methods and means for obtaining modified phenotypes
Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to...
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8183223 |
Method for detecting carcinoma and agent for suppressing carcinoma
The present invention is directed to methods for suppressing the growth of oral squamous-cell carcinoma cells. The methods include introducing at least one gene selected from miR-137 or miR-193a...
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8182989 |
Methods for indexing samples and sequencing multiple polynucleotide templates
The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such...
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8182988 |
Homogeneous luminescence bioassay
A homogenous bioassay including i) a first group containing a short lifetime fluorescent acceptor, and ii) a second group containing a quencher, with the first and second groups linked by at least...
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8182987 |
Probe for visualizing cell-cycle
An object of an embodiment of the present invention is to provide a method with which it is possible to easily distinguish a proliferation phase of a cell cycle from a resting phase thereof in real...
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8182997 |
Prostate cancer related gene STYK1
The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the STYK1 gene. The gene was discovered to...
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8178297 |
Method of detecting canine exercise-induced collapse
The present invention relates to diagnosing Canine Exercise-Induced Collapse (EIC).
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8178360 |
Dye compounds and the use of their labelled conjugates
Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a...
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8178298 |
Patched polypeptides and uses related thereto
Methods for isolating patched genes, including the mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Decreased expression of patched is associated...
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8178316 |
Evaluating proteins
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence...
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8178296 |
Methods and reagents for preserving RNA in cell and tissue samples
This specification relates to the field of molecular biology and provides novel methods and reagents for preserving and protecting the ribonucleic acid (RNA) content of samples from degradation...
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8178294 |
Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to...
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RE43389 |
Vessel for blood sampling
The present invention relates to a vessel for withdrawing blood, the vessel containing a solution which comprises a guanidinium salt, a buffer substance, a reducing agent, and/or a detergent as...
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8178299 |
Method to determine the risk for side effects of an SSRI treatment in a person
A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor...
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8178661 |
Molecules of the card-related protein family and uses thereof
Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides...
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8178295 |
Analyte evaluation apparatus
This analyte evaluation apparatus has an analyte space for holding a liquid containing an analyte, a working electrode, a counter electrode and a reference electrode, and the potential of the...
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8178291 |
Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods...
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8173370 |
Nucleic acid-based tests for RHD typing, gender determination and nucleic acid quantification
The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing,...
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8173417 |
Ruggedized apparatus for analysis of nucleic acid and proteins
The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as,...
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8173360 |
Cell death inhibitor
The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative...
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8173376 |
Method for identifying compounds for treatment of pain
Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride...
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8173401 |
Method for direct amplification from crude nucleic acid samples
The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the...
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8173367 |
In situ dilution of external controls for use in microarrays
An array in which an external control feature for normalization has been designed and tested for its ability to mimic the range of observed expression levels for a test set of oligos. The external...
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8173387 |
Method of examining chemical using gene-disrupted strain
A method having higher sensitivity in a bioassay method utilizing cell response of a microorganism, for detecting the presence of a chemical in a test specimen is provided. The method of the...
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8173368 |
Programmable oligonucleotide synthesis
The invention relates to methods and devices for preparing synthetic nucleic acids.
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8173400 |
Method of detecting or quantitating endogenous wheat DNA and method of determining contamination rate of genetically modified wheat in test sample
An object of the present invention is to discover an endogenous wheat sequence satisfying the conditions of: a) it is universally present in varieties of wheat, b) the amount present (detected...
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8168384 |
Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy
The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease....
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8168382 |
Methods for detecting DNA originating from different individuals
In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate...
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8168773 |
Methods for monitoring multiple gene expression
The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second...
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8168447 |
Multiple component nanoparticles for multiplexed signaling and optical encoding
The present invention provides multiple-luminophore silica nanoparticles for multiplexed signaling in bioanalysis. In specific embodiments, two inorganic luminophores,...
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8168383 |
Gene defects and mutant ALK kinase in human solid tumors
Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been...
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8163485 |
Differential enzymatic fragmentation
The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
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8163487 |
2′-terminator nucleotide-related methods and systems
The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. I...
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8163524 |
Comparative analysis of extracellular RNA species
The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA,...
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8163484 |
Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic...
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8163328 |
Compositions for marking objects with DNA and methods for marking and linking an object to its owner
The invention can be summarized as follows. There is provided one or more DNA coating compositions that comprise one or more polymer compounds, water, and optionally one or more non-water polar...
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8163483 |
Compositions and methods for spinocerebellar ataxia
Mutations in the KCNC3 (Kv3.3) voltage-gated potassium channel gene result in spinocerebellar ataxia.
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8163494 |
Method for assessing metastatic properties of breast cancer
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue...
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8163486 |
Probe, probe set, probe carrier, and testing method
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
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8163480 |
Nucleic acid size detection method
The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an...
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8163478 |
Fertility restoration for Ogura cytoplasmic male sterile Brassica and method
A Brassica plant comprising a unique recombination event resulting from a break at a position along a nucleic acid segment derived from ogura Raphanus sativus between the restorer locus and the...
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8163514 |
Methods of cleaving DNA with rationally-designed meganucleases
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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8163481 |
Method of extracting chromatin fractions from intact cells
Methods are provided for isolation of chromatin fractions of nucleoproteins containing histone H1, H2A, H2B, H3 and H4 proteins and/or histone H1, H2A, H2B, H3 and/or H4 proteins, from intact...
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8163490 |
Method of analyzing methylated DNA
The present invention provides a method of analyzing methylated DNA, comprising steps of: (A) treating a DNA-containing sample with a restriction enzyme to obtain a sample containing a DNA...
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8163477 |
Nuclease-based method for detecting and quantitating oligonucleotides
A method for quantitating an oligonucleotide in a sample of bodily fluid and/or extract is provided. The method provides for the detection and/or localization of oligonucleotides, including...
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8163489 |
Method for a continuous rapid thermal cycle system
Disclosed herein is an efficient, high speed production scale synthesis method for high molecular weight organic substances, such as DNA. The invention includes a method of conducting a polymerase...
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