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7582452 |
Assay for species sources
A family of PCR assays is disclosed for determining, both qualitatively and quantitatively, presence of material from a predetermined species source and for quantifying the amount of such material....
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7582738 |
Diagnostic assay for Wiskott-Aldrich syndrome and genetically related disorders
The methods and compositions of the invention find use in the clinical diagnosis of primary immunodeficiencies, particularly Wiskott-Aldrich related syndromes. The compositions of the invention...
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7582424 |
Accessory cholera enterotoxin and analogs thereof as activators of calcium dependent chloride channel
Vibrio cholerae accessory cholera enterotoxin (ACE) activates a calcium dependent chloride channel. Ace and Ace analogs can be administered to patients to treat diseases involving defects in...
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7582420 |
Multiplex nucleic acid reactions
The invention is directed to a variety of multiplexing methods used to amplify and/or genotype a variety of samples simultaneously.
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7582427 |
Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT...
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7582436 |
3′ end tagged oligonucleotides
The present invention provides compositions comprising oligonucleotides that have 3′ end groups (e.g. lipophilic moieties) that are useful in invasive cleavage reactions such as the INVADER...
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7583379 |
Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof
Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a virus, bacterium, or other infectious agent, are provided. A spectroscopic assay...
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7582419 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7582432 |
Dark quenchers for donor-acceptor energy transfer
The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially...
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7582260 |
Zwitterionic dyes for labeling in proteomic and other biological analyses
The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and...
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7582740 |
Methods and kits for detecting SARS-associated coronavirus
The present invention provides a synthetic nucleic acid sequence comprising 10-30 nucleotides of the N gene region and/or the 3′ non-coding region of the SARS-associated coronavirus genome, and a...
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7582470 |
Device for amplifying and detecting a target nucleic acid
Compositions, methods and devices for detecting nucleic acids. The invention particularly regards composite arrays of immobilized amplification primers and hybridization probes. Also disclosed are...
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7582746 |
siRNA targeting complement component 3 (C3)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7582428 |
Methods and compositions for identifying anti-HCV agents
The invention provides methods and compositions for identifying agents for treating infection by viruses that encode a nucleotide-binding NS4B protein, or functional equivalent thereof, e.g.,...
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7582429 |
Amplicon melting analysis with saturation dyes
Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50%...
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7582615 |
Antisense antiviral compound and method for treating arenavirus infection
The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Arenaviridae family and in the treatment of a viral infection....
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7579184 |
Methods to increase dynamic range and improve quantitative analysis in rapid biosensors
Conductimetric assay devices that have both low end and high end sensitivity are described. The geometric shape and/or arrangement of the capture zones make it possible for the assay devices to...
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7579146 |
Nucleic acid cloning
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be...
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7579454 |
Method for detecting gram-positive bacteria
The present invention relates to a method for detecting and/or identifying Gram-positive bacteria with high GC content, in particular mycobacteria. The method comprises a nucleic acid amplification...
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7579175 |
Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process...
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7579453 |
Variants of human taste receptor genes
Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur...
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7579145 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7579155 |
Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule
The invention relates to methods for identifying the sequence of one or more variant nucleotides in nucleic acid molecules. The method involves cleaving a double-stranded nucleic acid molecule...
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7579152 |
SENP1 as a marker of cancer development and target for cancer therapy
The present invention relates to compositions and methods for the use of SENP1 as a marker for cancer diagnosis, specifically prostate cancer. Still further, it relates to the use of inhibitors of...
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7579153 |
Isothermal DNA amplification
The present invention provides for amplification of one or more polynucleotides by multi-staged linear amplifications using one or more RNA polymerases. At each stage RNA transcripts are...
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7579167 |
Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention...
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7579151 |
Isolation and purification method of biomolecules using hydrogel
Provided is a method of isolating and purifying biomolecules using a hydrogel, the method including: bring a sample containing charged biomolecules into contact with a hydrogel to bind the...
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7579166 |
Glycoprotein and process for producing the same
A process for producing a lysosomal enzyme having a mannose-6-phosphate-containing acidic sugar chain, wherein the process comprising: culturing in a medium yeast cells obtained by introducing a...
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7579154 |
Annealing control primer and its uses
The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid...
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7579455 |
Oligonucleotide compositions and methods for treating disease including inflammatory conditions
The invention relates to therapeutic antisense oligonucleotides directed against genes coding for phosphodiesterase (PDEs) and the use of these in combination. These antisense oligonucleotides may...
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7579329 |
P450RAI-2 (P450 cytochrome 26B), encoding nucleic acid molecules and methods and uses thereof
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. It is...
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7579451 |
Oligonucleotides comprising a modified or non-natural nucleobase
One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl,...
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7579147 |
Mutations in the macrophage scavenger receptor 1 gene alter risk of prostate cancer, asthma, and cardiovascular disease
The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least...
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7579150 |
Mobile RNA acts as a signal to regulate plant growth and development
The present invention relates to isolated nucleic acid molecules which encode a BEL transcription factor from potato ( Solanum tuberosum L.) and the amino acid sequences encoded by such nucleic...
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7579172 |
Method and apparatus for amplifying nucleic acids
An apparatus for amplifying nucleic acids includes a substrate, a reaction vessel formed inside of the substrate, at least one first inlet channel formed inside the substrate, connected to an end...
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7579148 |
Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases
Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived...
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7579149 |
Method and apparatus to separate molecules according to their mobilities
A method and apparatus for separating molecules comprises placing different kinds of molecular species onto a probe; and introducing an electric field between the probe and a surface in proximity...
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7575883 |
Cytochrome c acetylation
Modulation of cytochrome c acetylation, e.g., with a SIR polypeptide, enables interventions that modulate lifespan regulation and cell proliferation, e.g., by modulating apoptosis and/or...
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7575867 |
Use of mass labelled probes to detect target nucleic acids using mass spectrometry
The invention relates to the use of mass labelled probes to characterize nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid...
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7575865 |
Methods of amplifying and sequencing nucleic acids
An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing,...
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7575866 |
Ligand/binding partner bio-labeling systems
The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A “target”...
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7575928 |
Genes for diagnosing colorectal cancer
This invention relates to provide the genes for diagnosing colorectal cancer, the gene sequences searching comprise the steps of: (1) deriving epithelium cells from normal intestines, polypus of...
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7575860 |
DNA joining method
The present invention provides a method to directionally clone any linear template DNA molecule into any linearized vector. The vector ends may be generated from any restriction enzyme cleavage....
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7575862 |
Assay systems, kits and methods for detecting microorganisms
The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis ) of suspected patient. The present invention also relates to an...
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7575902 |
Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases
Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and...
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7575863 |
Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific...
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7576196 |
siRNA targeting transducin (beta)-like 3 (TBL3)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7575939 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7577538 |
Computational method and system for mass spectral analysis
A method for analyzing data from a mass spectrometer including obtaining calibrated mass spectral data involving at least one ion with its isotopes, by processing raw spectral data; obtaining...
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7576205 |
Detectable threading intercalator
A threading intercalator of general formula I:
IG 1 -DG-IG 2 -(DG-IG 3 ) n (I)
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