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7611842 |
Automated seed sampler and methods of sampling, testing and bulking seeds
An automated seed sampler includes a sampling station; a sampler for removing material from a seed in the sampling station; a seed conveyer for conveying the seed from the sampling station to a...
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7608393 |
Methods of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hyperglycemic patients
A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of...
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7608399 |
Device and method for extraction and analysis of nucleic acids from biological samples
Device and methods for extracting and analyzing nucleic acids from biological samples.
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7608445 |
Nitrilases, nucleic acids encoding them and methods for making and using them
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
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7608402 |
DNA methylation specific signal amplification
This invention is related to a method for rapidly detecting gene specific methylation through signal amplification using the epi-barcode after hybrid capture of the methylated DNA sequence.
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7608401 |
Mutations in the ferroportin 1 gene associated with hereditary haemochromatosis
The present invention relates to mutations in the gene coding for ferroportin 1 associated with hereditary haemochromatosis and methods for the diagnosis of hereditary haemochromatosis based on the...
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7608707 |
siRNA targeting survivin
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
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7608398 |
Polynucleotides for use tags and tag complements, manufacture and use thereof
A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.
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7608395 |
Systemic lupus erythematosus diagnostic assay
The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608394 |
Methods and compositions for phenotype identification based on nucleic acid methylation
Methods and compositions for identifying an unknown phenotype of a tissue that correlates with changes in the methylation state of the tissue comprising, nucleic acid sample from the tissue with a...
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7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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7608396 |
Systems, tools and methods of assaying biological materials using spatially-addressable arrays
Systems, tools and methods are used to perform complex sandwich hybridization assays of biological material. The tools comprise biological solution probes having a first region for hybridizing to...
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7608698 |
Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
This invention provides HIF-3α nucleic acid and sequences. Also provided are methods for using HIF-3α nucleic acids, proteins, fragments, antibodies, probes, and cells, to characterize HIF-3α,...
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7608400 |
Methods for detecting a cyclophilin B SNP associated with HERDA
This invention provides compositions and methods for identification of carriers of Hereditary Equine Regional Dermal Asthenia (HERDA) in equine species. In particular, this invention identifies a...
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7608705 |
Oligonucleotides, agents containing these oligonucleotides, and the use thereof
The invention relates to particular oligonucleotides, pharmaceutical agents that contain these oligonucleotides, and to the therapeutic use thereof. The oligonucleotides are, in particular, capable...
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7608408 |
Methods of identifying compounds that inhibit Notch cleavage
In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying γ-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are...
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7608397 |
Method for determining biophysical properties
The invention is a method for detecting a change in the conformational or energetic state of a molecular species, comprising the steps of: (i) immobilizing the molecular species, under conditions...
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7608433 |
Method of detection of classical swine fever
The invention relates to a multiplex real-time RT-PCR assay with a heterologous internal control system (i.e., EGFP-RNA) for the simple and fast diagnosis of classical swine fever virus (CSFV)....
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7605253 |
Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation
This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and...
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7604942 |
Systems and methods of analyzing nucleic acid polymers and related components
Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.
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7604937 |
Encoding and decoding reactions for determining target polynucleotides
The present invention is directed to methods, reagents, and kits for detecting the presence or absence of (or quantifying) target polynucleotide sequences in at least one sample using encoding and...
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7604944 |
Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal...
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7605280 |
Anthraquinone and its derivatives
There is disclosed a compound of formula (I) wherein each of X 1 and X 2 are independently NH-A-NR 1 R 2 , and wherein A is A C 2-8 alkylene and R 1 and R 2 are independently selected from...
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7604936 |
Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases
Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level...
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7604965 |
Thermal reaction device and method for using the same
An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet...
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7604938 |
Devices and methods for monitoring genomic DNA of organisms
The invention provides an apparatus that can be used in methods of preparing, amplifying, detecting, and/or optionally selecting for further analysis the genomic material from an organism for the...
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7604969 |
Mutant glucose dehydrogenase
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having...
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7604940 |
Compositions and methods for analyzing isolated polynucleotides
Compositions and methods of use are disclosed for the analysis of polynucleotides isolated in individual reaction compartments.
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7605252 |
siRNA targeting kinase insert domain receptor (KDR)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
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7604963 |
Method for sequencing nucleic acid molecules
The sequence of a target polynucleotide can be determined by: (i) contacting the target polynucleotide with a polymerase enzyme and one of the nucleotides A, T(U), G, and C under conditions...
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7604998 |
Fingerprint analysis for a plurality of oligonucleotides
The invention provides a method for evaluating the accuracy of an oligonucleotide sample, specifically a sample containing a variety of oligonucleotides of potentially varying size and sequence....
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7604941 |
Nucleotide sequencing via repetitive single molecule hybridization
Methods of obtaining sequence information about target oligonucleotides by repetitive single molecule hybridization are disclosed. The methods include exposing a target oligonucleotide to one or...
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7604939 |
Methods of identifying active BRM expression-promoting HDAC inhibitors
The present invention provides screening methods for identifying BRM expression-promoting histone deacetylase (HDAC) inhibitors, diagnostic methods for determining the suitability of treatment of a...
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7604943 |
Systems and methods of analyzing nucleic acid polymers and related components
Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.
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7605243 |
Compounds and methods for labeling oligonucleotides
The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In...
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7604945 |
Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to asthma
A gene related to a susceptibility of infection and asthma—the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene—a method of detecting the asthma-associated gene, a method of...
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7604981 |
Excitable target marker detection
A variety of types of molecules are detected and/or analyzed using an integrated micro-circuit arrangement. According to an example embodiment of the present invention, a micro-circuit arrangement...
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7605303 |
Stress-responsive root-specific genes
The present inventors succeeded in cloning a rice stress-responsive gene, RSI1. They discovered that stress-responsive plants can be generated by using the isolated gene, or genes functionally...
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7604973 |
DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Pasteurella multocida hyaluronate synthase (PmHAS), and to the use of this...
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7601501 |
Controlling osteogenesis by inhibition of osteogenic suppressors
The present invention provides methods of screening for agents that inhibit the activity or expression of one or more polypeptides that contribute to the suppression of osteogenesis. The invention...
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7601699 |
Production of reprogrammed cells with restored potential
A method for treating cells and/or nuclear transfer units and/or stem cells in culture with such compounds, individually or in combinations, is described. The method results in a globally...
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7601499 |
Paired end sequencing
The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the...
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7601532 |
Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is...
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7601490 |
Development of influenza A antivirals
The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein...
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7601503 |
Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives
Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they...
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7601533 |
Reverse two-hybrid systems
Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ...
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7601500 |
Prime-boost vaccine for the protection of equines against viral infection
It has been found that adequate protection against viral infection in equines can be achieved when vaccination with a live viral vaccine (prime) is followed by vaccination with an inactivated...
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7601491 |
Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
The present invention relates to methods for pretreating biological samples for extraction of nucleic acid therefrom The present invention employs a combination of at least one protein denaturant...
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7601831 |
Methods, kits and assay system for detecting drug-resistant mycobacterium tuberculosis
The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces...
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