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7622280 |
Emulsion compositions
An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a...
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7622251 |
Molecular indicators of breast cancer prognosis and prediction of treatment response
The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer....
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7623969 |
Gene discovery for the system assignment of gene function
The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more...
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7622253 |
Classification of patients having diffuse large b-cell lymphoma based upon gene expression
Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to...
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7622287 |
Myceliophthora thermophila laccase variants
The present invention relates to a method of designing laccase mutants with increased oxidation potential and/or changed pH optimum and/or altered mediator pathway and/or altered O 2 /OH −...
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7622258 |
Screening methods and sequences relating thereto
A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of:
(a) obtaining a test sample...
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7622257 |
Screening method for Staufen activity in neurons
The present invention provides cell-based screening methods for identifying pharmaceutical agents which are capable of modulating (have the ability to modulate) STAUFEN function by screening for...
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7622279 |
Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry
This invention provides a method for determining the sequence of a DNA or an RNA, wherein (i) about 1000 or fewer copies of the DNA or RNA are bound to a solid substrate via 1,3-dipolar...
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7622566 |
Purification of a triple helix formation with an immobilized oligonucleotide
A method for double-stranded DNA purification, by which a solution containing DNA in a mixture with other components is passed over a support on which is covalently coupled an oligonucleotide...
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7622260 |
Diagnostic and prognostic tests
The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides...
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7622281 |
Methods and compositions for clonal amplification of nucleic acid
Described herein are methods and compositions relating to amplifying nucleic acid. In certain embodiments, the invention provides methods for labeling and amplifying a nucleic acid molecule.
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7622255 |
Methods of identifying and isolating stem cells and cancer stem cells
Methods and compositions are provided for the identification of stem cells and cancer stem cells. β-catenin is also identified as a target for the development of therapeutic moieties against...
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7622266 |
Identification of a synthetic ligand for retinoic acid receptor beta
A method for identifying a synthetic ligand for retinoic acid receptor β comprises providing a sample, including a synthetic compound, exposing the sample to cultured cells, wherein the cultured...
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7622256 |
Method for selecting compounds that modulate MIF-induced expression of ICAM-1 and/or VCAM-1
Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and...
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7622252 |
Generation of minicircle DNA with physiological supercoiling
Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein.
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7622453 |
Oligomeric compounds for the modulation of Bcl-2
The present invention provides improved oligomeric compound, in particular oligonucleotide compounds, and methods for modulating the expression of the Bcl-2 gene in humans. In particular, this...
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7622248 |
Ribozymes with broad tRNA aminoacylation activity
The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an...
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RE41005 |
Beads bound to a solid support and to nucleic acids
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are...
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7622934 |
Method and apparatus for sensing a time varying current passing through an ion channel
A capacitive sensing system is used to measure a time-varying ion current through a channel, such as an ion channel or protein pore. Such a capacitive system does not suffer problems of electrode...
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7622249 |
Method for diagnosing and/or predicting of a septic syndrome
The present invention relates to a method for diagnosing and/or predicting a septic syndrome, wherein:
a. a biological sample from the patient is made available and biological material is...
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7619079 |
Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7618947 |
Modulation of HIF-1 beta expression
Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of...
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7618795 |
Starch process
The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said...
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7618779 |
Chromosome 1p36 polymorphisms and low bone mineral density
The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in...
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7620502 |
Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure
In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination.
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7618781 |
Nucleic acids for detecting B-cell malignancy
This document provides methods and materials related to detecting gene rearrangements (e.g., MYC gene rearrangements). For example, nucleic acid probe sets for detecting MYC-immunoglobulin gene...
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7618776 |
Rolling circle replication reporter systems
Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic...
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7618778 |
Producing, cataloging and classifying sequence tags
The described method provides, methods, and kits to produce, identify, catalog and classify a comprehensive collection of nucleic acid targets produced from a nucleic acid sample. The method,...
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7618772 |
Methods and compositions for diagnosing and suppressing metastasis thereof
Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis...
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7618777 |
Composition and method for array hybridization
The present disclosure relates to a system, composition, and method for hybridizing a microarray. The composition includes a superwetting agent. The method includes contacting the microarray with...
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7618780 |
Use of mass labelled probes to detect target nucleic acids using mass spectrometry
The invention relates to the use of mass labelled probes to characterize nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid...
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7618773 |
Headloop DNA amplification
A method for the selective amplification of a target nucleic acid in a sample comprising the target nucleic acid and at least one non-target nucleic acid, the method comprising amplifying the...
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7618775 |
Expanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
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7618774 |
Materials and methods for identifying genes and/or agents that alter replicative lifespan
Recombinant materials, including DNA constructs, expression vectors, and host cells, and methods of identifying an environmental stimulus or a gene that alters the lifespan of an organism are...
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7615626 |
Methods, agents, and compound screening assays for inducing differentiation of undifferentiatied mammalian cells into osteoblasts
The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a...
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7616790 |
Histological assessment of nuclear pleomorphism
A method of histological assessment of nuclear pleomorphism to identify potential cell nuclei divides image data into overlapping sub-images. It uses principal component analysis to derive...
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7615681 |
Methods for modifying plant responses to stress and correspondingly derived plants
Plant stresses such as pest drought, and excessive temperatures can lead to significant losses of crops each year. There is a continuing need to develop novel plant varieties that are less...
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7615529 |
Methods and compositions for modulating hyperstabilized c-met
The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.
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7615350 |
Methods for haplotyping genomic DNA
The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention...
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7615353 |
Tivozanib response prediction
A diagnostic method for predicting quantitatively whether a human tumor will be responsive or resistant (non-responsive) to treatment with the VEGF inhibitor, tivozanib (AV-951), is disclosed. The...
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7615369 |
Reconfigurable protein patterning using electrowetting microelectrodes
A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called...
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7615351 |
Two stage nucleic acid amplification using an amplification oligomer
This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic...
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7615343 |
Electrical readout of the binding of analyte molecules to probe molecules
The invention relates to the detection of the binding of analyte molecules, for example biopolymer molecules, to immobilized capture substance molecules. The invention consists in using...
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7615345 |
Arrays formed of encoded beads having oligonucleotides attached
A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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7615344 |
Process for producing extract for cell-free protein synthesis and cell extract produced thereby
It is intended to provide a process for producing an extract for cell-free protein synthesis whereby the productivity of a protein and the production efficiency can be improved. Cells are cultured...
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7615620 |
Detection system for PCR assay
The present invention provides a detection system for a PCR process using FRET which comprises at least two single-labelled Oligonucleotide sequences of differing Tm that hybridize to one another...
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7615540 |
Formulations comprising antisense nucleotides to connexins
A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site...
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7615352 |
Detection of Epstein-Barr virus
The invention provides methods to detect EBV in biological samples using real-time PCR. Primers and probes for the detection of EBV are provided by the invention.
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7615340 |
Electronic detection of interaction and detection of interaction based on the interruption of flow
Porous members can be positioned so as to partially or fully span channels in microfluidic systems. The porous members can be assembled and/or disassembled in situ. The porous members can be made...
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7615347 |
Method for trapping nucleic acids using divalent metal ions
A method for trapping nucleic acids on a surface of a solid phase substrate, which comprises the step of contacting a sample containing nucleic acids and having a pH of 12 or higher with the...
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