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7537896 |
Androgen-regulated PMEPA1 gene and polypeptides
This invention relates to the androgen-regulated gene, PMEPA1, and proteins encoded by this gene, including variants and analogs thereof. Also provided are other androgen-regulated nucleic acids, a...
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7537919 |
Cytochrome P450RAI-2 and related proteins
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
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7534879 |
Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for...
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7534564 |
Methods and compositions for polypeptide engineering
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are...
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7534560 |
Simple catalytic DNA biosensors for ions based on color changes
Disclosed are compositions and methods for the sensitive and selective detection of ions using nucleic acid enzymes and DNA modified microparticles.
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7534875 |
Compositions for glioma classification
The present invention provides novel compositions and their use in classifying gliomas. In a preferred embodiment, the methods are used to discriminate between oligodendroglioma and glioblastoma.
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7534563 |
Methods for producing ligand arrays
Methods for producing ligand substrates and arrays, e.g., peptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same are...
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7534567 |
Detection of nucleic acid sequence differences by comparative genomic hybridization
The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to...
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7534935 |
Phospholipid:diacylglycerol acyltransferases
This invention relates to an isolated nucleic acid fragment encoding an acyltransferase, more specifically a phospholipid:diacylglycerol acyltransferase. The invention also relates to the...
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7536263 |
Robust genotyping method using DNA chip having discriminating probe and amplicon probe immobilized thereon and DNA chip used therein
Provided is a genotyping method. The genotyping method includes using a DNA chip on which just an optimal probe set is immobilized, the optimal probe sets composed of a discriminating probe which...
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7534877 |
Non-M, non-O HIV-1 strains, fragments and uses
Retroviral strains of the non-M, non-O HIV-1 group, in particular a strain designated YBE30, its fragments and also its uses as a diagnostic reagent and as an immunogenic agent. The HIV-1 viruses...
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7534570 |
Method for the detection of cytosine methylations in immobilized DNA samples
A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and...
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7534561 |
Nucleic acid array in situ fabrication methods and arrays produced using the same
Methods and devices for producing a nucleic acid arrays using in situ nucleic acid array synthesis protocols are provided. A feature of certain embodiments of the invention is that control probes...
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7534568 |
Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a cleavage resistant probe.
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7534559 |
Feline polynucleotide vaccine formula
Disclosed are plasmids that contain and express in vivo in a feline host cell nucleic acid molecules. The plasmid can include nucleic molecule(s) having sequence(s) encoding infectious peritonitis...
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7534597 |
Methods and materials for the production of L-lactic acid in yeast
Recombinant yeast are provided having, in one aspect, multiple exogenous LDH genes integrated into the genome, while leaving native PDC genes intact. In a second aspect, recombinant yeast are...
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7534419 |
Methods of diagnosis and treatment of osteoporosis
A method of detecting osteoporosis in a mammalian is disclosed herein which includes:
a) obtaining a sample of a bone related tissue or cells; and b) measuring the concentration of at least a...
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7534569 |
Method of generating long nucleic acid molecules of defined sequence
A method of generating a single-stranded nucleic acid molecule comprising (a) combining in a mixture under conditions suitable for a polymerase extension reaction, (i) a polymerase, (ii) an initial...
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7534565 |
DLC-1 gene deleted in cancers
A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the...
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7534562 |
Tetrahydrofolate synthetase gene
By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is...
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7534566 |
Nucleic acid labeling method and liquid composition
It is provided a nucleic acid labeling method that can reduce to a minimum the amount of a labeling substance used and can effectively incorporate the labeling substance into a product, a target...
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7534587 |
Microsatellite markers for plants of the genus Triticeae and use thereof
The invention relates to novel microsatellite markers for wheats ( Triticum aestivum ) and closely related species (Genus Triticeae ) and to the use of said markers for the genetic analysis of...
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7531304 |
Method for screening FGFR-4 agonists
The present invention relates to the use of Fibroblast-Growth Factor Receptor (FGFR) agonists for the diagnosis, prevention and/or treatment of pathological conditions including, but not limited to...
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7531303 |
Interrogating multi-featured arrays
A method, apparatus for executing the method, and computer program products for use in such an apparatus. The method includes scanning an interrogating light across multiple sites on an array...
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7531306 |
Nucleic acid hybridization methods
Disclosed herein are methods of destabilizing double-stranded nucleic acid hybridization using an enzyme comprising DNA N-glycosylase activity. Also disclosed herein is the detection of a...
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7531309 |
PCR based capsular typing method
The present invention relates to molecular diagnostics. In particular, the present invention relates to PCR based diagnostics for the typing of Group B streptococci.
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7531308 |
Process for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography
The present invention provides methods for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography.
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7531523 |
Sodium channel protein type III alpha-subunit splice variant
The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same.
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7531310 |
Methods of diagnosing Crohn's disease by measuring expression level of RNA encoding human G-protein coupled receptor, HGPRBMY11
The present invention provides novel polynucleotides encoding HGPRBMY11 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of the...
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7531305 |
Human Papilloma Virus detection with DNA microarray
A method is provided of detecting the presence of HPV comprising the following steps: a. amplification and labelling part of the E1 HPV gene, in particular its 3′ end; b. hydrizing the labelled...
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7531312 |
Simplified biological evaluation method of natural and artificial chemicals by using DNA injury index and apparatus therefor
A biological evaluation method for rational and simply evaluating biological harmfulness or usefulness of a great number of natural and artificial chemicals, foods, etc. This method comprises...
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7531342 |
Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences
The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae , of the family Paramyxoviridae . The invention also...
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7531302 |
Nucleic acid detection method by triple helix formation
A method for detecting the presence of a target nucleic acid sequence in a sample, the method comprising (a) amplifying the target nucleic acid so that the product of the amplification reaction...
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7531311 |
Methods of detecting or diagnosing inflammatory bowel disease using prokineticin polynucleotides
The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to...
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7531348 |
Recombinant yeast for lignocellulose raw materials
The present invention relates to a method for obtaining a recombinant yeast of Saccharomyces cerevisiae , which ferments lignocellulose raw materials to ethanol, including introducing DNA into a...
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7531649 |
Aptamers to human epidermal growth factor receptor-3
The disclosure provided herein provides compositions of nucleic acid aptamers that bind human epidermal growth factor receptor-3 and methods for their use.
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7531524 |
Modulators of coagulation factors with enhanced stability
The invention provides improved nucleic acid ligands with enhanced stability that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These...
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7531335 |
Modified cytochrome p450 monooxygenases
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
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7531307 |
Use of representations of DNA for genetic analysis
It is an object of the present invention to provide a solution to problems associated with the use of microarray technology for the analysis DNA. The present invention provides compositions and...
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7531358 |
Method of quantifying surfactant
A method of quantifying an ethylene oxide based nonionic surfactant in a sample containing a physiologically active protein, characterized in that quantitation is performed by colorimetry, in...
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7527925 |
Purified pol DNA, a recombinant DNA construct for expression of HIV pol polypeptide sequences and a cell containing such construct
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7527958 |
Truncated 1,3-1,4-β-D-glucanase
A truncated 1,3-1,4-β-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method.
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7527954 |
Method for in vitro evolution of polypeptides
The invention relates to a method for the production and allocation of nucleic acids and polypeptides coded thereby. The method can be used for evolutionary selection of polypeptides in vitro. The...
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7527948 |
Detection of HPV
The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for...
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7528116 |
Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis
The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids...
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7527929 |
Methods of isolating nucleic acids using multifunctional group-coated solid phase carriers
The present invention is directed to a method of isolating a target species (e.g., target nucleic acid species) from a mixture. In the methods of the present invention, the mixture is combined with...
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7527930 |
Compositions and methods of use of standardized mixtures for determining an amount of a nucleic acid
The present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions...
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7527928 |
Reactions on a solid surface
The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to...
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7528242 |
Methods and compositions comprising Renilla GFP
The invention relates to methods and compositions utilizing Renilla green fluorescent proteins (rGFP), and Ptilosarcus green fluorescent proteins (pGFP). In particular, the invention relates to...
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7527927 |
Stable recombinant yeasts for fermenting xylose to ethanol
Described are recombinant yeast which ferment xylose to ethanol and which maintain their ability to do so when cultured for numerous generations in non-selective media. The preferred yeast contain...
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