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7544475 |
Depression gene
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression...
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7544476 |
Identifying cancers sensitive to treatment with inhibitors of notch signaling
The disclosure provides a method for identifying cancer tissue sensitive to treatment with an inhibitor of Notch receptor activation. The method comprises determining the level of HeyL gene...
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7544474 |
Method for detection of multiple test materials in a sample
A method for sequentially detecting multiple target nucleic acid fragments in a sample includes steps of adding a sample into a column having a test snare which has thereon two or more single...
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7544470 |
Method for finding mutations caused by the insertion of repeated DNAs
The present invention provides a method for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a...
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7544638 |
Device for chemical and biochemical reactions using photo-generated reagents
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the...
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7544472 |
Apparatus for detecting biomolecular bonding and a method thereof
An apparatus and method for detecting biomolecular bonding are disclosed. The apparatus comprises a substrate; a rotation unit mounted on the substrate, a probe biomolecule immobilized on a surface...
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7544468 |
Simultaneous collection of DNA and non-nucleic analytes
This invention provides for a rapid and convenient method of simultaneous collection of both genomic and diagnostic information from a single sample on a bibulous pad by differential extraction of...
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7544482 |
Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7544471 |
Preparing RNA from a wax-embedded tissue specimen
In particular embodiments in accordance with the present invention, a wax-embedded tissue specimen is digested and the resulting digested tissue specimen is purified to provide a purified RNA...
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7544327 |
Biosensor and method for bone mineral density measurement
This invention is related a biosensor for bone mineral density measurement, comprising a stimulating source; a transducer having antibodies against TRAP 5a, TRAP 5b or total TRAP (i.e. TRAP 5a+TRAP...
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7544484 |
Nucleic acids encoding membrane-binding proteins and methods of using same
A secretory or membrane-binding chimeric protein composed of an energy-generating protein and an energy-receiving protein linked one another wherein energy transfer can arise between the...
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7544488 |
Secretion, transcription and sporulation genes in Bacillus clausii
The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to...
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7544469 |
Methods and compositions for optical detection of single-stranded polynucleotides
New Gp32F protein for determining, localizing or quantitating single-stranded DNA or RNA molecules comprises a Gp32 protein conjugated at an environment-sensitive amino acid (e.g. cysteine-166) to...
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7541142 |
Pancreatic cancer genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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7541448 |
Oligonucleotides containing molecular rods
The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3′ end of a first nucleotide residue with the 5′ end...
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7541454 |
Compounds and methods for fluorescent labeling
Compounds useful in the fluorescent labeling of biological materials are provided along with methods for their use and preparation.
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7541148 |
Method for detecting base mutation
The present invention relates to methods for precisely and effectively detecting mutations of organism.
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7541141 |
Method of using estrogen-related receptor alpha (ERRα) status to determine prognosis, treatment strategy and predisposition to breast cancer, and method of using ERRα as a therapeutic target for the treatment of breast cancer
The present invention provides that ERRα is a breast cancer biomarker of clinical course and treatment sensitivity and, itself, a target for breast cancer treatment. A high ERRα level in breast...
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7541144 |
RNA labeling method
Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled substrate to provide labeled RNA. Methods of...
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7542956 |
Autonomic computing method and apparatus
The disparate data and commands from are received from a managed resource ( 102 ) and have potentially different semantics. The disparate data and commands are processed according to rules received...
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7541146 |
Biomolecule retaining material and methods for attaching biomolecules to a surface
The present invention provides a method and material for attachment of biomolecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides, silicon wafers or...
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7541444 |
Modified nucleotides
The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group...
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7541143 |
Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
The present invention provides for novel reagents whose fluorescence changes upon cleavage or a change in conformation of a backbone. The reagents comprise a backbone (e.g. nucleic acid,...
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7541455 |
Microwave mediated synthesis of nucleic acid probes
A method for preparing a nucleic acid probe is provided. The method comprises forming an activated cytosine or cytidine by a bisulfite catalyzed reaction; and covalently linking a reporter molecule...
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7541145 |
Cleavage of nucleic acids
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7541165 |
Molecular detection systems utilizing reiterative oligonucleotide synthesis
The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis...
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7541314 |
Microarray having a base cleavable sulfonyl linker
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the...
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7541196 |
Planar optical waveguide based sandwich assay sensors and processes for the detection of biological targets including early detection of cancers
An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group...
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7541344 |
Modulation of survivin expression
Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded...
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7539579 |
Oligonucleotide probes for genosensor chips
Software for designing optimized sets of oligonucleotide probes for use in genosensors (oligonucleotide microarrays) is disclosed. The selection of probe sequences is based on multiple criteria...
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7537905 |
Amplified and overexpressed gene in colorectal cancers
This invention relates to methods to diagnose colon cancer and other proliferative diseases. Gene 26#77 is identified herein as a novel oncogene. Methods are provided for diagnosing and treating a...
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7537898 |
Compositions and methods of selective nucleic acid isolation
The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.
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7537888 |
Marker assisted selection of bovine for improved milk production using diacylglycerol acyltransferase gene DGAT1
The present invention provides a method of genotyping bovine for improved milk production traits by determining the DGAT1 genotypic state of said bovine, wherein the DGAT1 gene and polymorphisms...
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7537889 |
Assay for quantitation of human DNA using Alu elements
An assay for determining presence of human DNA in a sample in which non-human DNA may also be present and for quantitating such human DNA. One embodiment uses intra-Alu based PCR and another uses...
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7537897 |
Molecular counting
The invention provides methods and compositions for counting molecules in a sample, wherein each molecule is labeled with a unique oligonucleotide tag. Such tags are amplified and identified rather...
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7538202 |
Enzyme-free isothermal exponential amplification of nucleic acids and nucleic acid analog signals
An enzyme-free, isothermal method of generating an amplification signal indicative of a target nucleic acid molecule is provided, as are compositions for performing such a method. An advantage of...
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7537887 |
Net, a transcription factor of the TCF family, as regulator of angiogenic factor expression
The present invention relates to the regulation of the activity of NET (ERP/SAP-2) protein and to compounds which modify or regulate NET protein activity. The invention further relates to methods...
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7538194 |
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the...
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7537751 |
Labeling reagents and labeled targets comprising nonmetallic porphyrins
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
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7537893 |
Mitochondrial ND5 gene mutations in Parkinson's disease
The present invention provides methods for diagnosing and treating Parkinson's disease based on mitochondrial mutations. The present invention also provides methods for diagnosing and treating...
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7537924 |
Virus strains
The present invention relates to clinical herpes simplex virus (HSV) isolates with improved oncolytic capabilities as compared to reference laboratory HSV strains. The present invention also...
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7537892 |
Method and sequences for determinate nucleic acid hybridization
Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to...
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7538095 |
Genetic inhibition by double-stranded RNA
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with...
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7537917 |
Microwave assisted PCR amplification of DNA
A method of microwave assisted nucleic acid amplification by PCR is disclosed. The method includes denaturing, annealing, and extending a nucleic acid sample, with at least the denaturing and...
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7537894 |
Methods and kits for monitoring Barrett's metaplasia
Disclosed are methods and kits for assessing risk of progression of Barrett's esophagus to adenocarcinoma.
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7537886 |
Primers and methods for the detection and discrimination of nucleic acids
The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular...
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7537895 |
Comparative genomic hybridization
Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple...
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7537938 |
Biomarker detection in circulating cells
A method is provided for detecting biomarkers in rare circulating cells by forming an enriched population of cells immunomagnetically followed by biomarker detection using binding compounds having...
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7537891 |
Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
The present invention describes polynucleotides that have been discovered to correlate to the relative sensitivity or resistance of cells, e.g., breast cell lines, to treatment with compounds that...
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7537890 |
Methods of performing biochemical reactions in a convective flow field
The present invention provides methods and systems for running reactions, in particular, biological reactions and assays, in a Rayleigh-Bénard convection cell. The utilization of Rayleigh-Bénard...
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