|
Match
|
Document |
Document Title |
|
|
7015060 |
Cloverleaf microgyroscope with through-wafer interconnects and method of manufacturing a cloverleaf microgyroscope with through-wafer interconnects
The present invention relates to a method of manufacturing a cloverleaf microgyroscope containing an integrated post comprising: attaching a post wafer to a resonator wafer, forming a bottom post...
|
|
|
6815189 |
Gene from acremonium chrysogenum encoding a protein with cephalosporin C acetylhydrolase activity and methods of use of such gene
An isolated DNA sequence that encodes a peptide with CPC-acetylhydrolase enzymatic activity is disclosed. Also, a method of expressing CPC-acetylhydrolase activity that includes the steps of (a)...
|
|
|
6630338 |
Removing deacetylase contaminant from cephalosporin C acylase using cationic surfactant
An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A deacetylase contaminant is...
|
|
|
6518039 |
Process for the fermentative production of deacylated cephalosporins
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
|
|
|
6503727 |
Process for the preparation of an antibiotic
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
|
|
|
6465233 |
Nucleic acid molecule encoding a cephalosporin acetylesterase
The present invention relates to a nucleic acid molecule which codes for the cephalosporin acetylesterase from Bacillus subtilis ATCC 6633 (DSM 11909), vectors and host cells which comprise such...
|
|
|
6458558 |
Process for the preparation of β-lactam derivatives
A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for...
|
|
|
6383772 |
Enzymatic conversion in a solvent mixture containing water and flourinated, non-chlorinated solvent
A first compound is converted to a second compound enzymatically in a solvent mixture containing water and a fluorinated, non-chlorinated alkane, alkene, or alkyne having up to 4 carbon atoms....
|
|
|
6319684 |
Process for the fermentative production of cephalosporin
The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the...
|
|
|
6165758 |
Purifying cephalosporin C acylase and regenerating a carrier immobilizing cephalosporin C acylase
An enzyme in a mixture containing the enzyme and a contaminant enzyme is purified by selectively aggregating and precipitating the contaminant enzyme with a surfactant. A carrier containing an...
|
|
|
6071713 |
Bioprocesses for preparing 7-ACA and 7-ADAC
A bioprocess for preparing adipoyl-7-ACA comprising the steps: (a) transforming cells of a strain of Penicillium chrysogenum which produces isopenicillin N with an expression vector containing DNA...
|
|
|
6020151 |
Process for the production of 7-ADCA via expandase activity on penicillin G
A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum...
|
|
|
5804429 |
Cephalosporin C acylase
A mutant CC acylase wherein at least one amino acid at the Ala 49 , Met 164 , Ser 166 , Met 174 , Glu 358 , Met 465 , Met 506 , or Met 750 position of the amino acid sequence of the native CC...
|
|
|
5795733 |
Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA
An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum...
|
|
|
5780260 |
Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier
An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an...
|
|
|
5753458 |
Acylation method for penicillins and cephalosporins
A method for providing a semisynthetic β-lactam antibiotic by enzyme catalyzed acylation of the parent β-lactam with an activated derivative of the side chain acid wherein a modulator, which...
|
|
|
5726032 |
Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA
An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 2-(carboxyethylthio)acetyl- and 3-(carboxymethylthio)propionyl-7-ADCA, using a...
|
|
|
5677141 |
Process for producing 7-aminocephem compound or salts thereof
The present invention provides a process for producing 7-aminocephem compounds or salts thereof. 7-Aminocephem compounds are produced via microorganisms transformed with a vector containing a gene...
|
|
|
5641753 |
10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives combined with sulfisoxazole
Pharmaceutical compositions of an erythromycin derivative combined with sulfisoxazole according to the structural formulas: ##STR1## where R is hydrogen, C1-C10 alkylcarbonyl or C1-C10 alkyl...
|
|
|
5629171 |
Recombinant bioprocess for the preparation of 7-amino cephalosporanic acid (7-ACA)
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a...
|
|
|
5559005 |
Bioprocess for preparing 7-ACA and 7-ADAC
Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a...
|
|
|
5512454 |
Enzymatic acylation of 3-hydroxymethyl cephalosporins
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides...
|
|
|
5424196 |
Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives
Transformation of Cephalosporin C or its derivatives and salts into 7-aminocephalosporanic acid or its derivatives by an enzymatic two stage process with enzymes immobilized on a solid matrix.
|
|
|
5399685 |
Process for the preparation of 20-keto-21 alpha-01-steroids
A process for the preparation of a compound of the formula ##STR1## wherein R 1 is alkyl of 1 to 3 carbon atoms, R 2 is alkyl of 1 to 12 carbon atoms, R 3 is alkyl of 1 to 4 carbon atoms...
|
|
|
5354667 |
Process for the enzymatic preparation of 7-aminocephalosporanic acid
A process for the production of an E. coli strain producing high yields of 7β-(4-carboxybutanamido) cephalosporin acylase, comprises: (a) digesting the DNA of a microorganism whose DNA includes...
|
|
|
5332663 |
Process for the enzymatic preparation of 7-amino-cephalosporanic acids
7-amino-cephalosporanic acids having the formula ##STR1## are obtained by submitting compounds having the following formula to enzymatic conversion: ##STR2## wherein R represents H, OH, O--CO--R",...
|
|
|
5318896 |
Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
An important intermediate for preparing cephalosporin antibiotics, 7-aminodesacetoxy cephalosporanic acid (7-ADCA), is prepared by a novel bioprocess in which a transformed Penicillium chrysogenum...
|
|
|
5296358 |
Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412
The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R 1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1...
|
|
|
5246863 |
Karl Fischer titration techniques
An improved technique and apparatus for automatic titration for determining the water content of a sample by a Karl Fischer (K.F.) reaction. Rather than requiring titration from one endpoint to...
|
|
|
5079146 |
Method of protection of the carboxy groups in the chemistry of β-lactam compounds
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by...
|
|
|
4981789 |
One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and...
|
|
|
4774179 |
Process for preparing a 7-aminocephalosporanic acid compound
A process for preparing a 7-aminocephalosporanic acid compound which comprises treating a cephalosporin C compound with an enzyme-producing microorganism belonging to the genus Pseudomonas or a...
|
|
|
4316958 |
Process for producing optically active cephalosporin analogs
Optically active cephalosporin analogs are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of...
|
|
|
4141790 |
Process for the preparation of 7-amino-cephem compounds using mold fungi
Compounds are provided having the general formula I: ##STR1## wherein X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue. The formula I compounds are prepared from...
|
|
|
3972774 |
Enzymatic de-esterification of cephalosporin para-nitrobenzyl esters
Cephalosporin p-nitrobenzyl esters are de-esterified via an esterase enzyme derived from the genus Bacillus.
|
|
|
3962036 |
Process for the manufacture of 7-amino-cephalosporanic acid-type compounds
In compounds of formula ##SPC1## Wherein R represents a lower alkyl radical and R 1 the acyl radical of a carboxylic acid the acylamino group is deacylated to the amino group when the compounds...
|
|
|
3960662 |
Process for the production of 7-amino-cephem compounds
7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.
|
|
|
3930949 |
Process for the production of 7-amino-Δ.sup.3 -cephem derivatives
7-Amino-Δ 3 -cephem derivatives of the formula: ##SPC1## Wherein: R is hydrogen; hydroxy; amino; cyano; --O--CO--NH 2 ; ##EQU1## wherein n is an integer from 4 to 6; --O--CO--R 1 ;...
|
|
|
3915798 |
Process for producing 7-amino desacetoxy cephalosphoranic acid
7-Amino desacetoxy cephalosporanic acid represented by the general formula, ##EQU1## is produced according to a process in which a 7-acylamino desacetoxy cephalosporanic acid represented by the...
|
|
|
3880713 |
Cephalosporin compounds
A process for the N-deacylation of a 7β-phenoxyacetamido cephalosporin which comprises subjecting the cephalosporin to the action of an amidohydrolase enzyme which is derived from a bacterial...
|
|
|
3522250 |
DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID
|
|
|
3239394 |
Process for producing 7-amino-cephalosporanic acid
|
|
|
3821081 |
Title is not available
|
|
|
3749641 |
Title is not available
|