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7588913 |
Process for the preparation of cephradine
The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form...
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7241630 |
Paramagnetic particle detection
A method of determining the number of magnetic particles within a sample using a tuned circuit having a capacitor and a coil. The method comprises:
a. determining the difference in the...
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6942990 |
Glutaryl cephalosporin amidase from Pseudomonas diminuta BS-203
The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-β-(4-carboxybutanamido)-cephalosporanic acid to...
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6518039 |
Process for the fermentative production of deacylated cephalosporins
The present invention discloses a process for the production of N-deacylated cephalosporin compounds via the fermentative production of their 7-acylated counterparts.
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6503727 |
Process for the preparation of an antibiotic
The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a...
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6319684 |
Process for the fermentative production of cephalosporin
The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the...
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6287799 |
Process for the preparation of aβ-lactam antibiotic
Process for the preparation of a β-lactam antibiotic in which a β-lactam nucleus is subjected to an enzymatic acylation reaction with the aid of an acylation agent at a molar ratio of acylation...
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6218138 |
Synthesis of beta-lactam antibiotics with immobilized penicillin amidase
Beta-lactam antibiotics are synthesized by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component in the presence of penicillin amidase...
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6060268 |
Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer
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5874571 |
Process for the recovery of cephalexin
The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a...
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5780260 |
Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosiloxane polymer carrier
An enzyme selected from penicillin-G amidase, glutaryl-7-ACA acylase and D-amino acid oxidase is immobilized by covalent bonding on an aminofunctional organosiloxane polymer carrier to provide an...
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5753458 |
Acylation method for penicillins and cephalosporins
A method for providing a semisynthetic β-lactam antibiotic by enzyme catalyzed acylation of the parent β-lactam with an activated derivative of the side chain acid wherein a modulator, which...
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5525483 |
Process for preparation of β-lactams utilizing a combined concentration of acylating agent plus β-lactam derivative of at least 400 mm
β-Lactam derivatives are synthesized by an enzymatic reaction of the parent amino β-lactam with the corresponding acylating agent, the concentration of the acylating agent plus the concentration...
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5512454 |
Enzymatic acylation of 3-hydroxymethyl cephalosporins
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides...
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5470717 |
Method for the preparation of certain β-lactam antibiotics
The present invention relates to an improved method for the preparation of certain β-lactam antibiotics by enzymatic acylation or by deprotection of a protected intermediate.
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5296358 |
Process for the enzymatic preparation of cephalosporanic derivatives using a D-amino acid oxidase from Rhodotorula glutinis NCIMB 40412
The enzymatic preparation of cephalosporanic derivatives, or their salts, ving the formula: ##STR1## wherein R is --CO--COOH or --COOH, R 1 is H, OH, or --O--CO--R" and R" is an alkyl group with 1...
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5079146 |
Method of protection of the carboxy groups in the chemistry of β-lactam compounds
The present invention relates to a new method of protection of the carboxy group in the chemistry of the compounds of β-lactam type. According to such a method, the carboxy group is protected by...
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4945159 |
Formation of lactams and other amides under mild conditions by action of cyanogen
A method for the formation of intramolecular amide bonds by the action of cyanogen, under mild reaction conditions, in the preparation of cyclic amides, including lactams, in biologically active...
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4775622 |
Expression, processing and secretion of heterologous protein by yeast
Yeast organisms are caused to express, process, and secrete protein that is normally heterologous to yeast and not required for its viability by transforming yeast with an expression vector...
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4340672 |
Enzymatic synthesis of β-lactam antibacterials
Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl...
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4335211 |
Process for producing optically active cephalosporin analogs
Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.
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4073687 |
Enzymatic acylation to afford β-lactam antibiotics
Penicillin or cephalosporin antibiotics represented by following formula: ##STR1## where ##STR2## is an acyl group derived from an α-amino acid, N-ammonium salt of α-amino acid, or N--(C 1 to C...
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3945888 |
Method for the production of cephalosporins
A new method for production of a cephalosporin ester (I) which comprises reacting a derivative of an organic acid (II) with a 7-aminocephem compound (III) in the presence of an enzyme of a...
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3899394 |
Production of antibacterial agents
7-[Dα-Amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol
-5-yl thiomethyl)-3-cephem-4-carboxylic acid and its nontoxic, pharmaceutically acceptable salts exhibit highly desirable solubility in...
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3853705 |
ENZYMATIC PRODUCTION OF CEPHALOTHIN
Cephlothin is produced from 7-amino cephalosporanic acid and thienylacetic acid ester by enzymatic acylation with acylating enzyme derived from a microorganism belonging to genus Bacillus.
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3763000 |
ENZYMATIC PRODUCTION OF CEPHALEXIN
Cephalexin is produced from 7-amino desacetoxy cephalosporanic acid and phenylglycine ester by enzymatic acylation with acylating enzyme derived from a microorganism selected from the group...
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3761354 |
Title is not available
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