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9040234 Oligonucleotide analogs as therapeutic agents  
The invention relates to design of short oligonucleotides and analogs thereof (such as, di-, and trinucleotide compounds) useful for various therapeutic applications. It is believed that the...
9029082 Detection device for detecting biological microparticles such as bacteria, viruses, spores, pollen or biological toxins, and detection method  
A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be...
9023596 Recombinant pokeweed antiviral proteins, compositions and methods related thereto  
The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the...
9023594 Continuous directed evolution of proteins and nucleic acids  
The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from...
9017935 HIV-1 latency model for high throughput screening  
Isolated, latently infected T cell lines are provided that can be utilized in high throughput screening to discover compounds capable of activating HIV-I. The T cell lines harbor a latent HIV-I...
9012136 Detection of an analyte in a sample  
There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte...
9012146 Method for selectively enriching and isolating microbial and optionally additional viral nucleic acids  
The present invention relates to a method for selectively enriching and/or isolating microbial and optionally additionally viral nucleic acids from samples that contain a mixture of microbial...
9011835 Compositions, methods, and kits for eliciting an immune response  
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing...
9011874 Compositions, methods and uses for poxvirus elements in vaccine constructs  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza...
9011821 PLA2G16 as a target for antiviral compounds  
In some aspects, the invention provides compositions and methods for inhibiting viral infection. In some aspects, the invention provides compositions and methods useful for identifying antiviral...
9011820 Screening tool for antiviral agents  
A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small...
9005621 Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof  
Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses....
9005889 Synergistic antiviral compositions comprising a viral attachment inhibitor, integration inhibitor, and proviral transcription inhibitor  
Compounds, compositions and methods for the treatment of HIV/HSP/HPV, in particular, compositions and methods for a 3 part combination therapy for HIV/HSV/HPV, comprising a viral attachment...
9005632 Compositions, methods and uses for poxvirus elements in vaccine constructs against influenza virus subtypes or strains  
Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza...
9005985 Optical reporter compositions  
This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to...
9005887 Detection of an analyte in a sample  
There is provided mechanisms for the detection of an analyte in a sample. The mechanisms utilize at least a first measurement channel comprising a detection reactant corresponding to the analyte...
9000136 Recombinant vaccinia virus having hepatitis C virus gene  
Provided is a recombinant virus which is efficacious in preventing the onset of hepatitis C infection and has a high safety. Also provided is a vaccine for hepatitis C virus which contains the...
9000141 Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes and methods for their use  
Disclosed herein is a method for identifying flavivirus cross-reactive epitopes. Also provided are flavivirus E-glycoprotein cross-reactive epitopes and flavivirus E-glycoprotein cross-reactive...
8999290 Papillomavirus pseudoviruses for detection and therapy of tumors  
Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a...
8999317 Methods and compositions related to the structure and function of APOBEC3G  
Disclosed are methods and compositions related to the structure and function of APOBEC3G.
8993228 Antibody binding to envelope protein 2 of hepatitis C virus and method for identifying genotype of hepatitis C virus using the same  
The present invention provides an antibody that specifically binds to envelope protein 2 of HCV of genotype 2a but does not immunologically react with envelope protein 2 of HCV of genotype 1a.
8992860 Systems and methods for minimization or elimination of diffusion effects in a microfluidic system  
The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to...
8993245 Biosensor for detecting multiple epitopes on a target  
The present invention encompasses a method for detecting a target comprising a repeating epitope.
8993229 Method for detecting and distinguishing infectious norovirus from inactivated norovirus  
A method for extracting and distinguishing infectious norovirus from inactive norovirus using a solid support conjugated with a glycoprotein moiety capable of binding infectious norovirus wherein...
8986703 Peptide sequences and compositions  
Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells...
8986925 Method for in vitro detection and/or quantification and/or identification of infectious compounds in a biological material  
Method for in vitro detection and/or quantification and/or identification of infectious compounds present in a fluid medium M constituting a biological material, in which method a suspension of...
8986987 Herpesvirus of turkeys vectored vaccine against avian influenza in poultry  
The present application applies to the field of veterinary vaccines, in particular of vaccines for poultry against avian influenza. The vaccine is based on a recombinant viral vector expressing...
8986986 Cell lysis device and methods of lysing cells or viruses  
A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in...
8980547 Method for treating neurodegenerative tauopathy  
The present invention is directed to a filamentous bacteriophage for use in treating a neurodegenerative tauopathy or susceptibility to a neurodegenerative tauopathy and a method of using the...
8980546 Method for the detection of HIV-1-specific antibodies utilizing a Vpu polypeptide  
This invention relates to compositions and methods for the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-I) infection. The invention particularly concerns...
8980545 Divergent picornavirus: cosavirus  
Presented herein is the discovery of a new human picornavirus, Cosavirus (previously termed Dekavirus), methods of detecting the Cosavirus and diagnosing Cosavirus infection, methods of treating...
8980288 Emulsion vaccine compositions comprising antigen and adjuvant in the aqueous phase  
Emulsion vaccine formulations containing an antigen and an adjuvant in the aqueous phase are used for the vaccination of animals wherein the adjuvant is an acrylic polymer and/or dimethyl...
8975036 Methods for improved diagnosis of dysplasias  
The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly...
8975015 Antimicrobial compounds  
The compounds disclosed herein are isoxazole derivatives that are useful as antimicrobial compounds, particularly as anti-bacterial compounds. The disclosed methods comprise incubating at least...
8975016 Methods for direct fluorescent antibody virus detection in liquids  
The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the...
8968995 Detection, screening, and diagnosis of HPV-associated cancers  
Embodiments of the invention provide methods, polyclonal antibodies, monoclonal antibodies, assays, and kits for detecting HPV infection, including infection by various HPV genotypes, early and/or...
8969012 Immunogens for treatment of neoplastic and infectious disease  
The present invention relates to prophylactic and therapeutic methods of immunization against neoplastic and infectious diseases. The invention provides a method for identification of novel...
8968996 Compositions and methods for rapid immunization against dengue virus  
Embodiments of the present invention report compositions and methods for vaccinating a subject against all dengue virus serotypes. In some embodiments, multiple vaccine compositions may be...
8968997 Benzoxazole-based fluorescent metal ion indicators  
Disclosed are benzoxazole-based compounds, kits, and methods of producing and using the described compounds in fluorescence-based detection of analytes (e.g., metal ions). Also disclosed are uses...
8961978 Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses  
The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1...
8961997 Method for purifying the rabies virus  
The subject of the invention is a method for purifying the rabies virus, comprising a single ion-exchange chromatography step, said step being cation exchange chromatography according to which: a)...
8961898 Method for producing bilayer membrane and planar bilayer membrane  
The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a...
8962260 Method and device for combined detection of viral and bacterial infections  
A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for...
8962297 Bacteriophage lytic enzymes as alternative antimicrobials  
The present invention relates to isolated Clostridium perfringens bacteriophage lytic enzymes from baccteriophages CP26F and CP39O, and uses in controlling Clostridium perfringens.
8956812 Process for the preparation and purification of recombinant proteins  
A novel process for the purification of recombinant protein expressed as particle is herewith described. In this purification process, the protein is purified by hydrophobic interaction. The...
8951723 Serological screening for HHV-8 infection using antigen mixtures  
The invention provides compositions, methods, and kits for the diagnosis or detection of active, latent, or prior infection with human herpesvirus 8 in a subject sample.
8945509 Magnetic beads having surface glycoconjugates and use thereof  
Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to...
8945828 Method of identifying fetal antigens or cell surface markers using phage display technology  
The present application relates to methods for identification of foetal cells and generation and isolation of binding members recognizing foetal cells. The methods of the invention may further be...
8945584 Cell culture system of a hepatitis C genotype 3a and 2a chimera  
A robust and genetically stable cell culture system for Hepatitis C Virus (HCV) genotype 3a is provided. A genotype 3a/2a (S52/JFH1) recombinant containing the structural genes (Core, E1, E2), p7...
8946506 Plants having tomato torrado virus resistance  
The present invention relates to a tomato plant having within its genome at least one allele of a gene that confers resistance to Tomato torrado virus (ToTV), said virus having been deposited with...