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7618785 |
Diagnostic and therapeutic methods based on the L1 adhesion molecule for ovarian and endometrial tumors
A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1...
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7615348 |
Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen
The present disclosure provides methods and compositions for conducting an assay to detect a polynucleotide. In particular, ruthenium complexes having reduction potentials that do not coincide with...
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7615228 |
Polypeptide fragments of hepatitis E virus, the vaccine comprising said fragments and the diagnostic kits
A purified polypeptide comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of a polymer with n monomeric polypeptides,...
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7611837 |
Kit for detecting non-pathogenic or pathogenic influenza a subtype h5 virus
Current methods for detecting influenza A subtype H5 virus, for example cell culture, haemagglutination-inhibition, fluorescent antibody and enzyme immunoassay, and reverse transcriptase polymerase...
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7611718 |
Attenuation of cytomegalovirus virulence
A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
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7608410 |
Method of improving T cell receptors
A method of increasing the affinity and/or decreasing the off-rate of a given TCR specific for a given target pMHC, comprising creating a plurality of TCRs having an α chain CDR2 sequence and/or a...
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7608392 |
Diagnostic assay for measuring a cell mediated immune response
The present invention relates generally to a diagnostic assay and, more particularly, an assay for measuring cell-mediated immune reactivity. Even more particularly, the present invention provides...
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7604935 |
Soluble rubella E1 envelope protein variants
A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the...
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7604798 |
Methods and compositions for importing nucleic acids into cell nuclei
The present invention relates to methods and compositions for importing DNA into the nuclei of a specific cell type. In particular, the present invention provides methods and compositions for...
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7601505 |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast...
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7601498 |
Methods of using dyes in association with nucleic acid staining or detection and associated technology
Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection...
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7601490 |
Development of influenza A antivirals
The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein...
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7601344 |
Host cells obtained by introducing and expressing VHL gene in cancer cells or embryonic stem cells
The present invention relates to host cells that can function as neurons which are obtained by introducing and expressing von Hippel-Lindau gene in cancer cells, such as neuroblastoma cells and...
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7598064 |
Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between...
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7598046 |
Use of prion conversion modulating agents
The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically,...
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7598030 |
Antibodies against cancer produced using masked cancer cells as immunogen
This disclosure relates to methods for selecting antibodies having desirable characteristics from a population of diverse antibodies. More specifically, this disclosure provides methods for...
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7595170 |
Apparatus and method for measuring concentrations of molecules through a barrier
An apparatus and method for detecting the presence and measuring the concentrations of molecules through a barrier and/or at a distance utilizes the principle of chemical/electrostatic attraction...
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7595153 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7595152 |
Detection of influenza virus
The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats...
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7595151 |
Methods and compositions for diagnosis and treatment of influenza
The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for...
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7592169 |
Methods and compositions for treatment and prevention of HSV-2 infections and conditions
Live, attenuated, phenotypically stable HSV-2 viruses and methods of making and using the virus are provided. Live, attenuated HSV-2 viruses are constructed using recombinant techniques and can be...
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7592012 |
Chimeric proteins for cell targeting and apoptosis induction and methods of using the same
Fusion proteins which comprise an apoptosis inducing protein portion and a cell targeting portion are disclosed. Fusion proteins which comprise a protease portion and a cell targeting portion are...
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7591980 |
Biological alarm
Airborne particles are impacted on a collection surface, analyzed, and then the collection surface is regenerated. Thus, the same collection surface can be used in numerous cycles. The analysis can...
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7588929 |
Production of bacteriophage compositions for use in phage therapy
The present invention relates to the use of bacteriophages to treat infectious diseases. The invention provides a method for intermediate to large scale commercial production of bacteriophage...
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7588885 |
Use of biocistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation
The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or...
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7585641 |
Immunoassay and method of use
A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The...
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7585625 |
Storing and detecting nucleic acid administered to a solid carrier
The invention discloses a method for detecting a nucleic acid of interest in at least one sample comprising administering the sample to a solid carrier capable of at least in part absorbing the...
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7585621 |
Detection of West Nile virus infection and vaccination
A method and device for determining whether an animal is infected with West Nile Virus (WNV), or is either not infected or vaccinated with a WNV vaccine. The method includes contacting a biological...
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7585620 |
Method for identifying and for extracting endotoxin
The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
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7585619 |
Method for detecting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity
This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses...
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7582740 |
Methods and kits for detecting SARS-associated coronavirus
The present invention provides a synthetic nucleic acid sequence comprising 10-30 nucleotides of the N gene region and/or the 3′ non-coding region of the SARS-associated coronavirus genome, and a...
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7582428 |
Methods and compositions for identifying anti-HCV agents
The invention provides methods and compositions for identifying agents for treating infection by viruses that encode a nucleotide-binding NS4B protein, or functional equivalent thereof, e.g.,...
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7582419 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7582303 |
Avian hepatitis E virus, vaccines and methods of protecting against avian hepatitis-splenomegaly syndrome and mammalian hepatitis E
The present invention relates to a novel isolated avian hepatitis E virus having a nucleotide sequence set forth in SEQ ID NO:1 or its complementary strand. The invention further concerns...
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7579446 |
Binding molecules capable of neutralizing rabies virus and uses thereof
The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding...
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7579145 |
Detection of analytes using reorganization energy
The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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7579144 |
Methods for diagnosing chronic fatigue syndrome
Methods are provided for detecting enteroviral antigens in the stomach of patients having symptoms consistent with chronic fatigue syndrome (CFS). The presence of enteroviral viral antigens in the...
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7579143 |
Method of assessing the effectiveness of a non-nucleoside reverse transcriptase inhibitor (NNRTI) on a human immunodeficiency virus type 1 (HIV-1)-infected patient
This invention relates to methods for assessing the effectiveness of non-nucleoside reverse transcriptase inhibitor on an HIV that rely on detection of combinations of mutations in HIV reverse...
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7579142 |
Methods for purification of bacterial cells and components
The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
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7575939 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7575859 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
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7572828 |
Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or...
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7572643 |
Nanoparticle composite-coated glass microspheres for use in bioassays
A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of...
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7572620 |
H3 equine influenza A virus
The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
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7572455 |
Vaccine comprising an attenuated pestivirus
Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein E rns and at least another mutation in the coding sequence for N...
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7569397 |
Immunoassay devices and use thereof
An immunoassay device has a housing defining a first opening for receiving a solution and a second opening through which a liquid sample is deposited, a strip of sorbent material having a test site...
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7569340 |
Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof
A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by...
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7566533 |
Clinically intelligent diagnostic devices and methods
The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical...
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7566532 |
Methods for detecting retroviruses
Disclosed is a method for detecting human retroviral nucleic acids such as human immunodeficiency virus type I (HIV-1) nucleic acid, human T-cell leukemia virus type I (HTLV-I) nucleic acid, and...
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7566531 |
Selective whole cell quartz crystal microbalance biosensors
Selective whole cell QCM biosensors are disclosed. Also disclosed are methods of making and using such whole cell QCM biosensors, e.g., to screen drugs and diagnose diseases.
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