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8183044 |
Recombinant human hepatitis C virus-like particle and method for producing the same
The present invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising the steps of introducing into (i) a cell in which an RNA replicon comprising a...
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8182984 |
Recombinant North American type 1 porcine reproductive and respiratory syndrome virus and methods of use
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major problem in the pork industry worldwide. The inclusion of markers in vaccines will allow for diagnostic differentiation of...
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8182985 |
Anti-TSG101 antibodies and their uses for treatment of viral infections
The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for...
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8178320 |
Artificial antibody library with super-repertory
An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or...
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8178103 |
Porcine reproductive and respiratory syndrome virus strains and compositions
This invention relates to two attenuated strains of porcine reproductive and respiratory syndrome virus (PRRSV) and immunogenic compositions comprising one or more strains of attenuated porcine...
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8178291 |
Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods...
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8173362 |
Cytomegalovirus surface protein complex for use in vaccines and as a drug target
Immunogenic compositions and prophylactic or therapeutic vaccines for use in protecting and treating against human cytomegalovirus (CMV) are disclosed. Subunit vaccines comprising a human CMV...
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8173767 |
Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV
The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response...
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8168386 |
Methods for detecting Venezuelan equine encephalitis virus TC-83 and its use as a biological agent simulant
The present invention is generally related to products and methods that facilitate the use of Venezuelan equine encephalitis (VEE) virus TC-83 (TC-83) as a non-hazardous simulant, or surrogate, for...
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8168190 |
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core ant...
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8168379 |
Application of surface plasmon resonance technology for detecting and genotyping HPV
The present invention discloses using SPR technology to simultaneously and qualitatively detect different HPV genotypes. It also discloses an efficient formula to make a mixed SAM that can greatly...
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8168394 |
Method for simultaneously detecting an antigen of, and an antibody against, an infectious microorganism
The invention relates to a method for detecting, in vitro, an infection with a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneously detecting an antigen of this...
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8163474 |
NS1-NP diagnostics of influenza virus infection
The present application describes methods for assessing influenza infection, including prognosis. An assay that determines the amount of the NS1 and NP proteins of influenza virus shows enhanced...
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8158342 |
Method for the identification of human immunodeficiency virus related antibodies in blood
This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HIV related antibodies in a serum sample for the diagnosis of HIV infection. It also...
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8158341 |
Efficient algorithm for PCR testing of blood samples
A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an...
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8158343 |
Method to detect virus related immunological markers for the diagnosis of respiratory tract infections
This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used...
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8153445 |
Method for screening of infectious agents in blood
This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to...
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8153129 |
Antibodies against human cytimegalovirus (HCMV)
The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV...
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8153360 |
Flavivirus fusion inhibitors
The present invention provides an isolated peptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1 to SEQ ID NO:36, as well as derivatives thereof comprising various...
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8148497 |
Binding molecules capable of neutralizing rabies virus and uses thereof
The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding...
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8147845 |
Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with...
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8148060 |
Recombinant viral vector for gene transfer into lymphoid cells
A recombinant herpesvirus, a method for producing the recombinant herpesvirus, and a pharmaceutical composition comprising the recombinant herpesvirus, are provided with a method for producing a...
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8148059 |
Method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker
A method of detecting malignancy of nasopharyngeal carcinoma and a nasopharyngeal carcinoma malignancy biomarker are disclosed. Firstly, a specimen is obtained from a testee. Next, the specimen is...
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8142788 |
PRRSV GP5 based compositions and methods
The disclosure includes compositions and methods for the production of an immune response against porcine reproductive and respiratory syndrome (PRRS) virus, or PRRSV. The disclosure is based in...
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8142997 |
Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses
The present invention generally relates to the field of diagnostic microbiology, and, more particularly, to compositions and methods for detecting and differentiating one or more viruses or other...
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8133666 |
Method for identifying agents capable of inhibiting APOBEC3C activity in HIV-infected cells
The present invention provides methods of identifying agents that reduce a level of active APOBEC3C in a cell. The present invention provides agents that reduce a level of active APOBEC3C in a...
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8133712 |
Inactivated chimeric vaccines and related methods of use
Embodiments of the present invention provide an inactivated chimeric virus and immunogenic compositions for the treatment or prevention of infection with West Nile virus. Further, other embodiments...
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8131567 |
Value network
Systems and methods including a computer network are provided. The computer network includes a plurality of affiliate computing systems, each affiliate computing system including a processing unit...
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8129159 |
Attachment of molecules to surfaces
The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present...
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8129111 |
Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same
The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric...
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8129106 |
Sequence-specific detection of methylation in biomolecules
A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a...
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8124355 |
Detection and identification of groups of bacteria
The present invention concerns a method for the simultaneous detection of different bacteria, comprising the following steps: coupling one or more species of bacteriophage tail proteins onto a...
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8124747 |
HCV clade and prototype sequences thereof
The current invention relates to a previously unrecognized clade of HCV genotypes as well as to diagnostic, prophylactic and therapeutic applications of nucleic acids, proteins, and antibodies to...
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8124052 |
Method for identifying targeting domains and methods and compositions comprising the same
The present invention is directed to a method of identifying tissue targeting domains. In particular, the invention relates to methods for identifying a polynucleotide encoding a targeting domain...
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8119337 |
Decreasing potential iatrogenic risks associated with influenza vaccines
Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero,...
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8119339 |
Heteroduplex tracking assay
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown...
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8119338 |
Methods and compositions for detecting rhinoviruses
The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of human rhinovirus (HRV) in a sample. In general, the...
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8119336 |
Compositions for use in identification of alphaviruses
The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of alphaviruses by amplification of a segment of viral nucleic acid...
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8114977 |
Proteins derived from white spot syndrome virus and uses thereof
Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for...
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8114408 |
Peptide fragments reacting specifically with antibodies against highly pathogenic newcastle disease virus and uses thereof
We disclose synthetic peptide fragments comprising amino acid sequences of specific antigen sites of pathogenic Newcastle disease virus in birds, and more particularly synthetic peptide fragments...
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8114602 |
Detection of molecular interactions
A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of...
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8114402 |
Compositions and methods for the therapy and diagnosis of influenza
The present invention provides novel human anti-influenza antibodies and related compositions and methods. These antibodies are used in the diagnosis and treatment of influenza infection.
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8114586 |
Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
Conformational epitopes of the envelope proteins E1 and E2 of the Hepatitis C virus (HCV) have been identified and characterized using a panel of monoclonal antibodies derived from patients...
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8114585 |
Method for determining human immunodeficiency virus (HIV) coreceptor utilization by examining gp41 molecular determinants
The invention provides a method for determining whether a human immunodeficiency virus is likely to be have enhanced ability to enter a cell expressing CD4 and CXCR4 relative to a reference HIV. In...
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8110350 |
Human Bocavirus and methods of diagnosis and treatment
Human parvovirus, genus Bocavirus, associated with respiratory tract infections in children. Nucleic acid and polypeptide sequences of the virus. Methods and products for diagnosing presence of...
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8105606 |
Chimeric proteins that induce effects directed against viruses
The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against...
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8105843 |
Methods and devices to enhance sensitivity and evaluate sample adequacy and reagent reactivity in rapid lateral flow immunoassays
Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of...
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8105767 |
Cells for detection of enteroviruses
The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo...
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8106170 |
Compositions against SARS-coronavirus and uses thereof
The present invention provides compositions of binding molecules specifically binding to a coronavirus such as SARS-CoV and capable of neutralizing an infection caused by the virus. The...
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8101342 |
DNA vaccine for treating or preventing cervical cancer comprising a gene encoding HPV protein
Disclosed herein is a DNA vaccine for treating cervical cancer including an E5 gene of human papillomavirus (HPV). Also, disclosed is a combination DNA vaccine for preventing and treating cervical...
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