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7132234 |
Methods and compositions for the identification of anti-poxvirus agents
The invention provides methods for identifying an anti-poxviral agents. In many embodiments, the methods involve contacting a poxviral p28 polypeptide with a candidate agent, and determining an...
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7132122 |
Direct micro-patterning of lipid bilayers using UV light and selected uses thereof
This invention provides novel methods for creation of patterned lipid bilayer membranes as well as methods for refunctionalization of such patterned membranes with selected components. Such...
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7132232 |
Identification of viral agents in breast ducts and antiviral therapy therefore
Methods and systems for identifying a virus in breast ducts are provided. In addition, antiviral therapy for treating a virally infected breast duct is also provided. Patients with a viral...
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7129096 |
Sensor for use in testing biological, biochemical, chemical or environmental samples
Disclosed are sensors for use in testing biological, biochemical, chemical or environmental samples, and methods of making and using the same.
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7129042 |
Compositions and methods for detecting severe acute respiratory syndrome coronavirus
The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand...
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7129337 |
Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes...
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7129041 |
Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy....
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7125712 |
Bovine immunodeficiency virus (BIV) based vectors
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a)...
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7122302 |
Method for determining early HCV seroconversion
The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide...
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7118874 |
Immunogenic formulation and process for preparation thereof
A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from...
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7118859 |
Methods for inhibiting HIV-1 infection
This invention provides an antibody capable of specifically inhibiting the fusion of an HIV-1 envelope glycoprotein + cell with an appropriate CD4 + cell without cross reacting with the HIV-1...
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7115363 |
Retrovirus capable of causing AIDS, means and methods for detecting it in vitro
The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers...
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7115374 |
Compositions and methods for detecting West Nile virus
Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers for detecting...
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7112435 |
Uncoupling of DNA insert propagation and expression of protein for phage display
The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from...
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7112661 |
Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein Ib alpha
The present invention is directed to a method of selecting a clone that binds to human platelet glycoprotein Ib alpha using a human variable heavy chain and variable light chain immunoglobulin...
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7110195 |
Monolithic hard pellicle
A monolithic optical pellicle and method of making used to protect a photomask during photolithography processing. The monolithic optical pellicle is comprised of a pellicle plate having a recessed...
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7108856 |
CD4+ T-lymphocyte-specific Hepatitis C virus-epitopes
The invention relates to Hepatitis C virus epitopes which are specific in relation to CD4+ T lymphocytes, in addition to vaccinations which contain said epitopes.
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7108967 |
Hepatitis C viral antigen immunoassay detection systems
Immunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C...
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7108988 |
Methods of identifying agents for inhibiting lentivirus replication
The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the...
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7105301 |
Detecting molecular binding by monitoring feedback controlled cantilever deflections
The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached...
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7105341 |
In vivo production of cyclic peptides
The compositions relate to retroviral vectors encoding intein containing polypeptides which, when expressed in an eukaryotic cell, are capable of generating cyclic peptides. The retroviral vectors...
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7105169 |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
The present invention provides, among other things, methods of removing virus from a sample, a composition comprising a solid support matrix to which is attached a cyanovirin, a conjugate...
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RE39282 |
Nucleic acid derivatives
This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment.
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7105290 |
Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and a type I BMP receptor
The present invention relates to a method for determining whether a compound is capable of binding to a BMP receptor kinase protein complex, the method comprising introducing a sample comprising...
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7105303 |
Antibodies to hepatitis C virus asialoglycoproteins
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal...
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7105157 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
The present invention relates to cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells...
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7105358 |
Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
An apparatus to measure micro-forces includes a cantilever palette with a set of cantilever array blocks. Each cantilever array block includes a set of cantilevers, with each cantilever including a...
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7101554 |
Picornaviruses, vaccines and diagnostic kits
A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (I)...
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7101683 |
Methods for the simultaneous detection of HCV antigens and HCV antibodies
The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject...
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7101676 |
Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA
The present invention relates to methods of identifying a molecule from a library of molecules that inhibits binding of human immunodeficiency virus nucleocapsid 7 polypeptide (NCp7) to an...
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7101966 |
Selection of peptide ligands specific for baculovirus DNA-binding protein from the FliTrx™ random peptide display library
Autographa californica nucleopolyhedrovirus (AcNPV) is a baculovirus widely employed as a vector for the expression of foreign genes and pest control. Although baculoviruses efficiently replicate...
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7097987 |
Hepatitis C receptor protein CD81
The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for such...
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7097971 |
HIV-1 peptide, antigen, immunogenic composition, diagnostic method and immunoassay kit
The present invention comprises novel and modified peptides capable of inducing a HIV-1 specific immune response without antagonizing the cytotoxic T-cell activity in order to achieve an effective...
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7097970 |
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7098042 |
Internal quality control
This invention relates to the field of internal quality control in diagnostic analysis, particularly in the analysis of microorganisms or other small particles, such as the detection of bacteria,...
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7094868 |
Peptides for recognition and targeting of GLIAL cell tumors
Compositions for use in characterization, diagnosis, prognosis, and therapy of cancer cells are provided. The compositions comprise peptides and variants thereof which were isolated based on their...
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7094529 |
Bunyaviridal reaper proteins and uses therefore
Viral proteins with sequence and functional similarity to the drosophila cell death protein known as Reaper are provided. Reaper plays an important role in the apoptotic pathway. Methods using the...
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7094401 |
HCV core protein binding agents for treatment of hepatitis C virus infection
The present invention provides a method of treating or preventing hepatitis C virus infection in a subject which comprises administering an effective amount of an agent to the subject, wherein the...
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7090976 |
Methods and compositions comprising Renilla GFP
The invention relates to methods and compositions utilizing Renilla green fluorescent proteins (rGFP), and Ptilosarcus green fluorescent proteins (pGFP). In particular, the invention relates to...
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7091049 |
Enhanced diffraction-based biosensor devices
An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance...
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7087409 |
Humanization of murine antibody
A humanized murine antibody is provided. The amino acid sequences of a light chain complementarity determining region from a mouse antibody are grafted onto a human light chain, and a heavy chain...
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7087226 |
Lysin-deficient bacteriophages having reduced immunogenicity
The present invention features therapeutic bacteriophage deficient in the lysin protein (“Lys minus” phage). Lys minus bacteriophage are incapable of facilitating efficient lysis of the...
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7087376 |
Detection and identification of bacterial strains
The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the...
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7087375 |
Method for determining the mechanism of HIV RT inhibitors
The present invention is directed to the field of HIV resistance to RT inhibitors and methods of determining the levels and mechanisms of action of HIV resistance. The methods of the present...
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7087377 |
Method and kit for detection of tat protein with anti-tat oyi antibodies
The invention relates to an anti HIV 1 vaccine comprising the entire or part of the Tat HIV 1 protein, in addition to the identification of said protein in individuals affected by HIV. The Tat...
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7083912 |
MAb-based Dot-ELISA method and assay kit for the detection of viruses
A monoclonal antibody-based Dot-ELISA assay for the rapid detection of animal viruses such as avian influenza virus. The assay includes applying a specimen suspected of containing an animal virus...
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7083913 |
High through-put cloning of protooncogenes
The present invention provides a process of identifying protooncogenes using high-throughput provirus tagging (HPT), e.g., by recovering host/virus junction sequences from chimeric transcripts...
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7083936 |
Aminodextran compositions and conjugates and method of making and using them
A composition containing polydisperse aminodextran polymer molecules is soluble in an aqueous solution at a concentration of 10 mg/ml. The molecules therein have a narrow size distribution...
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7081352 |
Chemiluminescent influenza diagnostic kit
A chemiluminescent system for detecting the presence of influenza virus in a biological fluid sample is provided. An influenza diagnostic kit is provided which includes (1) a sampling device for...
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7078166 |
Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
The invention describes the display of exogenous polypeptides on filamentous phage using a fusion between the exogenous polypeptide and phage pVII or pIX proteins. In particular, phage particles...
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