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7195909 |
Measurement and use of molecular interactions
The subject invention pertains to a method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of:
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7195866 |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
Methods are disclosed for the production of anti-self antibodies and antibody fragments, being antibodies or fragments of a particular species of mammal which bind self antigens of that species....
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7195885 |
Hepatitis C virus assays
The present invention includes an assay useful for identifying inhibitors of Hepatitis C virus (HCV) activity. Particularly, the present invention is directed to a dual HCV assay useful for high...
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7192588 |
Vaccine composition and method of using the same
The present invention relates to a stable compacted, compressed or hard tableted injectable composition, including a vaccine composition comprising at least one freeze dried antigenic component and...
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7189505 |
Methods of assessing HIV integrase inhibitor therapy
The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic...
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7189403 |
Attenuated flavivirus strains containing a mutated M-ectodomain and their applications
The present invention relates to nine residue peptides (ApoptoM) from flavivirus M ectodomain able to modulate specifically the apoptotic activity of diverse flavivirus, to pharmaceutical...
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7186502 |
Process for preparing control samples of particles such as microorganisms and cells
Processes for preparing controlled samples of particles, including microorganisms and cells are described. A sample of particles is provided and separated into a predetermined number of desired...
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7186543 |
Preparation of vaccines using a photosensitizer and light
Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective,...
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7186504 |
Cells for detection of enteroviruses
The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo...
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7183100 |
Aconitase
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria...
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7183054 |
Assay for identifying biological targets of polynucleotide-binding compounds
The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also...
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7179456 |
Use of parvovirus for brain tumor therapy
Treatment of brain tumors by a composition including parvovirus, e.g., parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat...
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7179595 |
Compositions and methods for generating antigen-binding units
The present invention provides non-single-chain antigen-binding units that is stabilized by leucine zipper sequences. The experimental design is particularly useful for generating and screening for...
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7175987 |
Compositions and methods for treatment of herpes
Prophylactic and treatment methods for treatment of herpes, as well as methods for reducing or preventing the transmission of herpes. The methods comprise the step of administering to a mammal, an...
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7176303 |
Modulation of STAT5 expression
Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these...
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7172862 |
FBL2-specific agents as modulators of Flaviviridae RNA replication
Agents that modulate an interaction of an FBL2 protein with an NS5A or NS5B Flaviviridae protein in a mixture are identified by contacting the mixture with a candidate agent under conditions...
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7172893 |
Virus vectors and methods of making and administering the same
The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a...
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7169550 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a receptive material layer of radiation-absorbing member (RAM)-tagged biomolecules disposed thereon. The receptive material is specific for an analyte of...
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7169396 |
Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1
The nucleotide sequences of the genomes of eleven molecular clones for non-subtype B isolates of human immunodeficiency virus type 1 are disclosed. The invention relates to the nucleic acids and...
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7169551 |
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7169571 |
Methods for measurement of lymphocyte function
A method for measuring the responses of sets or subsets of lymphocytes to mitogens or antigens in a sample is disclosed comprising incubating a population of cells with a mitogen or antigen,...
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7166426 |
HCV assay
An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an...
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7166435 |
Compositions and methods for reducing the transmissivity of illnesses
Methods for prophylactic and anti-transmissivity uses of an anti-microbial composition are disclosed. The methods comprise the step of administering to a mammal or a bird, an amount of a...
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7166425 |
Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells
The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation...
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7163787 |
Methods for the identification of antiviral compounds
The present invention provides novel methods for determining whether a compound influences a phase in the life cycle of a virus comprising providing a cell with the compound and with at least a...
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7163818 |
Bacteriophage having multiple host range
The present invention discloses compositions and methods for the prophylaxis and treatment of bacterial infections by the use of polyvalent bacteriophage having multiple host range.
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7160736 |
Detection and amplification of ligands
Devices and systems for the detection of ligands comprising at least one receptor and an amplification mechanism comprising a liquid crystalline, where an amplified signal is produced as a result...
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7160677 |
Transcription factor DP-1
The invention provides a polynucleotide in substantially isolated form which includes a contiguous sequence of nucleotides which is capable of selectively hybridizing to SEQ ID NO: 1 or the...
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7157225 |
Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens
An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies...
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7157233 |
Methods and compositions for the detection of cervical disease
Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a...
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7153510 |
Recombinant vesiculoviruses and their uses
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
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RE39436 |
Interventions to mimic the effects of calorie restriction
Long term calorie restriction has the benefit of increasing life span. Methods to screen interventions that mimic the effects of calorie restriction are disclosed. Extensive analysis of genes for...
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7150965 |
Cells for detection of influenza and parainfluenza viruses
The invention provides cell lines which are useful for the rapid detection and production of influenza and parainfluenza viruses. In particular, the invention relates to transgenic mink lung cells...
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7151162 |
Nuclear protein
An isolated Shoca polypeptide comprising:
(i) the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4; or (ii) a variant thereof which is capable of interacting with a polypeptide of the wnt...
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7148013 |
Complex of Hepatitis B virus polymerase with p11 and method for controlling movement of the complex in HepG2 cell
Disclosed is a complex of the 11 kDa Ca 2+ binding protein of 11 and Hepatitis B virus polymerase (HBVPol) which moves to Promyelocytic Leukemia Nuclear Body (PMLNB). Furthermore, the present...
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7148325 |
Chimeric retroviral gag genes and screening assays
The subject invention provides novel and advantageous methods for identifying amino acid sequences in random peptide libraries that can bind to Gag polypeptides. The subject invention also...
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7148022 |
Assay for anti-viral agent
There is provided an assay for selecting an anti-viral agent effective against picornavirus infection. The assay selects an agent which disrupts the association between picornavirus protein 2C and...
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7148343 |
Compositions and methods for using a solid support to purify RNA
Reagents, methods and kits for the purification of RNA from biological materials are provided.
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7144698 |
Postweaning multisystemic wasting syndrome virus from pigs
The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and...
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7144697 |
Synthetic antigen for the detection of antibodies immunoreactive with HIV virus
Novel polypeptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the...
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7141242 |
Hepatitis B virus surface antigen mutant and methods of detection thereof
The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a...
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7138231 |
Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of HIV/AIDS
This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and...
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7138515 |
Translational activity-promoting higher-order structure
The present invention was conceived from the findings; that a specific higher-order structure can be formed in CrP-like viruses; that linkage of a gene reading frame downstream in the higher-order...
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7138376 |
Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
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7138266 |
Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
A bacterial strain of Escherichia coli is described which produces L-threonine, and is obtained by a process comprising transduction by bacteriophage P1 which bears a transposon which inactivates...
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7135281 |
Screening for papilloma viruses
The invention relates to a method of screening for precursor lesions which can lead to cervical malignancy, methods of detecting and typing human papilloma virus infections, and reagents of use in...
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7135282 |
Viral particles with exogenous internal epitopes
The present invention relates to the expression of peptides on viral particles, and more particularly to the expression of peptides on the interior or the viral capsid. Methods are described for...
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7135278 |
Method of screening for therapeutics for infectious diseases
The present invention relates to a method of screening for a host cell gene products which are useful as therapeutics for an infective disease. This method comprises identifying genes which are...
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7132237 |
Avian leukosis viruses and polypeptide display
The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules,...
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7132233 |
Identification of oligonucleotides for the capture, detection and quantitation of West Nile virus
West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the...
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