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7264923 |
Norovirus infected cell cultures and uses therefor
A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and...
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RE39815 |
Method for determining ion channel activity of a substance
A method for determining the ion channel activity of a substance comprises the steps of (i) expressing the substance as a heterologous protein in a host cell, and (ii) determining changes in...
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7262051 |
Use of biscistronic DNA constructs for identifying compounds that inhibit IRES-dependent translation
The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or...
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7255864 |
Diagnostic reagent for hepatitis C virus infection
A diagnostic reagent for hepatitis C virus infection obtained by sensitizing a solid phase with HCV antigen and a conjugated antigen prepared by chemical bonding of HCV antigen and a carrier...
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7255986 |
Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets
The present invention relates to the use of novel nucleotide sequences for the M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic...
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7255992 |
Methods for rapid detection and identification of bioagents for environmental and product testing
The present invention provides methods for rapid detection of bioagents for environmental and product testing. The methods can be used for testing air, water, soil, surfaces of buildings,...
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7253277 |
Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes
This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention...
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7252944 |
Methods and compositions for modulating cell proliferation
This invention provides methods for identifying novel SHMT modulators. The methods comprise first screening test agents for modulators of p38 activity and then further screening the identified...
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7252997 |
Structural protein of adeno-associated virus with modified antigenicity, its production and its use
The invention relates to a structural protein of adeno-associated virus (AAV) that contains at least one modification that reduces the antigenicity of the virus. The invention further relates to...
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7250251 |
Virion-based fusion assay
The present invention features methods and compositions relating to a virion-based fusion assay for detection of infection of a target cell by an enveloped retroviral virion such as HIV. The assay...
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7247457 |
Detection and identification of enteroviruses by semi-nested amplification of the enterovirus VP1 protein
Disclosed are methods of using enterovirus-specific primers for the detection and identification of enterovirus infection. Also provided are isolated nucleic acid molecules and kits useful for...
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7247425 |
Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a...
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7247439 |
Method of evaluating a patient antibody response to envelope proteins of a virus
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7244578 |
Methods for modeling infectious disease and chemosensitivity in cultured cells and tissues
The present invention provides methods for utilizing a form of optimized suspension culture to examine the infectivity of pathogenic organisms and agents in human cells and tissues. Also provided...
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7244558 |
Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newcastle disease vaccines
The present invention concerns cDNAs for making attentuated, infectious Newcastle disease virus (NDV). Another aspect of the invention relates to methods of making the cDNAs. Another aspect of the...
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7241630 |
Paramagnetic particle detection
A method of determining the number of magnetic particles within a sample using a tuned circuit having a capacitor and a coil. The method comprises:
a. determining the difference in the...
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7241582 |
Diagnostic test kits
This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus...
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7235356 |
Methods of evaluating cell surface receptor binding of a patient derived population of viral envelope protein constructs
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
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7235387 |
Method for mutation detection in HIV-1 using pol sequencing
The present invention relates to a method for mutation analysis of the HIV pol gene of HIV virions comprising amplifying virion RNA or DNA via nested PCR using outer primers as represented in SEQ...
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7235393 |
Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues
A method for isolating AAV viruses from cellular DNA of non-human primate (NHP) tissues by transfecting the DNA of NHP into 293 cells, rescuing the virus and amplifying it through serial passages...
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7232564 |
Methods of polyvalent bacteriophage preparation for the treatment of bacterial infections
The multivalent strains of bacteriophages, methods of obtaining these and their use in the treatment of bacterial infections, particularly those of drug-resistant bacterial strains, especially...
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7229777 |
Hairpin peptides with a novel structural motif and methods relating thereto
The invention is directed to a model system for structure-activity relationship analysis of peptide or protein molecules involved in important biological processes. Provided by the invention are...
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7229754 |
Sensing phage-triggered ion cascade (SEPTIC)
The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that...
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7226603 |
HBV core antigen particles with multiple immunogenic components attached via peptide ligands
This invention relates to hepatitis B virus (“HBV”) core antigen particles that are characterized by multiple immunogen specificities. More particularly, the invention relates to HBV core...
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7227632 |
Assembly for the optical illumination of a plurality of samples
An assembly for an optical read out device for biochips, in which in a manner known per se an optical path of light that is emitted from the samples is evaluated by a CCD camera. For this purpose,...
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7226774 |
Signal for packaging of influenza virus vectors
The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and...
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7223535 |
Synthetic peptides immunoreactive with hepatitis A virus antibodies
Synthetic peptides immunoreactive with hepatitis A virus (HAV) antibodies are provided. The peptides are useful as laboratory reagents to detect or quantify HAV antibodies in biological samples in...
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7223534 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the...
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7220405 |
Peptide-based conditioners and colorants for hair, skin, and nails
Peptides have been identified that bind with high affinity to hair, skin, and nails. Peptide-based hair conditioners, hair colorants, skin conditioners, skin colorants, and nail colorants are...
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7220540 |
Methods for detecting bacteriophage MS2
The present invention relates to methods and assays for detecting bacteriophage MS2 in a sample.
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7217512 |
Reagent and method for attaching target molecules to a surface
The present invention provides a method and reagent composition for attachment of target molecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides,...
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7217506 |
Mutational profiles in HIV-1 protease correlated with phenotypic protease inhibitor resistance
The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention...
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7217507 |
Method for detecting ligands and targets in a mixture
The invention provides a method of characterizing a target that binds to a ligand. The method comprises providing ligands, optionally attached to a support, and contacting the ligands with targets...
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7211378 |
Filovirus vectors and noninfectious filovirus-based particles
Cloned filovirus genomic cDNA and methods of using the cDNA are provided. Further provided are noninfectious lipid encapsulated filovirus-based particles.
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7211379 |
Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
Provided is a method for reducing viral load of porcine circovirus type 2 (PCV-2) in a pig by inducing an immune response against PCV-2 through the administration of an immunogenic composition...
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7211659 |
Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and...
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7208293 |
Directed evolution of novel binding proteins
In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal...
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7205280 |
Methods of suppressing microglial activation
Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral...
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7205101 |
Human immunodeficiency virus (HIV) nucleotide sequences, recombinant polypeptides, and applications thereof
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7204980 |
Methods for inhibiting viral replication in vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a...
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7205155 |
Method for the determination of substances using the evanescence field method
This invention relates to a method for the determination of substances using the evanescence field method. A cuvette, a microtiter well, a solution and a kit for application in a method according...
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7205100 |
Methods for reducing background fluorescence
This invention relates to methods for reducing background fluorescence in cell detection and measurement systems. In accordance with one aspect of the invention, cell-impermeant chemical agents are...
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7202021 |
Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an...
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7201902 |
Production of recombinant protein pap 31 for the diagnosis and prevention of Bartonella bacilliformis infection
The invention relates to a recombinant DNA and polypeptide sequence of an immuno-dominant phage particle associated protein from Bartonella bacilliformis . The recombinant protein is easily...
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7198934 |
Recombinant MVA virus, and the use thereof
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the...
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7198923 |
Method for the preparation of purified HCV RNA by exosome separation
The invention relates to a method for the isolation of hepatitis C virus. The method comprises the separation of particles termed exosomes from the blood plasma of an individual infected with...
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7198891 |
Hepatitis C virus peptides and uses thereof
Novel hepatitis C virus (HCV) polypeptides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine...
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7198793 |
Bovine immunodeficiency virus (BIV) based vectors
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a)...
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7195874 |
Detecting targets in heterologous mixtures
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily...
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7196183 |
Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
The present invention relates to genomic nucleotide sequences and amino acid sequences corresponding to the non-coding and coding region of a new type of HCV. The invention relates to new HCV types...
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