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7323331 |
Method for detecting or assaying HBV
A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody...
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7320857 |
Characterization of the earliest stages of the severe acute respiratory syndrome (SARS) virus and uses thereof
Severe Acute Respiratory Syndrome (“SARS”) is a human respiratory disease of recent origin, widespread infectivity, recurring incidence, and significant mortality. Although there is abundant...
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7320875 |
Hepatitis C virus E2 binding protein
HCV assays are described. The assays utilize a 24 kd protein capable of binding the E2 envelope protein of hepatitis C virus (HCV), or functionally equivalent variants or fragments of the 24 kd...
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7319001 |
High throughput system for producing recombinant viruses using site-specific recombination
Disclosed are the methods for producing recombinant viruses using site-specific recombination in vitro. In the present invention, circular viral genomic DNAs are digested with restriction enzymes...
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7319012 |
Protein arrays and methods and systems for producing the same
Methods of rapidly generating and analyzing a plurality of polypeptides are disclosed. More specifically, libraries and arrays of polypeptides are assayed in order to determine their individual...
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7319000 |
Compositions and methods for eliciting immune or anti-infective responses
Disclosed are compositions and methods for the prevention and treatment of viral infections. The identification of distinct classes of peptides for use in both anti-viral vaccines and therapeutic...
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7316898 |
Method of determining adenovirus particle concentration
The invention discloses a simple, accurate and reproducible method of determining viral particle concentration, especially for any serotype of adenovirus. More specifically, an accurate...
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7316905 |
Method for measurement of hepatitis C virus
A method for measurement of the hepatitis C virus (HCV) characterized by measuring HCV core antigen and HCV core antibody by their binding with probes in the presence of an anionic surfactant or a...
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7314710 |
Method for replicating the hepatitis C virus
The invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for...
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7312031 |
Alpha-complementation viral fusion assay
The present invention relates to the use of an alpha complementation assay as a quick, effective, and safe method for the detection of cell fusion mediated by viral proteins. Additionally, the...
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7312090 |
Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical...
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7311918 |
Rotavirus subunit vaccine
The present invention is directed to the generation and use of recombinant rotavirus fusion proteins as immunogens to produce a protective immune response from immunized individuals. In one...
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7312030 |
Adaptation sites of porcine reproductive and respiratory syndrome virus
A method for determining the capability of an arterivirus to replicate in a permissive cell is disclosed. The method includes determining an amino acid at a position that corresponds to an amino...
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7312041 |
Methods of diagnosing cervical cancer
The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal...
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7309566 |
Genetically biotinylated recombinant antibody in immunofiltration assay by light addressable potentiometric sensor for identification of Venezuelan equine encephalitis virus
A genetically biotinylated single chain fragment variable (scFv) antibody against Venezuelan equine encephalitis virus (VEE) being applied in a system consisting of an immunofiltration-enzyme assay...
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7309593 |
Attachment of molecules to surfaces
The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present...
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7309598 |
gM-negative EHV-mutants
This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of...
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7306902 |
Oncolytic viruses as phenotyping agents for neoplasms
The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For...
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7306901 |
Methods and means for assessing HIV envelope inhibitor therapy
The present invention relates to methods and products for the evaluation of HIV treatment. In particular, molecular events at the HIV envelope protein and their effect on therapeutic efficacy of...
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7306807 |
Hemorrhagic feline calicivirus, calicivirus vaccine and method for preventing calicivirus infection or disease
The present invention relates to a novel, isolated and purified hemorrhagic feline calicivirus FCV-DD1. The invention further embraces monovalent and multivalent vaccines containing the new FCV-DD1...
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7303913 |
Rapid diagnostic methods of Peste des Petits Ruminants using recombinant nucleocapsid protein expressed in insect cells and monoclonal antibody
The present invention relates to a diagnostic method of Peste des Petits Ruminants (PPR), a viral animal disease. More specifically, the invention relates to a new diagnostic method capable of...
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7300658 |
Recombinant poxvirus comprising at least two compox ATI promoters
Recombinant poxvirus are disclosed comprising in the viral genome at least two expression cassettes, each comprising a cowpox ATI promoter according to SEQ ID NO:1, a polynucleotide sequence in...
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7300750 |
Analyte assay device with preabsorbing zone
The present invention provides an assay device for detection of an analyte which is a member of a specific binding partner in a sample, the assay device comprising a sample application zone, a...
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7297476 |
Method of monitoring HIV assembly and maturation
The present invention provides methods to characterize the structure, stability, and intersubunit interfaces between the matrix, capsid, and nucleocapsid domains of the Gag polyprotein during HIV...
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7297477 |
Methods and compositions for detecting viral nucleic acid in a cell
Methods and compositions for identifying or detecting viral nucleic acids in a host cell are described. DNA fragments are bound to DNA-binding protein in a host cell and enriched using...
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7294502 |
Device for collecting liquid samples
The invention relates to a device for collecting samples of fluids, in particular of body fluids such as saliva, said device comprising an absorbent pad and two housing parts which are connected to...
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7294457 |
Direct binding assay for identifying inhibitors of HCV polymerase
A method for identifying compounds binding to HCV polymerase comprising the steps of: contacting said HCV polymerase or an analog thereof with a probe formula I:
wherein A is O, S, N, NR 1 , or...
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7294458 |
Analysis of HIV-1 coreceptor use in the clinical care of HIV-1-infected patients
A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown...
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7291453 |
Viral variants
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the...
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7291452 |
Erythrovirus and its applications
The invention concerns nucleic acids derived from human V9 erythrovirus, fragments thereof, encoded polypeptides, and applications as diagnostic reagents and as immunogenic agents.
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7291337 |
Peptide having an affinity for gp120
The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R(SEQ ID No. 1)
(in the formula,
H means hydrogen, A1 is aspartic...
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7288369 |
Replication competent hepatitis C virus and methods of use
The present invention provides a replication competent hepatitis C virus that includes a heterologous polynucleotide. The invention also includes methods for modifying a hepatitis C virus...
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7285381 |
Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same
The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also...
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7285382 |
Compositions and methods for treatment of cancer
The present invention concerns compositions and methods for the treatment of disorders characterized by the over-expression of an LIV-1. More specifically, the compositions include DNA and amino...
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7285271 |
Antigenic composition comprising an HIV gag or env polypeptide
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7282599 |
Dithiocarbamate antiviral agents and methods of using same
The invention discloses a use of dithiocarbamate compounds having the structural formula R 1 R 2 NCS 2 H, in which R 1 and R 2 , independently of each other, represent a straight or branched C 1...
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7282341 |
Assay for the diagnosis of flaviviral infection using antibodies with high affinity for NS1 protein of flavivirus in hexameric form
The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the...
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7279275 |
Methods and compositions for detection of segmented negative strand RNA viruses
The present invention provides compositions and methods for the detection of the presence, absence, or quantity of a segmented negative strand RNA virus such as an influenza virus. A genetically...
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7276333 |
Viral infection inhibitor targeting integrase N-terminal domain
The object of the present invention is to provide a screening method of a new integrase inhibitor being able to inhibit an HIV infection before the reverse transcription step and having a...
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7276373 |
Surrogate cell-based system and method for assaying the activity of hepatitis C virus NS3 protease
The present invention concerns the development of a cell-based assay system having improved sensitivity to HCV NS3 protease activity when compared to known assays, which is useful for screening...
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7276579 |
Immunogenic proteoliposomes, and uses thereof
An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or...
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7276334 |
Construction and characterization of monoclonal antibodies against western equine encephalitis virus
Construction and characterization of mouse monoclonal antibodies against western equine encephalitis virus (WEE) for potential use in detection, diagnosis, and immunotherapy are disclosed....
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7273695 |
HIV immunoassays using synthetic envelope polypeptides
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7271886 |
Uncaging device
Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged...
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7267955 |
Method for detecting loss of wild-type p53
Methods are provided for restoring wild-type p53 gene function to a cell. Such methods include gene therapy. Typically, this will stop tumor cells from proliferating.
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7267993 |
Phage ligand sensor devices and uses thereof
Methods and compositions for identifying and characterizing one or more ligands of a peptide are provided. In particular, the invention provides a phage ligand sensor device (PLSD) comprising a...
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7267940 |
HSV-2 type-specific immunoassays using glycoprotein G2 peptides
The present invention relates to peptides that are derived from HSV-2 glycoprotein G2 and represent HSV-2 type-specific epitopes. The present invention also provides for compositions comprising...
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7267957 |
Detection and amplification of ligands
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding...
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7267942 |
Diagnostic assay for the human virus causing severe acute respiratory syndrome (SARS)
The present invention relates to a diagnostic assay for the virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). In particular, the invention relates to a real-time...
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7264958 |
Method for obtaining a purified viral preparation
The invention concerns a method for purifying a crude viral preparation containing viral, in particular adenoviral, particles of interest. The invention is characterised in that it comprises a step...
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