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6979535 |
Human immunodeficiency virus type 2 (HIV-2) env polypeptide and diagnostic assays
A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a...
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6977180 |
Biosensor
The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is...
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6977144 |
Sid nucleic acids and polypeptides selected from a pathogenic strain of hepatitis C virus and applications thereof
The present invention relates to nucleic acids encoding SID® polypeptides which bind selectively to a polypeptide encoded by a pathogenic strain of the hepatitis C virus, as well as to the SID®...
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6974686 |
Recombinant tryptophan mutants of influenza
Recombinant PB2 tryptophan variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such...
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6972179 |
RRP sequences and knockout mice and uses thereof
RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of...
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6969584 |
Combinatorial enzymatic complexes
The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.
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6969598 |
Methods for producing high titre vectors and compositions used in such methods
A method for producing viral vectors is described using packaging and producer cell lines is described. The producer cell comprises: (i) a first nucleotide sequence (NS) encoding a toxic viral...
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6969583 |
Method for detecting variant HBV
The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a...
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6967075 |
HCV replicase complexes
This invention provides efficient HCV replicase complexes comprising novel RNA template and primer pair. Assay systems are also provided, which use such complexes, for detecting replicase activity,...
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6967076 |
Method for producing recombinant cells for detecting HIV
Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into...
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6964763 |
Methods and compositions for inhibiting HIV infectivity and blocking chemokine activity
The present invention relates to a method for suppressing infectivity of HIV which includes contacting the HIV or a cell targeted by HIV with an effective amount of a thrombospondin or a...
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6964843 |
Methods and reagents for the detection of antibodies to adenovirus
The present invention provides methods and reagents for detecting antibodies to adenovirus. In a preferred embodiment, the present invention is useful for detecting antibodies to adenovirus...
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6964852 |
Antigenic structural peptide, antigenic and immunogenic compounds, and uses for detecting, preventing and treating an HCV infection
The invention concerns a structural peptide, identified by antibodies directed against a polypeptide, comprising the 2-45 amino acid sequence of the N-terminal end of the Core or nucleocapsid (p21)...
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6960429 |
Inhibition of viral gene activities
A method of inhibiting viral gene activities (and cellular gene activities) is disclosed. In one embodiment, the method comprises the step of delivering an effective amount of an inhibitor of a...
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6960442 |
Immunoreactive regions of glycoprotein gpII of varicella zoster virus (VZV)
The present invention relates to immunoreactive peptides that are homologous with the region encompassing amino acid positions 450 to 655 of glycoprotein II of varicella zoster virus. In this...
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6960431 |
Therapeutic compositions and methods for treating viral infection
Methods for inhibiting viral propagation and treating viral infection are provided which include administering to cells infected with viruses a therapeutic peptide or a derivative thereof.
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6958210 |
Detection of herpes simplex virus
The invention provides methods to detect herpes simplex virus (HSV) in biological samples and further to distinguish between HSV-1 and HSV-2. Primers and probes for the differential detection of...
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6953661 |
Method of preventing transport of a neurotropic virus and identifying agents for achieving same
A method of preventing transport of a Herpes simplex virus within a neuron, comprising preventing interaction between a structural tegument protein US11 of the virus and a motor protein, Kinesin in...
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6951717 |
Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission
Parainfluenza virus types 1 to 4 (PIV1 to PIV4) are important human pathogens that cause upper and lower respiratory tract infections, particularly in infants and children. The claimed invention is...
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6951715 |
Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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6951761 |
Measurements of multiple molecules using a CryoArray
This disclosure relates to CryoArrays, which permit the analysis of samples (such as protein, nucleic acid, virus, or cell samples) in arrays that are prepared at low temperatures. Because...
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6951732 |
Virulence genes, proteins, and their use
A series of genes from Streptococcus pyogenes are shown to encode products which are implicated in virulence. The identification of these genes therefore allows attenuated microorganisms to be...
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6949353 |
Capping enzyme of flavivirus and utilization of this protein in a process to test drugs with antiviral properties
This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of flavivirus (CEF). The invention also...
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6949337 |
Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle
The present invention provides methods of identifying anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment...
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6949349 |
Insulin-like growth factor agonist molecules
Compounds are provided that inhibit the interaction of an IGF with any one of its binding proteins and not to a human IGF receptor. These IGF agonist compounds, which include peptides, are useful...
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6946125 |
Methods of treating West Nile virus infection
The present invention provides methods of preventing or treating West Nile virus as well as infections caused by other viruses of the Flaviviridae family in animals comprising administering to the...
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6946285 |
Arrays with elongated features
Arrays having multiple biopolymer features on a substrate, including elongated features which have a length/width ratio greater than 1.3 or more. Such arrays may be oriented in various directions...
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6946252 |
Sample preparation method and a sample preparation apparatus for DNA analysis
A sample preparation apparatus for DNA analysis comprises a holder for separating specific primers on the basis of size, color, weight, dimension, or degree of magnetization, the specific primers...
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6942858 |
Compositions containing bacteriophages and methods of using bacteriophages to treat infections
Purified, host-specific, non-toxic, wide host range and virulent bacteriophage preparations that are effective in killing bacterial organisms in vivo are disclosed. Also disclosed are compositions...
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6942965 |
Hepatitis A virus nucleotide sequences, recombinant proteins and uses thereof
Hepatitis A virus primers and probes derived from the capsid proteins and junction between the capsid precursor P1 and 2A of the HAV genome are disclosed. Also disclosed are nucleic acid-based...
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6939672 |
Nucleic acid extraction solution and use thereof
Disclosed are methods and compositions for extracting nucleic acids from a biological sample. In particular, disclosed is a nucleic acid extraction solution together with methods using such a...
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6936251 |
Peptide reagent for the detection of human cytomegalovirus (CMV)
The invention relates to a peptide reagent comprising peptides immunochemically reactive with antibodies to the human cytomegalovirus (CMV). New antibodies directed to said peptides or fragments...
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6936256 |
Sub-unit vaccine for infectious pancreatic necrosis virus
The present invention relates to sub-unit vaccines comprising structural polypeptides of Infectious Pancreatic Necrosis Virus (IPNV) comprising structural proteins VP2 and VP3 folded as an empty...
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6936455 |
Production of heterologous proteins using an Npro autoprotease of a pestivirus and inclusion bodies
The present invention relates to a process for the recombinant production of a desired heterologous polypeptide with a clearly defined homogenous N-terminus in a bacteria host cell. A fusion...
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6933108 |
Methods and compositions for use in the treatment of filovirus mediated disease conditions
Methods and compositions are provided for at least slowing the progression of a filovirus mediated disease condition in a host. In the subject methods, an effective amount of an agent that at least...
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6933123 |
Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers
An isolated protein sequence or peptide from the E2, E6 or E7 early coding region of human papillomavirus (HPV) that is soluble in an aqueous medium, and characterized by a relative paucity of...
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6933109 |
Rapid particle detection
Methods and reagents for rapid purification and/or identification of particles in a liquid sample are described. The technique uses centrifugation to concentrate particles against a slanted surface...
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6927281 |
Adeno-associated virus-its diagnostic use with early abortion
The present invention relates to a method of detecting a causative agent of the so-called spontaneous early abortion by investigating patients' samples for the presence of adeno-associated virias...
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6927031 |
Methods for identifying polypeptide factors interacting with RNA
The present invention relates to methods of screening for target polypeptides that bind to RNA, using affinity purification methods, and the use of such target polypeptide for drug discovery and in...
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6927023 |
Method of identifying modulators of HIV-1 Vpu and Gag interaction with U binding protein (Ubp)
A preparation of U binding protein (Ubp) and a gene sequence encoding Ubp and an anti-Ubp antibody are disclosed. An assay to identify modulators of Ubp/Vpu interaction and Gag/Ubp interaction is...
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6924094 |
Chip-based species identification and phenotypic characterization of microorganisms
This invention provides oligonucleotide based arrays and methods for speciating and phenotyping organisms, for example, using oligonucleotide sequences based on the Mycobacterium tubercluosis rpoB...
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6924362 |
Monoclonal antibodies specific for the E2 glycoprotein of hepatitic C virus and their use in the diagnosis, treatment, and prevention of hepatitis C
The present invention describes the identification and characterization of five human HC E1-specific monoclonal antibodies isolated from a phage display library and their use in the diagnosis,...
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6924095 |
Retrovirus isolated from mantle histiocytes in mantle cell lymphoma
The present invention features an isolated, intact virus associated with human lymphoma, and originally isolated from a mantle cell lymphoma, referred to herein as a mantle histiocyte retrovirus...
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6923971 |
Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes
Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are constructed by insertion, deletion or rearrangement...
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6921634 |
Replication competent hepatitus C virus and methods of use
The present invention provides a replication competent hepatitis C virus that includes a heterologous polynucleotide. The invention also includes methods for modifying a hepatitis C virus...
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6919196 |
Parvovirus NS1 variants
The present invention relates to a parvovirus NS1 variant having a shifted equilibrium between the DNA replication and transcription activities (a) and the cytotoxicity activity (b). Furthermore,...
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6919438 |
Nucleic sequence and deduced protein sequence family with human endogenous retroviral motifs, and their uses
The invention concerns a novel nucleic sequence and deduced protein sequence family with whole or partial human endogenous retroviral motifs. The invention also concerns the detection and/or the...
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6919173 |
Assay buffer, compositions containing the same, and methods of using the same
Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide...
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6916665 |
Biosensor compositions and methods of use
Provided are pore-subunit polypeptides covalently linked to one or more sensing moieties, and uses of these modified polypeptides to detect and/or measure analytes or physical characteristics...
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6916606 |
Electrochemiluminescent assays
Qualitative and quantitative electrochemiluminescent assays for analytes of interest present in multicomponent liquids are provided. These methods comprise contacting a sample with a reagent...
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